Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., Richter, J. F., Christ, M., Hillenbrand, B., Mankertz, J., Gitter, A. H., Bürgel, N., Fromm, M., et al. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.002 · Cited by 1,237 · see citing works

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.002 · Cited by 1,016 · see citing works

Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

Amasheh, S., Meiri, N., Gitter, A. H., Schöneberg, T., Mankertz, J., Schulzke, J. D., & Fromm, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.00165 · Cited by 812 · see citing works

Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis

Fuss, I. J., Heller, F., Boirivant, M., Leon, F., Yoshida, M., Fichtner‐Feigl, S., Yang, Z., Exley, M. A., Kitani, A., Blumberg, R. S., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19836 · Cited by 799 · see citing works

Manner of Interaction of Heterogeneous Claudin Species within and between Tight Junction Strands

Furuse, M., Sasaki, H., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.4.891 · Cited by 746 · see citing works

Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells

Furuse, M., Furuse, K., Sasaki, H., & Tsukita, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.2.263 · Cited by 712 · see citing works

Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis

Schmitz*, H., Barmeyer, C., Fromm, M., Runkel§, N., Foss, H., Bentzel, C. J., Riecken, E., & Schulzke, J.-D. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70126-5 · Cited by 607 · see citing works

Tumor necrosis factor-alpha (TNFα) regulates the epithelial barrier in the human intestinal cell line HT-29/B6

Schmitz, H., Fromm, M., Bentzel, C. J., Scholz, P., Detjen, K. M., Mankertz, J., Bode, H., Epple, H., Riecken, E., & Schulzke, J. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.1.137 · Cited by 375 · see citing works

Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging

Gitter, A. H., Wullstein, F., Fromm, M., & Schulzke, J. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.29694 · Cited by 270 · see citing works

Mechanisms of diarrhea in collagenous colitis

Bürgel, N., Bojarski, C., Mankertz, J., Zeitz, M., Fromm, M., & Schulzke, J. (2002) · Gastroenterology · doi:10.1053/gast.2002.34784 · Cited by 263 · see citing works

Leaks in the epithelial barrier caused by spontaneous and TNF‐α‐induced single‐cell apoptosis

Gitter, A. H., Bendfeldt, K., Schulzke, J.-D., & Fromm, M. (2000) · The FASEB Journal · doi:10.1096/fj.99-0898com · Cited by 250 · see citing works

CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: A possible role in ulcerative colitis

Sträter, J., Wellisch, I., Riedl, S., Walczak, H., Koretz, K., Tandara, A. A., Krammer, P. H., & Möller, P. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70091-x · Cited by 245 · see citing works

Cl- secretion in epithelial monolayers of mucus-forming human colon cells (HT-29/B6)

Kreusel, K., Fromm, M., Schulzke, J., & Hegel, U. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.261.4.c574 · Cited by 173 · see citing works

Increased epithelial uptake of protein antigens in the ileum of Crohn’s disease mediated by tumour necrosis factor α

Söderholm, J. D., Streutker, C., Yang, P.-C., Paterson, C., Singh, P. K., McKay, D. M., Sherman, P. M., Croitoru, K., & Perdue, M. H. (2004) · Gut · doi:10.1136/gut.2004.041426 · Cited by 160 · see citing works

Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease

Schürmann, G., Brüwer, M., Klotz, A., Schmid, K. W., Senninger, N. J., & Zimmer, K. ‐. (1999) · International Journal of Colorectal Disease · doi:10.1007/s003840050181 · Cited by 110 · see citing works

Measurement of paracellular epithelial conductivity by conductance scanning

Gitter, A. H., Bertog, M., Schulzke, J., & Fromm, M. (1997) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050472 · Cited by 74 · see citing works

Ulcerative colitis

Ordás, Í., Eckmann, L., Talamini, M. A., Baumgart, D. C., & Sandborn, W. J. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60150-0 · Cited by 2,095 · see citing works

Regulation of Intestinal Barrier Function by Microbial Metabolites

Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works

Roles of intestinal epithelial cells in the maintenance of gut homeostasis

Okumura, R., & Takeda, K. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.20 · Cited by 710 · see citing works

