Cited by 1,097Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition

Pouille, Frédéric, Scanziani, Massimo·2001·Science

Abstract

The temporal resolution of neuronal integration depends on the time window within which excitatory inputs summate to reach the threshold for spike generation. Here, we show that in rat hippocampal pyramidal cells this window is very narrow (less than 2 milliseconds). This narrowness results from the short delay with which disynaptic feed-forward inhibition follows monosynaptic excitation. Simultaneous somatic and dendritic recordings indicate that feed-forward inhibition is much stronger in the soma than in the dendrites, resulting in a broader integration window in the latter compartment. Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows.

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Registry

Crossref · 10.1126/science.1060342

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1 of 1 references verified0 citation errors · 0 not checkable

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  • The latency of disynaptic inhibition, including the latency to excite the PV cell, is less than 2 ms.

    “the latency of disynaptic inhibition, which will include the latency in exciting the PV cell is less than 2 ms”

    From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Pouille and Scanziani, 2001

  • A circuit similar in many details to thalamocortical communication is involved in CA3-to-CA1 communication in the hippocampus.

    “A circuit remarkably similar in many details to the one mediating thalamocortical communication is involved in CA3 to CA1 communication in the hippocampus (Pouille and Scanziani, 2001).”

    From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Pouille and Scanziani, 2001

  • This pattern creates a compound synaptic event that drives spiking with greater temporal precision than excitation alone.

    “This pattern of activity creates a compound synaptic event that drives spiking with much greater temporal precision than could be achieved by excitation alone (Pouille et al., 2009; Pouille and Scanziani, 2001).”

    From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Pouille and Scanziani, 2001

  • In most circuits, the short latency of feedforward inhibition enforces a narrow temporal window for action potential firing in principal cells.

    “In most circuits the short latency of feedforward inhibition enforces a narrow temporal window for action potential firing in principal cells (922).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [922]

  • The bulk of feedforward inhibitory inputs arise through perisomatic fast spiking basket cells, and inhibition onto dendritic compartments is modest by comparison.

    “Pouille and Scanziani (922) elegantly demonstrated that the bulk of feedforward inhibitory inputs arise through perisomatic fast spiking basket cells and that inhibition onto dendritic compartments was modest by comparison.”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [922]

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Authors
Pouille, F., & Scanziani, M.
Affiliations
  • Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
  • University of Zurich (CH)
Corresponding author
Scanziani, Massimo
Venue
Science
Published
2001-08-10
Volume
293
Issue
5532
Pages
1159-1163
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2067501282
Cited by
1,097
References
1
Citations by year
2026: 25 · 2025: 33 · 2024: 33 · 2023: 51 · 2022: 51 · 2021: 40 · 2020: 41 · 2019: 33 · 2018: 54 · 2017: 56 · 2016: 56 · 2015: 62 · 2014: 62 · 2013: 63 · 2012: 62
FWCI
8.84
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
temporal fidelity, feedforward inhibition, hippocampal pyramidal neurons, coincidence detection, somatic inhibition, dendritic integration, synaptic delay, disynaptic inhibition
MeSH terms
Action Potentials, Animals, Axons, Bicuculline, Dendrites, Electric Stimulation, Evoked Potentials, Hippocampus, Interneurons, Neural Inhibition, Synaptic Transmission, Pyridazines, Receptors, GABA-A, Time Factors, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, GABA Antagonists, Excitatory Postsynaptic Potentials, Rats, GABA-A Receptor Antagonists, In Vitro Techniques

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