Cited by 738Antifungal resistance and susceptibilityFungal and yeast genetics researchBacterial biofilms and quorum sensing

Candida albicans biofilms: development, regulation, and molecular mechanisms

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Gulati, Megha, Nobile, Clarissa J.·2016·Microbes and Infection

Abstract

A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed communities of cells adhered to a surface. These biofilms are intrinsically resistant to conventional antifungal therapeutics, the host immune system, and other environmental factors, making biofilm-associated infections a significant clinical challenge. Here, we review current knowledge on the development, regulation, and molecular mechanisms of C. albicans biofilms.

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Crossref · 10.1016/j.micinf.2016.01.002

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  • Biofilm formation helps fungal cells survive antifungal treatment by secreting extracellular matrix and enhancing drug efflux pump activity, which is closely related to antifungal tolerance and resistance.

    “Biofilm formation helps fungal cells survive antifungal treatment by secreting extracellular matrix and enhancing drug efflux pump activity, which is closely related to antifungal tolerance and resistance [75–77].”

    From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [75]

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Authors
Gulati, M., & Nobile, C. J.
Affiliations
University of California, Merced (US)
Corresponding author
Nobile, Clarissa J.
Venue
Microbes and Infection
Publisher
Elsevier BV
Published
2016-05
Volume
18
Issue
5
Pages
310-321
ISSN
1286-4579 (ISSN-L)
OpenAlex
W2252911663
Cited by
738
References
78
Citations by year
2026: 77 · 2025: 100 · 2024: 101 · 2023: 99 · 2022: 104 · 2021: 81 · 2020: 74 · 2019: 35 · 2018: 31 · 2017: 28 · 2016: 8
FWCI
5.23
Type
journal article
Language
en
Open access
Locations
  • Microbes and Infection (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
NIH (R00AI100896)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
Candida albicans, biofilm, biofilm formation, biofilm regulation, molecular mechanisms, antifungal resistance, host immune evasion, fungal virulence, biofilm-associated infections
MeSH terms
Candida albicans, Humans, Virulence, Gene Expression Regulation, Fungal, Biofilms

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