Elledge, Stephen J.

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 4,368

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 3,213

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science

DNA Repair MechanismsProtein Kinase Regulation and GTPase Signaling

Cited by 3,075

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science

DNA Repair MechanismsFungal and yeast genetics research

Cited by 2,693

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 2,113

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Bjornevik, K., Cortese, M., Healy, B. C., Kuhle, J., Mina, M. J., Leng, Y., Elledge, S. J., Niebuhr, D. W., Scher, A. I., Munger, K. L., et al. (2022) · Science

Multiple Sclerosis Research StudiesViral-associated cancers and disorders

Cited by 2,049

Principles of cancer therapy: oncogene and non-oncogene addiction

Luo, J., Solimini, N. L., & Elledge, S. J. (2009) · Cell

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 1,765

The DNA Damage Response: Ten Years After

Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,705

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,625

A quantitative atlas of mitotic phosphorylation

Dephoure, N., Zhou, C., Villén, J., Beausoleil, S. A., Bakalarski, C. E., Elledge, S. J., & Gygi, S. P. (2008) · Proceedings of the National Academy of Sciences

Advanced Proteomics Techniques and ApplicationsUbiquitin and proteasome pathways

Cited by 1,608

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

Zheng, N., Schulman, B. A., Song, L., Miller, J. J., Jeffrey, P. D., Wang, P., Chu, C., Koepp, D. M., Elledge, S. J., Pagano, M., et al. (2002) · Nature

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 1,507

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

Dulić, V., Kaufmann, W. K., Wilson, S. J., Tisty, T. D., Lees, E., Harper, J. W., Elledge, S. J., & Reed, S. I. (1994) · Cell

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 1,465

Identification of host proteins required for HIV infection through a functional genomic screen

Brass, A. L., Dykxhoorn, D. M., Benita, Y., Yan, N., Engelman, A., Xavier, R. J., Lieberman, J., & Elledge, S. J. (2008) · Science

HIV Research and TreatmentVirus-based gene therapy research

Cited by 1,449

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,320

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 1,221

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

Sicinski, P., Donaher, J. L., Parker, S. B., Li, T., Fazeli, A., Gardner, H., Haslam, S. Z., Bronson, R. T., Elledge, S. J., & Weinberg, R. A. (1995) · Cell

Cancer-related Molecular PathwaysRetinal Development and Disorders

Cited by 1,021

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 1,020

A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

Luo, J., Emanuele, M. J., Li, D., Creighton, C. J., Schlabach, M. R., Westbrook, T. F., Wong, K.-K., & Elledge, S. J. (2009) · Cell

Protein Kinase Regulation and GTPase SignalingMicrotubule and mitosis dynamics

Cited by 1,017

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 985

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

Kang, C., Xu, Q., Martin, T. D., Li, M. Z., Demaria, M., Aron, L., Lu, T., Yankner, B. A., Campisi, J., & Elledge, S. J. (2015) · Science

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 982

MDC1 is a mediator of the mammalian DNA damage checkpoint

Stewart, G. S., Wang, B., Bignell, C. R., Taylor, A. M. R., & Elledge, S. J. (2003) · Nature

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 874

Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome

Davoli, T., Xu, A. W., Mengwasser, K. E., Sack, L. M., Yoon, J. C., Park, P. J., & Elledge, S. J. (2013) · Cell

Cancer Genomics and DiagnosticsGenomic variations and chromosomal abnormalities

Cited by 815

Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

Wang, B., Matsuoka, S., Ballif, B. A., Zhang, D., Smogorzewska, A., Gygi, S. P., & Elledge, S. J. (2007) · Science

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 695

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

Shrock, E., Fujimura, E., Kula, T., Timms, R. T., Lee, I.-H., Leng, Y., Robinson, M. L., Sie, B. M., Li, M. Z., Chen, Y., et al. (2020) · Science

SARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testing

Cited by 678