Evidence for a Functional Thymic Stromal Lymphopoietin Signaling Axis in Fibrotic Lung Disease
Open accessAbstract
Thymic stromal lymphopoietin (TSLP) recently has emerged as a key cytokine in the development of type 2 immune responses. Although traditionally associated with allergic inflammation, type 2 responses are also recognized to contribute to the pathogenesis of tissue fibrosis. However, the role of TSLP in the development of non–allergen-driven diseases, characterized by profibrotic type 2 immune phenotypes and excessive fibroblast activation, remains underexplored. Fibroblasts represent the key effector cells responsible for extracellular matrix production but additionally play important immunoregulatory roles, including choreographing immune cell recruitment through chemokine regulation. The aim of this study was to examine whether TSLP may be involved in the pathogenesis of a proto-typical fibrotic disease, idiopathic pulmonary fibrosis (IPF). We combined the immunohistochemical analysis of human IPF biopsy material with signaling studies by using cultured primary human lung fibroblasts and report for the first time, to our knowledge, that TSLP and its receptor (TSLPR) are highly upregulated in IPF. We further show that lung fibroblasts represent both a novel cellular source and target of TSLP and that TSLP induces fibroblast CCL2 release (via STAT3) and subsequent monocyte chemotaxis. These studies extend our understanding of TSLP as a master regulator of type 2 immune responses beyond that of allergic inflammatory conditions and suggest a novel role for TSLP in the context of chronic fibrotic lung disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Levels of TSLP are significantly elevated in BALF and lung tissue from patients with IPF.
“Levels of TSLP are significantly elevated in BALF43 and lung tissue from patients with IPF44”
From Inhaled LTI-03 for idiopathic pulmonary fibrosis: a randomized dose escalation study (2026) · cites this paper as [44]
In IPF, TSLP may promote fibrogenesis by activating fibroblasts and recruiting immune cells to sites of epithelial injury.
“In IPF, TSLP may promote fibrogenesis by activating fibroblasts and recruiting immune cells to sites of epithelial injury44.”
From Inhaled LTI-03 for idiopathic pulmonary fibrosis: a randomized dose escalation study (2026) · cites this paper as [44]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848 · see citing works
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Soumelis, V., Reche, P. A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M. F., Ho, S., Antonenko, S. V., Lauerma, A., et al. (2002) · Nature Immunology · doi:10.1038/ni805 · Cited by 2,186 · see citing works
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,974 · see citing works
Molecular identification of a danger signal that alerts the immune system to dying cells
Shi, Y., Evans, J. E., & Rock, K. L. (2003) · Nature · doi:10.1038/nature01991 · Cited by 1,684 · see citing works
Ito, T., Wang, Y.-H., Duramad, O., Hori, T., Delespesse, G. J., Watanabe, N., Qin, F. X.-F., Yao, Z., Cao, W., & Liu, Y.-J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051135 · Cited by 1,129 · see citing works
A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration
Falk, W., Goodwin, R. H., & Leonard, E. J. (1980) · Journal of Immunological Methods · doi:10.1016/0022-1759(80)90211-2 · Cited by 942 · see citing works
Ying, S., O'Connor, B. J., Ratoff, J. C., Meng, Q., Mallett, K., Cousins, D. J., Robinson, D. S., Zhang, G., Zhao, J., Lee, T. H., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.8183 · Cited by 874 · see citing works
Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1
Gu, L., Tseng, S., Horner, R. M., Tam‐Amersdorfer, C., Loda, M. F., & Rollins, B. J. (2000) · Nature · doi:10.1038/35006097 · Cited by 832 · see citing works
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
Fortini, M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm910 · Cited by 824 · see citing works
Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
Zhou, B., Comeau, M. R., Smedt, T. D., Liggitt, H. D., Dahl, M. E., Lewis, D. B., Gyarmati, D., Aye, T., Campbell, D., & Ziegler, S. F. (2005) · Nature Immunology · doi:10.1038/ni1247 · Cited by 818 · see citing works
Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation
Buckley, C. D., Pilling, D., Lord, J. M., Akbar, A. N., Scheel-Toellner, D., & Salmon, M. (2001) · Trends in Immunology · doi:10.1016/s1471-4906(01)01863-4 · Cited by 796 · see citing works
Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
Watanabe, N., Wang, Y.-H., Lee, H. K., Ito, T., Wang, Y., Cao, W., & Liu, Y. (2005) · Nature · doi:10.1038/nature03886 · Cited by 772 · see citing works
Monte, L. B. D., Reni, M., Tassi, E., Clavenna, D., Papa, I., Recalde, H. R., Braga, M., Carlo, V. D., Doglioni, C., & Protti, M. P. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101876 · Cited by 692 · see citing works
Yoo, J. Y., Omori, M., Gyarmati, D., Zhou, B., Aye, T., Brewer, A. W., Comeau, M. R., Campbell, D., & Ziegler, S. F. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041503 · Cited by 612 · see citing works
Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice
Kujawski, M., Kortylewski, M., Lee, H., Herrmann, A., Kay, H. D., & Yu, H. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35213 · Cited by 581 · see citing works
Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation.
