The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy
Open accessAbstract
The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. In this study, we demonstrate cell type-specific delivery of anti-human immunodeficiency virus (anti-HIV) siRNAs through fusion to an anti-gp120 aptamer. The envelope glycoprotein is expressed on the surface of HIV-1-infected cells, allowing binding and internalization of the aptamer-siRNA chimeric molecules. We demonstrate that the anti-gp120 aptamer-siRNA chimera is specifically taken up by cells expressing HIV-1 gp120, and that the appended siRNA is processed by Dicer; this releases an anti-tat/rev siRNA which, in turn, inhibits HIV replication. We show for the first time a dual functioning aptamer-siRNA chimera in which both the aptamer and the siRNA portions have potent anti-HIV activities. We also show that gp120 expressed on the surface of HIV-infected cells can be used for aptamer-mediated delivery of anti-HIV siRNAs.
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Self-citationCell type–specific delivery of siRNAs with aptamer-siRNA chimeras
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Cited by
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Diverse Applications of Nanomedicine
Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano · doi:10.1021/acsnano.6b06040 · Cited by 1,350
Analysis of aptamer discovery and technology
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The delivery of therapeutic oligonucleotides
Juliano, R. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw236 · Cited by 854
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Metadata
- Authors
- Zhou, J., Li, H., Li, S., Zaia, J., & Rossi, J. J.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 16
- Issue
- 8
- Pages
- 1481-1489
- ISSN
- 1525-0016 (ISSN-L)
- OpenAlex
- W2002961521
- Cited by
- 301
- References
- 48
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhou, J., Li, H., Li, S., Zaia, J., & Rossi, J. J. (2008). Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy. Molecular Therapy. https://doi.org/10.1038/mt.2008.92
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
