MDC1 is a mediator of the mammalian DNA damage checkpoint

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Items 601–700 of 868

  1. Differences in RAD51 transcriptional response and cell cycle dynamics reveal varying sensitivity to DNA damage among Arabidopsis thaliana root cell types
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  3. BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling
    Melissa Bradbury, Eva Borràs, Josep Castellví, Olga Méndez, José Luís Sánchez-Iglesias, Assumpció Pérez‐Benavente, Antonio Gil‐Moreno, Eduard Sabidó, Anna Santamaría · 2022 · Scientific Reports
  4. TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11
    Hyeongsun Jeong, Minwoo Wie, In‐Joon Baek, Gyuwon Sohn, Si-Hyeon Um, Seon‐gyeong Lee, Yuri Seo, Jaesun Ra, Eun A Lee, Shinseog Kim et al. · 2022 · Cells
  5. HDGFRP3 interaction with 53BP1 promotes DNA double-strand break repair
    Zhen Zhang, William E. Samsa, Yanyan De, Fan Zhang, Ofer Reizes, Alexandru Almasan, Zihua Gong · 2023 · Nucleic Acids Research
  6. Image-based quantitative determination of DNA damage signal reveals a threshold for G2 checkpoint activation in response to ionizing radiation
    Aya Ishikawa, Motohiro Yamauchi, Keiji Suzuki, Shunichi Yamashita · 2010 · Genome Integrity
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    Laura A. Baker, Holly Holliday, Daniel Lee Roden, Christoph Krisp, Sunny Z. Wu, Simon R. Junankar, Aurélien A. Sérandour, Hisham Mohammed, Radhika Nair, Geetha Sankaranarayanan et al. · 2020 · Breast Cancer Research
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    H. Peter Rodemann, Michael A. Baumann, Stephan B. Bodis, Ekkehard Dikomey · 2004 · Radiotherapy and Oncology
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    Yi Xu, Changying Li, Huan Yin, Somaira Nowsheen, Xin Xu, Wenjuan Kang, Xin Liu, Lifeng Chen, Zhenkun Lou, Junlin Yi et al. · 2024 · Nucleic Acids Research
  10. NFBD1/MDC1 Regulates Cav1 and Cav2 Independently of DNA Damage and p53
    Kathleen A. Wilson, Sierra A. Colavito, Vincent Schulz, Patricia Heffernan Wakefield, William C. Sessa, David P. Tuck, David F. Stern · 2011 · Molecular Cancer Research
  11. DNA Damage Response Pathways in Dinoflagellates
    Chongping Li, Joseph T.Y. Wong · 2019 · Microorganisms
  12. Dynamic recruitment of UFM1-specific peptidase 2 to the DNA double-strand breaks regulated by WIP1
    Bo Qin, Jia Yu, Fei Zhao, Jinzhou Huang, Qin Zhou, Zhenkun Lou · 2022 · Genome Instability & Disease
  13. Role of ataxia‐telangiectasia mutated (ATM) in porcine oocyte in vitro maturation
    Zili Lin, Nam‐Hyung Kim · 2015 · Cell Biology International
  14. NFBD1/MDC1 Is Phosphorylated by PLK1 and Controls G2/M Transition through the Regulation of a TOPOIIα-Mediated Decatenation Checkpoint
    Kiyohiro Ando, Toshinori Ozaki, Toru Hirota, Akira Nakagawara · 2013 · PLoS ONE
  15. The Mre11-Rad50-Nbs1 complex mediates the robust recruitment of Polo to DNA lesions during mitosis in Drosophila
    Cedric Landmann, Priscillia Pierre-Elies, Damien Goutte-Gattat, Émilie Montembault, Marie-Charlotte Claverie, Anne Royou · 2020 · Journal of Cell Science
  16. Interplay Between KSHV and the Host DNA Damage Response
    Eriko Ohsaki, Keiji Ueda · 2020 · Frontiers in Cellular and Infection Microbiology
  17. Novel therapeutic approaches in GEP-NETs based on genetic and epigenetic alterations
    Javier Pozas, Teresa Alonso‐Gordoa, María San Román, Matteo Santoni, Christina Thirlwell, Enrique Grande, Javier Molina‐Cerrillo · 2022 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  18. Marks to stop the clock: histone modifications and checkpoint regulation in the DNA damage responseThis paper is one of a selection of papers published in this Special Issue, entitled 29th Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.