(1997) · Europe PMC (PubMed Central) · Cited by 510 · see citing works
Kato, A., Favoreto, S., Avila, P. C., & Schleimer, R. P. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1080 · Cited by 494 · see citing works
Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin
Pandey, A., Ozaki, K., Baumann, H., Levin, S. D., Puel, A., Farr, A. G., Ziegler, S. F., Leonard, W. J., & Lodish, H. F. (2000) · Nature Immunology · doi:10.1038/76923 · Cited by 446 · see citing works
Loetscher, P., Seitz, M., Baggiolini, M., & Moser, B. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.569 · Cited by 418 · see citing works
IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes
Humphreys, N. E., Xu, D., Hepworth, M. R., Liew, F. Y., & Grencis, R. K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2443 · Cited by 417 · see citing works
Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor
Park, L., Martin, U., Garka, K. E., Gliniak, B., Santo, J. P. D., Müller, W., Largaespada, D. A., Copeland, N. G., Jenkins, N. A., Farr, A. G., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.659 · Cited by 417 · see citing works
Differential CC chemokine-induced enhancement of T helper cell cytokine production
Karpus, W. J., Lukacs, N. W., Kennedy, K. J., Smith, W., Hurst, S. D., & Barrett, T. A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.9.4129 · Cited by 414 · see citing works
Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis
Gasse, P., Riteau, N., Charron, S., Girre, S., Fick, L., Pétrilli, V., Tschopp, J., Lagente, V., Quesniaux, V. F. J., Ryffel, B., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200808-1274oc · Cited by 410 · see citing works
Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells
Reche, P. A., Soumelis, V., Gorman, D. M., Clifford, T., Liu, M.-R., Travis, M. A., Zurawski, S., Johnston, J., Liu, Y.-J., Spits, H., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.336 · Cited by 402 · see citing works
Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis
Riteau, N., Gasse, P., Fauconnier, L., Gombault, A., Couegnat, M., Fick, L., Kanellopoulos, J., Quesniaux, V. F. J., Marchand-Adam, S., Crestani, B., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201003-0359oc · Cited by 397 · see citing works
Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis
Andersson‐Sjöland, A., de Alba, C. G., Nihlberg, K., Becerril, C., Ramı́rez, R., Pardo, A., Westergren‐Thorsson, G., & Selman, M. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.02.012 · Cited by 360 · see citing works
Cytokines, allergy, and asthma
Ngoc, L. P., Gold, D. R., Tzianabos, A. O., Weiss, S. T., & Celedon, J. C. (2005) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/01.all.0000162309.97480.45 · Cited by 357 · see citing works
Kouzaki, H., O’Grady, S. M., Lawrence, C. B., & Kita, H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900904 · Cited by 356 · see citing works
Friend, S. L., Hosier, S., Nelson, A., Foxworthe, D., Williams, D. E., & Farr, A. G. (1994) · PubMed · Cited by 352 · see citing works
Taylor, B. C., Zaph, C., Troy, A. E., Du, Y., Guild, K. J., Comeau, M. R., & Artis, D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081499 · Cited by 343 · see citing works
Lee, H., & Ziegler, S. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607305104 · Cited by 338 · see citing works
Scotton, C. J., Krupiczojc, M. A., Königshoff, M., Mercer, P. F., Lee, G., Kaminski, N., Morser, J., Post, J. M., Maher, T. M., Nicholson, A. G., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci33288 · Cited by 318 · see citing works
Self-citationWang, Y., Ito, T., Wang, Y.-H., Homey, B., Watanabe, N., Martin, R., Barnes, C. J., McIntyre, B. W., Gilliet, M. F., Kumar, R., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.03.019 · Cited by 318 · see citing works
Filer, A. D., Ross, E. A., Bofill, M., Martin, S., Salmon, M., Parsonage, G. N., Francesco Falciani, B., Burman, A. C., & Buckley, C. D. (2003) · Thrombosis and Haemostasis · doi:10.1160/th03-04-0208 · Cited by 306 · see citing works
A stromal address code defined by fibroblasts
Parsonage, G., Filer, A. D., Haworth, O., Nash, G. B., Rainger, G. E., Salmon, M., & Buckley, C. D. (2005) · Trends in Immunology · doi:10.1016/j.it.2004.11.014 · Cited by 297 · see citing works
Keerthisingam, C. B., Jenkins, G. R., Harrison, N. K., Hernández-Rodríguez, N. A., Booth, H., Laurent, G. J., Hart, S. L., Foster, M. L., & McAnulty, R. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64092-8 · Cited by 241 · see citing works
A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development
