The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Programming gene expression with combinatorial promoters
Open accessAbstract
Promoters control the expression of genes in response to one or more transcription factors (TFs). The architecture of a promoter is the arrangement and type of binding sites within it. To understand natural genetic circuits and to design promoters for synthetic biology, it is essential to understand the relationship between promoter function and architecture. We constructed a combinatorial library of random promoter architectures. We characterized 288 promoters in Escherichia coli, each containing up to three inputs from four different TFs. The library design allowed for multiple -10 and -35 boxes, and we observed varied promoter strength over five decades. To further analyze the functional repertoire, we defined a representation of promoter function in terms of regulatory range, logic type, and symmetry. Using these results, we identified heuristic rules for programming gene expression with combinatorial promoters.
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Cites
Foundations for engineering biology
Endy, D. (2005) · Nature · doi:10.1038/nature04342 · Cited by 1,511
Salgado, H. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj156 · Cited by 368
Bjarnason, J., Southward, C. M., & Surette, M. G. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.16.4973-4982.2003 · Cited by 173
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Cited by
Genetic circuit design automation
Nielsen, A. A. K., Der, B. S., Shin, J., Vaidyanathan, P., Paralanov, V., Strychalski, E. A., Ross, D., Densmore, D., & Voigt, C. A. (2016) · Science · doi:10.1126/science.aac7341 · Cited by 1,020
Bistability, Epigenetics, and Bet-Hedging in Bacteria
Veening, J.-W., Smits, W. K., & Kuipers, O. P. (2008) · Annual Review of Microbiology · doi:10.1146/annurev.micro.62.081307.163002 · Cited by 1,018
Principles of genetic circuit design
Brophy, J. A. N., & Voigt, C. A. (2014) · Nature Methods · doi:10.1038/nmeth.2926 · Cited by 931
Engineering dynamic pathway regulation using stress-response promoters
Dahl, R. H., Zhang, F., Alonso-Gutierrez, J., Baidoo, E., Batth, T. S., Redding-Johanson, A. M., Petzold, C. J., Mukhopadhyay, A., Lee, T. S., Adams, P. D., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2689 · Cited by 473
Sharon, E., Kalma, Y., Sharp, A., Raveh-Sadka, T., Levo, M., Zeevi, D., Keren, L., Yakhini, Z., Weinberger, A., & Segal, E. (2012) · Nature Biotechnology · doi:10.1038/nbt.2205 · Cited by 457
Metadata
- Authors
- Cox, R. S., Surette, M. G., & Elowitz, M. B.
- Venue
- Molecular Systems Biology
- Published
- 2007-01
- Volume
- 3
- Issue
- 1
- Pages
- 145-145
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2121806138
- Cited by
- 363
- References
- 3
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- gold
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