Analysis of aptamer discovery and technology

Initial sequencing and analysis of the human genome

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The sequence of the human genome

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In vitro selection of RNA molecules that bind specific ligands

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Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

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Ranibizumab and bevacizumab for neovascular age-related macular degeneration

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The evolving role of natural products in drug discovery

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Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration

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Aptamers as therapeutics

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Aptamers as targeted therapeutics: current potential and challenges

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Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics

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Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

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Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

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Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

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Challenges and opportunities for structural DNA nanotechnology

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The chemical evolution of oligonucleotide therapies of clinical utility

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In Vitro Selection of Functional Nucleic Acids

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Selecting and screening recombinant antibody libraries

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Molecular robots guided by prescriptive landscapes

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Aptamers: An Emerging Class of Therapeutics

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Applications of Aptamers as Sensors

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Gene Synthesis Machines: DNA Chemistry and Its Uses

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The chemical repertoire of natural ribozymes

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2′-Fluoropyrimidine RNA-based Aptamers to the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF165)

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Synthetic genetic polymers capable of heredity and evolution

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High-affinity binders selected from designed ankyrin repeat protein libraries

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Aptamers from Cell-Based Selection for Bioanalytical Applications

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Reproducibility: Standardize antibodies used in research

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Emerging Concepts in the Immunopathogenesis of AIDS

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Antibody validation

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An RNA motif that binds ATP

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The Chemical Biology of Aptamers

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Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen.

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Chemical Etiology of Nucleic Acid Structure: The α-Threofuranosyl-(3'→2') Oligonucleotide System

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RNA aptamers as reversible antagonists of coagulation factor IXa

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Generation of high-affinity DNA aptamers using an expanded genetic alphabet

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In Vitro Evolution of Functional DNA Using Capillary Electrophoresis

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The use of mRNA display to select high-affinity protein-binding peptides

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Real-Time, Aptamer-Based Tracking of Circulating Therapeutic Agents in Living Animals

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Directed evolution of polymerase function by compartmentalized self-replication

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Mirror-image RNA that binds D-adenosine

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Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

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Amplification of complex gene libraries by emulsion PCR

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Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

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The human proteome project: current state and future direction

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Direct In Vitro Selection of a 2′-O-Methyl Aptamer to VEGF

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Antidote-mediated control of an anticoagulant aptamer in vivo

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In vitro selection with artificial expanded genetic information systems

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Expanding the Chemistry of DNA for in Vitro Selection

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Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

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A Brief History of G‐Protein Coupled Receptors (Nobel Lecture)

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Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay

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In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits

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Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

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SELEX with modified nucleotides

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In vivo selection of tumor-targeting RNA motifs

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Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor

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Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics

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The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

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In vivo SELEX for Identification of Brain-penetrating Aptamers

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Unlocking Biomarker Discovery: Large Scale Application of Aptamer Proteomic Technology for Early Detection of Lung CancerPreprint

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A synthetic molecular system capable of mirror-image genetic replication and transcription

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Embracing proteins: structural themes in aptamer–protein complexes

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Selection of DNA aptamers with two modified bases

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Alternative affinity tools: more attractive than antibodies?

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Modified RNA sequence pools forin vitroselection

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Model-Driven Engineering of RNA Devices to Quantitatively Program Gene Expression

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The involvement of RNA in ribosome function

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Aptamer based electrochemical sensors for emerging environmental pollutants

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Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer

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A general strategy for expanding polymerase function by droplet microfluidics

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Analysis of In Vitro Aptamer Selection Parameters

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New Technologies Provide Quantum Changes in the Scale, Speed, and Success of SELEX Methods and Aptamer Characterization

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In vitro genetics

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Crystal structure of an RNA aptamer bound to thrombin

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Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor

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A Versatile Approach Towards Nucleobase‐Modified Aptamers

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Synthetic therapeutic antibodies

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In vitro evolution of nucleic acids

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Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors

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Aptamer-Based Analysis: A Promising Alternative for Food Safety Control

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High-Affinity DNA Aptamer Generation Targeting von Willebrand Factor A1-Domain by Genetic Alphabet Expansion for Systematic Evolution of Ligands by Exponential Enrichment Using Two Types of Libraries Composed of Five Different Bases

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Artificial, non-antibody binding proteins for pharmaceutical and industrial applications

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Particle Display: A Quantitative Screening Method for Generating High‐Affinity Aptamers

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Selection of 2′-deoxy-2′-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinity

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Functional In Vivo Delivery of Multiplexed Anti-HIV-1 siRNAs via a Chemically Synthesized Aptamer With a Sticky Bridge

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Evoking picomolar binding in RNA by a single phosphorodithioate linkage

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Combinatorial protein design: strategies for screening protein libraries

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Creating Protein Affinity Reagents by Combining Peptide Ligands on Synthetic DNA Scaffolds

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Synthesis and Biophysical Properties of Arabinonucleic Acids (ANA): Circular Dichroic Spectra, Melting Temperatures, and Ribonuclease H Susceptibility of ANA·RNA Hybrid Duplexes

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A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial

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Finding the right antibody for the job

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RNA folding and unfolding

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PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1

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Post-SELEX combinatorial optimization of aptamers

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Destabilization of B2 RNA by EZH2 Activates the Stress Response

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