Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate cells
Open accessAbstract
Accumulating evidence indicates that Hedgehog (Hh) signaling becomes activated in chronic liver injury and plays a role in the pathogenesis of hepatic fibrosis. Hepatic stellate cells (HSCs) are Hh-responsive cells and activation of the Hh pathway promotes transdifferentiation of HSCs into myofibroblasts. Targeting Hh signaling may be a novel therapeutic strategy for treatment of liver fibrosis. We previously reported that curcumin has potent antifibrotic effects in vivo and in vitro, but the underlying mechanisms are not fully elucidated. This study shows that curcumin downregulated Patched and Smoothened, two key elements in Hh signaling, but restored Hhip expression in rat liver with carbon tetrachloride-induced fibrosis and in cultured HSCs. Curcumin also halted the nuclear translocation, DNA binding, and transcription activity of Gli1. Moreover, the Hh signaling inhibitor cyclopamine, like curcumin, arrested the cell cycle, induced mitochondrial apoptosis, reduced fibrotic gene expression, restored lipid accumulation, and inhibited invasion and migration in HSCs. However, curcumin's effects on cell fate and fibrogenic properties of HSCs were abolished by the Hh pathway agonist SAG. Furthermore, curcumin and cyclopamine decreased intracellular levels of adenosine triphosphate and lactate, and inhibited the expression and/or function of several key molecules controlling glycolysis. However, SAG abrogated the curcumin effects on these parameters of glycolysis. Animal data also showed that curcumin downregulated glycolysis-regulatory proteins in rat fibrotic liver. These aggregated data therefore indicate that curcumin modulated cell fate and metabolism by disrupting the Hh pathway in HSCs, providing novel molecular insights into curcumin reduction of HSC activation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bleomycin-induced fibrosis, but not inflammation, is inhibited in chimaeric mice with Cebpb−/− haematopoietic cells, and adoptive transfer of SatM into Cebpb−/− mice results in fibrosis.
“Bleomycin-induced fibrosis, but not inflammation, was inhibited in chimaeric mice with Cebpb−/− haematopoietic cells, and adoptive transfer of SatM into Cebpb−/− mice resulted in fibrosis.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [68]
A newly identified population of atypical monocytes termed segregated-nucleus-containing atypical monocytes (SatM) plays a key role in lung fibrogenesis.
“a newly identified population of atypical monocytes carcinoembryonic antigen-related adhesion molecules (Ceacam)1+Msr1+Ly6C−F4/80−Mac1+ monocytes)68 termed segregated-nucleus-containing atypical monocytes (SatM) and sharing granulocyte characteristics, have been shown to play a key role in lung fibrogenesis.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [68]
SatM are derived from Ly6C−FcεRI+ granulocyte/macrophage progenitors, but not from macrophage/dendritic cell progenitors.
“Interestingly, SatM were derived from Ly6C−FcεRI+ granulocyte/macrophage progenitors, but not from macrophage/dendritic cell progenitors.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [68]
SatM are regulated by C/EBPβ, and Cebpb deficiency leads to a complete deficiency of SatM.
“SatM were found to be regulated by CCAAT/enhancer binding protein β (C/EBPβ), with Cebpb deficiency leading to a complete deficiency of SatM.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [68]
Several recent studies have identified subpopulations of monocytes and macrophages that can regulate fibrosis and tissue remodelling.
