Production of lentiviral vectors

Merten, Otto-Wilhelm, Hebben, Matthias, Bovolenta, Chiara·2016·Molecular Therapy - Methods & Clinical Development

Cited by (294)

Items 201–294 of 294

  1. Adoptive T cell therapy: engineering and biomanufacturing chimeric antigen receptor-T cell
    Jackson P. Jenkins, Jaeyoung Park, Kristen Petersen, Kahmil Shajihan, Srivalli Kruthiventi, Michael J. Betenbaugh · 2018 · Current Opinion in Chemical Engineering
  2. A guide to approaching regulatory considerations for lentiviral-mediated gene therapies
    Michael S. White, Roger G. Whittaker, Elizabeth Ann Stoll · 2017 · Human Gene Therapy Methods
  3. Stipulations of cell and gene therapy and the ties to biomanufacturing
    Justin Allisha, Juthika Das, Thomas Dunnigan, Susan T. Sharfstein, Payel Datta · 2025 · Biotechnology Progress
  4. Vesicular Stomatitis Virus Glycoprotein- and Lentiviral RNA-Based Robust Approach for Rapid and Accurate Quantification of Viable Lentiviral Vectors
    Meng Wang, Haonan Zheng, Hanyue Ding, Siyuan Liu, Ziquan Wang, Liyun Zheng, Zhiwei Sui · 2025 · Analytical Chemistry
  5. Gene modification: Exploring the potential in treating kidney diseases
    Ubong S. Ekperikpe, Serena Zhao, Ilse Sofia Daehn · 2026 · Pharmacological Research
  6. Rethinking viral vector quantification: a microfluidic approach to standardised functional titre assays
    Daria Andreea Farcas, Charles Moore-Kelly, Philippa Stevenson, Rui André Saraiva Raposo, Marco P. C. Marques, Nicolas Szita · 2026 · Frontiers in Bioengineering and Biotechnology
  7. Purifying Viral Vectors: A Review of Chromatography Solutions
    Louis Crowley, Jennifer J. Labisch, Maja Leskovec, Mojca Tajnik Sbaizero, K McLaughlin, Piergiuseppe Nestola, Amélie Boulais · 2023 · Springer eBooks
  8. HIV-1 Integrase Inhibitor, Dihydroobionin B, and the Investigation of Its Extraordinary Specific Rotation
    Kazuki Hashimoto, Kana Kimura, Kotaro Ishida, Eiji Morita, Kazuaki Tanaka, Masaru Hashimoto · 2023 · Journal of Natural Products
  9. Integrated Semi-Continuous Manufacturing of Lentiviral Vectors Using a HEK-293 Producer Cell Line
    Michelle Yen Tran, Shantoshini Dash, Zeyu Yang, Amine Kamen · 2023 · Processes
  10. Improved Manufacturing Methods of Extracellular Vesicles Pseudotyped with the Vesicular Stomatitis Virus Glycoprotein
    Juliette Champeil, Mathias Mangion, Rénald Gilbert, Bruno Gaillet · 2024 · Molecular Biotechnology
  11. In Vivo Bioluminescence and Fluorescence Imaging: Optical Tool for Cancer Research
    Duško Lainšček, Anja Golob-Urbanc, Sara Orehek · 2024 · Methods in molecular biology
  12. shRNA Targeting Lentiviral Vector Minus-Strand Product Improves the Viral Titer During Viral Packaging
    Jiahui Wu, Wenchen Shen, Qianhai Fan, Jingzhi Zhang, Fanyi Zeng · 2024 · Molecular Biotechnology
  13. Stable Expression by Lentiviral Transduction of Cells
    Natascha Gödecke, H. Häuser, Dagmar Wirth · 2024 · Methods in molecular biology
  14. Optogenetics and Its Transformative Role in Tissue Engineering and Regenerative Medicine
    Emine Camcıoglu, Deniz Ghasemi Mohammadrezaloo, Bi̇rcan Di̇nç · 2024 · Nano Select
  15. Comparison of insulin secretion by transduced adipose‐derived and endometrial‐derived stem cells in 2D and 3D cultures on fibrin scaffold