    Stephen E. Humpal, David A. Robinson, Jocelyn E. Krebs · 2009 · Biochemistry and Cell Biology
  19. Mediator of DNA damage checkpoint protein 1 (MDC1) as a prognostic marker for patients with oral squamous cell carcinoma
    Jigna Harshadbhai Dave, Hemangini H. Vora, Nandita Ghosh, Trupti Indravadan Trivedi · 2017 · Journal of Oral Pathology and Medicine
  20. Targeting epigenetics using synthetic lethality in precision medicine
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  21. A Newfound Association between MDC1 Functional Polymorphism and Lung Cancer Risk in Chinese
    Bo Wang, Lisha Zhang, Fuman Qiu, Wenxiang Fang, Jieqiong Deng, Yifeng Zhou, Jiachun Lü, Lei Yang · 2014 · PLoS ONE
  22. NFBD1/MDC1 participates in the regulation of proliferation and apoptosis in human laryngeal squamous cell carcinoma
    X. Liu, Zhu Qiu, Z. Wang, Wenqi Zuo, Z. Gong, Chi Liu, Q. Zeng, Qian Yi, Lizhu Jiang, Yue Li et al. · 2017 · Clinical & Translational Oncology
  23. ADAD2 regulates heterochromatin in meiotic and post-meiotic male germ cells via translation of MDC1
    Lauren G. Chukrallah, Aditi Badrinath, Gabrielle G. Vittor, Elizabeth M. Snyder · 2022 · Journal of Cell Science
  24. Recruitment of proteins to DNA double-strand breaks: MDC1 directly recruits RAP80
    Carmit Strauss, Michal Goldberg · 2011 · Cell Cycle
  25. Phosphorylation of the BRCA1 C Terminus (BRCT) Repeat Inhibitor of hTERT (BRIT1) Protein Coordinates TopBP1 Protein Recruitment and Amplifies Ataxia Telangiectasia-mutated and Rad3-related (ATR) Signaling
    Bo Zhang, Edward Wang, Hui Dai, Jianfeng Shen, Hui-Ju Hsieh, Xiongbin Lu, Guang Peng · 2014 · Journal of Biological Chemistry
  26. Tagging Single Nucleotide Polymorphisms in Phosphoinositide-3-Kinase–Related Protein Kinase Genes Involved in DNA Damage “Checkpoints” and Lung Cancer Susceptibility
    Zhibin Hu, Hongliang Liu, Haifeng Wang, Ruifen Miao, Weiwei Sun, Guangfu Jin, Ying Wang, Hongxia Ma, Jin Li, Qingyi Wei et al. · 2008 · Clinical Cancer Research
  27. Negative regulation of BRCA1 by transforming acidic coiled-coil protein 3 (TACC3)
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  28. Differential effect of MMSET mRNA levels on survival to first-line FOLFOX and second-line docetaxel in gastric cancer
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  29. Growth inhibition, morphology change, and cell cycle alterations in NFBD1-depleted human esophageal cancer cells
    Zhengmei Yang, Youquan Bu, Changdong Wang, Geli Liu, Fangzhou Song · 2010 · Molecular and Cellular Biochemistry
  30. VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair
    W.J. Wu, Zhenzhen Fan, Hui Fu, Xiaolu Ma, Dongzhou Wang, Hongmei Liu, Chuanchao Zhang, Hui Zheng, Yeran Yang, Honglin Wu et al. · 2024 · Science Advances
  31. Small RNAs: Emerging key players in DNA double-strand break repair
    Zhaoqing Ba, Yijun Qi · 2013 · Science China Life Sciences
  32. An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells
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  37. Proline-serine-threonine-repeat region of MDC1 mediates Chk1 phosphorylation and the DNA double-strand break repair
    Seung Ho Choi, Kyoungjoo Cho, Eun Seon Kim, Hae Yong Yoo · 2021 · The International Journal of Biochemistry & Cell Biology
  38. Allyl isothiocyanate induces DNA damage and inhibits DNA repair‐associated proteins in a human gastric cancer cells in vitro
    Yung‐Luen Shih, Sheng‐Yao Hsu, Kuang‐Chi Lai, Fu‐Shin Chueh, Yuan‐Li Huang, Chao‐Lin Kuo, Yung‐Liang Chen, Chiung‐Ju Chen, Shu‐Fen Peng, Wen‐Wen Huang et al. · 2023 · Environmental Toxicology