Al-Shami, A., Spolski, R. J., Kelly, J., Fry, T. J., Schwartzberg, P. L., Pandey, A., Mackall, C. L., & Leonard, W. J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031975 · Cited by 240 · see citing works
Levin, S. D., Koelling, R. M., Friend, S. L., Isaksen, D. E., Ziegler, S. F., Perlmutter, R. M., & Farr, A. G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.2.677 · Cited by 237 · see citing works
TSLP enhances the function of helper type 2 cells
Kitajima, M., Lee, H., Nakayama, T., & Ziegler, S. F. (2011) · European Journal of Immunology · doi:10.1002/eji.201041195 · Cited by 235 · see citing works
Interaction of IL-13 and C10 in the Pathogenesis of Bleomycin-Induced Pulmonary Fibrosis
Belperio, J. A., Dy, M. C., Burdick, M. D., Xue, Y., Li, K., Elias, J. A., & Keane, M. P. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0009oc · Cited by 229 · see citing works
Novel therapeutic approaches for pulmonary fibrosis
Datta, A., Scotton, C. J., & Chambers, R. C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01247.x · Cited by 203 · see citing works
Self-citationThe P2Y11 Receptor Mediates the ATP-Induced Maturation of Human Monocyte-Derived Dendritic Cells
Wilkin, F., Duhant, X., Bruyns, C., Suarez-Huerta, N., Boeynaems, J., & Robaye, B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7172 · Cited by 201 · see citing works
Wallace, W. A., Ramage, E., Lamb, D., & Howie, S. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb03131.x · Cited by 200 · see citing works
Kitamura, H., Cambier, S., Somanath, S., Barker, T., Minagawa, S., Markovics, J., Goodsell, A., Publicover, J., Reichardt, L., Jablons, D., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45589 · Cited by 189 · see citing works
Weninger, W., Carlsen, H. S., Goodarzi, M., Moazed, F., Crowley, M. A., Bækkevold, E. S., Cavanagh, L. L., & von Andrian, U. H. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4638 · Cited by 189 · see citing works
Piguet, P. F., Ribaux, C., Karpuz, V., Grau, G. E., & Kapançi, Y. (1993) · PubMed Central · Cited by 187 · see citing works
Vu, A. T., Baba, T., Chen, X., Lê, T. A., Kinoshita, H., Xie, Y., Kamijo, S., Hiramatsu, K., Ikeda, S., Ogawa, H., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.002 · Cited by 186 · see citing works
Constant, S. L., Brogdon, J. L., Piggott, D. A., Herrick, C. A., Visintin, I., Ruddle, N. H., & Bottomly, K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16109 · Cited by 181 · see citing works
Marchal-Sommé, J., Uzunhan, Y., Marchand-Adam, S., Valeyre, D., Soumelis, V., Crestani, B., & Soler, P. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.5735 · Cited by 179 · see citing works
Functional Analysis of the Thymic Stromal Lymphopoietin Variants in Human Bronchial Epithelial Cells
Harada, M., Hirota, T., Jodo, A. I., Doi, S., Kameda, M., Fujita, K., Miyatake, A., Enomoto, T., Noguchi, E., Yoshihara, S., et al. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0041oc · Cited by 178 · see citing works
Qin, S., LaRosa, G. J., Campbell, J. J., Smith‐Heath, H., Kassam, N., Shi, X., Zeng, L., Butcher, E. C., & Mackay, C. R. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260320 · Cited by 167 · see citing works
Roles of T lymphocytes in pulmonary fibrosis
Luzina, I. G., Todd, N. W., Iacono, A. T., & Atamas, S. P. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0707504 · Cited by 163 · see citing works
Zhang, K., Shan, L., Rahman, M. S., Unruh, H. W., Halayko, A. J., & GOUNNI, A. S. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00045.2007 · Cited by 161 · see citing works
Nakamura, Y., Miyata, M., Ohba, T., Ando, T., Hatsushika, K., Suenaga, F., Shimokawa, N., Ohnuma, Y., Katoh, R., Ogawa, H., et al. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.09.022 · Cited by 158 · see citing works
Constant, S. L., Brogdon, J. L., Piggott, D. A., Herrick, C. A., Visintin, I., Ruddle, N. H., & Bottomly, K. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216109 · Cited by 157 · see citing works
Hyper-responsiveness of IPF/UIP fibroblasts: Interplay between TGFβ1, IL-13 and CCL2
Murray, L. A., Argentieri, R. L., Farrell, F. X., Bracht, M., Sheng, H., Whitaker, B., Beck, H., Tsui, P., Cochlin, K., Evanoff, H. L., et al. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.02.016 · Cited by 150 · see citing works
Cose, S., Brammer, C., Khanna, K. M., Masopust, D., & Lefrançois, L. (2006) · European Journal of Immunology · doi:10.1002/eji.200535539 · Cited by 149 · see citing works
IL-13 Induces Skin Fibrosis in Atopic Dermatitis by Thymic Stromal Lymphopoietin
Oh, M. H., Oh, S. Y., Yu, J., Myers, A. C., Leonard, W. J., Liu, Y.-J., Zhu, Z., & Zheng, T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100504 · Cited by 142 · see citing works
