Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset and remission from depression

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477 · see citing works

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473 · see citing works

Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression

David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267 · see citing works

Cellular changes in the postmortem hippocampus in major depression

Stockmeier, C. A., Mahajan, G. J., Konick, L. C., Overholser, J. C., Jurjus, G. J., Meltzer, H. Y., Uylings, H. B. M., Friedman, L., & Rajkowska, G. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.022 · Cited by 732 · see citing works

Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder

Cotter, D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.386 · Cited by 634 · see citing works

The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling

Bessa, J. M., Ferreira, D., Melo, I., Marques, F., Cerqueira, J. J., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.119 · Cited by 598 · see citing works

Adult hippocampal neurogenesis is involved in anxiety-related behaviors

Revest, J.-M., Dupret, D., Koehl, M., Funk-Reiter, C., Grosjean, N., Piazza, P.-V., & Abrous, D. N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.15 · Cited by 549 · see citing works

Antidepressants recruit new neurons to improve stress response regulation

Surget, A., Tanti, A., Leonardo, E. D., Laugeray, A., Rainer, Q., Touma, C., Palme, R., Griebel, G., Ibarguen-Vargas, Y., Hen, R., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.48 · Cited by 471 · see citing works

Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

Banasr, M., Chowdhury, G. M. I., Terwilliger, R., Newton, S. S., Duman, R. S., Behar, K. L., & Sanacora, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.106 · Cited by 458 · see citing works

Optical controlling reveals time-dependent roles for adult-born dentate granule cells

Gu, Y., Arruda-Carvalho, M., Wang, J., Janoschka, S., Josselyn, S. A., Frankland, P. W., & Ge, S. (2012) · Nature Neuroscience · doi:10.1038/nn.3260 · Cited by 423 · see citing works

Sustained remission from depressive-like behavior depends on hippocampal neurogenesis

Mateus-Pinheiro, A., Pinto, L., Bessa, J. M., Morais, M., Alves, N. D., Monteiro, S., Patrício, P., Almeida, O. F. X., & Sousa, N. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.141 · Cited by 149 · see citing works

Basolateral amygdala regulation of adult hippocampal neurogenesis and fear-related activation of newborn neurons

Kirby, E. D., Friedman, A. R., Covarrubias, D., Ying, C., Sun, W. G., Goosens, K. A., Sapolsky, R. M., & Kaufer, D. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.71 · Cited by 87 · see citing works

Decreased cell proliferation in the dentate gyrus does not associate with development of anhedonic-like symptoms in rats

Jayatissa, M. N., Henningsen, K., West, M. J., & Wiborg, O. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.001 · Cited by 79 · see citing works

Anxiety- rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety- and comorbid depression-like behavior

Sah, A., Schmuckermair, C., Sartori, S. B., Gaburro, S., Kandasamy, M., Irschick, R., Klimaschewski, L. P., Landgraf, R., Aigner, L., & Singewald, N. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.94 · Cited by 67 · see citing works

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

Brites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00476 · Cited by 599 · see citing works

Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder

Cobb, J. A., O’Neill, K., Milner, J., Mahajan, G. J., Lawrence, T. J., May, W. L., Miguel-Hidalgo, J., Rajkowska, G., & Stockmeier, C. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.044 · Cited by 254 · see citing works

Mesenchymal stem cells secretome as a modulator of the neurogenic niche: basic insights and therapeutic opportunities

Salgado, A. J., Sousa, J. C., Costa, B. M., Pires, A. O., Mateus‐Pinheiro, A., Teixeira, F. G., Pinto, L., & Sousa, N. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00249 · Cited by 113 · see citing works

CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases

Quach, T., Honnorat, J., Kolattukudy, P. E., Khanna, R., & Duchemin, A. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.77 · Cited by 108 · see citing works

Consequences of cancer treatments on adult hippocampal neurogenesis: implications for cognitive function and depressive symptoms

Pereira Dias, G., Hollywood, R., Bevilaqua, M. C. D. N., da Silveira da Luz, A. C. D., Hindges, R., Nardi, A. E., & Thuret, S. (2014) · Neuro-Oncology · doi:10.1093/neuonc/not321 · Cited by 85 · see citing works

Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression

Alves, N. D., Correia, J. S., Patrício, P., Mateus-Pinheiro, A., Machado-Santos, A. R., Loureiro-Campos, E., Morais, M., Bessa, J. M., Sousa, N., & Pinto, L. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.29 · Cited by 79 · see citing works

Development of Anxiety-Like Behavior via Hippocampal IGF-2 Signaling in the Offspring of Parental Morphine Exposure: Effect of Enriched Environment

Li, C.-Q., Luo, Y., Bi, F., Cui, T.-T., Song, L., Cao, W.-Y., Zhang, J. J., Li, F., Xu, J., Hao, W., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.128 · Cited by 71 · see citing works

L ‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA 1

Lambertus, M., Øverberg, L. T., Andersson, K. A., Hjelden, M. S., Hadzic, A., Haugen, Ø. P., Storm‐Mathisen, J., Bergersen, L. H., Geiseler, S. J., & Morland, C. (2020) · Acta Physiologica · doi:10.1111/apha.13587 · Cited by 62 · see citing works

Differential and Converging Molecular Mechanisms of Antidepressants’ Action in the Hippocampal Dentate Gyrus

Patrício, P., Mateus-Pinheiro, A., Irmler, M., Alves, N. D., Machado-Santos, A. R., Morais, M., Correia, J. S., Korostynski, M., Piechota, M., Stoffel, R., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.176 · Cited by 57 · see citing works

Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABAA Receptor Expression in a Preclinical Model of Depression

Brymer, K. J., Fenton, E. Y., Kalynchuk, L., & Caruncho, H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00121 · Cited by 49 · see citing works

The Sweet Drive Test: refining phenotypic characterization of anhedonic behavior in rodents

Mateus‐Pinheiro, A., Patrício, P., Alves, N. D., Machado-Santos, A. R., Morais, M., Bessa, J. M., Sousa, N., & Pinto, L. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00074 · Cited by 48 · see citing works

AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior

Mateus‐Pinheiro, A., Alves, N. D., Patrício, P., Machado-Santos, A. R., Loureiro‐Campos, E., Silva, J. M., Sardinha, V. M., Reis, J. S., Schorle, H., Oliveira, J. F., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.169 · Cited by 38 · see citing works

Chronic stress targets adult neurogenesis preferentially in the suprapyramidal blade of the rat dorsal dentate gyrus

Alves, N. D., Patrício, P., Correia, J. S., Mateus‐Pinheiro, A., Machado-Santos, A. R., Loureiro‐Campos, E., Morais, M., Bessa, J. M., Sousa, N., & Pinto, L. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1490-3 · Cited by 37 · see citing works

Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects

Kanzari, A., Bourcier-Lucas, C., Freyssin, A., Abrous, D. N., Haddjeri, N., & Lucas, G. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.94 · Cited by 33 · see citing works

Beyond New Neurons in the Adult Hippocampus: Imipramine Acts as a Pro-Astrogliogenic Factor and Rescues Cognitive Impairments Induced by Stress Exposure

Machado-Santos, A. R., Loureiro‐Campos, E., Patrício, P., Araújo, B., Alves, N. D., Mateus‐Pinheiro, A., Correia, J. S., Morais, M., Bessa, J. M., Sousa, N., et al. (2022) · Cells · doi:10.3390/cells11030390 · Cited by 22 · see citing works

Hippocampal cytogenesis abrogation impairs inter-regional communication between the hippocampus and prefrontal cortex and promotes the time-dependent manifestation of emotional and cognitive deficits

Mateus‐Pinheiro, A., Patrício, P., Alves, N. D., Martins‐Macedo, J., Caetano, I., Silveira‐Rosa, T., Araújo, B., Mateus‐Pinheiro, M., Silva‐Correia, J., Sardinha, V. M., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01287-8 · Cited by 21 · see citing works

Association between Sirtuin 1 Gene rs10997870 Polymorphism and Suicide Behaviors in Bipolar Disorder

Nivoli, A., Porcelli, S., Albani, D., Forloni, G., Fusco, F., Colom, F., Vieta, E., & Serretti, A. (2016) · Neuropsychobiology · doi:10.1159/000446921 · Cited by 20 · see citing works

Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats

Khalil, H. M. A., Mahmoud, D. B. E. D., El‐Shiekh, R. A., Bakr, A. F., Boseila, A. A., Mehanna, S., Naggar, R. A., & Eliwa, H. A. (2022) · AAPS PharmSciTech · doi:10.1208/s12249-022-02387-6 · Cited by 18 · see citing works

Unveiling GABA and Serotonin Interactions During Neurodevelopment to Re-Open Adult Critical Periods for Neuropsychiatric Disorders

Beretta, E., Cuboni, G., & Deidda, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125508 · Cited by 12 · see citing works

miR-409 and miR-411 Modulation in the Adult Brain of a Rat Model of Depression and After Fluoxetine Treatment

Patrício, P., Mateus‐Pinheiro, A., Alves, N. D., Morais, M., Rodrigues, A. J., Bessa, J. M., Sousa, N., & Pinto, L. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00136 · Cited by 9 · see citing works

Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation

Martins-Macedo, J., Araújo, B., Anjo, S. I., Silveira-Rosa, T., Patrício, P., Alves, N. D., Silva, J. M., Teixeira, F. G., Manadas, B., Rodrigues, A. J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02490-z · Cited by 6 · see citing works

AP2γ: A New Player on Adult Hippocampal Neurogenesis Regulation

Mateus‐Pinheiro, A., Alves, N. D., Sousa, N., & Pinto, L. (2018) · Journal of Experimental Neuroscience · doi:10.1177/1179069518766897 · Cited by 6 · see citing works

Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods

Loureiro‐Campos, E., Mateus-Pinheiro, A., Patrício, P., Soares‐Cunha, C., Silva, J., Sardinha, V. M., Mendes-Pinheiro, B., Silveira‐Rosa, T., Domingues, A. V., Rodrigues, A. J., et al. (2021) · eLife · doi:10.7554/elife.70685 · Cited by 5 · see citing works

Lesion-Induced Dendritic Remodeling as a New Mechanism of Homeostatic Structural Plasticity in the Adult Brain

Platschek, S., Cuntz, H., Deller, T., & Jedlička, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803784-3.00009-3 · Cited by 5 · see citing works

Chronic stress and cytogenesis ablation disrupt hippocampal neuron connectivity, with fluoxetine restoring function with sex-specific effects

Ribeiro, I., Silveira‐Rosa, T., Martins‐Macedo, J., Marques-Ferraz, L., Dourado, A. R., Martins-Ferreira, G., Farrugia, F., Rodrigues, A. J., Abrous, D. N., Alves, N. D., et al. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100743 · Cited by 3 · see citing works

Neural Stem Cell‐Derived Astrogliogenesis: The Hidden Player of the Adult Hippocampal Cytogenic Niche

Ferreira, G. A. M., & Pinto, L. (2025) · Glia · doi:10.1002/glia.70031 · Cited by 2 · see citing works

Ketamine strengthens synaptic inputs to the dorsal raphé to boost serotonergic activity: pivotal for rapid antidepressant-like effectsPreprint

Es-Safi, S., Bourcier‐Lucas, C., Abrial, E., Cathala, A., Lesté-Lasserre, T., Deurwaerdère, P. D., Revest, J., Mazella, J., Haddjeri, N., & Lucas, G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.24.684353

Etude de la dérégulation de l'axe HPA dans la création d'une résistance aux antidépresseurs et son implication dans la prolifération cellulaire et la neurogénèse hippocampique

Khemissi, W. (2014) · doi:10.70675/d4dad780z3358z4ca4zb903z0ac2400ade77

Sex Differences in Depression: Adult Cytogenesis as Potential Target for Precision Psychiatry

Rodrigues-Freitas, L., Pinto, L., & Canedo, T. (2026) · Cells · doi:10.3390/cells15121059

OPEN PERSPECTIVE

Genesis, C. (2016)

憂鬱症生理病因之“神經可塑性”假說

蘇宗偉, & 李明濱 (2005) · 北市醫學雜誌 · doi:10.6200/tcmj.2005.2.2.01

Neuroimaging and neurogenesis of depression

Frodl, T. (2011) · European Psychiatry · doi:10.1016/s0924-9338(11)73754-3

Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications

Tartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408 · see citing works

Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy

Païzanis, E., Hamon, M., & Lanfumey, L. (2007) · Neural Plasticity · doi:10.1155/2007/73754 · Cited by 94 · see citing works