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Cited by 1,020

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

Open access
Parkhurst, Maria R, Yang, James C, Langan, Russell C, Dudley, Mark E, Nathan, Debbie-Ann N, Feldman, Steven A, Davis, Jeremy L, Morgan, Richard A, Merino, Maria J, Sherry, Richard M, Hughes, Marybeth S, Kammula, Udai S, Phan, Giao Q, Lim, Ramona M, Wank, Stephen A, Restifo, Nicholas P, Robbins, Paul F, Laurencot, Carolyn M, Rosenberg, Steven A·2011·Molecular Therapy
DOI 10.1038/mt.2010.272
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Abstract

Autologous T lymphocytes genetically engineered to express a murine T cell receptor (TCR) against human carcinoembryonic antigen (CEA) were administered to three patients with metastatic colorectal cancer refractory to standard treatments. All patients experienced profound decreases in serum CEA levels (74-99%), and one patient had an objective regression of cancer metastatic to the lung and liver. However, a severe transient inflammatory colitis that represented a dose limiting toxicity was induced in all three patients. This report represents the first example of objective regression of metastatic colorectal cancer mediated by adoptive T cell transfer and illustrates the successful use of a TCR, raised in human leukocyte antigen (HLA) transgenic mice, against a human tumor associated antigen. It also emphasizes the destructive power of small numbers of highly avid T cells and the limitations of using CEA as a target for cancer immunotherapy.

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Crossref · 10.1038/mt.2010.272

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Metadata

Authors
Parkhurst, M. R., Yang, J. C., Langan, R. C., Dudley, M. E., Nathan, D.-A. N., Feldman, S. A., Davis, J. L., Morgan, R. A., Merino, M. J., Sherry, R. M., Hughes, M. S., Kammula, U. S., Phan, G. Q., Lim, R. M., Wank, S. A., Restifo, N. P., Robbins, P. F., Laurencot, C. M., & Rosenberg, S. A.
Venue
Molecular Therapy
Publisher
Elsevier BV
Published
2011-03
Volume
19
Issue
3
Pages
620-626
ISSN
1525-0016 (ISSN-L)
DOI
10.1038/mt.2010.272
OpenAlex
W1983143892
Cited by
1,020
References
28
FWCI
14.75
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis. https://app.cochat.ai/papers/10.1038/mt.2010.272
The paper
Parkhurst, M. R., Yang, J. C., Langan, R. C., Dudley, M. E., Nathan, D.-A. N., Feldman, S. A., Davis, J. L., Morgan, R. A., Merino, M. J., Sherry, R. M., Hughes, M. S., Kammula, U. S., Phan, G. Q., Lim, R. M., Wank, S. A., Restifo, N. P., Robbins, P. F., Laurencot, C. M., & Rosenberg, S. A. (2011). T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis. Molecular Therapy. https://doi.org/10.1038/mt.2010.272

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.