Antidepressants recruit new neurons to improve stress response regulation
Open accessAbstract
Recent research suggests an involvement of hippocampal neurogenesis in behavioral effects of antidepressants. However, the precise mechanisms through which newborn granule neurons might influence the antidepressant response remain elusive. Here, we demonstrate that unpredictable chronic mild stress in mice not only reduces hippocampal neurogenesis, but also dampens the relationship between hippocampus and the main stress hormone system, the hypothalamo-pituitary-adrenal (HPA) axis. Moreover, this relationship is restored by treatment with the antidepressant fluoxetine, in a neurogenesis-dependent manner. Specifically, chronic stress severely impairs HPA axis activity, the ability of hippocampus to modulate downstream brain areas involved in the stress response, the sensitivity of the hippocampal granule cell network to novelty/glucocorticoid effects and the hippocampus-dependent negative feedback of the HPA axis. Remarkably, we revealed that, although ablation of hippocampal neurogenesis alone does not impair HPA axis activity, the ability of fluoxetine to restore hippocampal regulation of the HPA axis under chronic stress conditions, occurs only in the presence of an intact neurogenic niche. These findings provide a mechanistic framework for understanding how adult-generated new neurons influence the response to antidepressants. We suggest that newly generated neurons may facilitate stress integration and that, during chronic stress or depression, enhancing neurogenesis enables a dysfunctional hippocampus to restore the central control on stress response systems, then allowing recovery.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The hippocampus governs HPA axis activity by modulating hypothalamic function.
“The hippocampus governs HPA axis activity by modulating the function of the hypothalamus (30).”
From Neuroanatomic differences associated with stress susceptibility and resilience (2016) · cites this paper as [30]
Adult cytogenesis (neurogenesis and gliogenesis) and morphological changes in the hippocampus are altered by chronic stress and reverted by antidepressants.
“neuroplastic events, including adult cytogenesis (neurogenesis9, 10, 11 and gliogenesis12) and morphological changes, are described to be altered by chronic stress and reverted by antidepressants (ADs).13, 14”
From Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression (2017) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
Self-citationNeural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318 · see citing works
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · see citing works
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181 · see citing works
The three-dimensional organization of the hippocampal formation: A review of anatomical data
Amaral, D. G., & Witter, M. P. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90424-7 · Cited by 2,180 · see citing works
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,829 · see citing works
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485 · see citing works
Gould, E., Tanapat, P., McEwen, B. S., Flügge, G., & Fuchs, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3168 · Cited by 1,395 · see citing works
Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322 · see citing works
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292 · see citing works
David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267 · see citing works
Self-citationThe ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198 · see citing works
Saxe, M. D., Battaglia, F., Wang, J.-W., Malleret, G., David, D. J., Monckton, J. E., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., Santarelli, L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607207103 · Cited by 1,020 · see citing works
Self-citationAdult neurogenesis is regulated by adrenal steroids in the dentate gyrus
Cameron, H. A., & Gould, E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90224-0 · Cited by 999 · see citing works
Kempermann, G., Gast, D., Kronenberg, G., Yamaguchi, M., & Gage, F. H. (2002) · Development · doi:10.1242/dev.00203 · Cited by 983 · see citing works
A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.002 · Cited by 927 · see citing works
Kee, N., Teixeira, C. M., Wang, A. H., & Frankland, P. W. (2007) · Nature Neuroscience · doi:10.1038/nn1847 · Cited by 875 · see citing works
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.6174 · Cited by 758 · see citing works
Limbic-frontal circuitry in major depression: a path modeling metanalysis
Seminowicz, D. A., Mayberg, H. S., McIntosh, A. R., Goldapple, K., Kennedy, S., Segal, Z., & Rafi-Tari, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.015 · Cited by 710 · see citing works
Antidepressants increase neural progenitor cells in the human hippocampus
Boldrini, M., Underwood, M. D., Hen, R., Rosoklija, G. B., Dwork, A. J., John Mann, J., & Arango, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.75 · Cited by 686 · see citing works
Self-citationThe combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders
Heuser, I., Yassouridis, A., & Holsboer, F. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90017-5 · Cited by 662 · see citing works
Research and treatment approaches to depression
Wong, M.-L., & Licinio, J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072566 · Cited by 656 · see citing works
Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus
Seri, B., García‐Verdugo, J. M., Collado-Morente, L., McEwen, B. S., & Álvarez-Buylla, A. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20288 · Cited by 628 · see citing works
Short‐term and long‐term survival of new neurons in the rat dentate gyrus
Dayer, A. G., Ford, A. A., Cleaver, K. M., Yassaee, M., & Cameron, H. A. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10675 · Cited by 628 · see citing works
Effects of Adult Neurogenesis on Synaptic Plasticity in the Rat Dentate Gyrus
Snyder, J. S., Kee, N., & Wojtowicz, J. M. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2423 · Cited by 619 · see citing works
Depression: a case of neuronal life and death?