Epidemiology and Pathogenesis of Ulcerative Colitis

Du, L., & Ha, C. Y. (2020) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2020.07.005 · Cited by 657 · see citing works

Claudins and Other Tight Junction Proteins

Günzel, D., & Fromm, M. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110045 · Cited by 401 · see citing works

Bletilla striata: Medicinal uses, phytochemistry and pharmacological activities

He, X., Wang, X., Fang, J., Zhao, Z., Huang, L., Guo, H., & Zheng, X. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.11.026 · Cited by 307 · see citing works

Ulcerative colitis: Recent advances in the understanding of disease pathogenesis

Porter, R. J., Kalla, R., & Ho, G. (2020) · F1000Research · doi:10.12688/f1000research.20805.1 · Cited by 299 · see citing works

Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation

Luettig, J., Rosenthal, R., Barmeyer, C., & Jd, S. (2015) · Tissue Barriers · doi:10.4161/21688370.2014.977176 · Cited by 281 · see citing works

Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn’s Disease and Ulcerative Colitis

Berkowitz, L., Schultz, B. M., Salazar, G. A., Pardo‐Roa, C., Sebastián, V. P., Álvarez-Lobos, M. M., & Bueno, S. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00074 · Cited by 232 · see citing works

The Role of Innate and Adaptive Immune Cells in the Pathogenesis and Development of the Inflammatory Response in Ulcerative Colitis

Kałużna, A., Olczyk, P., & Komosińska‐Vassev, K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11020400 · Cited by 208 · see citing works

Tight junctions as targets and effectors of mucosal immune homeostasis

Zuo, L., Kuo, W.-T., & Turner, J. R. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.04.001 · Cited by 191 · see citing works

Revisiting Inflammatory Bowel Disease: Pathology, Treatments, Challenges and Emerging Therapeutics Including Drug Leads from Natural Products

Yeshi, K., Ruscher, R., Hunter, L., Daly, N. L., Loukas, A. C., & Wangchuk, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051273 · Cited by 190 · see citing works

Strategies targeting the IL-4/IL-13 axes in disease

May, R. D., & Fung, M. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.018 · Cited by 166 · see citing works

Antimicrobial peptides and the gut microbiome in inflammatory bowel disease

Gubatan, J. M. B., Holman, D., Puntasecca, C. J., Polevoi, D., Rubin, S. J. S., & Rogalla, S. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i43.7402 · Cited by 116 · see citing works

Molecular Pathophysiology of Epithelial Barrier Dysfunction in Inflammatory Bowel Diseases

Lee, J., Wasinger, V. C., Yau, Y. Y., Chuang, E., Yajnik, V., & Leong, R. W. L. (2018) · Proteomes · doi:10.3390/proteomes6020017 · Cited by 102 · see citing works

Tumour Necrosis Factor Superfamily Members in the Pathogenesis of Inflammatory Bowel Disease

Ślebioda, T. J., & Kmieć, Z. (2014) · Mediators of Inflammation · doi:10.1155/2014/325129 · Cited by 100 · see citing works

Matrix Metalloproteinase-9 (MMP-9) induced disruption of intestinal epithelial tight junction barrier is mediated by NF-κB activation

Al-Sadi, R., Engers, J., Haque, M., King, S., Al-Omari, D., & Ma, T. Y. (2021) · PLOS ONE · doi:10.1371/journal.pone.0249544 · Cited by 93 · see citing works

Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis

Krug, S. M., Bojarski, C., Fromm, A., Lee, I. M., Dames, P., Richter, J. F., Turner, J. R., Fromm, M., & Schulzke, J.-D. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.52 · Cited by 91 · see citing works

Advances in treatment of ulcerative colitis with herbs: From bench to bedside

Wan, P. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14099 · Cited by 84 · see citing works

Interleukin-13: A promising therapeutic target for autoimmune disease

Mao, Y., Zhao, C., Leng, J., Leng, R., Ye, D., Zheng, S. G., & Pan, H. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.12.001 · Cited by 81 · see citing works

Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice—A Pathway Associated With Ulcerative Colitis

Kawashima, R., Kawamura, Y. I., Oshio, T., Son, A., Yamazaki, M., Hagiwara, T., Okada, T., Inagaki-Ohara, K., Wu, P., Szak, S. T., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.08.040 · Cited by 82 · see citing works

12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma

Mabalirajan, U., Rehman, R., Ahmad, T., Kumar, S., Leishangthem, G. D., Singh, S., Dinda, A. K., Biswal, S. S., Agrawal, A., & Ghosh, B. (2013) · Scientific Reports · doi:10.1038/srep01540 · Cited by 78 · see citing works

Evidence for a Functional Thymic Stromal Lymphopoietin Signaling Axis in Fibrotic Lung Disease

Datta, A., Alexander, R., Sulikowski, M. G., Nicholson, A. G., Maher, T. M., Scotton, C. J., & Chambers, R. C. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300588 · Cited by 73 · see citing works

The role of interleukin-13 in chronic inflammatory intestinal disorders

Giuffrida, P., Caprioli, F., Facciotti, F., & Sabatino, A. D. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.03.012 · Cited by 71 · see citing works

Reviewing the potential of probiotics, prebiotics and synbiotics: advancements in treatment of ulcerative colitis

Jadhav, A., Jagtap, S., Vyavahare, S., Sharbidre, A. A., & Kunchiraman, B. N. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1268041 · Cited by 70 · see citing works

Scanning Ion Conductance Microscopy Measurement of Paracellular Channel Conductance in Tight Junctions

Chen, C., Zhou, Y., Morris, C. A., Hou, J., & Baker, L. A. (2013) · Analytical Chemistry · doi:10.1021/ac303441n · Cited by 63 · see citing works

The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases; focus on inflammatory bowel diseases

Dohi, T., & Burkly, L. C. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0112042 · Cited by 62 · see citing works

Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon

Bücker, R., Krug, S. M., Moos, V., Bojarski, C., Schweiger, M. R., Kerick, M., Fromm, A., Janßen, S., Fromm, M., Hering, N. A., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.66 · Cited by 61 · see citing works

Structure and Regulation of Intestinal Epithelial Tight Junctions

Ivanov, A. I. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4711-5_6 · Cited by 59 · see citing works

Idiopathic pulmonary fibrosis is associated with tight junction protein alterations

Zou, J., Li, Y., Yu, J., Dong, L., Husain, A. N., Shen, L., & Weber, C. R. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183205 · Cited by 56 · see citing works

Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity

Yu, L. C. (2011) · Journal of Allergy · doi:10.1155/2012/596081 · Cited by 55 · see citing works

Increased T-Helper 2 Cytokines in Bile From Patients With IgG4-Related Cholangitis Disrupt the Tight Junction–Associated Biliary Epithelial Cell Barrier

Müller, T., Beutler, C., Picó, A. H., Otten, M., Dürr, A., Al‐Abadi, H., Guckelberger, O., Büschenfelde, D. M. Z., Jöhrens, K., Volkmann, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.055 · Cited by 55 · see citing works

Interleukin-13 (IL-13)/IL-13 Receptor α1 (IL-13Rα1) Signaling Regulates Intestinal Epithelial Cystic Fibrosis Transmembrane Conductance Regulator Channel-dependent Cl− Secretion

Wu, D. X.-Y., Ahrens, R., Osterfeld, H., Noah, T. K., Groschwitz, K. R., Foster, P. S., Steinbrecher, K. A., Rothenberg, M. E., Shroyer, N. F., Matthaei, K. I., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.214965 · Cited by 54 · see citing works

MicroRNA-31 and MicroRNA-155 Are Overexpressed in Ulcerative Colitis and Regulate IL-13 Signaling by Targeting Interleukin 13 Receptor α-1

Gwiggner, M., Martínez-Nuñez, R. T., Whiteoak, S. R., Bondanese, V. P., Claridge, A., Collins, J. E., Cummings, F. J. R., & Sánchez-Elsner, T. (2018) · Genes · doi:10.3390/genes9020085 · Cited by 55 · see citing works