    Roya Karimi, Zahra Barabadi, Bagher A. Larijani, Gholamreza Tavoosidana, Nasrin Lotfibakhshaiesh, Moloud Absalan, Zahra Jabbarpour, Seyed Nasser Ostad, Jafar Ai · 2020 · Journal of Biomedical Materials Research Part A
  16. Effective Transduction of Brain Neurons with Lentiviral Vectors Purified by Ion-Exchange Chromatography
    Dmitriy A. Lanshakov · 2020 · Biotekhnologiya
  17. Manufacturing of Viral Gene Therapies
    G. Anthony Ramirez, Mehdi Gasmi · 2021 · International Ophthalmology Clinics
  18. Towards routine manufacturing of gene therapy drugs
    Otto‐Wilhelm Merten, John Fraser Wright · 2016 · Molecular Therapy — Methods & Clinical Development
  19. Production and Use of Gesicles for Nucleic Acid Delivery
    Mathias Mangion, Marc-André Robert, Igor Slivac, Rénald Gilbert, Bruno Gaillet · 2021 · Molecular Biotechnology
  20. Characterization of CAR T Cells Manufactured using Genetically Engineered Artificial Antigen Presenting Cells
    Ali Sayadmanesh, Mohammad Azadbakht, Kheirollah Yari, Ali Abedelahi, Hajar Shafaei, Dariush Shanehbandi, Behzad Baradaran, Mohsen Basiri · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  21. In vivo generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearance
    Kepler S. Mears, Kyrellos E. Ibrahim, Peter M. Allen, Jordan M. Chinai, Omar I. Avila, Audrey J. Muscato, Sarah Kate Lane-Reticker, Alexánder Rojas, Nelson H. Knudsen, Chun‐Cheih Chao et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  22. The Establishment of In Vitro Human Induced Pluripotent Stem Cell-Derived Neurons
    Izyan Mohd Idris, Fazlina Nordin, Nur Jannaim Muhamad, Julaina Abdul Jalil, Fatimah Diana Amin Nordin, Rosnani Mohamed, Adiratna Mat Ripen, Gee Jun Tye, Wan Safwani Wan Kamarul Zaman, Muhammad Dain Yazid et al. · 2023 · Sains Malaysiana
  23. Cloning of a BDV-NS3 Conserved Fragment for the Preparation of a Reporter Cell Line
    Mehdi Khorami, Azam Mokhtari, behnaz saffar, Mohammadreza Mahzounieh · 2023 · Jentashapir Journal of Cellular and Molecular Biology
  24. Effects of an indole derivative on cell proliferation, transfection, and alternative splicing in production of lentiviral vectors by transient co-transfection
    Nataly Carolina Mier, Donald Keith Roper · 2024 · PLoS ONE
  25. From bench to bedside: the future of stable lentiviral packaging cell lines in gene therapy
    Kumitaa Theva Das · 2025 · Gene Therapy
  26. Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems
    Dalton W. Staller, Flobater I. Gawargi, Sanjali S. Panigrahi, Paras Kumar Mishra, Ram I. Mahato · 2025 · Pharmacological Reviews
  27. USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF
    Wancong Zhang, Liyun Chen, Jing Zhao, Aiwei Ma, Wenqi Shi, Yiwen Zhang, Zixuan Tang, Jiarui Guo, Zaihua Xu, Jianda Zhou et al. · 2025 · Advanced Science
  28. Stable and Predictable Lentiviral Vector Production at Clinical Scale
    Niels Heinz, Laura Mosbacher, Lisa C Cordie, Katharina Zeller, Florian Rohn, Melanie Naeher, Melina Hien, Stefan Ohlinger, Klaus Kuehlcke, Rainer Loew · 2025 · Human Gene Therapy
  29. Development of a Gene Therapy with Lentiviral Vectors for Spinocerebellar Ataxias
    Tiago Moreira‐Gomes, Clévio Nóbrega · 2025 · Methods in molecular biology
  30. Enhancing the transduction efficiency of lentiviral vectors in CAR-T cell therapy through an optimization workflow
    Rita Ferreira, Jaciara Fernanda Gomes Gama, Ana Godinho‐Santos, J. Ricardo M. Gonçalves · 2026 · Frontiers in Medicine