Duman, R. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.033 · Cited by 612 · see citing works
Bessa, J. M., Ferreira, D., Melo, I., Marques, F., Cerqueira, J. J., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.119 · Cited by 598 · see citing works
Touma, C., Sachser, N., Möstl, E., & Palme, R. (2003) · General and Comparative Endocrinology · doi:10.1016/s0016-6480(02)00620-2 · Cited by 581 · see citing works
Self-citationSurget, A., Saxe, M., Leman, S., Ibarguen-Vargas, Y., Chalon, S., Griebel, G., Hen, R., & Belzung, C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.022 · Cited by 556 · see citing works
Self-citationFloresco, S., Todd, C. L., & Grace, A. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04915.2001 · Cited by 556 · see citing works
Wang, J.-W., David, D. J., Monckton, J. E., Battaglia, F., & Hen, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3632-07.2008 · Cited by 550 · see citing works
Self-citationAdult hippocampal neurogenesis is involved in anxiety-related behaviors
Revest, J.-M., Dupret, D., Koehl, M., Funk-Reiter, C., Grosjean, N., Piazza, P.-V., & Abrous, D. N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.15 · Cited by 549 · see citing works
Jiang, W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25509 · Cited by 527 · see citing works
Tashiro, A., Makino, H., & Gage, F. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4941-06.2007 · Cited by 521 · see citing works
Herman, J. P., Schafer, M., Young, E. A., Thompson, R. C., DOUGLASS, J. O., Akil, H., & Watson, S. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03072.1989 · Cited by 467 · see citing works
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
Meshi, D., Drew, M. R., Saxe, M., Ansorge, M. S., David, D. J. P., Santarelli, L., Malapani, C., Moore, H. M., & Hen, R. (2006) · Nature Neuroscience · doi:10.1038/nn1696 · Cited by 458 · see citing works
Self-citationLopez-Duran, N. L., Kovacs, M., & George, C. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.016 · Cited by 425 · see citing works
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
Airan, R. D., Meltzer, L. A., Roy, M., Gong, Y., Chen, H., & Deisseroth, K. (2007) · Science · doi:10.1126/science.1144400 · Cited by 396 · see citing works
The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?
Kempermann, G. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.002 · Cited by 372 · see citing works
Czéh, B., Welt, T., Fischer, A., Erhardt, A., Schmitt, W. B., Müller, M. B., Toschi, N., Fuchs, E., & Keck, M. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01457-9 · Cited by 370 · see citing works
Touma, C., Palme, R., & Sachser, N. (2003) · Hormones and Behavior · doi:10.1016/j.yhbeh.2003.07.002 · Cited by 370 · see citing works
Self-citationMizoguchi, K., Ishige, A., Aburada, M., & Tabira, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00105-2 · Cited by 369 · see citing works
Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus
Laplagne, D. A., Esposito, M. S., Piatti, V. C., Morgenstern, N. A., Zhao, C., van Praag, H., Gage, F. H., & Schinder, A. F. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040409 · Cited by 359 · see citing works
Ising, M., Horstmann, S., Kloiber, S., Lucae, S., Binder, E. B., Kern, N., Künzel, H. E., Pfennig, A., Uhr, M., & Holsboer, F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.039 · Cited by 341 · see citing works
Integration of New Neurons into Functional Neural Networks
Ramı́rez-Amaya, V., Marrone, D. F., Gage, F. H., Worley, P. F., & Barnes, C. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2195-06.2006 · Cited by 332 · see citing works
Alonso, R., Griebel, G., Pavone, G., Stemmelin, J., Fur, G. L., & Soubrié, P. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001464 · Cited by 319 · see citing works
Self-citationHolick, K. A., Lee, D. C., Hen, R., & Dulawa, S. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301399 · Cited by 313 · see citing works
Self-citationNeuroendocrine Aspects of Primary Endogenous Depression
Rubín, R. T. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800160032006 · Cited by 287 · see citing works
What is the mammalian dentate gyrus good for?
