Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals
Thess, Andreas, Grund, Stefanie, Mui, Barbara L, Hope, Michael J, Baumhof, Patrick, Fotin-Mleczek, Mariola, Schlake, Thomas·2015·Molecular Therapy
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- Perspective Chapter: Next-Generation Vaccines Based on Self-Amplifying RNAFatemeh Nafian, Simin Nafian, Ghazal Soleymani, Zahra Pourmanouchehri, Mahnaz Kiyanjam, Sharareh Berenji Jalaei, Hanie Jeyroudi, Sayed Mohammad Mohammdi · 2021 · IntechOpen eBooks
- Advances in mRNA Delivery and Clinical ApplicationsBo Hu, Abid Hussain, Qing Lin Liu, Yuhua Weng, Yuanyu Huang · 2022 · RNA technologies
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- Just the messengerAmanda B. Keener · 2018 · Nature Medicine
- Application of quantitative and engineering biology in mRNA gene therapyHong Xiang, Lei Ke, Xiaohu Yang, Jianmin Guo, Wei Yang, Yong Hu · 2020 · Chinese Science Bulletin (Chinese Version)
- pDNA and mRNA vaccinesKanwal Gill, Leanne Minall, Aslin Rodríguez Nassif · 2021 · Elsevier eBooks
- A Peptide Barcode Based Approach for Efficient in vivo Screening of RNA Delivery SystemsUchechukwu Odunze, Nitin Rustogi, Paul Devine, Lorraine Miller, Sara Pereira, Surender Vashist, Arjan Snijder, Dominic J. Corkill, Alan Sabirsh, Julie A. Douthwaite et al. · 2023 · Research Square
- Transient growth factor expression via mRNA in lipid nanoparticles promotes hepatocyte cell therapy to treat murine liver diseasesAnna R. Smith, Fatima Rizvi, Elissa Everton, Anisah Adeagbo, Susan Y. Wu, Ying K. Tam, Hiromi Muramatsu, Norbert Pardi, Drew Weissman, Valerie Gouon–Evans · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Modified or Unmodified mRNA Vaccines? – The Biochemistry of Pseudouridine and mRNA PseudouridylationPedro Morais, Yi‐Tao Yu · 2024 · Wiley eBooks
- Design and Development of mRNA Vaccines to Combat the COVID ‐19 PandemicIstván Tombácz · 2024 · Wiley eBooks
- New Challenges In Non-Linear Signal And Image ProcessingStephen Marshall, Edward R. Dougherty · 2004
- Future Horizons and New Target Class OpportunitiesHerren Wu, Carl I. Webster, Judy Paterson, Sandrine Guillard, Ron Jackson, Ralph Minter · 2017 · Methods and principles in medicinal chemistry
- mRNA-basierte Therapien für eine passive ImmunisierungMoritz Thran · 2017 · BIOspektrum
- Lipid nanoparticles for delivery of nucleic acid therapeuticsSam Chen · 2017 · cIRcle (University of British Columbia)
- Evaluation of Biodistribution, Toxicology, and Toxicologic Pathology of Nanomaterials Used to Deliver Nucleic AcidsH. Denny Liggitt · 2019 · Springer eBooks
- Deciphering the Plasmodium epitranscriptome as a mechanism of translational controlAmeya Sinha · 2019
- Exigent Encounters with Vaccines PerplexesSangeeta Kumari · 2021 · International Journal of Health Sciences and Research
- mRNA Vaccine: An Advanced and Transformative Technology for Vaccine DevelopmentVikas Kushwaha, Anuprabha, R.C. Sobti · 2021 · Springer eBooks
- Faculty Opinions recommendation of Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose.Donald A. Tomalia · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Messenger RNA Based Vaccines and Their immunological effect on diseasesOsama Mohammed Hasan · 2022 · Al Mustansiriyah Journal of Pharmaceutical Sciences