“Several recent studies have identified subpopulations of monocytes and macrophages which have the capacity to regulate fibrosis and tissue remodelling18,61,68–71.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [68]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Transcriptional regulation of adipogenesis.Preprint
Rosen, E., Walkey, C., Puigserver, P., & Spiegelman, B. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 2,180 · see citing works
Pathogenesis of Liver Fibrosis
Hernandez-Gea, V., & Friedman, S. L. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130246 · Cited by 1,809 · see citing works
Schmittgen, T. D., Zakrajsek, B. A., Mills, A., Gorn, V. V., Singer, M. J., & Reed, M. W. (2000) · Analytical Biochemistry · doi:10.1006/abio.2000.4753 · Cited by 1,036 · see citing works
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
Satyanarayana, A., & Kaldis, P. (2009) · Oncogene · doi:10.1038/onc.2009.170 · Cited by 772 · see citing works
Hepatic stellate cells in liver development, regeneration, and cancer
Yin, C., Evason, K. J., Asahina, K., & Stainier, D. Y. R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66369 · Cited by 719 · see citing works
Katoh, Y., & Katoh, M. (2009) · Current Molecular Medicine · doi:10.2174/156652409789105570 · Cited by 525 · see citing works
Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E
Duman‐Scheel, M., Weng, L., Xin, S., & Du, W. (2002) · Nature · doi:10.1038/417299a · Cited by 434 · see citing works
Fu, Y., Zheng, S., Lin, J., Ryerse, J. S., & Chen, A. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.039818 · Cited by 394 · see citing works
Self-citationHedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism
Chen, Y., Choi, S. S., Michelotti, G., Chan, I. S., Swiderska-Syn, M., Karaca, G., Xie, G., Moylan, C. A., Garibaldi, F., Premont, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.115 · Cited by 279 · see citing works
Hedgehog signaling in the liver
Omenetti, A., Choi, S. S., Michelotti, G. A., & Diehl, A. M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.10.003 · Cited by 278 · see citing works
Transcriptional Regulation of bcl-2 Mediated by the Sonic Hedgehog Signaling Pathway through gli-1
Bigelow, R. L. H., Chari, N. S., Undén, A. B., Spurgers, K. B., Lee, S., Roop, D. R., Toftgård, R., & McDonnell, T. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310589200 · Cited by 248 · see citing works
Xu, J., Fu, Y., & Chen, A. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00474.2002 · Cited by 220 · see citing works
Choi, S. S., Omenetti, A., Witek, R. P., Moylan, C. A., Syn, W.-K., Jung, Y., Yang, L., Sudan, D. L., Sicklick, J. K., Michelotti, G. A., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00292.2009 · Cited by 219 · see citing works
Guy, C. D., Suzuki, A., Zdanowicz, M., Abdelmalek, M. F., Burchette, J. L., Ünalp, A., & Diehl, A. M. (2011) · Hepatology · doi:10.1002/hep.25559 · Cited by 217 · see citing works
Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
Yang, L., Wang, Y., Mao, H., Fleig, S. V., Omenetti, A., Brown, K. D., Sicklick, J. K., Li, Y., & Diehl, A. M. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.07.032 · Cited by 200 · see citing works
Balordi, F., & Fishell, G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1040-07.2007 · Cited by 173 · see citing works
Zhang, F., Zhang, Z., Chen, L., Kong, D., Zhang, X., Lu, C., Lu, Y., & Zheng, S. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12286 · Cited by 135 · see citing works
Self-citationBao, W., Li, K., Rong, S., Yao, P., Hao, L., Ying, C., Zhang, X., Nussler, A. K., & Liu, L. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.01.029 · Cited by 127 · see citing works
Elamin, M. H., Shinwari, Z., Hendrayani, S., Al‐Hindi, H., Shail, E. A., Khafaga, Y., Al‐Kofide, A., & Aboussekhra, A. (2009) · Molecular Carcinogenesis · doi:10.1002/mc.20604 · Cited by 126 · see citing works
Jung, Y., McCall, S. J., Li, Y., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21660 · Cited by 122 · see citing works
The hedgehog pathway regulates remodelling responses to biliary obstruction in rats
Omenetti, A., Popov, Y. V., Jung, Y., Choi, S. S., Witek, R. P., Yang, L., Brown, K. D., Schuppan, D., & Diehl, A. M. (2008) · Gut · doi:10.1136/gut.2008.148619 · Cited by 122 · see citing works
