The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome
Open accessAbstract
Prostate cancer (PCa) contains a small population of cancer stem cells (CSCs) that contribute to its initiation and progression. The development of specific markers for identification of the CSCs may lead to new diagnostic strategies of PCa. Increased aldehyde dehydrogenase 1A1 (ALDH1A1) activity has been found in the stem cell populations of leukemia and some solid tumors. The aim of the study was to investigate the stem-cell-related function and clinical significance of the ALDH1A1 in human PCa. ALDEFLUOR assay was used to isolate ALDH1A1+ cells from PCa cell lines. Stem cell characteristics of the ALDH1A1+ cells were then investigated by in vitro and in vivo approaches. The ALDH1A1 expression was also analyzed by immunohistochemistry in 18 normal prostate and 163 PCa tissues. The ALDH1A1+ PCa cells showed high clonogenic and tumorigenic capacities, and serially reinitiated transplantable tumors that resembled histopathologic characteristics and heterogeneity of the parental PCa cells in mice. Immunohistochemical analysis of human prostate tissues showed that ALDH1A1+ cells were sparse and limited to the basal component in normal prostates. However, in tumor specimens, increased ALDH1A1 immunopositivity was found not only in secretory type cancer epithelial cells but also in neuroendocrine tumor populations. Furthermore, the high ALDH1A1 expression in PCa was positively correlated with Gleason score (P=0.01) and pathologic stage (P=0.01), and inversely associated with overall survival and cancer-specific survival of the patients (P=0.00093 and 0.00017, respectively). ALDH1A1 could be a prostate CSC-related marker. Measuring its expression might provide a potential approach to study tumorigenesis of PCa and predict outcome of the disease.
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Cites
Stem cells, cancer, and cancer stem cells
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Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer
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Self-citationCD133, a novel marker for human prostatic epithelial stem cells
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Zhao, J. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.02.008 · Cited by 437
A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms
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Aldehyde Dehydrogenases: Not Just Markers, but Functional Regulators of Stem Cells
Vassalli, G. (2019) · Stem Cells International · doi:10.1155/2019/3904645 · Cited by 300
Devalaraja, S., To, T. K. J., Folkert, I. W., Natesan, R., Alam, M. Z., Li, M., Tada, Y., Budagyan, K., Dang, M. T., Zhai, L., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.042 · Cited by 257
Chemical approaches to targeting drug resistance in cancer stem cells
Sotiropoulou, P. A., Christodoulou, M. S., Silvani, A., Herold-Mende, C., & Passarella, D. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.05.002 · Cited by 100
Metadata
- Authors
- Li, T., Su, Y., Mei, Y., Leng, Q., Leng, B., Liu, Z., Stass, S. A., & Jiang, F.
- Venue
- Laboratory Investigation
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 90
- Issue
- 2
- Pages
- 234-244
- ISSN
- 0023-6837 (ISSN-L)
- OpenAlex
- W2012619882
- Cited by
- 362
- References
- 31
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, T., Su, Y., Mei, Y., Leng, Q., Leng, B., Liu, Z., Stass, S. A., & Jiang, F. (2010). ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Laboratory Investigation. https://doi.org/10.1038/labinvest.2009.127
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