Strategies for silencing human disease using RNA interference

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456 · see citing works

The nuclear RNase III Drosha initiates microRNA processing

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Role for a bidentate ribonuclease in the initiation step of RNA interference

Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 4,896 · see citing works

MicroRNA genes are transcribed by RNA polymerase II

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A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

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Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

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RNA interference is mediated by 21- and 22-nucleotide RNAsPreprint

Elbashir, S. M., Lendeckel, W., & Tuschl, T. (2001) · Genes & Development · doi:10.1101/gad.862301 · Cited by 3,308 · see citing works

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsPreprint

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The Microprocessor complex mediates the genesis of microRNAs

Gregory, R. I., Yan, K.-P., Amuthan, G., Chendrimada, T. P., Doratotaj, B., Cooch, N. S., & Shiekhattar, R. (2004) · Nature · doi:10.1038/nature03120 · Cited by 2,724 · see citing works

Nuclear Export of MicroRNA Precursors

Lund, E., Güttinger, S., Calado, Â., Dahlberg, J. E., & Kutay, U. (2003) · Science · doi:10.1126/science.1090599 · Cited by 2,705 · see citing works

RNAi

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Mechanisms of gene silencing by double-stranded RNA

Meister, G., & Tuschl, T. (2004) · Nature · doi:10.1038/nature02873 · Cited by 2,539 · see citing works

Argonaute2 is the catalytic engine of mammalian RNAi

Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J.-J., Hammond, S. M., Joshua-Tor, L., & Hannon, G. J. (2004) · Science · doi:10.1126/science.1102513 · Cited by 2,353 · see citing works

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

Soutschek, J., Akinc, A., Bramlage, B., Charissé, K., Constien, R., Donoghue, M., Elbashir, S. M., Geick, A., Hadwiger, P., Harborth, J., et al. (2004) · Nature · doi:10.1038/nature03121 · Cited by 2,189 · see citing works

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

Chendrimada, T. P., Gregory, R. I., Kumaraswamy, E., Norman, J. A., Cooch, N. S., Nishikura, K., & Shiekhattar, R. (2005) · Nature · doi:10.1038/nature03868 · Cited by 2,103 · see citing works

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

Hutvágner, G., & Zamore, P. D. (2002) · Science · doi:10.1126/science.1073827 · Cited by 2,081 · see citing works

MicroRNA-Directed Cleavage of <i>HOXB8</i> mRNA

Yekta, S., Shih, I.-H., & Bartel, D. P. (2004) · Science · doi:10.1126/science.1097434 · Cited by 1,702 · see citing works

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

Grimm, D., Streetz, K. L., Jopling, C. L., Storm, T. A., Pandey, K., Davis, C. R., Marion, P., Salazar, F., & Kay, M. A. (2006) · Nature · doi:10.1038/nature04791 · Cited by 1,677 · see citing works

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cellsPreprint

Paddison, P. J., Caudy, A. A., Bernstein, E., Hannon, G. J., & Conklin, D. S. (2002) · Genes & Development · doi:10.1101/gad.981002 · Cited by 1,554 · see citing works

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.

Martı̂nez, J., Patkaniowska, A., Urlaub, H., Lührmann, R., & Tuschl, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00908-x · Cited by 1,550 · see citing works

Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

Bartel, D. P., & Chen, C. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1328 · Cited by 1,417 · see citing works

RNA polymerase III transcribes human microRNAs

Borchert, G. M., Lanier, W., & Davidson, B. L. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1167 · Cited by 1,397 · see citing works

The role of a mutant CCR5 allele in HIV–1 transmission and disease progression

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RNAi-mediated gene silencing in non-human primates

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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

Judge, A. D., Sood, V., Shaw, J. R., Fang, D., McClintock, K., & MacLachlan, I. (2005) · Nature Biotechnology · doi:10.1038/nbt1081 · Cited by 1,250 · see citing works

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

Liu, J., Valencia-Sanchez, M. A., Hannon, G. J., & Parker, R. (2005) · Nature Cell Biology · doi:10.1038/ncb1274 · Cited by 1,234 · see citing works

Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

Hornung, V., Guenthner‐Biller, M., Bourquin, C., Ablasser, A., Schlee, M., Uematsu, S., Noronha, A. M., Manoharan, M., Akira, S., de Fougerolles, A., et al. (2005) · Nature Medicine · doi:10.1038/nm1191 · Cited by 1,233 · see citing works

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

Morrissey, D. V., Lockridge, J. A., Shaw, L., Blanchard, K. S., Jensen, K., Breen, W., Hartsough, K. C., Machemer, L., Radka, S. F., Jadhav, V., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1122 · Cited by 1,168 · see citing works

Unlocking the potential of the human genome with RNA interference

Hannon, G. J., & Rossi, J. J. (2004) · Nature · doi:10.1038/nature02870 · Cited by 1,065 · see citing works

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

Song, E., Zhu, P., Lee, S., Chowdhury, D., Kussman, S., Dykxhoorn, D. M., Feng, Y., Palliser, D., Weiner, D. B., Shankar, P., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1101 · Cited by 1,022 · see citing works

Cell type–specific delivery of siRNAs with aptamer-siRNA chimeras

McNamara, J. O., Andrechek, E. R., Wang, Y., Viles, K. D., Rempel, R. E., Gilboa, E., Sullenger, B. A., & Giangrande, P. H. (2006) · Nature Biotechnology · doi:10.1038/nbt1223 · Cited by 1,005 · see citing works

Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes

Matranga, C., Tomari, Y., Shin, C., Bartel, D. P., & Zamore, P. D. (2005) · Cell · doi:10.1016/j.cell.2005.08.044 · Cited by 969 · see citing works

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

Lee, N. S., Dohjima, T., Bauer, G., Li, H., Li, M.-J., Ehsani, A., Salvaterra, P. M., & Rossi, J. J. (2002) · Nature Biotechnology · doi:10.1038/nbt0502-500 · Cited by 955 · see citing works

Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity

Jackson, A. L., Burchard, J., Schelter, J. M., Chau, B. N., Cleary, M. A., Lim, L. P., & Linsley, P. S. (2006) · RNA · doi:10.1261/rna.25706 · Cited by 953 · see citing works

Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells

Morris, K. V., Chan, S. W.-L., Jacobsen, S. E., & Looney, D. J. (2004) · Science · doi:10.1126/science.1101372 · Cited by 925 · see citing works

3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets

Birmingham, A., Anderson, E. M., Reynolds, A., Ilsley-Tyree, D., Leake, D., Fedorov, Y., Baskerville, S., Maksimova, E., Robinson, K., Karpilow, J., et al. (2006) · Nature Methods · doi:10.1038/nmeth854 · Cited by 920 · see citing works

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy

Kim, D.-H., Behlke, M. A., Rose, S. D., Chang, M.-S., Choi, S., & Rossi, J. J. (2004) · Nature Biotechnology · doi:10.1038/nbt1051 · Cited by 884 · see citing works

siRNA function in RNAi: A chemical modification analysis

Chiu, Y., & Rana, T. M. (2003) · RNA · doi:10.1261/rna.5103703 · Cited by 863 · see citing works

RNAi-mediated pathways in the nucleus

Matzke, M. A., & Birchler, J. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1500 · Cited by 840 · see citing works

Both Natural and Designed Micro RNAs Can Inhibit the Expression of Cognate mRNAs When Expressed in Human Cells

Zeng, Y., Wagner, E. J., & Cullen, B. R. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00541-5 · Cited by 833 · see citing works

Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation

Rand, T., Petersen, S., Du, F., & Wang, X. (2005) · Cell · doi:10.1016/j.cell.2005.10.020 · Cited by 784 · see citing works

siRNA-directed inhibition of HIV-1 infection

Novina, C. D., Murray, M. F., Dykxhoorn, D. M., Beresford, P. J., Riess, J. W., Lee, S., Collman, R. G., Lieberman, J., Shankar, P., & Sharp, P. A. (2002) · Nature Medicine · doi:10.1038/nm725 · Cited by 775 · see citing works

