The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops
Open accessAbstract
Circadian clocks synchronise biological processes with the day/night cycle, using molecular mechanisms that include interlocked, transcriptional feedback loops. Recent experiments identified the evening complex (EC) as a repressor that can be essential for gene expression rhythms in plants. Integrating the EC components in this role significantly alters our mechanistic, mathematical model of the clock gene circuit. Negative autoregulation of the EC genes constitutes the clock's evening loop, replacing the hypothetical component Y. The EC explains our earlier conjecture that the morning gene Pseudo-Response Regulator 9 was repressed by an evening gene, previously identified with Timing Of CAB Expression1 (TOC1). Our computational analysis suggests that TOC1 is a repressor of the morning genes Late Elongated Hypocotyl and Circadian Clock Associated1 rather than an activator as first conceived. This removes the necessity for the unknown component X (or TOC1mod) from previous clock models. As well as matching timeseries and phase-response data, the model provides a new conceptual framework for the plant clock that includes a three-component repressilator circuit in its complex structure.
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Cites
A synthetic oscillatory network of transcriptional regulators
Elowitz, M. B., & Leibler, S. (2000) · Nature · doi:10.1038/35002125 · Cited by 4,630
Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive Advantage
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Self-citationReciprocal Regulation Between TOC1 and LHY / CCA1 Within the Arabidopsis Circadian Clock
Alabadı́, D., Oyama, T., Yanovsky, M. J., Harmon, F. G., Más, P., & Kay, S. A. (2001) · Science · doi:10.1126/science.1061320 · Cited by 1,161
FKF1 and GIGANTEA Complex Formation Is Required for Day-Length Measurement in Arabidopsis
Sawa, M., Nusinow, D. A., Kay, S. A., & Imaizumi, T. (2007) · Science · doi:10.1126/science.1146994 · Cited by 909
The ELF4–ELF3–LUX complex links the circadian clock to diurnal control of hypocotyl growth
Nusinow, D. A., Helfer, A., Hamilton, E. E., King, J. J., Imaizumi, T., Schultz, T. F., Farré, E. M., & Kay, S. A. (2011) · Nature · doi:10.1038/nature10182 · Cited by 907
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Le Novere, N. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj092 · Cited by 762
The Circadian System in Higher Plants
Harmer, S. L. (2009) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.043008.092054 · Cited by 719
Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops
Tsai, T. Y.-C., Choi, Y. S., Ma, W., Pomerening, J. R., Tang, C., & Ferrell, J. E. (2008) · Science · doi:10.1126/science.1156951 · Cited by 690
LHY and CCA1 Are Partially Redundant Genes Required to Maintain Circadian Rhythms in Arabidopsis
Mizoguchi, T., Wheatley, K., Hanzawa, Y., Wright, L., Mizoguchi, M., Song, H.-R., Carré, I. A., & Coupland, G. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00170-3 · Cited by 638
Cited by
Plant Flavoprotein Photoreceptors
Christie, J. M., Blackwood, L., Petersen, J., & Sullivan, S. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcu196 · Cited by 294
Evolution of circadian rhythms: from bacteria to human
Bhadra, U., Thakkar, N., Das, P., & Pal Bhadra, M. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.04.008 · Cited by 167
Abundant clock proteins point to missing molecular regulation in the plant circadian clock
(2025) · doi:10.1038/s44320-025-00086-5 · Cited by 4
Metadata
- Authors
- Pokhilko, A., Fernández, A. P., Edwards, K. D., Southern, M. M., Halliday, K. J., & Millar, A. J.
- Venue
- Molecular Systems Biology
- Published
- 2012-01
- Volume
- 8
- Issue
- 1
- Pages
- 574-574
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2156444576
- Cited by
- 409
- References
- 58
- FWCI
- 57.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Pokhilko, A., Fernández, A. P., Edwards, K. D., Southern, M. M., Halliday, K. J., & Millar, A. J. (2012). The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops. Molecular Systems Biology. https://doi.org/10.1038/msb.2012.6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