The role of Hedgehog signaling in fibrogenic liver repair
Choi, S. S., Omenetti, A., Syn, W., & Diehl, A. M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.10.015 · Cited by 117 · see citing works
Zheng, S., & Chen, A. (2004) · Biochemical Journal · doi:10.1042/bj20040928 · Cited by 115 · see citing works
Self-citationWang, M., Chen, Y., Chen, I.-S., Hsieh, S., Chen, S., & Chiu, C. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.08.004 · Cited by 115 · see citing works
Sun, X., LIU, X.-E., & Huang, D. (2013) · Oncology Reports · doi:10.3892/or.2013.2385 · Cited by 111 · see citing works
Zhou, Y., Zheng, S., Lin, J., Zhang, Q.-J., & Chen, A. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700532 · Cited by 94 · see citing works
Self-citationHedgehog Signaling in Germ Cell Migration
Deshpande, G., Swanhart, L. M., Chiang, P., & Schedl, P. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00488-3 · Cited by 92 · see citing works
Anti‐adipogenic regulation underlies hepatic stellate cell transdifferentiation
Tsukamoto, H., She, H., Hazra, S., Cheng, J. H., & Miyahara, T. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04573.x · Cited by 88 · see citing works
Wang, K., Fan, H., Chen, Q., Ma, G., Ming, Z., Zhang, X., Zhang, Y., & Yu, J. (2014) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000132 · Cited by 88 · see citing works
Fleig, S. V., Choi, S. S., Yang, L., Jung, Y., Omenetti, A., VanDongen, H. M. A., Huang, J., Sicklick, J. K., & Diehl, A. M. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700689 · Cited by 85 · see citing works
Zheng, S., & Chen, A. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00450.2005 · Cited by 85 · see citing works
Self-citationKatoh (2009) · International Journal of Oncology · doi:10.3892/ijo_00000328 · Cited by 81 · see citing works
Mo, W., Xu, X., Xu, L., Wang, F., Ke, A., Wang, X., & Guo, C. (2011) · Pancreatology · doi:10.1159/000333542 · Cited by 78 · see citing works
Bhatia, B., Hsieh, M., Kenney, A. M., & Nahle, Z. A. (2010) · Oncogene · doi:10.1038/onc.2010.454 · Cited by 77 · see citing works
Zheng, S., & Chen, A. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00200.2006 · Cited by 77 · see citing works
Self-citationTang, Y., & Chen, A. (2010) · Endocrinology · doi:10.1210/en.2010-0191 · Cited by 65 · see citing works
Hedgehog pathway regulators influence cervical cancer cell proliferation, survival and migration
Samaržija, I., & Beard, P. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.051 · Cited by 58 · see citing works
Zhang, Z., Guo, Y., Zhang, S., Zhang, Y., Wang, Y., Ni, W., Kong, D., Chen, W., & Zheng, S. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.09.042 · Cited by 57 · see citing works
Self-citationBao, C., Namgung, H., Lee, J., Park, H.-C., Ko, J., Moon, H., Ko, H. W., & Lee, H. J. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500231t · Cited by 54 · see citing works
Zhang, F., Ni, C., Kong, D., Zhang, X., Zhu, X., Chen, L., Lu, Y., & Zheng, S. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.09.016 · Cited by 53 · see citing works
Self-citationSrinivasan, M., Sudheer, A. R., Pillai, K. R., Kumar, P. R., Sudhakaran, P. R., & Menon, V. P. (2007) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2007.03.001 · Cited by 49 · see citing works
Li, F., Duman‐Scheel, M., Yang, D., Du, W., Zhang, J., Zhao, C., Qin, L., & Xin, S. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.208520 · Cited by 47 · see citing works
Curcumin Attenuates Insulin Resistance in Hepatocytes by Inducing Nrf2 Nuclear Translocation
Zhao, S., Li, Q., Liu, Z., Wang, J., Wang, X.-X., Qin, M., & Qin-sheng, W. (2011) · Hepatogastroenterology · doi:10.5754/hge11219 · Cited by 35 · see citing works
BARRETO, R., KAWAKITA, S., TSUCHIYA, J., Minelli, E., PAVASUTHIPAISIT, K., Helmy, A. M., & Marotta, F. (2005) · Chinese Journal of Digestive Diseases · doi:10.1111/j.1443-9573.2005.00184.x · Cited by 29 · see citing works
Chan, I. S., Guy, C. D., Machado, M. V., Wank, A., Kadiyala, V., Michelotti, G. A., Choi, S. S., Swiderska‐Syn, M., Karaca, G., Pereira, T. A., et al. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12279 · Cited by 29 · see citing works