Perspectives on tight junction research

Schulzke, J., Günzel, D., John, L., & Fromm, M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06485.x · Cited by 54 · see citing works

Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives

Chen, M., Lan, H., Jin, K., & Chen, Y. (2023) · Drug Delivery · doi:10.1080/10717544.2023.2219427 · Cited by 51 · see citing works

Therapeutic activity of an interleukin‐4/interleukin‐13 dual antagonist on oxazolone‐induced colitis in mice

Kasaian, M. T., Page, K. M., Fish, S. C., Brennan, A., Cook, T. A., Moreira, K. E., Zhang, M., Jesson, M. I., Marquette, K., Agostinelli, R., et al. (2014) · Immunology · doi:10.1111/imm.12319 · Cited by 52 · see citing works

Present and Future Therapeutic Approaches to Barrier Dysfunction

Fortea, M., Albert-Bayo, M., Abril-Gil, M., Mall, J. G., Serra-Ruiz, X., Henao-Paez, A., Expósito, E., González-Castro, A. M., Guagnozzi, D., Lobo, B., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718093 · Cited by 48 · see citing works

Helminths and intestinal barrier function

McKay, D. M., Shute, A., & Lopes, F. (2017) · Tissue Barriers · doi:10.1080/21688370.2017.1283385 · Cited by 49 · see citing works

MicroRNAs in Inflammatory Bowel Disease and Its Complications

Krishnachaitanya, S. S., Liu, M., Fujise, K., & Li, Q. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158751 · Cited by 48 · see citing works

Probiotic supplementation induces remission and changes in the immunoglobulins and inflammatory response in active ulcerative colitis patients: A pilot, randomized, double-blind, placebo-controlled study

Agraib, L. M., Yamani, M. I., Tayyem, R., Sneineh, A. T. A., & Rayyan, Y. M. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.08.020 · Cited by 46 · see citing works

Improvement of Oxazolone-Induced Ulcerative Colitis in Rats Using Andrographolide

Zhang, L., Cao, N., Wang, Y., Wang, Y., Wu, C., Cheng, X. M., & Wang, C. (2019) · Molecules · doi:10.3390/molecules25010076 · Cited by 46 · see citing works

Interleukin-13 (IL-13)—A Pleiotropic Cytokine Involved in Wound Healing and Fibrosis

Roeb, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612884 · Cited by 45 · see citing works

NKT cells and the regulation of intestinal immunity: a two‐way street

Brailey, P. M., Lebrusant‐Fernandez, M., & Barral, P. (2020) · FEBS Journal · doi:10.1111/febs.15238 · Cited by 45 · see citing works

The mechanism of alopolysaccharide protecting ulceralive colitis

Hu, L., Honglang, L., Li, W., Junmin, C., Jiantao, Y., & Junjing, G. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.11.138 · Cited by 43 · see citing works

Microparticles in nasal lavage fluids in chronic rhinosinusitis: Potential biomarkers for diagnosis of aspirin-exacerbated respiratory disease

Takahashi, T., Kato, A., Berdnikovs, S., Stevens, W. W., Suh, L. A., Norton, J. E., Carter, R. G., Harris, K. E., Peters, A. T., Hulse, K. E., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.01.022 · Cited by 43 · see citing works

The Role of Dietary Fibers in the Management of IBD Symptoms

Rosa, C. D., Altomare, A., Imperia, E., Spiezia, C., Khazrai, Y. M., & Guarino, M. P. L. (2022) · Nutrients · doi:10.3390/nu14224775 · Cited by 40 · see citing works

CXCR4 Antagonist AMD3100 Modulates Claudin Expression and Intestinal Barrier Function in Experimental Colitis

Xia, X., Wang, F., Zhou, J., Hu, K.-F., Li, S., & Zou, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027282 · Cited by 40 · see citing works

CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis

Xia, X. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i23.2873 · Cited by 40 · see citing works

Donkey milk lysozyme ameliorates dextran sulfate sodium-induced colitis by improving intestinal barrier function and gut microbiota composition

