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Cited by 511

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Subcortical volumetric abnormalities in bipolar disorder

Open access
the Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar Endophenotypes, Hibar, D P, for the ENIGMA Bipolar Disorder Working Group, Westlye, L T, van Erp, T G M, Rasmussen, J, Leonardo, C D, Faskowitz, J, Haukvik, U K, Hartberg, C B, Doan, N T, Agartz, I, Dale, A M, Gruber, O, Krämer, B, Trost, S, Liberg, B, Abé, C, Ekman, C J, Ingvar, M, Landén, M, Fears, S C, Freimer, N B, Bearden, C E, Sprooten, E, Glahn, D C, Pearlson, G D, Emsell, L, Kenney, J, Scanlon, C, McDonald, C, Cannon, D M, Almeida, J, Versace, A, Caseras, X, Lawrence, N S, Phillips, M L, Dima, D, Delvecchio, G, Frangou, S, Satterthwaite, T D, Wolf, D, Houenou, J, Henry, C, Malt, U F, Bøen, E, Elvsåshagen, T, Young, A H, Lloyd, A J, Goodwin, G M, Mackay, C E, Bourne, C, Bilderbeck, A, Abramovic, L, Boks, M P, van Haren, N E M, Ophoff, R A, Kahn, R S, Bauer, M, Pfennig, A, Alda, M, Hajek, T, Mwangi, B, Soares, J C, Nickson, T, Dimitrova, R, Sussmann, J E, Hagenaars, S, Whalley, H C, McIntosh, A M, Thompson, P M, Andreassen, O A·2016·Molecular Psychiatry
DOI 10.1038/mp.2015.227
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Abstract

Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case–control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen’s d =−0.232; P =3.50 × 10 −7 ) and thalamus ( d =−0.148; P =4.27 × 10 −3 ) and enlarged lateral ventricles ( d =−0.260; P =3.93 × 10 −5 ) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.

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Authors
the Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar Endophenotypes, Hibar, D. P., for the ENIGMA Bipolar Disorder Working Group, Westlye, L. T., van Erp, T. G. M., Rasmussen, J., Leonardo, C. D., Faskowitz, J., Haukvik, U. K., Hartberg, C. B., Doan, N. T., Agartz, I., Dale, A. M., Gruber, O., Krämer, B., Trost, S., Liberg, B., Abé, C., Ekman, C. J., Ingvar, M., Landén, M., Fears, S. C., Freimer, N. B., Bearden, C. E., Sprooten, E., Glahn, D. C., Pearlson, G. D., Emsell, L., Kenney, J., Scanlon, C., McDonald, C., Cannon, D. M., Almeida, J., Versace, A., Caseras, X., Lawrence, N. S., Phillips, M. L., Dima, D., Delvecchio, G., Frangou, S., Satterthwaite, T. D., Wolf, D., Houenou, J., Henry, C., Malt, U. F., Bøen, E., Elvsåshagen, T., Young, A. H., Lloyd, A. J., Goodwin, G. M., Mackay, C. E., Bourne, C., Bilderbeck, A., Abramovic, L., Boks, M. P., van Haren, N. E. M., Ophoff, R. A., Kahn, R. S., Bauer, M., Pfennig, A., Alda, M., Hajek, T., Mwangi, B., Soares, J. C., Nickson, T., Dimitrova, R., Sussmann, J. E., Hagenaars, S., Whalley, H. C., McIntosh, A. M., Thompson, P. M., & Andreassen, O. A.
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2016-02-09
Volume
21
Issue
12
Pages
1710-1716
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/mp.2015.227
OpenAlex
W2266075323
Cited by
511
References
55
FWCI
38.81
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Subcortical volumetric abnormalities in bipolar disorder. https://app.cochat.ai/papers/10.1038/mp.2015.227
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the Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar Endophenotypes, Hibar, D. P., for the ENIGMA Bipolar Disorder Working Group, Westlye, L. T., van Erp, T. G. M., Rasmussen, J., Leonardo, C. D., Faskowitz, J., Haukvik, U. K., Hartberg, C. B., Doan, N. T., Agartz, I., Dale, A. M., Gruber, O., Krämer, B., Trost, S., Liberg, B., Abé, C., Ekman, C. J., . . . Andreassen, O. A. (2016). Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry. https://doi.org/10.1038/mp.2015.227

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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