Quantitative Measurement of GLUT4 Translocation to the Plasma Membrane by Flow Cytometry
Koshy, S., Alizadeh, P., Timchenko, L., & Beeton, C. (2010) · Journal of Visualized Experiments · doi:10.3791/2429 · Cited by 20 · see citing works
Flagged first, then by citations
1 of the 47 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics
Ying, H., Chen, Q., Zhang, W., Zhang, H., Ma, Y., Zhang, S., Fang, J., & Yu, C.-H. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7641 · Cited by 238 · see citing works
Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis
Khomich, O. A., Ivanov, A. V., & Bartosch, B. (2019) · Cells · doi:10.3390/cells9010024 · Cited by 227 · see citing works
Akkız, H., Gieseler, R. K., & Canbay, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147873 · Cited by 191 · see citing works
Wang, F., Chen, L., Kong, D., Zhang, X., Xia, S., Liang, B., Yang, L., Zhou, Y., Zhang, Z., Shao, J., et al. (2023) · Hepatology · doi:10.1097/hep.0000000000000569 · Cited by 168 · see citing works
Self-citationDomitrović, R., & Potočnjak, I. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1580-z · Cited by 155 · see citing works
Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis
Hou, W., & Syn, W. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00150 · Cited by 121 · see citing works
Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step
Weiskirchen, R. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00303 · Cited by 112 · see citing works
Zhang, F., Hao, M., Jin, H., Yao, Z., Lian, N., Wu, L., Shao, J., Chen, A., & Zheng, S. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13701 · Cited by 76 · see citing works
Self-citationYang, J., Tang, X., Zhu, L., Chen, M., & Sun, L. (2023) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0327 · Cited by 70 · see citing works
Zhang, F., Lü, S., He, J., Jin, H., Wang, F., Wu, L., Shao, J., Chen, A., & Zheng, S. (2017) · Theranostics · doi:10.7150/thno.22237 · Cited by 66 · see citing works
Self-citationMicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway
Shi, Y. P., Du, W., Wang, F., Han, B. R., Cui, Y., Yang, D., Chen, H., Liu, D., Liu, X., Zhai, X., et al. (2016) · Cancer Biology & Therapy · doi:10.1080/15384047.2016.1250981 · Cited by 56 · see citing works
Wang, F., Jia, Y., Li, M., Wang, L.-C., Shao, J.-J., Guo, Q.-L., Tan, S., Ding, H., Chen, A.-P., Zhang, F., et al. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0324-8 · Cited by 55 · see citing works
Self-citationAmeer, S. F., Mohamed, M. Y., Elzubair, Q. A., Sharif, E. A. M., & Ibrahim, W. N. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1438040 · Cited by 52 · see citing works
Jin, H., Lian, N., Zhang, F., Bian, M., Chen, X., Zhang, C., Jia, Y., Lu, C., Hao, M., Yao, S., et al. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.10.002 · Cited by 51 · see citing works
Self-citationPan, X., Ma, X., Jiang, Y., Wen, J., Yang, L., Chen, D., Cao, X., & Peng, C. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/7171498 · Cited by 52 · see citing works
Self-citationZhao, S., Zhang, Z., Yao, Z., Shao, J., Chen, A., Zhang, F., & Zheng, S. (2017) · IUBMB Life · doi:10.1002/iub.1598 · Cited by 48 · see citing works
Self-citationLu, Y., Wang, J., Liu, L., Yu, L.-Q., Zhao, N., Zhou, X.-J., & Lu, X. (2017) · Tumor Biology · doi:10.1177/1010428317698353 · Cited by 42 · see citing works
Self-citationNew Concepts on Reversibility and Targeting of Liver Fibrosis; A Review Article
Ebrahimi, H., Naderian, M., & Sohrabpour, A. A. (2018) · Middle East Journal of Digestive Diseases · doi:10.15171/mejdd.2018.103 · Cited by 38 · see citing works
The role of metabolism in the pathogenesis of systemic sclerosis
Zhu, H., Chen, W., Liu, D., & Luo, H. (2018) · Metabolism · doi:10.1016/j.metabol.2018.12.004 · Cited by 38 · see citing works
Ban, D., Hua, S., Zhang, W., Shen, C., Miao, X., & Liu, W. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0179-4 · Cited by 36 · see citing works
MicroRNA Expression Profiling in CCl4-Induced Liver Fibrosis of Mus musculus
Hyun, J., Park, J., Wang, S., Kim, J., Lee, H., Seo, Y., & Jung, Y. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060961 · Cited by 34 · see citing works
Farahmand, L., Darvishi, B., Majidzadeh‐A, K., & Ansari, A. M. (2016) · Cell Proliferation · doi:10.1111/cpr.12299 · Cited by 31 · see citing works