Jiang, L., Lv, J., Liu, J., Hao, X., Ren, F., & Guo, H. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.07.005 · Cited by 38 · see citing works

Claudins and Other Tight Junction Proteins

Günzel, D., & Fromm, M. (2012) · Comprehensive physiology · doi:10.1002/j.2040-4603.2012.tb00450.x · Cited by 37 · see citing works

Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function

Sebag, S. C., Koval, O. M., Paschke, J. D., Winters, C. J., Comellas, A. P., & Grumbach, I. M. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.12.003 · Cited by 37 · see citing works

Zinc treatment is efficient against Escherichia coli α-haemolysin-induced intestinal leakage in mice

Wiegand, S., Zakrzewski, S. S., Eichner, M., Schulz, E., Günzel, D., Pieper, R., Rosenthal, R., Barmeyer, C., Bleich, A., Dobrindt, U., et al. (2017) · Scientific Reports · doi:10.1038/srep45649 · Cited by 36 · see citing works

Regulation of IL-6/STAT-3/Wnt axis by nifuroxazide dampens colon ulcer in acetic acid-induced ulcerative colitis model: Novel mechanistic insight

Ali, F. E. M., Elfiky, M. M., Fadda, W. A., Ali, H. S., Mahmoud, A. R., Mohammedsaleh, Z. M., & Abd‐Elhamid, T. H. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119433 · Cited by 35 · see citing works

Mucosal Healing in Ulcerative Colitis

Seidelin, J. B., Coskun, M., & Nielsen, O. H. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-405211-6.00004-8 · Cited by 33 · see citing works

Defence and adaptation mechanisms of the intestinal epithelium upon infection

Iftekhar, A., & Sigal, M. J. (2021) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2021.151486 · Cited by 33 · see citing works

Contribution of Epithelial Apoptosis and Subepithelial Immune Responses in Campylobacter jejuni-Induced Barrier Disruption

Butkevych, E., de Sá, F. D. L., Nattramilarasu, P. K., & Bücker, R. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00344 · Cited by 32 · see citing works

Targeting IL-13 as a Host-Directed Therapy Against Ulcerative Colitis

Hoving, J. C. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00395 · Cited by 31 · see citing works

miRNA Molecules—Late Breaking Treatment for Inflammatory Bowel Diseases?

Aggeletopoulou, I., Mouzaki, Α., Thomopoulos, K., & Triantos, C. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032233 · Cited by 31 · see citing works

Current Status of Medical Therapy for Inflammatory Bowel Disease: The Wealth of Medications

Nadpara, N., Reichenbach, Z. W., Ehrlich, A. C., & Friedenberg, F. K. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06471-4 · Cited by 24 · see citing works

Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease

Epple, H., Friebel, J., Moos, V., Troeger, H., Krug, S. M., Allers, K., Schinnerling, K., Fromm, A., Siegmund, B., Fromm, M., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.6 · Cited by 21 · see citing works

Creation of a Claudin-2 Binder and Its Tight Junction–Modulating Activity in a Human Intestinal Model

Takigawa, M., Iida, M., Nagase, S., Suzuki, H., Watari, A., Tada, M., Okada, Y., Doi, T., Fukasawa, M., Yagi, K., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.242214 · Cited by 21 · see citing works

Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model

Nestor-Bergmann, A., Blanchard, G. B., Hervieux, N., Fletcher, A. G., Etienne, J., & Sanson, B. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009812 · Cited by 21 · see citing works

Potentiometric-scanning ion conductance microscopy for measurement at tight junctions

Zhou, Y., Chen, C., Weber, A. E., Zhou, L., Baker, L. A., & Hou, J. (2013) · Tissue Barriers · doi:10.4161/tisb.25585 · Cited by 21 · see citing works

Interleukin-13 interferes with activation-induced t-cell apoptosis by repressing p53 expression

Yang, L., Xu, L., Liu, Z., Yang, G., Geng, X., Mo, L., Liu, Z., Zheng, P., & Yang, P. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.50 · Cited by 20 · see citing works