Treves, A., Tashiro, A., Witter, M. P., & Moser, E. I. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.073 · Cited by 282 · see citing works
Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?: Figure 1.
Eisch, A. J., Cameron, H. A., Encinas, J. M., Meltzer, L. A., Ming, G., & Overstreet‐Wadiche, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3798-08.2008 · Cited by 247 · see citing works
Vollmayr, B., Simonis, C., Weber, S., Gass, P., & Henn, F. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00527-4 · Cited by 229 · see citing works
Snyder, J. S., Radik, R., Wojtowicz, J. M., & Cameron, H. A. (2008) · Hippocampus · doi:10.1002/hipo.20525 · Cited by 224 · see citing works
Holsboer, F., von Bardeleben, U., Wiedemann, K., Müller, O. A., & Stalla, G. K. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90237-x · Cited by 221 · see citing works
Naber, P. A., & Witter, M. P. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980413)393:3 · Cited by 219 · see citing works
Herman, J. P., Cullinan, W. E., Morano, M. I., Akil, H., & Watson, S. J. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00784.x · Cited by 214 · see citing works
Lucassen, P. J., Stumpel, M. W., Wang, Q., & Aronica, E. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.01.012 · Cited by 213 · see citing works
A model of hippocampal neurogenesis in memory and mood disorders
Becker, S., & Wojtowicz, J. M. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.10.013 · Cited by 213 · see citing works
Garcia, A. D. R., Steiner, B., Kronenberg, G., Bick‐Sander, A., & Kempermann, G. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00130.x · Cited by 209 · see citing works
A Molecular Signature of Depression in the Amygdala
Sibille, E. L., Wang, Y., Joeyen-Waldorf, J., Gaiteri, C., Surget, A., Oh, S., Belzung, C., Tseng, G. C., & Lewis, D. A. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121760 · Cited by 208 · see citing works
Self-citationKunugi, H., Ida, I., Owashi, T., Kimura, M., Inoue, Y., Nakagawa, S., Yabana, T., Urushibara, T., Kanai, R., Aihara, M., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300868 · Cited by 200 · see citing works
Surget, A., Wang, Y., Leman, S., Ibargüen-Vargas, Y., Edgar, N. M., Griebel, G., Belzung, C., & Sibille, E. L. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.76 · Cited by 195 · see citing works
Self-citationNeurogenesis and depression: etiology or epiphenomenon?
Henn, F. A., & Vollmayr, B. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.011 · Cited by 192 · see citing works
Is impaired neurogenesis relevant to the affective symptoms of depression?
