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Programming gene expression with combinatorial promoters
Open accessAbstract
Promoters control the expression of genes in response to one or more transcription factors (TFs). The architecture of a promoter is the arrangement and type of binding sites within it. To understand natural genetic circuits and to design promoters for synthetic biology, it is essential to understand the relationship between promoter function and architecture. We constructed a combinatorial library of random promoter architectures. We characterized 288 promoters in Escherichia coli, each containing up to three inputs from four different TFs. The library design allowed for multiple -10 and -35 boxes, and we observed varied promoter strength over five decades. To further analyze the functional repertoire, we defined a representation of promoter function in terms of regulatory range, logic type, and symmetry. Using these results, we identified heuristic rules for programming gene expression with combinatorial promoters.
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Cites
Foundations for engineering biology
Endy, D. (2005) · Nature · doi:10.1038/nature04342 · Cited by 1,511
Salgado, H. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj156 · Cited by 368
Bjarnason, J., Southward, C. M., & Surette, M. G. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.16.4973-4982.2003 · Cited by 173
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Cited by
Genetic circuit design automation
Nielsen, A. A. K., Der, B. S., Shin, J., Vaidyanathan, P., Paralanov, V., Strychalski, E. A., Ross, D., Densmore, D., & Voigt, C. A. (2016) · Science · doi:10.1126/science.aac7341 · Cited by 1,020
Sharon, E., Kalma, Y., Sharp, A., Raveh-Sadka, T., Levo, M., Zeevi, D., Keren, L., Yakhini, Z., Weinberger, A., & Segal, E. (2012) · Nature Biotechnology · doi:10.1038/nbt.2205 · Cited by 457
Mimee, M., Tucker, A. C., Voigt, C. A., & Lu, T. K. (2015) · Cell Systems · doi:10.1016/j.cels.2015.06.001 · Cited by 387
Biomolecular computing systems: principles, progress and potential
Benenson, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3197 · Cited by 373
Next-generation synthetic gene networks
Lu, T. K., Khalil, A. S., & Collins, J. J. (2009) · Nature Biotechnology · doi:10.1038/nbt.1591 · Cited by 365
Metadata
- Authors
- Cox, R. S., Surette, M. G., & Elowitz, M. B.
- Venue
- Molecular Systems Biology
- Published
- 2007-01
- Volume
- 3
- Issue
- 1
- Pages
- 145-145
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2121806138
- Cited by
- 363
- References
- 3
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cox, R. S., Surette, M. G., & Elowitz, M. B. (2007). Programming gene expression with combinatorial promoters. Molecular Systems Biology. https://doi.org/10.1038/msb4100187
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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