The Construction and Comprehensive Analysis of Inflammation‐Related ceRNA Networks and Tissue‐Infiltrating Immune Cells in Ulcerative Colitis Progression

Lu, J., Rouzigu, A., Teng, L.-H., & Liu, W. (2021) · BioMed Research International · doi:10.1155/2021/6633442 · Cited by 18 · see citing works

Malaria-induced bacteremia as a consequence of multiple parasite survival strategies

Donnelly, E. L., de Water, J. V., & Luckhart, S. (2021) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2021.100036 · Cited by 18 · see citing works

Rictor/Mammalian Target of Rapamycin Complex 2 Signaling Protects Colonocytes from Apoptosis and Prevents Epithelial Barrier Breakdown

Castro-Martínez, F., Candelario‐Martínez, A., Encarnacion‐Garcia, M. R., Piedra-Quintero, Z. L., Bonilla‐Moreno, R., Betanzos, A., Perez-Orozco, R., Hernandez‐Cueto, M. A., Muñoz‐Medina, J. E., Patiño‐López, G., et al. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.06.004 · Cited by 17 · see citing works

Phosphatidylcholine in Intestinal Mucus Protects against Mucosal Invasion of Microbiota and Consequent Inflammation

Stremmel, W., & Weiskirchen, R. (2024) · Livers · doi:10.3390/livers4030034 · Cited by 16 · see citing works

Nonlethal Plasmodium yoelii Infection Drives Complex Patterns of Th2-Type Host Immunity and Mast Cell-Dependent Bacteremia

Céspedes, N., Donnelly, E. L., Garrison, S. M., Haapanen, L. A. D., de Water, J. V., & Luckhart, S. (2020) · Infection and Immunity · doi:10.1128/iai.00427-20 · Cited by 15 · see citing works

The Pathogenesis of Inflammatory Bowel Diseases

Chauhan, G., & Rieder, F. (2024) · Surgical Clinics of North America · doi:10.1016/j.suc.2024.10.008 · Cited by 11 · see citing works

Frizzled 7 modulates goblet and Paneth cell fate, and maintains homeostasis in mouse intestine

Gu, N.-X., Guo, Y., Lin, S., Wang, Y.-H., Lin, I., Chen, Y., & Yen, Y. (2023) · Development · doi:10.1242/dev.200932 · Cited by 10 · see citing works

Changes in respiratory tract and gut microbiota in AR mice and their relationship with Th1/Th2/Treg

Zhang, P., Huang, J., Li, Q., Bo, D., Zhang, J., Hui, S., & Sun, X. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106881 · Cited by 10 · see citing works

Intestinal TLR9 deficiency exacerbates hepatic IR injury via altered intestinal inflammation and short‐chain fatty acid synthesis

Han, S. J., Kim, M., Novitsky, E., D’Agati, V. D., & Lee, H. T. (2020) · The FASEB Journal · doi:10.1096/fj.202000314r · Cited by 10 · see citing works

Could IL-25 be a potential therapeutic target for intestinal inflammatory diseases?

Chen, J., Wang, Y., Shen, L., Xiu, Y., & Wang, B. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.07.001 · Cited by 9 · see citing works

Immune modulation for the patterns of epithelial cell death in inflammatory bowel disease

Jiang, Y., Chen, J., Du, Y., Fan, M., & Shen, L. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114462 · Cited by 9 · see citing works

Therapeutic potential of butyrate against heat Stress–Induced intestinal damage, systemic inflammation, and multiple organ Dysfunction: Insights from in vitro and in vivo experiments

Ke, H., Chen, M., Tsao, C., Hii, H., Kuo, C.-W., Ka, S., Wu, C.-C., & Shih, C. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177710 · Cited by 9 · see citing works

Tight joints and zonulin in the formation of oral tolerance and food allergy

Приходченко, Н. Г., Александровна, Ш. Т., Grigoryan, L. A., & Васильевна, Г. А. (2019) · Pacific Medical Journal · doi:10.34215/1609-1175-2019-4-5-9 · Cited by 9 · see citing works

Differential IL-13 Production by Small Intestinal Leukocytes in Active Coeliac Disease versus Refractory Coeliac Disease