Sapolsky, R. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.012 · Cited by 188 · see citing works
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus
Lacefield, C. O., Itskov, V., Reardon, T., Hen, R., & Gordon, J. A. (2012) · Hippocampus · doi:10.1002/hipo.20860 · Cited by 188 · see citing works
Self-citationSuppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response
Schloesser, R. J., Manji, H. K., & Martinowich, K. (2009) · Neuroreport · doi:10.1097/wnr.0b013e3283293e59 · Cited by 187 · see citing works
Holsboer-Trachsler, E., Stohler, R., & Hatzinger, M. (1991) · Psychiatry Research · doi:10.1016/0165-1781(91)90041-m · Cited by 160 · see citing works
Neural circuitry and neuroplasticity in mood disorders: Insights for novel therapeutic targets
Carlson, P. J., Singh, J. B., Zarate, C. A., Drevets, W. C., & Manji, H. K. (2006) · NeuroRx · doi:10.1016/j.nurx.2005.12.009 · Cited by 154 · see citing works
Appelhof, B. C., Huyser, J., Verweij, M., Brouwer, J. P., van Dyck, R., Fliers, E., Hoogendijk, W. J. G., Tijssen, J. G. P., Wiersinga, W. M., & Schene, A. H. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.008 · Cited by 154 · see citing works
Differential plasma corticosterone responses to hippocampal stimulation
Dunn, J. D., & Orr, S. E. (1984) · Experimental Brain Research · doi:10.1007/bf00235813 · Cited by 152 · see citing works
Crespo, D., Stanfield, B. B., & Cowan, W. M. (1986) · Experimental Brain Research · doi:10.1007/bf00236032 · Cited by 150 · see citing works
Corticosteroid responses to limbic stimulation in man: Localization of stimulus sites
Rubin, R. T., Mandell, A. J., & Crandall, P. H. (1966) · Science · doi:10.1126/science.153.3737.767 · Cited by 148 · see citing works
Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal
Ibargüen-Vargas, Y., Surget, A., Touma, C., Palme, R., & Belzung, C. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.07.010 · Cited by 116 · see citing works
Self-citationDatson, N. A., Speksnijder, N., Mayer, J. L., Steenbergen, P. J., Korobko, O. B., Goeman, J. J., de Kloet, E. R., Joëls, M., & Lucassen, P. J. (2010) · Hippocampus · doi:10.1002/hipo.20905 · Cited by 100 · see citing works
Effect of Clinical Doses of Fluoxetine on Psychological Variables in Healthy Volunteers
Gelfin, Y., Gorfine, M., & Lerer, B. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.2.290 · Cited by 78 · see citing works
Huang, G.-J., Bannerman, D. M., & Jonathan Flint, C. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002104 · Cited by 77 · see citing works
Effects of fluoxetine administration on mood response to tryptophan depletion in healthy subjects
Barr, L. C., Heninger, G. R., Goodman, W. K., Ds, C., & Price, L. H. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00224-7 · Cited by 62 · see citing works
Approximate entropy of symptoms of mood: an effective technique to quantify regularity of mood
Yeragani, V. K., Pohl, R. B., Mallavarapu, M., et al. (2003) · Bipolar Disorders · doi:10.1034/j.1399-5618.2003.00012.x · Cited by 50 · see citing works
Septo-temporal gradients of neurogenesis and activity in 13-month-old rats
Snyder, J. S., Ramchand, P., Rabbett, S., Radik, R., Wojtowicz, J. M., & Cameron, H. A. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.022 · Cited by 44 · see citing works
Gap junctional coupling between progenitor cells of regenerating retina in the adult newt
Chiba, C., & Saito, T. (2000) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(20000205)42:2 · Cited by 19 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4 th edn American Psychiatric Press: Washington DC, 1994.
- Wang S, Scott BW, Wojtowicz JM. Heterogenous properties of dentate granule neurons in the adult rat. J Neurobiol 2000; 42: 248-257.