  31. Multi-dimensional orchestration of binders for improved CAR-T immunotherapy
    Chaoyang Zhu, Z H Jiang, Rui Jing, Wei Guo, Yong Lu · 2026 · Cancer Letters
  32. Simplifying the Efficient Clinical-Grade Production of Viruses
    Alengo Nyamay’Antu, Valérie Kedinger, Patrick Erbacher · 2017 · Genetic Engineering & Biotechnology News
  33. Generation of In Vitro Model of Epithelial Mesenchymal Transition (EMT) Via the Expression of a Cytoplasmic Mutant Form of Promylocytic Leukemia Protein (PML)
    Anna Di Biase, Amanda Kathleen Miles, Tarik Regad · 2017 · Methods in molecular biology
  34. A versatile genomic transgenesis platform with enhanced λ integrase for human Expi293F cells
    Asim Azhar Siddiqui, Sabrina Peter, Eve Zi Xian Ngoh, Cheng‐I Wang, Shirelle Ng, John A. Dangerfield, Walter H. Günzburg, Peter Dröge, Harshyaa Makhija · 2023 · Frontiers in Bioengineering and Biotechnology
  35. Optimization of YF17D-Vectored Zika Vaccine Production by Employing Small-Molecule Viral Sensitizers to Enhance Yields
    Sven Göbel, Tilia Zinnecker, Ingo Jordan, Volker Sandig, Andrea Vervoort, Jondavid de Jong, Jean‐Simon Diallo, Peter Satzer, Manfred Satzer, Kai Dallmeier et al. · 2025 · Vaccines
  36. Safety markers for rhabdomyosarcoma cells using an in�vivo imaging system
    Shutong Du, Lian Meng, Lingxie Song, Pengpeng Zhang, Xi Shou, Chunxia Liu, Feng Li · 2018 · Oncology Letters
  37. Production of high‐titer transmission‐defective RNA virus‐based episomal vector using tangential flow filtration
    Yumiko Komatsu, Yoji Kakuya, Keizō Tomonaga · 2020 · Microbiology and Immunology
  38. Generation of stably expressing IRF5 spliced isoform in Jurkat cells
    Ashwinder Kaur, Chee-Mun Fang · 2020 · Progress In Microbes & Molecular Biology
  39. Efficient Transduction of T-Lymphocytes by Lentiviral Particles in Oncoimmunological Studies
    Ekaterina Konstantinovna Zaikova, Ksenia Levchuk, D.Yu. Pozdnyakov, Alexandra A. Daks, Andrey Yu. Zaritskey, Alexey Petukhov · 2020 · Clinical oncohematology
  40. Manufacturing of CAR-T Cells: The Assembly Line
    Xiuyan Wang, Isabelle Rivière · 2022 · Cancer drug discovery and develogment/Cancer drug discovery and development
  41. Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies
    Mc Cann, Andréa, Mathy, Grégory, Laetitia Malphettes · 2018 · BMC Proceedings
  42. Homology mediated end joining enables efficient non-viral targeted integration of large DNA templates in primary human T cells
    Beau R. Webber, Matthew J. Johnson, Nicholas J. Slipek, Walker S. Lahr, Anthony P. DeFeo, Joseph G. Skeate, Xiaohong Qiu, Blaine Rathmann, Miechaleen D. Diers, Bryce J. Wick et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Engineering high-titer lentiviral vectors for robust expression of RNA-based gene circuits
    Kasey S. Love, Brittany A Lende-Dorn, Kate E. Galloway · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  44. A Single-Cell Platform for Monitoring Viral Proteolytic Cleavage in Different Cellular Compartments
    Darin Abbadessa, Cameron A. Smurthwaite, Connor W. Reed, Roland Wolkowicz · 2015 · Biochemistry Insights
  45. Hurdles Associated with the Translational Use of Genetically Modified Cells
    Sunil S. Raikar, Harold Trent Spencer · 2018 · Current Stem Cell Reports
  46. Easy In Vitro Synthesis of Optimised Functioning Reporter mRNA from Common eGFP Plasmid
