Cited by 186Acute Myeloid Leukemia ResearchHematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

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The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

Burda, P, Laslo, P, Stopka, T·2010·Leukemia

DOI 10.1038/leu.2010.104

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Abstract

Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed.

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Additional file 2 of Measuring cell-to-cell expression variability in single-cell RNA-sequencing data: a comparative analysis and applications to B cell aging
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Additional file 1 of Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs
Lorzadeh, A., Hammond, C., Wang, F., Knapp, D. J. H. F., Wong, J. C., Zhu, J. Y. A., Cao, Q., Heravi‐Moussavi, A., Carles, A., Wong, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19759434
Additional file 3 of Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs
Lorzadeh, A., Hammond, C., Wang, F., Knapp, D. J. H. F., Wong, J. C., Zhu, J. Y. A., Cao, Q., Heravi‐Moussavi, A., Carles, A., Wong, M., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19759440
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Self-citation

Authors: Burda, P., Laslo, P., & Stopka, T.
Affiliations: Charles University (CZ)
St James's University Hospital (GB)
Corresponding author: Stopka, T
ORCID: Burda, P
Laslo, P
Stopka, T
Venue: Leukemia
Publisher: Springer Science and Business Media LLC
Published: 2010-06-03
Volume: 24
Issue: 7
Pages: 1249-1257
ISSN: 0887-6924 (ISSN-L)
1476-5551
DOI: 10.1038/leu.2010.104
OpenAlex: W2023603100
Cited by: 184
References: 109
Citations by year: 2026: 10 · 2025: 19 · 2024: 14 · 2023: 18 · 2022: 25 · 2021: 19 · 2020: 10 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 8 · 2012: 7
FWCI: 1.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Leukemia (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Ministerstvo Zdravotnictví Ceské Republiky
Topics: Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: PU.1, GATA-1, transcription factors, hematopoiesis, leukemogenesis, protein-protein interaction, negative regulation, differentiation therapy
MeSH terms: Proto-Oncogene Protein Spi-1, Animals, Hematopoiesis, Humans, Leukemia, Proto-Oncogene Proteins, Trans-Activators, GATA Transcription Factors

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The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

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