Severe interstitial lung disease in connective tissue disease: rituximab as rescue therapy
Keir, G. J., Maher, T. M., Hansell, D. M., Denton, C. P., Ong, V. H., Singh, S., Wells, A. U., & Renzoni, E. A. (2012) · European Respiratory Journal · doi:10.1183/09031936.00163911 · Cited by 137 · see citing works
Self-citationHeller, F., Fromm, A., Gitter, A. H., Mankertz, J., & Schulzke, J.-D. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.46 · Cited by 135 · see citing works
Strieter, R. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200710-160dr · Cited by 134 · see citing works
Soluble TNF Mediates the Transition from Pulmonary Inflammation to Fibrosis
Oikonomou, N., Harokopos, V., Zalevsky, J., Valavanis, C., Kotanidou, Α., Szymkowski, D. E., Kollias, G. A., & Aidinis, V. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000108 · Cited by 134 · see citing works
Weng, H., Liu, Y., Chen, J., Huang, T., Xu, L., Godoy, P., Hu, J.-H., Zhou, C., Stickel, F., Marx, A., et al. (2009) · Hepatology · doi:10.1002/hep.22934 · Cited by 129 · see citing works
Mercer, P. F., Johns, R., Scotton, C. J., Krupiczojc, M. A., Königshoff, M., Howell, D. C. J., McAnulty, R. J., Das, A., Thorley, A. J., Tetley, T., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200712-1827oc · Cited by 129 · see citing works
Self-citationShan, L., Redhu, N. S., Saleh, A. J., Halayko, A. J., Chakir, J., & GOUNNI, A. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902515 · Cited by 128 · see citing works
Dendritic Cells Accumulate in Human Fibrotic Interstitial Lung Disease
Marchal-Sommé, J., Uzunhan, Y., Marchand-Adam, S., Kambouchner, M., Valeyre, D., Crestani, B., & Soler, P. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200609-1347oc · Cited by 123 · see citing works
Oh, K., Park, H.-B., Byoun, O.-J., Shin, D.-M., Jeong, E. M., Kim, Y. W., Kim, Y. S., Melino, G., Kim, I.-G., & Lee, D.-S. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101457 · Cited by 118 · see citing works
Thymic Stromal Lymphopoietin Is a Key Mediator of Breast Cancer Progression
Olkhanud, P. B., Rochman, Y., Bodogai, M., Malchinkhuu, E., Wejksza, K., Xu, M., Gress, R. E., Hesdorffer, C., Leonard, W. J., & Biragyn, A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100463 · Cited by 112 · see citing works
Bleck, B., Tse, D. B., de Lafaille, M. A. C., Zhang, F., & Reibman, J. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9149-0 · Cited by 107 · see citing works
FcϵRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells
Okayama, Y., Okumura, S., Sagara, H., Yuki, K., Sasaki, T., Watanabe, N., Fueki, M., Sugiyama, K., Takeda, K., Fukuda, T., et al. (2009) · European Respiratory Journal · doi:10.1183/09031936.00121008 · Cited by 100 · see citing works
Hillion, J., Dhara, S., Sumter, T. F., Mukherjee, M., Di Cello, F., Belton, A., Turkson, J., Jaganathan, S., Cheng, L., Ye, Z., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2121 · Cited by 89 · see citing works
A Role for Dendritic Cells in Bleomycin-induced Pulmonary Fibrosis in Mice?
Bantsimba-Malanda, C., Marchal-Sommé, J., Goven, D., Freynet, O., Michel, L., Crestani, B., & Soler, P. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200907-1164oc · Cited by 86 · see citing works
Wohlmann, A., Sebastian, K., Borowski, A., Krause, S., & Friedrich, K. (2010) · Biological Chemistry · doi:10.1515/bc.2010.029 · Cited by 86 · see citing works
Redhu, N. S., Saleh, A. J., Halayko, A. J., Ali, A. S., & GOUNNI, A. S. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00301.2009 · Cited by 85 · see citing works
Thorley, A. J., Goldstraw, P. G., Young, A., & Tetley, T. D. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0196oc · Cited by 81 · see citing works
Schröer, N., Pahne, J., Walch, B., Wickenhauser, C., & Smola, S. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2193 · Cited by 78 · see citing works
A possible role for TSLP in inflammatory arthritis
Koyama, K., Ozawa, T., Hatsushika, K., Ando, T., Takano, S., Wako, M., Suenaga, F., Ohnuma, Y., Ohba, T., Katoh, R., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.081 · Cited by 72 · see citing works
Hartgring, S. A. Y., Willis, C. R., Dean, C., Broere, F., van Eden, W., Bijlsma, J. W. J., Lafeber, F. P. J. G., & van Roon, J. A. G. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30336 · Cited by 63 · see citing works
Barr, R. K., Boehm, I., Attwood, P. V., Watt, P. M., & Bogoyevitch, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402181200 · Cited by 61 · see citing works
