Cited by 721Immunotherapy and Immune ResponsesImmune Response and InflammationT-cell and B-cell Immunology

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Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium

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Mabbott, N A, Donaldson, D S, Ohno, H, Williams, I R, Mahajan, A·2013·Mucosal Immunology

DOI 10.1038/mi.2013.30PMC PMC3686595

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Abstract

The transcytosis of antigens across the gut epithelium by microfold cells (M cells) is important for the induction of efficient immune responses to some mucosal antigens in Peyer's patches. Recently, substantial progress has been made in our understanding of the factors that influence the development and function of M cells. This review highlights these important advances, with particular emphasis on: the host genes which control the functional maturation of M cells; how this knowledge has led to the rapid advance in our understanding of M-cell biology in the steady state and during aging; molecules expressed on M cells which appear to be used as "immunosurveillance" receptors to sample pathogenic microorganisms in the gut; how certain pathogens appear to exploit M cells to infect the host; and finally how this knowledge has been used to specifically target antigens to M cells to attempt to improve the efficacy of mucosal vaccines.

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Authors: Mabbott, N. A., Donaldson, D. S., Ohno, H., Williams, I. R., & Mahajan, A.
Affiliations: Roslin Institute (GB)
RIKEN Center for Integrative Medical Sciences (JP)
Emory University (US)
Corresponding author: Mabbott, N A
ORCID: Mabbott, N A
Donaldson, D S
Ohno, H
Williams, I R
Mahajan, A
Venue: Mucosal Immunology
Publisher: Elsevier BV
Published: 2013-07
Volume: 6
Issue: 4
Pages: 666-677
ISSN: 1933-0219 (ISSN-L)
DOI: 10.1038/mi.2013.30
PMC: PMC3686595
OpenAlex: W2085355903
Cited by: 721
References: 118
Citations by year: 2026: 52 · 2025: 48 · 2024: 61 · 2023: 66 · 2022: 50 · 2021: 68 · 2020: 71 · 2019: 54 · 2018: 78 · 2017: 56 · 2016: 43 · 2015: 46 · 2014: 22 · 2013: 5
FWCI: 3.37
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3132 d)
Locations: Mucosal Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders: National Institutes of Health
Directorate for Biological Sciences
Biotechnology and Biological Sciences Research Council (BB/G003947/1, BB/F019726/1, BB/J014672/1, BBS/E/D/20231759, BB/J0004332/1, BB/K021257/1, BBS/E/D/20251968, BBS/E/D/20251967, JPA1797)
Japan Society for the Promotion of Science (24249029)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064730, DK-064730)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: M cells, Peyer's patches, intestinal epithelium, mucosal immunity, immune surveillance, host genes, aging, mucosal vaccines, antigen targeting
MeSH terms: Age Factors, Animals, Antigens, Antigens, Surface, Cell Communication, Cell Differentiation, Humans, Intestinal Mucosa, Peyer's Patches, Stem Cells, Transcription Factors, Monitoring, Immunologic, Receptors, G-Protein-Coupled, RANK Ligand, Host-Pathogen Interactions

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Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium

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