The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mucins in the mucosal barrier to infection
Open accessAbstract
The mucosal tissues of the gastrointestinal, respiratory, reproductive, and urinary tracts, and the surface of the eye present an enormous surface area to the exterior environment. All of these tissues are covered with resident microbial flora, which vary considerably in composition and complexity. Mucosal tissues represent the site of infection or route of access for the majority of viruses, bacteria, yeast, protozoa, and multicellular parasites that cause human disease. Mucin glycoproteins are secreted in large quantities by mucosal epithelia, and cell surface mucins are a prominent feature of the apical glycocalyx of all mucosal epithelia. In this review, we highlight the central role played by mucins in accommodating the resident commensal flora and limiting infectious disease, interplay between underlying innate and adaptive immunity and mucins, and the strategies used by successful mucosal pathogens to subvert or avoid the mucin barrier, with a particular focus on bacteria.
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Cites
Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002) · Science · doi:10.1126/science.1069094 · Cited by 936
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Self-citationKoninkx, J. F. J. G., Mirck, M. H., Hendriks, H. G. C. J. M., Mouwen, J. M. V. M., & van Dijk, J. E. (1988) · Experimental Parasitology · doi:10.1016/0014-4894(88)90109-9 · Cited by 65
Cited by
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A., van der Post, S., Svensson, F., Rodríguez‐Piñeiro, A. M., Nyström, E. E. L., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12182 · Cited by 1,363
The microbiota of the respiratory tract: gatekeeper to respiratory health
Man, W. H., de Steenhuijsen Piters, W. A. A., & Bogaert, D. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.14 · Cited by 1,384
Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice
Jin, Y., Lu, L., Tu, W., Luo, T., & Fu, Z. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.08.353 · Cited by 1,100
Candida albicans biofilms: development, regulation, and molecular mechanisms
Gulati, M., & Nobile, C. J. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.01.002 · Cited by 738
Metadata
- Authors
- Linden, S. K., Sutton, P., Karlsson, N. G., Korolik, V, & McGuckin, M. A.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 1
- Issue
- 3
- Pages
- 183-197
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W2039478605
- Cited by
- 1,234
- References
- 3
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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