Bian, Y., Yin, G., Wang, G., Liu, T., Liang, L., Yang, X., Zhang, W., & Tang, D. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09681-2 · Cited by 30 · see citing works
Ramos‐Tovar, E., & Muriel, P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814466-4.00009-4 · Cited by 29 · see citing works
Curcumin increases efficiency of γ-irradiation in gliomas by inhibiting Hedgehog signaling pathway
Meng, X., Cai, J., Liu, J., Han, B. R., Gao, F., Gao, W., Zhang, Y., Zhang, J., Zhao, Z., & Jiang, C. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1320000 · Cited by 27 · see citing works
Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts
Nwosu, Z. C., Alborzinia, H., Wölfl, S., Dooley, S., & Liu, Y. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00191 · Cited by 27 · see citing works
Sun, J., Zhang, H., Li, L., Yu, L., & Fu, L. (2017) · Oncology Reports · doi:10.3892/or.2017.5382 · Cited by 25 · see citing works
RetractedThe Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors
Liu, B., Lu, Y., Taledaohan, A., Qiao, S., Li, Q., & Wang, Y. (2023) · Molecules · doi:10.3390/molecules29010075 · Cited by 24 · see citing works
Self-citationMaghmomeh, A. O., El-Gayar, A. M., El-Karef, A. A., & Abdel‐Rahman, N. (2019) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01734-y · Cited by 25 · see citing works
Li, L., Ji, Y., Zhang, L., Cai, H., Ji, Z., Gu, L., & Yang, S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108222 · Cited by 21 · see citing works
A review of edible plant-derived natural compounds for the therapy of liver fibrosis
Xu, W., Wang, L., Niu, Y., Mao, L., Du, X., Zhang, P., Li, Z., Li, H., & Li, N. (2022) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002483 · Cited by 19 · see citing works
Mahjoub, M. A., Bakhshinejad, B., Sadeghizadeh, M., & Babashah, S. (2017) · Molecular Biology Reports · doi:10.1007/s11033-017-4115-2 · Cited by 19 · see citing works
Xiong, H., & Guo, J. (2025) · Pharmaceuticals · doi:10.3390/ph18040507 · Cited by 20 · see citing works
Jo, S.-L., Yang, H. J., Heo, J. H., Lee, S. R., Lee, H. W., & Hong, E. (2022) · Nutrients · doi:10.3390/nu14081587 · Cited by 17 · see citing works
Curcumin raises lipid content by Wnt pathway in hepatic stellate cell
Zhang, F., Lu, C., Xu, W., Shao, J., Wu, L., Lu, Y., & Zheng, S. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2015.08.040 · Cited by 17 · see citing works
Self-citationZhang, L., Pan, X., Xu, L., Zhang, L., & Huang, H. (2021) · RSC Advances · doi:10.1039/d0ra09589c · Cited by 16 · see citing works
Gao, W., Sun, J. F., Wang, F., Lu, Y., Wen, C., Bian, Q., & Wu, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.07.015 · Cited by 16 · see citing works
Self-citationTranscriptomic signatures of progressive and regressive liver fibrosis and portal hypertension
Petrenko, O., Königshofer, P., Brusilovskaya, K., Hofer, B., Bareiner, K., Simbrunner, B., Jühling, F., Baumert, T. F., Lupberger, J., Trauner, M. A., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109301 · Cited by 14 · see citing works
Yu, F., Chen, J., Wang, X., Hou, S., Li, H., Yao, Y., He, Y., & Chen, K. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02113-2 · Cited by 13 · see citing works
Hypoxia-induced factor and its role in liver fibrosis
Omar, J. M., Hai, Y., & Jin, S. (2022) · PeerJ · doi:10.7717/peerj.14299 · Cited by 13 · see citing works
Lead compounds with the potentials for the treatment of chronic liver diseases
Ezhilarasan, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817890-4.00012-3 · Cited by 12 · see citing works
A role for curcumin in preventing liver fibrosis in animals: a systematic review and meta-analysis
Huang, B.-H., Guo, Z., Lv, B., Zhao, X., Li, Y., & Lv, W. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1396834 · Cited by 11 · see citing works
Zhang, L., Li, Q., Deng, Y., Zou, Y., Wang, L., & Li, J. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13655 · Cited by 10 · see citing works
Gerami, H., Mozaffari–Khosravi, H., Mansour, A., Sohrabpour, A. A., Poustchi, H., Taheri, A. P. H., Jaafari, M. R., Jambarsang, S., & Khayyatzadeh, S. S. (2025) · Scientific Reports · doi:10.1038/s41598-025-21862-1 · Cited by 10 · see citing works