Cited by
Sorted by citations
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473 · see citing works
Neuroinflammation and depression: A review
Troubat, R., Barone, P., Leman, S., Desmidt, T., Cressant, A., Atanasova, B., Brizard, B., El Hage, W., Surget, A., Belzung, C., et al. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14720 · Cited by 1,107 · see citing works
Self-citationAdult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Anacker, C., & Hen, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.45 · Cited by 1,014 · see citing works
Self-citationThe chronic mild stress (CMS) model of depression: History, evaluation and usage
Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959 · see citing works
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719 · see citing works
Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus
Kheirbek, M. A., Drew, L. J., Burghardt, N. S., Costantini, D. O., Tannenholz, L., Ahmari, S. E., Zeng, H., Fenton, A. A., & Hen, R. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.038 · Cited by 713 · see citing works
Self-citationStress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works
Hill, A. S., Sahay, A., & Hen, R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.85 · Cited by 557 · see citing works
Self-citationThe neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
Self-citationThe current state of the neurogenic theory of depression and anxiety
Miller, B. R., & Hen, R. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.012 · Cited by 386 · see citing works
Self-citationBoldrini, M., Hen, R., Underwood, M. D., Rosoklija, G. B., Dwork, A. J., Mann, J. J., & Arango, V. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.024 · Cited by 348 · see citing works
Self-citationNeuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works
Anacker, C., Cattaneo, A., Musaelyan, K., Zunszain, P. A., Horowitz, M., Molteni, R., Luoni, A., Calabrese, F., Tansey, K., Gennarelli, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300886110 · Cited by 319 · see citing works
Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond
Zorumski, C. F., Paul, S. M., Covey, D. F., & Mennerick, S. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100196 · Cited by 305 · see citing works
Campos, A. C., Ortega, Z., Palazuelos, J., Fogaça, M. V., Aguiar, D. C., Díaz-Alonso, J., Ortega-Gutiérrez, S., Vázquez-Villa, H., Moreira, F. A., Guzmán, M., et al. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001502 · Cited by 313 · see citing works
Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
Levy, M. J. F., Boulle, F., Steinbusch, H. W., van den Hove, D. L. A., Kenis, G., & Lanfumey, L. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4950-4 · Cited by 308 · see citing works
Vialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1787-13.2014 · Cited by 283 · see citing works
“, 2006), amygdala (Akirav and Maroun, 2007), hippocampus (Surget et al., 2011), and NAc (Vialou et al.”
BackgroundMicheli, L., Ceccarelli, M., D’Andrea, G., & Tirone, F. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.09.002 · Cited by 288 · see citing works
State-dependent changes in hippocampal grey matter in depression
Arnone, D., McKie, S., Elliott, R., Juhasz, G., Thomas, E. J., Downey, D., Williams, S., Deakin, J. F. W., & Anderson, I. M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.150 · Cited by 287 · see citing works
Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume
Schoenfeld, T. J., McCausland, H. C., Morris, H. D., Padmanaban, V., & Cameron, H. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.013 · Cited by 260 · see citing works
Petrik, D., Lagace, D. C., & Eisch, A. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.003 · Cited by 241 · see citing works
Role of adult hippocampal neurogenesis in stress resilience
Levone, B. R., Cryan, J. F., & O'Leary, O. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.11.003 · Cited by 218 · see citing works
Zhang, K., Wang, F., Zhai, M., He, M., Hu, Y., Feng, L., Li, Y., Yang, J., & Wu, C. (2023) · Theranostics · doi:10.7150/thno.81067 · Cited by 217 · see citing works
Garza, J. C., Guo, M., Zhang, W., & Lu, X.-Y. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.161 · Cited by 209 · see citing works
Alboni, S., van Dijk, R. M., Poggini, S., Milior, G., Perrotta, M., Drenth, T., Brunello, N., Wolfer, D. P., Limatola, C., Amrein, I., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2015.142 · Cited by 207 · see citing works