    Gustavo Torres de Souza, Rafaela C.R. Hell, Jéssica Fernanda da Silva Souza, Luiz Sérgio de Almeida Camargo · 2018 · Molecular Biotechnology
  47. Estabelecimento de uma plataforma para produção de vetores lentivirais para a modificação de linfócitos T com CAR anti-CD19
    Pablo Diego Moço · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  48. Triagem para a identificação de novos compostos com atividade sobre linhagem celular infectada pelo HTLV-1
    Daiane Fernanda dos Santos · 2019
  49. Gene Therapy: Principles and Clinical Potential
    Suzanne M. K. Buckley, Anna Louise David · 2019 · Cambridge University Press eBooks
  50. Viruses, the vehicle for cancer gene therapy: A Review
    Nurliyana Mohd Yusof, Natasha Nur Afiqah Mohamed Noor Fuadi, Mohd Azuraidi Osman, Mohd Azmi Mohd Lila, Nik Mohd Afizan Nik Abd Rahman · 2020 · African Journal of Biological Sciences
  51. Lesion-Targeted Anti-Cancer Gene Delivery with Clinical Survival Benefits: A Molecular “Rosetta Stone” for Veterinary Hematology-Oncology and Precision Gene Therapy
    Erlinda Maria Gordon · 2021 · Biomedical Journal of Scientific & Technical Research
  52. Los vectores virales y su relación con la bioseguridad en el laboratorio
    Catalina S. Romano, Susana E. Mersich · 2018 · Redalyc (Universidad Autónoma del Estado de México)
  53. Produção de vetores lentivirais em condições escalonáveis para geração de células T-CAR para terapia celular
    Mariane Cariati Tirapelle · 2021 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  54. Peer Review #2 of "Transfection types, methods and strategies: a technical review (v0.3)"
    2021 · PeerJ
  55. Peer Review #1 of "Transfection types, methods and strategies: a technical review (v0.3)"
    2021 · PeerJ
  56. Peer Review #1 of "Transfection types, methods and strategies: a technical review (v0.2)"
    2021 · PeerJ
  57. Peer Review #1 of "Transfection types, methods and strategies: a technical review (v0.1)"
    2021 · PeerJ
  58. Peer Review #2 of "Transfection types, methods and strategies: a technical review (v0.1)"
    2021 · PeerJ
  59. A Risk Assessment Study of SARS-CoV-2 Propagation in the Manufacturing of Cellular Products
    Enric Redondo Monte, David O’Neill, Karin M Abitorabi · 2022 · Regenerative Medicine
  60. Lentiviral shRNA Construction in Gene Therapy for Knock Down CYPIA1, and YWHAZ gene in Lung Cancer
    Henik Anjayati · 2021 · Journal of Biological Science and Education
  61. The Use of Viral Vectors in the Treatment of Diseases (Viral Vectors for Gene Therapy)
    2023 · International Journal of Agriculture and Biosciences
  62. ADVANCING THE PRODUCTION OF VIRAL VECTORS FOR CAR-T CELL THERAPY IN KAZAKHSTAN
    Laura Syzdykova, Viktoriya V. Keyer, Roman Arsienko, B. Inirbay, Alexandr V. Shustov · 2023 · Eurasian journal of applied biotechnology
  63. Biomanufacturing Aspects of Gene Therapy
    James N. Warnock · 2023 · Cell engineering
  64. Evaluation of Lentiviral Based Gene Delivery System in Adherent and Suspension in vitro Cell Models
    Izyan Mohd Idris, Fazlina Nordin, Nur Jannaim Muhamad, Siti Zuleha Idris, Gee Jun Tye, Wan Safwani Wan Kamarul Zaman, Min Hwei Ng · 2024 · Sains Malaysiana
  65. In Vitro Generation and Characterization of The Wu Syndrome Model That Causes Mental Retardation in Neural Cell Lines