Hogaboam, C. M., Lukacs, N. W., Chensue, S. W., Strieter, R. M., & Kunkel, S. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.9.4606 · Cited by 60 · see citing works
Christmann, R., Mathes, A. L., Affandi, A. J., Padilla, C. M., Nazari, B., Bujor, A. M., Stifano, G., & Lafyatis, R. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37859 · Cited by 59 · see citing works
Deng, X., Mercer, P. F., Scotton, C. J., Gilchrist, A., & Chambers, R. C. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-07-0720 · Cited by 55 · see citing works
Self-citationA profibrotic role for thymic stromal lymphopoietin in systemic sclerosis
Usategui, A., Criado, G., Izquierdo, E., Rey, M. J. D., Carreira, P. E., Ortiz-Romero, P. L., Leonard, W. J., & Pablos, J. L. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202279 · Cited by 52 · see citing works
Role of IL-13 in systemic sclerosis
Fuschiotti, P. (2011) · Cytokine · doi:10.1016/j.cyto.2011.08.030 · Cited by 51 · see citing works
Targeted therapies for systemic sclerosis
Denton, C. P., & Ong, V. H. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.46 · Cited by 49 · see citing works
Thymic Stromal Lymphopoietin Promotes Lung Inflammation Through Activation of Dendritic Cells
Li, Y., Li, H.-J., Ji, F., Zhang, X., Wang, R., Hao, J.-Q., Bi, W., & Dong, L. (2010) · Journal of Asthma · doi:10.3109/02770900903483816 · Cited by 41 · see citing works
Borowski, A., Kuepper, M., Horn, U., Knüpfer, U., Zissel, G., Höhne, K., Luttmann, W., Krause, S., Virchow, J. C., Jr., & Friedrich, K. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.02944.x · Cited by 38 · see citing works
Sphingosylphosphorylcholine Stimulates CCL2 Production from Human Umbilical Vein Endothelial Cells
Lee, H. Y., Lee, S., Kim, S. D., Shim, J. W., Kim, H. J., Jung, Y. S., Kwon, J. Y., Baek, S., Chung, J., & Bae, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002068 · Cited by 30 · see citing works
Flagged first, then by citations
1 of the 89 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Role of thymic stromal lymphopoietin in allergy and beyond
Ebina-Shibuya, R., & Leonard, W. J. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00735-y · Cited by 289 · see citing works
Biologics and airway remodeling in severe asthma
Varricchi, G., Ferri, S., Pepys, J., Poto, R., Spadaro, G., Nappi, E., Paoletti, G., Virchow, J. C., Jr., Heffler, E. M., & Canonica, G. W. (2022) · Allergy · doi:10.1111/all.15473 · Cited by 269 · see citing works
Divekar, R. D., & Kita, H. (2014) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000133 · Cited by 257 · see citing works
Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer
Varricchi, G., Pecoraro, A., Marone, G., Criscuolo, G., Spadaro, G., Genovese, A., & Marone, G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01595 · Cited by 210 · see citing works
Corren, J., & Ziegler, S. F. (2019) · Nature Immunology · doi:10.1038/s41590-019-0524-9 · Cited by 187 · see citing works
CXCL12/CXCR4: An amazing challenge and opportunity in the fight against fibrosis
Wu, X., Lu, Q., Zhao, H., Lei, W., Liu, Y., Xu, X., Li, J., Yang, Z., Wang, D., Zhang, Y., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101809 · Cited by 109 · see citing works
Tezepelumab: a novel biological therapy for the treatment of severe uncontrolled asthma
Marone, G., Spadaro, G., Braile, M., Poto, R., Criscuolo, G., Pahima, H. T., Loffredo, S., Levi‐Schaffer, F., & Varricchi, G. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1672657 · Cited by 98 · see citing works
The cytokines of pulmonary fibrosis: Much learned, much more to learn
Luzina, I. G., Todd, N. W., Sundararajan, S., & Atamas, S. P. (2014) · Cytokine · doi:10.1016/j.cyto.2014.11.008 · Cited by 90 · see citing works
Burkly, L. C. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.02.006 · Cited by 90 · see citing works
Thymic Stromal Lymphopoietin: To Cut a Long Story Short
Tsilingiri, K., Fornasa, G., & Rescigno, M. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.01.005 · Cited by 88 · see citing works
Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside
Ghonim, M. A., Boyd, D. F., Flerlage, T., & Thomas, P. G. (2023) · Journal of Clinical Investigation · doi:10.1172/jci170499 · Cited by 87 · see citing works
TSLP Inhibitors for Asthma: Current Status and Future Prospects
Matera, M. G., Rogliani, P., Calzetta, L., & Cazzola, M. (2020) · Drugs · doi:10.1007/s40265-020-01273-4 · Cited by 83 · see citing works
Forkel, M., Berglin, L., Kekäläinen, E., Carlsson, A., Svedin, E., Michaëlsson, J., Nagasawa, M., Erjefalt, J. S., Mori, M., Flodström‐Tullberg, M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646890 · Cited by 79 · see citing works
