The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Determinants of translation efficiency and accuracy
Open accessAbstract
Proper functioning of biological cells requires that the process of protein expression be carried out with high efficiency and fidelity. Given an amino-acid sequence of a protein, multiple degrees of freedom still remain that may allow evolution to tune efficiency and fidelity for each gene under various conditions and cell types. Particularly, the redundancy of the genetic code allows the choice between alternative codons for the same amino acid, which, although 'synonymous,' may exert dramatic effects on the process of translation. Here we review modern developments in genomics and systems biology that have revolutionized our understanding of the multiple means by which translation is regulated. We suggest new means to model the process of translation in a richer framework that will incorporate information about gene sequences, the tRNA pool of the organism and the thermodynamic stability of the mRNA transcripts. A practical demonstration of a better understanding of the process would be a more accurate prediction of the proteome, given the transcriptome at a diversity of biological conditions.
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Codon optimality, bias and usage in translation and mRNA decay
Hanson, G., & Coller, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.91 · Cited by 825
Rate-Limiting Steps in Yeast Protein Translation
Shah, P., Ding, Y., Niemczyk, M., Kudla, G., & Plotkin, J. B. (2013) · Cell · doi:10.1016/j.cell.2013.05.049 · Cited by 463
Exploring the costs of horizontal gene transfer
Baltrus, D. A. (2013) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2013.04.002 · Cited by 398
Efficient translation initiation dictates codon usage at gene start
Bentele, K., Saffert, P., Rauscher, R., Ignatova, Z., & Blüthgen, N. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.32 · Cited by 309
A code within the genetic code: codon usage regulates co-translational protein folding
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Metadata
- Authors
- Gingold, H., & Pilpel, Y.
- Venue
- Molecular Systems Biology
- Published
- 2011-01
- Volume
- 7
- Issue
- 1
- Pages
- 481-481
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2166752189
- Cited by
- 489
- References
- 126
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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