The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Viral adaptation to host: a proteome‐based analysis of codon usage and amino acid preferences
Open accessAbstract
Viruses differ markedly in their specificity toward host organisms. Here, we test the level of general sequence adaptation that viruses display toward their hosts. We compiled a representative data set of viruses that infect hosts ranging from bacteria to humans. We consider their respective amino acid and codon usages and compare them among the viruses and their hosts. We show that bacteria-infecting viruses are strongly adapted to their specific hosts, but that they differ from other unrelated bacterial hosts. Viruses that infect humans, but not those that infect other mammals or aves, show a strong resemblance to most mammalian and avian hosts, in terms of both amino acid and codon preferences. In groups of viruses that infect humans or other mammals, the highest observed level of adaptation of viral proteins to host codon usages is for those proteins that appear abundantly in the virion. In contrast, proteins that are known to participate in host-specific recognition do not necessarily adapt to their respective hosts. The implication for the potential of viral infectivity is discussed.
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Mobile Elements: Drivers of Genome Evolution
Kazazian, H. H. (2004) · Science · doi:10.1126/science.1089670 · Cited by 1,922
Coding-Sequence Determinants of Gene Expression in Escherichia coli
Kudla, G., Murray, A. W., Tollervey, D., & Plotkin, J. B. (2009) · Science · doi:10.1126/science.1170160 · Cited by 1,458
Virus attenuation by genome-scale changes in codon pair bias
Coleman, J. R., Papamichail, D., Skiena, S., Futcher, B., Wimmer, E., & Mueller, S. (2008) · Science · doi:10.1126/science.1155761 · Cited by 715
Coronavirus Spike Proteins in Viral Entry and Pathogenesis
Gallagher, T. M., & Buchmeier, M. J. (2001) · Virology · doi:10.1006/viro.2000.0757 · Cited by 658
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Metadata
- Authors
- Bahir, I., Fromer, M., Prat, Y., & Linial, M.
- Venue
- Molecular Systems Biology
- Published
- 2009-01
- Volume
- 5
- Issue
- 1
- Pages
- 311-311
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2101551832
- Cited by
- 268
- References
- 4
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bahir, I., Fromer, M., Prat, Y., & Linial, M. (2009). Viral adaptation to host: a proteome‐based analysis of codon usage and amino acid preferences. Molecular Systems Biology. https://doi.org/10.1038/msb.2009.71
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