5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response
Samuels, B. A., Anacker, C., Hu, A., Levinstein, M. R., Pickenhagen, A., Tsetsenis, T., Madroñal, N., Donaldson, Z. R., Drew, L. J., Dranovsky, A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4116 · Cited by 200 · see citing works
Self-citationMolecular mechanisms in the regulation of adult neurogenesis during stress
Egeland, M., Zunszain, P. A., & Pariante, C. M. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3855 · Cited by 203 · see citing works
Neuroanatomic differences associated with stress susceptibility and resilience
Anacker, C., Scholz, J., O’Donnell, K. J., Allemang-Grand, R., Diorio, J., Bagot, R. C., Nestler, E. J., Hen, R., Lerch, J. P., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.009 · Cited by 167 · see citing works
Self-citationGlucocorticoids Orchestrate Divergent Effects on Mood through Adult Neurogenesis
Lehmann, M. L., Brachman, R. A., Martinowich, K., Schloesser, R. J., & Herkenham, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3878-12.2013 · Cited by 168 · see citing works
Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A.-M., Czeh, B., & Korosi, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021303 · Cited by 166 · see citing works
Neuropathology of suicide: Recent findings and future directions
Lutz, P.-E., Mechawar, N., & Turecki, G. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.141 · Cited by 158 · see citing works
Disconnection and reconnection: The morphological basis of (mal)adaptation to stress
Sousa, N., & Almeida, O. F. X. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.006 · Cited by 159 · see citing works
Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150 · see citing works
Sustained remission from depressive-like behavior depends on hippocampal neurogenesis
Mateus-Pinheiro, A., Pinto, L., Bessa, J. M., Morais, M., Alves, N. D., Monteiro, S., Patrício, P., Almeida, O. F. X., & Sousa, N. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.141 · Cited by 149 · see citing works
GABAergic Control of Depression-Related Brain States
Luscher, B., & Fuchs, T. (2015) · Advances in Pharmacology · doi:10.1016/bs.apha.2014.11.003 · Cited by 149 · see citing works
Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine
Siopi, E., Chevalier, G., Katsimpardi, L., Saha, S., Bigot, M., Moigneu, C., Eberl, G., & Lledo, P.-M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.099 · Cited by 116 · see citing works
Kino, T. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00230 · Cited by 111 · see citing works
Mechanisms of antidepressant resistance
El-Hage, W., Leman, S., Camus, V., & Belzung, C. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00146 · Cited by 111 · see citing works
Self-citationEgeland, M., Guinaudie, C., Du Preez, A., Musaelyan, K., Zunszain, P. A., Fernandes, C., Pariante, C. M., & Thuret, S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.68 · Cited by 98 · see citing works
Lima da Cruz, R. V., Moulin, T. C., Petiz, L. L., & Leão, R. N. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00312 · Cited by 84 · see citing works
Farooq, R. K., Tanti, A., Ainouche, S., Roger, S., Belzung, C., & Camus, V. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.07.016 · Cited by 83 · see citing works
Self-citationAdult hippocampal neuroplasticity triggers susceptibility to recurrent depression
Alves, N. D., Correia, J. S., Patrício, P., Mateus-Pinheiro, A., Machado-Santos, A. R., Loureiro-Campos, E., Morais, M., Bessa, J. M., Sousa, N., & Pinto, L. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.29 · Cited by 79 · see citing works
Liu, J., Dietz, K., Hodes, G. E., Russo, S. J., & Casaccia, P. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22533 · Cited by 75 · see citing works
Klomp, A., Václavů, L., Meerhoff, G. F., Reneman, L., & Lucassen, P. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097603 · Cited by 65 · see citing works
Brooker, S. M., Gobeske, K. T., Chen, J., Peng, C.-Y., & Kessler, J. A. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.160 · Cited by 61 · see citing works
Patrício, P., Mateus-Pinheiro, A., Irmler, M., Alves, N. D., Machado-Santos, A. R., Morais, M., Correia, J. S., Korostynski, M., Piechota, M., Stoffel, R., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.176 · Cited by 57 · see citing works
