The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia
Open accessAbstract
We analyzed the long-term outcome of 1011 patients treated in five successive clinical trials (Total Therapy Studies 11, 12, 13A, 13B, and 14) between 1984 and 1999. The event-free survival improved significantly (P=0.003) from the first two trials conducted in the 1980s to the three more recent trials conducted in the 1990s. Approximately 75% of patients treated in the 1980s and 80% in the 1990s were cured. Early intensive triple intrathecal therapy, together with more effective systemic therapy, including consolidation and reinduction treatment (Studies 13A and 13B) as well as dexamethasone (Study 13B), resulted in a very low rate of isolated central nervous system (CNS) relapse rate (<2%), despite the reduced use of cranial irradiation. Factors consistently associated with treatment outcome were age, leukocyte count, immunophenotype, DNA index, and minimal residual disease level after remission induction treatment. Owing to concerns about therapy-related secondary myeloid leukemia and brain tumors, in our current trials we reserve the use of etoposide for patients with refractory or relapsed leukemia undergoing hematopoietic stem cell transplantation, and cranial irradiation for those with CNS relapse. The next main challenge is to further increase cure rates while improving quality of life for all patients.
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Treatment of Acute Lymphoblastic Leukemia
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Self-citationPui, C.-H., Robison, L. L., & Look, A. T. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60457-2 · Cited by 1,564
Self-citationDeletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia
Mullighan, C. G., Su, X., Zhang, J., Radtke, I., Phillips, L. A. A., Miller, C. B., Ma, J., Liu, W., Cheng, C., Schulman, B. A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808253 · Cited by 1,422
Self-citationTreating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation
Pui, C.-H., Campana, D., Pei, D., Bowman, W. P., Sandlund, J. T., Kaste, S. C., Ribeiro, R. C., Rubnitz, J. E., Raimondi, S. C., Onciu, M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900386 · Cited by 1,215
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Self-citationEarly T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia
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Cited by
Vora, A., Goulden, N., Wade, R., Mitchell, C., Hancock, J., Hough, R., Rowntree, C., & Richards, S. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70600-9 · Cited by 478
Möricke, A., Zimmermann, M., Valsecchi, M. G., Stanulla, M., Biondi, A., Mann, G., Locatelli, F., Cazzaniga, G., Niggli, F., Aricò, M., et al. (2016) · Blood · doi:10.1182/blood-2015-09-670729 · Cited by 283
Retractions in the medical literature: how many patients are put at risk by flawed research?
Steen, R. G. (2011) · Journal of Medical Ethics · doi:10.1136/jme.2011.043133 · Cited by 156
Abrahão, R., Lichtensztajn, D. Y., Ribeiro, R. C., Marina, N. M., Keogh, R. H., Marcos-Gragera, R., Glaser, S. L., & Keegan, T. H. M. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25544 · Cited by 89
Self-citationImproving Enrollment in Clinical Trials for Adolescents With Cancer
Shaw, P. H., Hayes-Lattin, B., Johnson, R., & Bleyer, A. (2014) · Pediatrics · doi:10.1542/peds.2014-0122f · Cited by 35
Metadata
- Authors
- Pui, C. H., Pei, D., Sandlund, J. T., Ribeiro, R. C., Rubnitz, J. E., Raimondi, S. C., Onciu, M., Campana, D., Kun, L. E., Jeha, S., Cheng, C., Howard, S. C., Metzger, M. L., Bhojwani, D., Downing, J. R., Evans, W. E., & Relling, M. V.
- Venue
- Leukemia
- Published
- 2009-12-10
- Volume
- 24
- Issue
- 2
- Pages
- 371-382
- ISSN
- 0887-6924 (ISSN-L)
- 1476-5551
- OpenAlex
- W2129291628
- Cited by
- 293
- References
- 49
- FWCI
- 26.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Pui, C. H., Pei, D., Sandlund, J. T., Ribeiro, R. C., Rubnitz, J. E., Raimondi, S. C., Onciu, M., Campana, D., Kun, L. E., Jeha, S., Cheng, C., Howard, S. C., Metzger, M. L., Bhojwani, D., Downing, J. R., Evans, W. E., & Relling, M. V. (2010). Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia. Leukemia. https://doi.org/10.1038/leu.2009.252
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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