Groß, S., van Wanrooij, R. L. J., Nijeboer, P., Gelderman, K. A., Cillessen, S. A. G. M., Meijer, G. A., Mulder, C. J. J., Bouma, G., Blomberg, B. M. E. V., & Bontkes, H. J. (2013) · Mediators of Inflammation · doi:10.1155/2013/939047 · Cited by 9 · see citing works

Recent Insights into the Evolving Role of the Gut Microbiome in Critical Care

Lee, S., Wischmeyer, P. E., Mintz, C. D., & Serbanescu, M. A. (2024) · Critical Care Clinics · doi:10.1016/j.ccc.2024.11.002 · Cited by 11 · see citing works

Intestinal Fibrogenesis in Inflammatory Bowel Diseases: Exploring the Potential Role of Gut Microbiota Metabolites as Modulators

Cicchinelli, S., Gemma, S., Pignataro, G., Piccioni, A., Ojetti, V., Gasbarrini, A., Franceschi, F., & Candelli, M. (2024) · Pharmaceuticals · doi:10.3390/ph17040490 · Cited by 8 · see citing works

Effect of Kangfuxin Liquid enema combined with mesalazine on gestational outcomes and quality of life in child-bearing female with active ulcerative colitis

Wang, T., Lu, H., Li, F., & Zhang, Q. (2021) · Medicine · doi:10.1097/md.0000000000023915 · Cited by 8 · see citing works

Advancements in ulcerative colitis management: A critical assessment of etrasimod therapy

Seni, K., Saini, A., Debnath, R., Singh, A., Sharma, A., Bisht, D. S., Chawla, V., & Chawla, P. A. (2024) · Health Sciences Review · doi:10.1016/j.hsr.2024.100196 · Cited by 7 · see citing works

Primary human colonic epithelial cells are transiently protected from anoikis by a Src-dependent mechanism

Hofmann, C., Lippert, E., Falk, W., Schölmerich, J., Rogler, G., & Obermeier, F. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.10.075 · Cited by 7 · see citing works

Flagellin: A crucial virulence factor coordinating bacterial pathogenesis and host immune responses

Xia, P., Lian, S., Liu, J., Ji, X., Zhao, T., Yang, C., Meng, X., Duan, Q., & Zhu, G. (2025) · Animals and zoonoses. · doi:10.1016/j.azn.2025.09.001 · Cited by 9 · see citing works

Microbiota-Immune Interactions in Ulcerative Colitis and Colitis Associated Cancer and Emerging Microbiota-Based Therapies

Popov, J., Caputi, V., Nandeesha, N., Rodriguez, D. A., & Pai, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111365 · Cited by 8 · see citing works

Protective role of estrogen through G-protein coupled receptor 30 in a colitis mouse model

Fidya, Choijookhuu, N., Ikenoue, M., Yano, K., Yamaguma, Y., Shirouzu, S., Kai, K., Ishizuka, T., & Hishikawa, Y. (2023) · Histochemistry and Cell Biology · doi:10.1007/s00418-023-02235-z · Cited by 6 · see citing works

Experimental allergic airway inflammation impacts gut homeostasis in mice

Nascimento, C. M., Casaro, M. B., Perez, E. R., Ribeiro, W. R., Mayer, M. P. A., Ishikawa, K. H., Lino‐dos‐Santos‐Franco, A., Pereira, J. N. B., & Ferreira, C. M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16429 · Cited by 6 · see citing works

Recent Updates on the Therapeutics Benefits, Clinical Trials, and Novel Delivery Systems of Chlorogenic Acid for the Management of Diseases with a Special Emphasis on Ulcerative Colitis

Harwansh, R. K., Bhati, H., & Deshmukh, R. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128295753240129074035 · Cited by 6 · see citing works

Probing the leak pathway: Live‐cell imaging of macromolecule passage through epithelia

Richter, J. F., Hildner, M., Mrowka, R., & Schmauder, R. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14847 · Cited by 5 · see citing works

Myrrh protects against IL-13-induced epithelial barrier breakdown in HT-29/B6 cells