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

Ma, J., Ye, K., & Patel, D. J. (2004) · Nature · doi:10.1038/nature02519 · Cited by 727 · see citing works

Modulation of HIV-1 replication by RNA interference

Jacqué, J.-M., Triques, K., & Stevenson, M. (2002) · Nature · doi:10.1038/nature00896 · Cited by 727 · see citing works

Inhibition of respiratory viruses by nasally administered siRNA

Bitko, V., Musiyenko, A., Shulyayeva, O., & Barik, S. (2004) · Nature Medicine · doi:10.1038/nm1164 · Cited by 725 · see citing works

The role of PACT in the RNA silencing pathway

Lee, Y., Hur, I., Park, S. Y., Kim, Y. K., Suh, M. R., & Kim, V. N. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600942 · Cited by 698 · see citing works

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia

Xia, H., Mao, Q.-W., Eliason, S., Harper, S., Martins, I. H., Orr, H., Paulson, H., Yang, L., Kotin, R., & Davidson, B. (2004) · Nature Medicine · doi:10.1038/nm1076 · Cited by 689 · see citing works

Progress towards in Vivo Use of siRNAs

Behlke, M. A. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.01.001 · Cited by 677 · see citing works

Therapeutic EphA2 Gene Targeting In vivo Using Neutral Liposomal Small Interfering RNA Delivery

Landen, C. N., Chávez‐Reyes, A., Bucana, C. D., Schmandt, R. E., Deavers, M. T., Lopez‐Berestein, G., & Sood, A. K. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0530 · Cited by 674 · see citing works

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

Czauderna, F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg393 · Cited by 625 · see citing works

Second-generation shRNA libraries covering the mouse and human genomes

Silva, J. M., Li, M. Z., Chang, K. C. N., Ge, W., Golding, M. C., Rickles, R. J., Siolas, D., Hu, G., Paddison, P. J., Schlabach, M. R., et al. (2005) · Nature Genetics · doi:10.1038/ng1650 · Cited by 624 · see citing works

Sequence-Specific Knockdown of EWS-FLI1 by Targeted, Nonviral Delivery of Small Interfering RNA Inhibits Tumor Growth in a Murine Model of Metastatic Ewing's Sarcoma

Hu‐Lieskovan, S., Heidel, J. D., Bartlett, D. W., Davis, M. E., & Triche, T. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0565 · Cited by 568 · see citing works

Structural insights into mRNA recognition from a PIWI domain–siRNA guide complex

Parker, J. S., Roe, S. M., & Barford, D. (2005) · Nature · doi:10.1038/nature03462 · Cited by 531 · see citing works

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

Ralph, G. S., Radcliffe, P. A., Day, D. M., Carthy, J. M., Leroux, M. A., Lee, D. C. P., Wong, L., Bilsland, L. G., Greensmith, L., Kingsman, S. M., et al. (2005) · Nature Medicine · doi:10.1038/nm1205 · Cited by 506 · see citing works

Antiviral innate immunity pathways

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Interactions between Double-Stranded RNA Regulators and the Protein Kinase DAI

Manche, L., Green, S. R., Schmedt, C., & Mathews, M. B. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5238 · Cited by 484 · see citing works

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS

Raoul, C., Abbas‐Terki, T., Bensadoun, J., Guillot, S., Haase, G., Szulc, J., Henderson, C. E., & Aebischer, P. (2005) · Nature Medicine · doi:10.1038/nm1207 · Cited by 464 · see citing works

Aptamer mediated siRNA delivery

Chu, T. C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl388 · Cited by 447 · see citing works

Synthetic shRNAs as potent RNAi triggers

Siolas, D., Lerner, C. G., Burchard, J., Ge, W., Linsley, P. S., Paddison, P. J., Hannon, G. J., & Cleary, M. A. (2004) · Nature Biotechnology · doi:10.1038/nbt1052 · Cited by 445 · see citing works

