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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

A new molecular network comprising PU.1, interferon regulatory factor proteins and miR-342 stimulates ATRA-mediated granulocytic differentiation of acute promyelocytic leukemia cells

De Marchis, M L, Ballarino, M, Salvatori, B, Puzzolo, M C, Bozzoni, I, Fatica, A·2009·Leukemia
DOI 10.1038/leu.2008.372
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Abstract

In the acute promyelocytic leukemia (APL) bearing the t(15;17), all-trans-retinoic acid (ATRA) treatment induces granulocytic maturation and complete remission of leukemia. We identified miR-342 as one of the microRNAs (miRNAs) upregulated by ATRA during APL differentiation. This miRNA emerged as a direct transcriptional target of the critical hematopoietic transcription factors PU.1 and interferon regulatory factor (IRF)-1 and IRF-9. IRF-1 maintains miR-342 at low levels, whereas the binding of PU.1 and IRF-9 in the promoter region following retinoic ATRA-mediated differentiation, upregulates miR-342 expression. Moreover, we showed that enforced expression of miR-342 in APL cells stimulated ATRA-induced differentiation. These data identified miR-342 as a new player in the granulocytic differentiation program activated by ATRA in APL.

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Crossref · 10.1038/leu.2008.372

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Research works printed but not linked: 19

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Metadata

Authors
De Marchis, M. L., Ballarino, M., Salvatori, B., Puzzolo, M. C., Bozzoni, I., & Fatica, A.
Venue
Leukemia
Publisher
Springer Science and Business Media LLC
Published
2009-01-08
Volume
23
Issue
5
Pages
856-862
ISSN
  • 0887-6924
  • 1476-5551
DOI
10.1038/leu.2008.372
Cited by
71
References
3
Language
en
Licence

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