Hader, H., Hering, N. A., Schulzke, J., Bücker, R., & Rosenthal, R. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1301800 · Cited by 5 · see citing works

Retocolite ulcerativa e citocinas: uma revisão da literatura

Cavalcante, R. M. S., de Moura, M. S. B., Bráz, D. C., & Nogueira, N. D. N. (2020) · Research Society and Development · doi:10.33448/rsd-v9i9.7145 · Cited by 4 · see citing works

Cardiac and intestinal tissue conduct developmental and reparative processes in response to lymphangiocrine signaling

Kurup, S., Tan, C., & Kume, T. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1329770 · Cited by 4 · see citing works

Investigational cytokine-targeted therapies for ulcerative colitis

Monteleone, G., Pallone, F., & Caprioli, F. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.813931 · Cited by 4 · see citing works

Astaxanthin and astaxanthin-responsive microbial consortia synergistically ameliorate colitis in Mice: A new strategy for precision nutrition

Huan, Y., Zhang, W., Xue, L., Tang, Q., Wang, Y., Xu, J., & Xue, C. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107547 · Cited by 3 · see citing works

Chronic skin damage induces small intestinal damage via IL-13-induced apoptosis

Tanemoto, R., Higashiyama, M., Tomioka, A., Ito, S., Mizoguchi, A., Nishii, S., Inaba, K., Wada, A., Sugihara, N., Hanawa, Y., et al. (2024) · Clinical & Experimental Immunology · doi:10.1093/cei/uxae050 · Cited by 3 · see citing works

Current Research in Crohn's Disease and Ulcerative Colitis: Highlights from the 2010 ACG Meeting.

Lichtenstein, G. R. (2010) · PubMed Central · Cited by 3 · see citing works

Role of the Barrier Dysfunction of the Intestines in the Development of Alimentary Allergy in Children

Borovik, T. E., Makarova, S. G., Yatsyk, G. V., Степанова, Т. Н., & Грибакин, С. Г. (2013) · Вопросы современной педиатрии · doi:10.15690/vsp.v12i2.615 · Cited by 3 · see citing works

Pathogenetic factors of ulcerative colitis: mainstream for 2020

Равильевна, Б. Г., Livzan, M. A., & Lozinskaya, M. Y. (2021) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2021-2-130-138 · Cited by 2 · see citing works

Maximizing Treatment Options for IBD through Drug Repurposing

Barjasteh, A. H., Al-Asady, A. M., Latifi, H., Al-Okla, S., Al-Nazwani, N. S., Avan, A., Khazaei, M., Ryzhikov, M., Yazdi, H. N., & Hassanian, S. M. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128318032240702045822 · Cited by 2 · see citing works

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Heller, F., Florian, P., Bojarski, C., Richter, J. F., Christ, M., Hillenbrand, B., Mankertz, J., Gitter, A. H., Bürgel, N., Fromm, M., et al. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.002 · Cited by 1,237 · see citing works

Disrupted Barrier Function through Epithelial Cell Apoptosis

Schulzke, J.-D., Bojarski, C., Zeißig, S., HELLER, F., Gitter, A. H., & Fromm, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.027 · Cited by 190 · see citing works

Epithelial Tight Junctions in Intestinal Inflammation

Schulzke, J. D., Plöger, S., Amasheh, M., Fromm, A., Zeißig, S., Troeger, H., Richter, J. F., Bojarski, C., Schümann, M., & Fromm, M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04062.x · Cited by 400 · see citing works

Myrrh protects against IL-13-induced epithelial barrier breakdown in HT-29/B6 cells

Hader, H., Hering, N. A., Schulzke, J., Bücker, R., & Rosenthal, R. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1301800 · Cited by 5 · see citing works

Interleukin–13 hat bei Colitis ulcerosa eine zentrale Rolle und beeinflusst die intestinale Barriere, Tight-junctions, Apoptoserate und Wundheilung wesentlich

Heller, F., Florian, P., Bojarski, C., Christ, M., Mankertz, J., Fromm, M., Zeitz, M., & Schulzke, J. (2004) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2004-831436