Potent and Specific Inhibition of Human Immunodeficiency Virus Type 1 Replication by RNA Interference

Coburn, G. A., & Cullen, B. R. (2002) · Journal of Virology · doi:10.1128/jvi.76.18.9225-9231.2002 · Cited by 415 · see citing works

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

Palliser, D., Chowdhury, D., Wang, Q.-Y., Lee, S. J., Bronson, R. T., Knipe, D. M., & Lieberman, J. (2006) · Nature · doi:10.1038/nature04263 · Cited by 410 · see citing works

Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells

Kim, D. H., Villeneuve, L. M., Morris, K. V., & Rossi, J. J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1142 · Cited by 407 · see citing works

RISC is a 5′ phosphomonoester-producing RNA endonucleasePreprint

Martı̂nez, J., & Tuschl, T. (2004) · Genes & Development · doi:10.1101/gad.1187904 · Cited by 407 · see citing works

Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase

Kim, D.-H., Longo, M., Han, Y. S., Lundberg, P. S., Cantin, E. M., & Rossi, J. J. (2004) · Nature Biotechnology · doi:10.1038/nbt940 · Cited by 382 · see citing works

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells

Marques, J. T., Devosse, T., Wang, D., Zamanian-Daryoush, M., Serbinowski, P., Hartmann, R., Fujita, T., Behlke, M. A., & Williams, B. R. G. (2006) · Nature Biotechnology · doi:10.1038/nbt1205 · Cited by 380 · see citing works

Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

Zhang, W., Yang, H., Kong, X., Mohapatra, S., San-Juan-Vergara, H. G., Hellermann, G., Behera, S., Singam, R., Lockey, R. F., & Mohapatra, S. S. (2004) · Nature Medicine · doi:10.1038/nm1174 · Cited by 364 · see citing works

Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome

Orbán, T. I., & Izaurralde, E. (2005) · RNA · doi:10.1261/rna.7231505 · Cited by 356 · see citing works

Prospects of RNA interference therapy for cancer

Pai, S. I., Lin, Y.-Y., Macaes, B., Meneshian, A., Hung, C.-F., & Wu, T. ‐. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302694 · Cited by 351 · see citing works

Involvement of AGO1 and AGO2 in mammalian transcriptional silencing

Janowski, B. A., Huffman, K. E., Schwartz, J. C., Ram, R. R., Nordsell, R., Shames, D. S., Minna, J. D., & Corey, D. R. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1140 · Cited by 327 · see citing works

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication†

Morrissey, D. V., Blanchard, K. S., Shaw, L., Jensen, K., Lockridge, J. A., Dickinson, B., McSwiggen, J. A., Vargeese, C., Bowman, K., Shaffer, C. S., et al. (2005) · Hepatology · doi:10.1002/hep.20702 · Cited by 291 · see citing works

Long-term gene silencing by RNAi

Vastenhouw, N. L., Brunschwig, K., Okihara, K. L., Müller, F., Tijsterman, M., & Plasterk, R. H. A. (2006) · Nature · doi:10.1038/442882a · Cited by 288 · see citing works

The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells

Weinberg, M. S., Villeneuve, L. M., EHSANI, A., Amarzguioui, M., Aagaard, L., CHEN, Z.-X., Riggs, A. D., Rossi, J. J., & Morris, K. V. (2005) · RNA · doi:10.1261/rna.2235106 · Cited by 277 · see citing works

Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation

Ting, A. H., Schuebel, K. E., Herman, J. G., & Baylin, S. B. (2005) · Nature Genetics · doi:10.1038/ng1611 · Cited by 264 · see citing works

Long-Term Inhibition of HIV-1 Infection in Primary Hematopoietic Cells by Lentiviral Vector Delivery of a Triple Combination of Anti-HIV shRNA, Anti-CCR5 Ribozyme, and a Nucleolar-Localizing TAR Decoy

Li, M.-J., Kim, J., Li, S. X., Zaia, J. A., Yee, J., Anderson, J. S., Akkina, R., & Rossi, J. J. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.07.524 · Cited by 243 · see citing works