The possible pathogenesis of liver fibrosis: therapeutic potential of natural polyphenols
Niu, C., Zhang, J., & Okolo, P. I., III (2024) · Pharmacological Reports · doi:10.1007/s43440-024-00638-w · Cited by 7 · see citing works
Li, H., Yang, L., Sun, Y., Zhang, Y., Chai, J., Liu, B., & Ye, Y. (2021) · Cytotechnology · doi:10.1007/s10616-021-00460-9 · Cited by 7 · see citing works
9-cis-Retinoic Acid Improves Disease Modelling in iPSC-Derived Liver Organoids
Dastjerd, M. K., Merens, V., Smout, A., Wolf, R. D., Chesné, C., Verfaillie, C. M., Verhulst, S., & van Grunsven, L. A. (2025) · Cells · doi:10.3390/cells14130983 · Cited by 6 · see citing works
Wei, W., Lin, C., Luo, S., Huang, J., Hu, R.-T., Li, J., Ma, H., Wei, J.-Z., Wang, C., Lim, C.-S.-Y., et al. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152703 · Cited by 6 · see citing works
Shi, Y., Guo, Q., Jing, F., Shang, X., Zhou, C., & Jing, F. (2023) · Translational Cancer Research · doi:10.21037/tcr-23-435 · Cited by 3 · see citing works
Cellular Pharmacology of Curcumin With and Without PiperinePreprint
Mahran, R. I., Pan, S., Colacino, J. A., Hagras, M. M., Sun, D., & Brenner, D. E. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.14.452424 · Cited by 3 · see citing works
Unveiling the cellular and molecular mechanisms of traditional Chinese medicine in hepatic fibrosis
Li, X., Yang, X., Xu, Y., Zhao, Q., Xu, Y., Geng, J., Yin, D., Wang, J., & Song, X. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121571 · Cited by 1 · see citing works
The Protective Effect of Curcumin Against Cisplatin- Induced Nephrotoxicity Experimentally in Rats
Maghmomeh, A. O. (2019) · Archives of Pharmacy & Pharmacology Research · doi:10.33552/appr.2019.02.000542 · Cited by 1 · see citing works
Areshidze, D. A., Timchenko, L. D., Kozlova, M., Rzhepakovsky, I. V., & Syomin, I. A. (2016) · Journal of Pharmacy and Nutrition Sciences · doi:10.6000/1927-5951.2016.06.02.4 · Cited by 1 · see citing works
Curcumin in hepatic stellate cell activation in health
Tang, Y. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802972-5.00022-6
Effect of Curcumin and Gliotoxin on Rat Liver Myofibroblast Culture
Shafigullina, A. K., Mijanović, O., Prottoy, R. A., Zhuravleva, M. N., Gomzikova, M. O., Gumerova, A. A., Rizvanov, A. A., & Kiyasov, A. P. (2017) · BioNanoScience · doi:10.1007/s12668-017-0494-z
Curcumin interrupts leptin-regulated microRNA-122 in hepatic stellate cells in vitro and in vivo.
Limin, H., & Xu, F. (2023) · Pakistan Journal of Pharmaceutical Sciences · doi:10.36721/pjps.2023.36.2.reg.417-423.1
Liu, L. R., Zheng, J., Wang, Y., Yang, C., Shan, Y., & Jia, C. (2026) · Liver International · doi:10.1111/liv.70696
- Authors
- Lian, N., Jiang, Y., Zhang, F., Jin, H., Lu, C., Wu, X., Lu, Y., & Zheng, S.
- Affiliations
- Nanjing University of Chinese Medicine (CN)
- Corresponding author
- Zheng, Shizhong
- Venue
- Laboratory Investigation
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 95
- Issue
- 7
- Pages
- 790-803
- ISSN
- 0023-6837 (ISSN-L)
- OpenAlex
- W1603377209
- Cited by
- 64
- References
- 47
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 4 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 9 · 2016: 8 · 2015: 2
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31401210, ysxk-2010, 81270514)
- Government of Jiangsu Province (BK20140955)
- Natural Science Foundation of Jiangsu Province (BK20140955)
- Nanjing University of Chinese Medicine (13XZR20)
- Nanjing University
- Priority Academic Program Development of Jiangsu Higher Education Institutions ((ysxk-2010), 31401210)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- curcumin, Hedgehog signaling, hepatic stellate cells, liver fibrosis, hepatic stellate cell activation, Patched, Smoothened, HHIP, Gli1, cyclopamine, glycolysis, mitochondrial apoptosis, cell migration and invasion, carbon tetrachloride-induced fibrosis, antifibrotic therapy
- MeSH terms
- Patched Receptors, Smoothened Receptor, Animals, Antineoplastic Agents, Curcumin, Glycolysis, Liver Cirrhosis, Male, Phytotherapy, Random Allocation, Receptors, Cell Surface, Rats, Sprague-Dawley, Apoptosis, Curcuma, Receptors, G-Protein-Coupled, Hedgehog Proteins, Hepatic Stellate Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