- Broadly Neutralizing Antibodies Against Omicron Variants of SARS-CoV-2 Derived from mRNA-Lipid Nanoparticle-Immunized MiceRuei‐Min Lu, Kang-Hao Liang, Hsiao-Ling Chiang et al. · 2022 · SSRN Electronic Journal
- Condon Optimization: Codon Optimization of Therapeutic Proteins: Suggested Criteria for Increased Efficacy and SafetyVincent P. Mauro · 2022 · Springer eBooks
- Lipid Nanoparticles to Harness the Therapeutic Potential of mRNA for Cancer TreatmentMaria L. Guevara, Francesca Persano, Stefano Persano · 2022 · RNA technologies
- Synthetic mRNA Gene Therapies and Hepatotropic Non-viral Vectors for the Treatment of Chronic HBV InfectionsDylan Kairuz, Prashika Singh, Tiffany S. Smith, Patrick B. Arbuthnot, Abdullah Ely, Kristie M. Bloom · 2022 · RNA technologies
- Multivalent Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccines Demonstrate a Greater Breadth in T cell but not Antibody ResponsesHsuan-Yuan Wang, Leike Li, Cody S. Nelson, Richard Barfield, Sarah M. Valencia, Cliburn C. W. Chan, Hiromi Muramatsu, Paulo J.C. Lin, Norbert Pardi, Zhiqiang An et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Agent-Based Model of the Impact of Higher Influenza Vaccine Efficacy on Seasonal Influenza BurdenMary G. Krauland, Richard Kent Zimmerman, Katherine V. Williams · 2022 · SSRN Electronic Journal
- Vaccine Design Strategies: Pathogens to GenomesNiall McMullan · 2021 · Royal Society of Chemistry eBooks
- mRNA vaccine encoding neoantigen for cancer immunotherapy using mouse melanoma as a modelChutamath Sittplangkoon, Tanapat Palaga · 2021 · Chula Digiverse
- Protein expression and inflammatory response after delivery of mRNA encoding platelet-derived growth factor-BB in sucrose citrate buffer into rat gingivaPhan Bhongsatiern, Wichaya Wisitrasameewong, Rangsini Mahanonda · 2019 · Chula Digiverse
- [Research Progress of Lung Cancer Vaccines].Hao Fan, Xiangwei Ge, Xin Zhou, Yao Li, An Wang, Yi Hu · 2023 · PubMed Central
- mRNA vaccines: a promising solution for incurable diseasesHongnuo Ge, YanYuen Hei, Jingxuan Wu · 2024 · International Conference on Biological Engineering and Medical Science (ICBioMed)
- mRNA Vaccines in Treatment Tumor: Advancement and ChallengesWen Cao · 2024 · Transactions on Materials Biotechnology and Life Sciences
- It is all in the deliveryJasmine E. Francis, Peter M. Smooker · 2024 · Elsevier eBooks
- mRNA Vaccine: The Starting Point of the Human Body RevolutionWenhao Jiang · 2024 · Highlights in Science Engineering and Technology
- Formulations and mechanisms of action of novel vaccine adjuvantsSusu M. Zughaier, Amna Hashim, Nidal H. Khodr, Abdul Rahman Al Abiad, Mohannad Natheef AbuHaweeleh · 2024 · Elsevier eBooks
- mRNA vaccines: the next frontier in disease preventionQuratul ain Babar, Maryam Maryam, ALI MUSTAPHA MUHAMMAD, Muhammad Farrukh Tahir, Anwar Mohamed Ali · 2024 · Elsevier eBooks
- RNA Therapies in CancerFatemeh Khatami, Setareh Zahedian, Leila Zareian Baghdadabad, Rahil Mashhadi, Mandana Hasanzad, Zeinab Ahadi, Seyed Mohamamd Kazem Aghamir · 2024 · Springer eBooks
- Advances in the development of therapeutic mRNA vaccines for cancer therapyKexin Deng, Xiaobin Li, Wanwan Liu, Junyu Liu, Runming Wang, Yandong Yin, Can Yang Zhang · 2024 · Chinese Science Bulletin (Chinese Version)