Approaches for chemically synthesized siRNA and vector‐mediated RNAi

Amarzguioui, M., Rossi, J. J., & Kim, D.-H. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.08.070 · Cited by 222 · see citing works

The Role of the RNAi Machinery in Heterochromatin Formation

Wassenegger, M. (2005) · Cell · doi:10.1016/j.cell.2005.06.034 · Cited by 209 · see citing works

Knocking down Disease with siRNAs

Dykxhoorn, D. M., & Lieberman, J. (2006) · Cell · doi:10.1016/j.cell.2006.07.007 · Cited by 198 · see citing works

Optimization and Functional Effects of Stable Short Hairpin RNA Expression in Primary Human Lymphocytes via Lentiviral Vectors

An, D. S., Qin, F. X.-F., Auyeung, V. C., Mao, S. H., Kung, S. K. P., Baltimore, D., & Chen, I. S. Y. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.05.015 · Cited by 155 · see citing works

MicroRNAs: expression, avoidance and subversion by vertebrate viruses

Sarnow, P., Jopling, C. L., Norman, K. L., Schütz, S., & Wehner, K. A. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1473 · Cited by 123 · see citing works

RNAi: RISC Gets Loaded

Preall, J. B., & Sontheimer, E. J. (2005) · Cell · doi:10.1016/j.cell.2005.11.006 · Cited by 114 · see citing works

Lentiviral-mediated delivery of siRNAs for antiviral therapy

Morris, K. V., & Rossi, J. J. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302688 · Cited by 110 · see citing works

Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro

Robbins, M., Li, M., Leung, I., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1206 · Cited by 105 · see citing works

Therapeutic short hairpin RNA expression in the liver: viral targets and vectors

Grimm, D., & Kay, M. A. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302727 · Cited by 85 · see citing works

RNAi As a Treatment for HIV-1 Infection

Rossi, J. J. (2006) · BioTechniques · doi:10.2144/000112167 · Cited by 71 · see citing works

Viral-based modelling and correction of neurodegenerative diseases by RNA interference

Raoul, C., Barker, S. D., & Aebischer, P. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302690 · Cited by 65 · see citing works

Silencing Viral Infection

Dykxhoorn, D. M., & Lieberman, J. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030242 · Cited by 53 · see citing works

News Feature: A crucial test

Check, E. (2005) · Nature Medicine · doi:10.1038/nm0305-243 · Cited by 49 · see citing works

Detection of foreign RNA: Implications for RNAi

de Veer, M. J., Sledz, C. A., & Williams, B. R. G. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01337.x · Cited by 47 · see citing works

Gene therapy for proliferative ocular diseases

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siRNA versus miRNA as therapeutics for gene silencing

Lam, J. K. W., Chow, M. Y. T., Zhang, Y., & Leung, S. W. S. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.23 · Cited by 1,081 · see citing works

Alterations of the microRNA network cause neurodegenerative disease

Hébert, S. S., & De Strooper, B. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.003 · Cited by 452 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

Dual Targeting of HSC70 and HSP72 Inhibits HSP90 Function and Induces Tumor-Specific Apoptosis

Powers, M. V., Clarke, P. A., & Workman, P. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.08.002 · Cited by 307 · see citing works

Nonviral methods for siRNA delivery

Gao, K., & Huang, L. (2009) · Molecular Pharmaceutics · doi:10.1021/mp800134q · Cited by 244 · see citing works

Small‐Molecule‐Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

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In vivo delivery of RNAi with lipid-based nanoparticles

Huang, L., & Liu, Y. (2011) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124709 · Cited by 174 · see citing works

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Closed Chromatin Architecture Is Induced by an RNA Duplex Targeting the HIV-1 Promoter Region

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Influence of diverse storage conditions of double‐stranded RNA in vitro on the RNA interference efficiency in vivo insect Tribolium castaneum

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Mechanisms, Applications, and Challenges of Insect RNA Interference

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