    Sumeyye Seher Karaman, Tuba Sevik, Selin Akdemir, Burak Bilgin, Esra Karadeli, Dilay Yalcin, Buse Baran, Beste Gelsin, Buket Budaklar, Berranur Sert et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  66. Geração e caracterização funcional de nova molécula recombinante da β-glicosilceramidase humana portadora de mutações sinônimas
    Ana Carolina Lunardello Coelho · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  67. Geração de uma linhagem celular humana com produção permanente da enzima lisossomal β-glicosilceramidase recombinante por meio do sistema lentiviral
    Jéssica Luana Souza Cardoso · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  68. CAR-T Cells – Main Steps for Obtaining a Proper “Live Drug” Adoptive Therapy
    Monica Teodora Neagu, Carolina Constantin · 2024 · South East European Journal of Immunology
  69. Preclinical development of viral vector gene therapies
    Mary S. Newman, Eloïse Hudry, Jacqueline A. Brassard, Justine J. Cunningham · 2024 · Elsevier eBooks
  70. Recent animal models of bladder cancer and their application in drug discovery: an update of the literature
    Inês Aires, B. Parada, Rita M. Ferreira, Paula A. Oliveira · 2025 · Expert Opinion on Drug Discovery
  71. Hope Unlocked: Gene Therapy with Viral Vectors and Gene Editing
    Jennifer J. Thiaville, Mariana Santana Dias, Sayuri E. M. Kato, Shashwati Basak, Srinivas Rengarajan, Hilda Petrs Silva, Natasha Rivas, Susan M. D’Costa · 2025 · Springer eBooks
  72. CRISPR.BOT an autonomous platform for streamlined genetic engineering and molecular biology applications
    Fatmanur Erkek, Rana Kizilkaya, Seyma Baybara, Gamze Gülden, Berranur Sert, Muzeyyen Sena Yazicilar, Menekse Cagla Yilmaz, Sibel Pınar Odabaş, Enes Bal, Gamze Yelgen et al. · 2025 · Scientific Reports
  73. Efficacy and safety of lentivirus gene therapy in the correction of sickle cell disease
    Ioanna Myrtzious Kanaki, Perpetua U. Emeagi, Chikadibia Fyneface Amadi · 2025 · IMC Journal of Medical Science
  74. Sulbactam-mediated inhibition of TEM-1 β-lactamase increases specific yields of ampicillin-resistant plasmids
    Stanislav Pepeliaev · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  75. SLC20A1 knockout to stably express a fusogenic gibbon ape leukemia virus envelope glycoprotein for lentiviral vector production
    Rodrigo José Nogueira, Ana Filipa Rodrigues, Daniel Alexandre Mestre, Ana Sofia Coroadinha · 2025 · Molecular Therapy — Methods & Clinical Development
  76. Lentiviral Vector-Mediated Gene Delivery for iPSC-Related Neuroscience Research
    Taro Okunomiya, Keiko Imamura, Taku Kashiyama, Takashi Sakurai, Hiroyuki Hioki, Haruhisa Inoue · 2025 · Methods in molecular biology
  77. Development and Application of Respiratory Pseudovirus Packaging System
    Jingwen Fu, Ran Chen, Shihuan Zhong, Han Jiang, Jiayue Yang, Xuezheng Ma, Chenze Lu · 2025 · Aerosol Science and Engineering
  78. Applications of Nanotechnology to Bioprocessing
    Setare Adibzadeh, Stephanie M. Curley, Suman Saha, Susan T. Sharfstein · 2026 · Elsevier eBooks
  79. Upstream insights for lentiviral vector production: cell platforms, culture parameters, and titer yields
    Pedram Abdollahpour, Alireza Shafizadeh, Ehsan Arefian · 2026 · Cytotechnology
  80. Optimized High‐Titer Lentivirus Production and Efficient CAR‐T Cell Generation
