The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Routing of spike series by dynamic circuits in the hippocampus
Abstract
Recurrent inhibitory loops are simple neuronal circuits found in the central nervous system, yet little is known about the physiological rules governing their activity. Here we use simultaneous somatic and dendritic recordings in rat hippocampal slices to show that during a series of action potentials in pyramidal cells recurrent inhibition rapidly shifts from their soma to the apical dendrites. Two distinct inhibitory circuits are sequentially recruited to produce this shift: one, time-locked with submillisecond precision to the onset of the action potential series, transiently inhibits the somatic and perisomatic regions of pyramidal cells; the other, activated in proportion to the rate of action potentials in the series, durably inhibits the distal apical dendrites. These two operating modes result from the synergy between pre- and postsynaptic properties of excitatory synapses onto recurrent inhibitory neurons with distinct projection patterns. Thus, the onset of a series of action potentials and the rate of action potentials in the series are selectively captured and transformed into different spatial patterns of recurrent inhibition.
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“excitatory inputs onto Sst INs, apparently regardless of subtypes, are strongly facilitating”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Pouille and Scanziani, 2004
In the citing paper
“Indeed, the restriction of horizontally oriented O-LM soma and spiny dendrites within s.o. and the alveus dictates that the dominant source of excitatory recruitment is from CA1 pyramidal cell collaterals while the preferential axonal targeting to s.l.m. then distributes inhibition back to the distal apical dendritic tufts of CA1 pyramidal cells to gate excitatory input from the entorhinal cortex”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [923]
In the citing paper
“Trains of action potentials from CA1 pyramidal cells drive excitation onto two populations of interneurons termed “onset transient” and “late persistent” interneurons (923).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [923]
In the citing paper
“Pouille and Scanziani (923) provided the first demonstration that recurrent inhibition onto CA1 pyramidal cells occurs via a dynamic rerouting of inhibitory drive that commences via perisomatic inhibitory input followed by a delayed primarily dendritic inhibition.”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [923]
Citations
Cites
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Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition
Pouille, F., & Scanziani, M. (2001) · Science · doi:10.1126/science.1060342 · Cited by 1,097
Self-citationMegı́as, M., Emri, Z., Freund, T. F., & Gulyás, A. I. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00496-6 · Cited by 950
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Michon, F.-X., Laplante, I., Bosson, A., Robitaille, R., & Lacaille, J. (2023) · Figshare · doi:10.6084/m9.figshare.23621571
Upchurch, C. M., Knowlton, C. J., Chamberland, S., & Canavier, C. C. (2024) · eNeuro · doi:10.1523/eneuro.0190-24.2024
Grosmark, A., Milstein, A. D., Losonczy, A., & Soltész, I. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0007
Branch logic: Dendritic computations diversify inhibition
Rannio, S., Alageswaran, S., & Sjöström, P. J. (2025) · Neuron · doi:10.1016/j.neuron.2025.07.023
Activity-dependent lateral inhibition in the mouse olfactory bulb
Arevian, A. C. (2008) · D-Scholarship@Pitt (University of Pittsburgh)
Trans-cellular control of synapse properties by a cell type-specific splicing regulatorPreprint
Traunmüller, L., Schulz, J. M., Ortiz, R., Feng, H., Furlanis, E., Gomez, A. M., Schreiner, D., Bischofberger, J., Zhang, C., & Scheiffele, P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.07.519444
Michon, F.-X., Laplante, I., Bosson, A., Robitaille, R., & Lacaille, J. (2023) · Figshare · doi:10.6084/m9.figshare.23621565
Michon, F.-X., Laplante, I., Bosson, A., Robitaille, R., & Lacaille, J. (2023) · Figshare · doi:10.6084/m9.figshare.23621562
Michon, F.-X., Laplante, I., Bosson, A., Robitaille, R., & Lacaille, J. (2023) · Figshare · doi:10.6084/m9.figshare.23621559
Michon, F.-X., Laplante, I., Bosson, A., Robitaille, R., & Lacaille, J. (2023) · Figshare · doi:10.6084/m9.figshare.23621568
Presynaptic control of top-down signaling in neocortical layer 1Preprint
Bonekamp, K. E., Ratz, M. L., Gillie, G. R., Xiong, L., Sebek, M., & Crandall, S. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.31.703032
Köhler, J., Bartos, M., & Elgueta, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.11.710817
Novais, A. R. B. (2012) · theses.fr (ABES) · doi:10.70675/1f22637fz3f72z44b1zb311zb48edc101c77
Modulation of cerebellar Purkinje cell discharge by subthreshold granule cell inputs
Vilmint, A. G. (2016) · theses.fr (ABES) · doi:10.70675/e445bd7ez1c40z47baz9e82z0f61c692d789
Neuronal properties and synaptic connectivity in rodent presubiculum
Simonnet, J. (2014) · theses.fr (ABES) · doi:10.70675/bdae6cc1z374ez4e36z8d20zce45fe5c356e
Michon, F.-X. (2018) · theses.fr (ABES) · doi:10.70675/6fbbdcbaz764ez4136z96f1z5e7b485b0942
On the developmental origin of CA1 pyramidal neuron diversity in the adult mouse hippocampus
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All-optical interrogation of the role of interneurons in CA1 cell assemblies
Vorobyev, A. (2023) · theses.fr (ABES) · doi:10.70675/eb10a4e1za595z4f16z9e3bz115344f3d87a
A unified law for inhibitory control in active dendritesPreprint
He, Y., He, G., Huang, B., Poirazi, P., Huang, T., & Du, K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.15.725398
Synaptic plasticity processes underlying consolidation and reconsolidation of Pavlovian conditioning
Rigby, P. T. (2012) · The University of Bath Online Publications Store (The University of Bath)
Metadata
- Authors
- Pouille, F., & Scanziani, M.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Scanziani, Massimo
- ORCID
- Scanziani, Massimo
- Venue
- Nature
- Published
- 2004-05-30
- Volume
- 429
- Issue
- 6993
- Pages
- 717-723
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2047403459
- Cited by
- 434
- References
- 33
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 13 · 2023: 24 · 2022: 20 · 2021: 28 · 2020: 14 · 2019: 24 · 2018: 22 · 2017: 12 · 2016: 12 · 2015: 17 · 2014: 23 · 2013: 17 · 2012: 25
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Foundation for the National Institutes of Health
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- recurrent inhibition, hippocampus, pyramidal neurons, dendritic inhibition, inhibitory interneurons, excitatory synapses, synaptic plasticity, rat hippocampal slices
- MeSH terms
- Action Potentials, Animals, Dendrites, Electrophysiology, Hippocampus, Interneurons, Rats, Wistar, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques
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