  39. Mediator of DNA Damage Checkpoint 1 (MDC1) Contributes to High NaCl-Induced Activation of the Osmoprotective Transcription Factor TonEBP/OREBP
    Margarita Kunin, Natalia I. Dmitrieva, Morgan Gallazzini, Rong‐Fong Shen, Guanghui Wang, Maurice B. Burg, Joan D. Ferraris · 2010 · PLoS ONE
  40. MCPH1 Protein Expression in Normal and Neoplastic Lung Tissues
    Ji Zhang, Xiaobin Wu, Jianjun Fan, Li Mai, Wei Cai, Dan Li, Chengfu Yuan, Youquan Bu, Fangzhou Song · 2013 · Asian Pacific Journal of Cancer Prevention
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    Peng Cao, Qinlong Dai, Cao Deng, Xiang Zhao, Shishan Qin, Jian Yang, Ran Ju, Zhiwen Wang, Guoqing Lu, Xiaodong Gu et al. · 2021 · Science China Life Sciences
  42. An SR protein is essential for activating DNA repair in malaria parasites
    Brajesh Kumar Singh, Manish Goyal, Karina Simantov, Yotam Kaufman, Shiri Eshar, Ron Dzikowski · 2021 · Journal of Cell Science
  43. BRCA1 and BRCA2 in Breast Cancer Predisposition and Recombination Control
    Ralph Scully, Anyong Xie · 2004 · Journal of Mammary Gland Biology and Neoplasia
  44. Polyaromatic Hydrocarbons Cause Histone H2AX Phosphorylation in the S-phase of the Cell Cycle
    Chiaki Shimohara, Tomoko Sawai, Takashi Yagi · 2008 · Genes and Environment
  45. Loss of MDC1 in Endometrial Carcinoma Is Associated With Loss of MRN Complex and MMR Deficiency
    DANAE MERENTITIS, Bich Doan Nguyen-Sträuli, Eleftherios Pierre Samartzis, Aurelia Noske, Simone Brandt, Konstantin Johannes Dedes · 2019 · Anticancer Research
  46. Telomeric Double Strand Breaks in G1 Human Cells Facilitate Formation of 5′ C-Rich Overhangs and Recruitment of TERRA
    Christopher B. Nelson, Taghreed M. Al-Turki, Jared J. Luxton, Lynn E. Taylor, David G. Maranon, Keiko Muraki, John P. Murnane, Susan M. Bailey · 2021 · Frontiers in Genetics
  47. Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach
    Vaishnavee Thote, Susha Dinesh, Sameer Sharma · 2024 · Systems Biology in Reproductive Medicine
  48. Diffusion of activated ATM explains γH2AX and MDC1 spread beyond the DNA damage site
    Georgi Danovski, Greta Panova, B. D. Keister, Georgi S. Georgiev, Aleksandar Atemin, Sonya Uzunova, Rumen Stamatov, Petar-Bogomil Kanev, Radoslav Aleksandrov, Krastan B. Blagoev et al. · 2024 · iScience
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  50. Functional defects of cancer-associated MDC1 mutations in DNA damage repair
    Rong Xie, Zhenzhen Yan, Ju Jing, Yukun Wang, Jiajia Zhang, Yipeng Li, Xiuhua Liu, Xiaochun Yu, Chen Wu · 2022 · DNA repair
  51. Emerging Features of DNA Double-Strand Break Repair in Humans
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  52. Twilight effects of low doses of ionizing radiation on cellular systems: a bird’s eye view on current concepts and research
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    Gregory Bick, Fan Zhang, Amom Ruhikanta Meetei, Paul R. Andreassen · 2016 · Chromosoma
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  56. Karyopherin α-2 Mediates MDC1 Nuclear Import through a Functional Nuclear Localization Signal in the tBRCT Domain of MDC1
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  59. The fanconi anemia pathway promotes homologous recombination repair in DT40 cell line
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  60. NFBD1/MDC1 stabilizes oncogenic MDM2 to contribute to cell fate determination in response to DNA damage
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  61. Role of MERIT40 in stabilization of BRCA1 complex: A protein–protein interaction study
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