The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung
Open accessAbstract
Influenza virus infection is considered a major worldwide public health problem. Seasonal infections with the most common influenza virus strains (e.g., H1N1) can usually be resolved, but they still cause a high rate of mortality. The factors that influence the outcome of the infection remain unclear. Here, we show that deficiency of interleukin (IL)-6 or IL-6 receptor is sufficient for normally sublethal doses of H1N1 influenza A virus to cause death in mice. IL-6 is necessary for resolution of influenza infection by protecting neutrophils from virus-induced death in the lung and by promoting neutrophil-mediated viral clearance. Loss of IL-6 results in persistence of the influenza virus in the lung leading to pronounced lung damage and, ultimately, death. Thus, we demonstrate that IL-6 is a vital innate immune cytokine in providing protection against influenza A infection. Genetic or environmental factors that impair IL-6 production or signaling could increase mortality to influenza virus infection.
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Cites
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Cited by
IL-6 as a keystone cytokine in health and disease
Hunter, C. A., & Jones, S. A. (2015) · Nature Immunology · doi:10.1038/ni.3153 · Cited by 2,511
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Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies
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Metadata
- Authors
- Dienz, O., Rud, J. G., Eaton, S. M., Lanthier, P. A., Burg, E., Drew, A., Bunn, J., Suratt, B. T., Haynes, L., & Rincon, M.
- Venue
- Mucosal Immunology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 5
- Issue
- 3
- Pages
- 258-266
- ISSN
- 1933-0219 (ISSN-L)
- OpenAlex
- W2002012748
- Cited by
- 275
- References
- 55
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung. https://app.cochat.ai/papers/10.1038/mi.2012.2
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- Dienz, O., Rud, J. G., Eaton, S. M., Lanthier, P. A., Burg, E., Drew, A., Bunn, J., Suratt, B. T., Haynes, L., & Rincon, M. (2012). Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung. Mucosal Immunology. https://doi.org/10.1038/mi.2012.2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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