- Cancer Vaccines Based on mRNA: Hype or Hope?Wout de Mey, Dorien Autaers, Giada Bertazzon, Arthur Esprit, Marta Marco Aragon, Lorenzo Franceschini, Karine Breckpot · 2024 · Wiley eBooks
- mRNA vaccines: The new frontierZhipeng Yan, Ming Jin Yang, Elaine Tian, Ching‐Lung Lai · 2025 · Elsevier eBooks
- mRNA Vaccines: Unlocking Potential, Exploring Applications, and Envisioning Future HorizonsGaurav Mishra, Sunny Rathee, Munish Garg, Umesh Kumar Patil · 2025 · Current Drug Delivery
- mRNA-Based Biosimilars as Next-Generation VaccinesAnam Upadhyay, Vibha Rani · 2025 · Advances in Science, Technology & Innovation/Advances in science, technology & innovation
- Awakening Sleeping Beauties from articles on mRNA vaccines against COVID-19Artemis Chaleplioglou, Efstathia Selinopoulou, Konstantinos Kyprianos, Alexandros Koulouris · 2026 · Scientometrics
- Application of synthetic biology in vaccine developmentAyon Dutta, Dipanjana Ash, Biswajit Basu, Bhupendra Gopalbhai Prajapati · 2025 · Elsevier eBooks
- Robust Functionality and Regulation of Selectively Expressed RNA as AAV Vectors and In Vitro Transcribed MoleculesFrederik Rastfeld, Nils Hersch, Georg Dreissen, Hajaani Manoharan, Laura Wagner, Lukas Lövenich, Elke Barczak, Hildegard Büning, Rudolf Merkel, Bernd Hoffmann · 2025 · Pharmaceutics
- mRNA-based therapies: current progress and future prospects for treating kidney diseaseYiyun Song, Hua Su · 2025 · Clinical and Experimental Nephrology
- Sensitive detection Cu/Zn SOD mRNA with CRISPR/Cas9Geng Qiuyu, Xing Hanxin, Cang Song, Fan Ronghua, Zheng Anqi · 2025 · Talanta Open
- Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer ImmunotherapyKexin Deng, Juping Sun, Junyu Liu, Yong Zhang, Wanwan Liu, Xiaobin Li, H. T. Wu, Juan Li, Jisong Zhang, Chanyuan Jin et al. · 2025 · Advanced NanoBiomed Research
- mRNA Technology Beyond Vaccines: Exploring Potential mRNA-Based Therapies for Autoimmune DiseasesMayur Gulab Kharat, Vedangi Arvind Kulkarni, Shivani Parmeshwar Chavan, Nilesh Bhimrao Gawali, Shivali M. Khandarkar · 2026 · Asian Journal of Pharmaceutical Research
- Integrative bioinformatics approach to the mRNA vaccine development for the human papillomavirus using the capsid proteinShan He, Akmal Zubair, Faisal Ahmad, Muhammad Yaqoob Shahani, Li Zeng, Naila Afghan · 2026 · Biology Direct
- Recent Progress in Sequence Optimization of mRNA Vaccine: Biological Mechanism, Quantitative Metrics, and Computational ModelYunwei Wang, Yuheng Cai, Zhixing Wu, Jingming Zhang, Lance C. W. Turtle, Jia Meng · 2026 · Bioinformatics and Biology Insights
- Formulation et vectorisation d’un ARN messager vaccinal codant l’antigène Gag du VIH-1 à l’aide de nanoparticules biodégradables de poly(acide lactique)Anne-Line Coolen · 2018 · theses.fr (ABES)
- In vitro synthesis and expression validation of unmodified mRNA encoding a multi-epitope chimeric L1/L2 antigen of human papillomavirusSylvere Nshimiyimana, James Hungo Kimotho, Caroline Wangare Ngugi · 2026 · Multidisciplinary Science Journal
- A single-nucleotide change in the Kozak sequence enhances protein expressionRenzo A. Knol, Tahmina Fariaby, Eveline A. de Vlieger, Alexander Kros, Bram Slütter · 2026 · bioRxiv (Cold Spring Harbor Laboratory)