    Atul Kumar Roy, Ashwani Singh, Jyotsna Dandotiya, Rucha R. Chandwaskar, Srikanth Sadhu, Amit Awasthi · 2026 · Current Protocols
  81. Développement d'une stratégie Cheval de Troie dans le traitement du carcinome hépatocellulaire
    Benjamin Nayagom · 2019 · theses.fr (ABES)
  82. Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production
    Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte · 2026 · Biotechnology and Bioengineering
  83. Suspension-Adapted HEK293FT Cells Enable High-Density Transfection for Efficient Lentiviral Vector Production in CAR-T Therapy
    Alexandr Shevtsov, Aitolkyn Kydyrbayeva, Gaziza Nigmatulla, Viktoriya V. Keyer, Tolganay Kulatay, Gulzat Zauatbayeva, Bakytkali Ingirbay, Maral Zhumabekova, Dinara Zharlyganova, Alexandr V. Shustov · 2026 · Bioengineering
  84. Quasi-perfusion method for scaling and optimisation of a suspension stable producer cell line for continuous manufacturing of lentiviral vectors at high cell density
    Ciara Lucas, Cristina Aleu Heredia, Yasuhiro Takeuchi, David Mainwaring, Martina Micheletti · 2026 · Biochemical Engineering Journal
  85. GAA engineered to improve cellular uptake enhances correction in a preclinical hematopoietic stem cell gene therapy model of Pompe disease
    Slawomir Wantuch, Steven J. Tuske, Sara Benedetti, Nickita Mehta, Jon J. Brudvig, Hung Do, Russell R. Gotschall, Jessie Feng, Anna B. Gaspar, Chiara Recchi et al. · 2026 · Molecular Therapy Advances
  86. In vivo CAR-T therapy: The shift from ex vivo culturing to direct in situ immune reprogramming
    Janani Gopalakrishnan, Bhagyashri Rathod, Sachin Puri · 2026 · International Immunopharmacology
  87. Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective
    Rajath Samaga, Udisha Singh, Sachin Dattram Pawar · 2026 · Biotechnology and Bioengineering
  88. A Pooled CRISPR Screen Protocol for Comparative Pathway Analysis Across Multiple Stressors
    Truc T. Losier, Karyn E. King, J. Taylor, Maxime W.C. Rousseaux, Ryan Charles Russell · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  89. Going with the flow: peptide affinity membranes for high-throughput, high-yield purification of adenovirus and lentiviral vectors
    Yuxuan Wu, Arianna Minzoni, Aishwarya Gangadhar, William Kojo Smith, Eduardo Barbieri, Irfan Ismail, Luke A. Remmler, Michael Angelo-Anthony Daniele, Stefano Menegatti · 2026 · Journal of Chromatography A
  90. Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice
    Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, H Wang, Xiao‐jie Wang, Xiao‐Lin Yu, Zhang Gui-feng, Rui‐tian Liu · 2026 · Advanced Science
  91. Xeno-free production of lentiviral particles: implementing hPL as FBS replacement in cell culture
    Mariana Soares Guedes, Marnie Cole, Daniela Yildiz · 2026 · Frontiers in Toxicology
  92. Electrolyte and Voltage Operating Window for Reversible Plasmid Capture
    Lisa Meier, Manfei Li, Paula Fraga‐García, Sonja Berensmeier · 2026 · Research Square
  93. A mechanistic model of lentiviral vector production identifies intracellular plasmid availability and vRNA-GagPol temporal asynchrony as key yield-limiting factors
    Daoyuan Na, Lei Cao, Naixiang Cui, Wen-Song Tan · 2026 · Biochemical Engineering Journal
  94. BindingDB Entry 50020441: HIV-1 Integrase Inhibitor, Dihydroobionin B, and the Investigation of Its Extraordinary Specific Rotation.
    BindingDB · 2024 · UC San Diego