Lee, J.-U., Chang, H. S., Lee, H. J., Jung, C. A., Bae, D. J., Song, H. J., Park, J. S., Uh, S.-T., Kim, Y. H., Seo, K.-H., et al. (2017) · BMC Pulmonary Medicine · doi:10.1186/s12890-017-0380-z · Cited by 73 · see citing works
Herro, R., Antunes, R. D. S., Aguilera, A. R., Tamada, K., & Croft, M. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1936 · Cited by 62 · see citing works
Smolińska, S., Antolín‐Amérigo, D., Popescu, F., & Jutel, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612725 · Cited by 59 · see citing works
Structural basis of the proinflammatory signaling complex mediated by TSLP
Verstraete, K., van Schie, L., Vyncke, L., Bloch, Y., Tavernier, J. H., Pauwels, E., Peelman, F., & Savvides, S. N. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2794 · Cited by 59 · see citing works
The Epithelial-Immune Crosstalk in Pulmonary Fibrosis
Planté-Bordeneuve, T., Pilette, C., & Froidure, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631235 · Cited by 55 · see citing works
Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases
Wang, S.-H., & Zuo, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.698522 · Cited by 54 · see citing works
Shin, J. U., Kim, S. H., Kim, H.-R., Noh, J. Y., Jin, S., Park, C. O., Lee, W. J., Lee, D. W., Lee, J. H., & Lee, D. W. (2015) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.11.008 · Cited by 52 · see citing works
CC Chemokines in Idiopathic Pulmonary Fibrosis: Pathogenic Role and Therapeutic Potential
Liu, S., Liu, C., Wang, Q., Liu, S., & Min, J. (2023) · Biomolecules · doi:10.3390/biom13020333 · Cited by 48 · see citing works
Truchetet, M., Demoures, B., Guimaraes, J. E., Bertrand, A., Laurent, P., Jolivel, V., Douchet, I., Jacquemin, C., Khoryati, L., Duffau, P., et al. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39817 · Cited by 48 · see citing works
Braile, M., Fiorelli, A., Sorriento, D., Crescenzo, R. M. D., Galdiero, M. R., Marone, G., Santini, M., Varricchi, G., & Loffredo, S. (2021) · Cells · doi:10.3390/cells10082012 · Cited by 41 · see citing works
Emson, C. L., Diver, S. E., Chachi, L., Megally, A., Small, C. L., Downie, J., Parnes, J. R., Bowen, K., Colice, G., & Brightling, C. E. (2020) · Respiratory Research · doi:10.1186/s12931-020-01513-x · Cited by 40 · see citing works
Canè, L., Poto, R., Palestra, F., Pirozzi, M., Parashuraman, S., Iacobucci, I., Ferrara, A. L., Rocca, A. L., Mercadante, E., Pucci, P., et al. (2024) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2024.02.020 · Cited by 38 · see citing works
Biancheri, P., Sabatino, A. D., Rescigno, M., Giuffrida, P., Fornasa, G., Tsilingiri, K., Pender, S. L. F., Papadia, C., Wood, E., Pasini, A., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308876 · Cited by 38 · see citing works
Niclosamide Prevents Systemic Sclerosis in a Reactive Oxygen Species–Induced Mouse Model
Morin, F., Kavian, N., Nicco, C., Cerles, O., Chéreau, C., & Batteux, F. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502482 · Cited by 37 · see citing works
Ntelis, K., Bogdanos, D. P., Dimitroulas, T., Sakkas, L. I., & Daoussis, D. (2019) · Current Rheumatology Reports · doi:10.1007/s11926-019-0815-z · Cited by 35 · see citing works
Kwon, O. C., Lee, E., Chang, E., Youn, J., Ghang, B., Hong, S., Lee, C., Yoo, B., & Kim, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01544 · Cited by 31 · see citing works
Chao Hui, Z. H. O. U., Wang, P., Lei, L., Huang, Y., & Wu, Y. (2020) · Aging · doi:10.18632/aging.103172 · Cited by 27 · see citing works
Severe Asthmatic Responses: The Impact of TSLP
Theofani, E., Tsitsopoulou, A., Morianos, I., & Semitekolou, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087581 · Cited by 21 · see citing works
Jin, A., Bao, R., Roth, M., Liu, L., Yang, X., Tang, X., Yang, X., Sun, Q., & Lu, S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28718 · Cited by 21 · see citing works
A Novel Fibroblast Reporter Cell Line for in vitro Studies of Pulmonary Fibrosis
Németh, J., Schundner, A., Quast, K., Winkelmann, V. E., & Frick, M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.567675 · Cited by 19 · see citing works
Improvement of Sclerodermatous Graft-Versus-Host Disease in Mice by Niclosamide
Morin, F., Kavian, N., Nicco, C., Cerles, O., Chéreau, C., & Batteux, F. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.06.624 · Cited by 19 · see citing works
Li, Y., Lund, C., Nervik, I. H., Loevenich, S., Døllner, H., Anthonsen, M. W., & Johnsen, I. B. (2018) · Scientific Reports · doi:10.1038/s41598-018-19225-0 · Cited by 19 · see citing works