Morais, M., Patrício, P., Mateus-Pinheiro, A., Alves, N. D., Machado-Santos, A. R., Correia, J. S., Pereira, J., Pinto, L., Sousa, N., & Bessa, J. M. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.120 · Cited by 56 · see citing works
Christiansen, S., Bouzinova, E. V., Palme, R., & Wiborg, O. (2012) · Stress · doi:10.3109/10253890.2011.654370 · Cited by 55 · see citing works
Self-citationUnified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy
Nehls, M. (2016) · Journal of Molecular Psychiatry · doi:10.1186/s40303-016-0018-8 · Cited by 41 · see citing works
Synergistic effects of diet and exercise on hippocampal function in chronically stressed mice
Hutton, C. P., Déry, N., Rosa, E., Lemon, J. A., Rollo, C. D., Boreham, D. R., Fahnestock, M., deCatanzaro, D., Wojtowicz, J. M., & Becker, S. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.005 · Cited by 41 · see citing works
Zavvari, F., Nahavandi, A., & Goudarzi, M. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.101711 · Cited by 38 · see citing works
McAvoy, K., Russo, C., Kim, S., Rankin, G., & Sahay, A. (2015) · Hippocampus · doi:10.1002/hipo.22464 · Cited by 36 · see citing works
Stotland, N. L. (2012) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.11.007 · Cited by 30 · see citing works
Mateus-Pinheiro, A., Patrício, P., Bessa, J. M., Sousa, N., & Pinto, L. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.56 · Cited by 29 · see citing works
Khemissi, W., Farooq, R. K., Le Guisquet, A.-M., Sakly, M., & Belzung, C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00340 · Cited by 28 · see citing works
Self-citationRunning‐induced anxiety is dependent on increases in hippocampal neurogenesis
Onksen, J. L., Briand, L. A., Galante, R. J., Pack, A. I., & Blendy, J. A. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00788.x · Cited by 29 · see citing works
Xiao, S., Yang, Z., Yan, H., Chen, G., Zhong, S., Chen, P., Zhong, H., Yang, H., Jia, Y., Yin, Z., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03012-9 · Cited by 23 · see citing works
Feng, M., Crowley, N. A., Patel, A., Guo, Y., Bugni, S. E., & Luscher, B. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.03.003 · Cited by 20 · see citing works
Rodrigues, R. S., Moreira, J. B., Mateus, J. M., Barateiro, A., Paulo, S. L., Vaz, S. H., Lourenço, D. M., Ribeiro, F. F., Soares, R., Loureiro-Campos, E., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02877-0 · Cited by 12 · see citing works
Martins-Macedo, J., Araújo, B., Anjo, S. I., Silveira-Rosa, T., Patrício, P., Alves, N. D., Silva, J. M., Teixeira, F. G., Manadas, B., Rodrigues, A. J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02490-z · Cited by 6 · see citing works
- Authors
- Surget, A., Tanti, A., Leonardo, E. D., Laugeray, A., Rainer, Q., Touma, C., Palme, R., Griebel, G., Ibarguen-Vargas, Y., Hen, R., & Belzung, C.
- Affiliations
- Inserm (FR)
- Université de Tours (FR)
- Columbia University (US)
- Max Planck Institute of Psychiatry (DE)
- University of Veterinary Medicine Vienna (AT)
- Sanofi (France) (FR)
- Corresponding author
- Surget, A
- Venue
- Molecular Psychiatry
- Published
- 2011-05-03
- Volume
- 16
- Issue
- 12
- Pages
- 1177-1188
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC3223314
- OpenAlex
- W2060918456
- Cited by
- 471
- References
- 84
- Citations by year
- 2026: 18 · 2025: 14 · 2024: 14 · 2023: 14 · 2022: 25 · 2021: 36 · 2020: 32 · 2019: 35 · 2018: 27 · 2017: 33 · 2016: 46 · 2015: 35 · 2014: 47 · 2013: 41 · 2012: 37
- FWCI
- 14.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- Molecular Psychiatry (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- European Commission
- International Brain Research Organization
- Institut National de la Santé et de la Recherche Médicale
- National Institutes of Health
- National Institute of Mental Health (K08MH076083)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- antidepressants, hippocampal neurogenesis, fluoxetine, chronic unpredictable mild stress, hypothalamic-pituitary-adrenal axis, stress response, depression, hippocampal granule cells, glucocorticoids, novelty, neurogenic niche, negative feedback
- MeSH terms
- Animals, Antidepressive Agents, Cell Count, Corticosterone, Depression, Dexamethasone, Disease Models, Animal, Fluoxetine, Hippocampus, Humans, Hydrocarbons, Halogenated, Hypothalamo-Hypophyseal System, Male, Mice, Inbred BALB C, Pituitary-Adrenal Function Tests, Pituitary-Adrenal System, Radiography, Stress, Psychological, Thiazines, Mice, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