Xu, X., Dai, H., & Zhang, J. (2022) · The Clinical Respiratory Journal · doi:10.1111/crj.13541 · Cited by 18 · see citing works
Xu, X., Zhang, J., & Dai, H. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220915428 · Cited by 19 · see citing works
Truffault, F., Nazzal, D., Verdier, J., Gradolatto, A., Fadel, É., Roussin, R., Eymard, B., Panse, R. L., & Berrih‐Aknin, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00782 · Cited by 16 · see citing works
Thymic Stromal Lymphopoietin (TSLP) Is Cleaved by Human Mast Cell Tryptase and Chymase
Canè, L., Poto, R., Palestra, F., Iacobucci, I., Pirozzi, M., Parashuraman, S., Ferrara, A. L., Illiano, A., Rocca, A. L., Mercadante, E., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074049 · Cited by 14 · see citing works
Majewski, S., Szewczyk, K., Białas, A. J., Miłkowska-Dymanowska, J., Górski, P., & Piotrowski, W. J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101590 · Cited by 14 · see citing works
Kang, J., Yang, H., Park, J., Shin, J., Kim, T., Lee, S. H., Lee, H., & Park, I. (2020) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22641 · Cited by 14 · see citing works
Majewski, S., Tworek, D., Szewczyk, K., Kurmanowska, Z., Antczak, A. J., Górski, P., & Piotrowski, W. J. (2019) · The Clinical Respiratory Journal · doi:10.1111/crj.13075 · Cited by 13 · see citing works
Functions of thymic stromal lymphopoietin in non-allergic diseases
Ying, G., Zhang, Y., Tang, G., & Chen, S. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.03.006 · Cited by 10 · see citing works
Chen, Z., Meng, P., Li, H., Li, M., Yang, L., Yan, Y., Li, Y., Zou, X., Wang, D.-Y., & Zhang, T. (2017) · Journal of Asthma · doi:10.1080/02770903.2017.1386213 · Cited by 9 · see citing works
TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts
Wang, D., Wang, F., Huang, Y., Wang, J., Luo, H., Zhang, P., Peng, J., Tang, G., Wang, Y., Yu, L., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110430 · Cited by 8 · see citing works
Usman, K., Fouadi, M., Nwozor, K. O., Aminazadeh, F., Nair, P. K., Luo, H., Sin, D. D., Osei, E. T., & Hackett, T. (2024) · Matrix Biology · doi:10.1016/j.matbio.2024.06.007 · Cited by 8 · see citing works
TSLP: contrasting roles in cancer
Poto, R., Marone, G., Ziegler, S. F., & Varricchi, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1627235 · Cited by 7 · see citing works
Froidure, A., Joannes, A., Mailleux, A., & Crestani, B. (2016) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2016.1171140 · Cited by 7 · see citing works
Immune mechanisms and novel therapies for idiopathic pulmonary fibrosis
Gao, D., Gao, W., Zhai, Z., & Zhu, W. (2023) · Pharmaceutical Science Advances · doi:10.1016/j.pscia.2023.100030 · Cited by 6 · see citing works
Potential New Inflammatory Markers in Bronchiectasis: A Literature Review
Bertuccio, F. R., Baio, N., Montini, S., Ferroni, V., Chino, V., Pisanu, L., Russo, M., Giana, I., Cascina, A., Conio, V., et al. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46070398 · Cited by 5 · see citing works
Beyond inflammation: alarmins as critical drivers of pulmonary fibrosis
Pianigiani, T., Dilroba, A., Gambini, C., Hernández‐González, F., d’Alessandro, M., Bergantini, L., Sellarés, J., Bargagli, E., & Cameli, P. (2025) · ERJ Open Research · doi:10.1183/23120541.00747-2025 · Cited by 5 · see citing works
Efficacy of tezepelumab in patients with severe asthma and persistent airflow obstruction
Israel, E., Castro, M., Ambrose, C. S., Llanos, J., Molfino, N. A., Martin, N. L., Ponnarambil, S. S., & Martin, N. (2024) · ERJ Open Research · doi:10.1183/23120541.00164-2024 · Cited by 5 · see citing works
Hypoxia and Local Inflammation in Pulmonary Artery Structure and Function
Thompson, M., Britt, R. D., Pabelick, C. M., & Prakash, Y. S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_20 · Cited by 5 · see citing works
Thymic stromal lymphopoietin (TSLP) – pro-inflammatory cytokine and antimicrobial peptide
Döhner, K., John, O. P., & Werfel, T. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2026.120127 · Cited by 4 · see citing works
Another Piece in the Fibrotic Puzzle: TSLP as a Novel Ligand for Fibrocyte Activation
Christmann, R. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.11.014 · Cited by 4 · see citing works
Hsieh, P., Liu, S., Hung, T., Hung, C., Liu, G.-Z., Chuang, L., Chen, M.-F., Wang, J., Shi, M., Hsu, C. H., et al. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.07.027 · Cited by 4 · see citing works
The role of atopy in the pathogenesis of bleomycin pulmonary toxicity
Özyiğit, L. P., Çetin, E. A., ŞENBAŞ, Z. A., Öztürk, A. B., Öztürk, E., Ergonul, M. O., Tabak, L., Ferhanoğlu, B., Çeti̇ner, M., & Deniz, G. (2019) · Respiratory Medicine · doi:10.1016/j.rmed.2019.06.020 · Cited by 4 · see citing works
An up-to-date review of approved and emerging antibody therapies for idiopathic pulmonary fibrosis
Simonetti, J., Sgalla, G., & Richeldi, L. (2023) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2023.2268014 · Cited by 4 · see citing works
High plasma levels of the TSLP cytokine in Saudi patients with chronic stable asthma
Alturaiki, W. (2022) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2022.102271 · Cited by 3 · see citing works
LTI-03 peptide demonstrates anti-fibrotic activity in ex vivo lung slices from patients with IPF
MacKenzie, B., Mahavadi, P., Pinho Jannini-Sa, Y. A., Creyns, B., Coelho, A. L., Espindola, M., Ruppert, C., Windsor, B., Aigner, C., Hogaboam, C. M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113437 · Cited by 2 · see citing works
MacKenzie, B., Mahavadi, P., de Sá, Y. A. P. J., Creyns, B., Coelho, A. L., Espíndola, M. S., Ruppert, C., Hötzenecker, K., Hogaboam, C. M., & Günther, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.24.589970 · Cited by 2 · see citing works
Inhaled LTI-03 for idiopathic pulmonary fibrosis: a randomized dose escalation study
Molyneaux, P. L., Hirani, N. A., Chia, C. C. K., Kulkarni, T., Zaman, T., Kaner, R. J., Coelho, A. L., Jannini-Sa, Y. A. P., Windsor, B., Kruger, S., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75291-3 · Cited by 1 · see citing works
Cha, H., Jo, A., Lim, H.-S., Eun, K. M., Park, J.-N., Hong, S., & Kim, D. W. (2025) · Clinical and Experimental Otorhinolaryngology · doi:10.21053/ceo.2025-00142 · Cited by 1 · see citing works
Collaborative functionality between three types of inflammation in idiopathic pulmonary fibrosis
Fabre, T., Wynn, T. A., & Hart, K. M. (2026) · Nature Immunology · doi:10.1038/s41590-026-02616-1 · Cited by 1 · see citing works
P105 Endoplasmic reticulum stress mediates dermal fibrosis
O’Reilly, S. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-ewrr2018.121
P103 Pro-fibrotic responses induced by thymic stromal lymphopoetin
Wang, L., Wang, S., Taneja, V., & Vassallo, R. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-ewrr2018.119
P104 Synovial fibroblast relationship status: it's complicated
Byrne, R., Calvo, I. O., Kartnig, F., Platzer, A., Zheden, V., Lovicar, L., Holinka, J., Steiner, G. E., Ertl, P., Smolen, J., et al. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-ewrr2018.120
P107 Targeting activated synovial fibroblasts using photodynamic therapy in experimental arthritis
Dorst, D. N., Rijpkema, M., Buitinga, M., Brom, M., Bos, D., Freimoser–Grundschober, A., Klein, C., Walgreen, B., van der Kraan, P., Gotthardt, M., et al. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-ewrr2018.122
Hirt, P. A., Aickara, D. J., Sanchez, D. P., & Lev‐Tov, H. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-84744-5.00021-8
Hou, S., Yang, B., Wang, L., Yu, C., & Wang, J. (2025) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2025.117106
Asthma: Is It Time for Monocytes to Share the Spotlight?
Vliagoftis, H., & Palikhe, N. S. (2026) · Cells · doi:10.3390/cells15141233
The cutaneous vasculature: Development, repair, and disease.
Wang, K., Quintana, J., Yang, V., Kawasumi, K., & Kam, C. Y. (2026) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2026.103704
- Authors
- Datta, A., Alexander, R., Sulikowski, M. G., Nicholson, A. G., Maher, T. M., Scotton, C. J., & Chambers, R. C.
- Affiliations
- University College London (GB)
- Royal Brompton Hospital (GB)
- Corresponding author
- Datta, Arnab
- Alexander, Robert
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-11-01
- Volume
- 191
- Issue
- 9
- Pages
- 4867-4879
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC3836180
- OpenAlex
- W2108352507
- Cited by
- 73
- References
- 89
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 4
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- GlaxoSmithKline
- Wellcome Trust (084382, 084382/Z/07/Z)
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- thymic stromal lymphopoietin, idiopathic pulmonary fibrosis, Th2 immune response, lung fibroblasts, TSLP receptor, MCP-1, STAT3, monocyte chemotaxis, fibrosis, chemokine regulation, extracellular matrix
- MeSH terms
- Thymic Stromal Lymphopoietin, Cells, Cultured, Chemotaxis, Fibroblasts, Fibrosis, Humans, Inflammation, Lung, Signal Transduction, Interleukin-7, Cytokines, Receptors, Cytokine, Chemokine CCL2, RNA Interference, RNA, Small Interfering, STAT3 Transcription Factor, Idiopathic Pulmonary Fibrosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
