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Algae acquire vitamin B12 through a symbiotic relationship with bacteria
Abstract
Vitamin B12 (cobalamin) was identified nearly 80 years ago as the anti-pernicious anaemia factor in liver, and its importance in human health and disease has resulted in much work on its uptake, cellular transport and utilization. Plants do not contain cobalamin because they have no cobalamin-dependent enzymes. Deficiencies are therefore common in strict vegetarians, and in the elderly, who are susceptible to an autoimmune disorder that prevents its efficient uptake. In contrast, many algae are rich in vitamin B12, with some species, such as Porphyra yezoensis (Nori), containing as much cobalamin as liver. Despite this, the role of the cofactor in algal metabolism remains unknown, as does the source of the vitamin for these organisms. A survey of 326 algal species revealed that 171 species require exogenous vitamin B12 for growth, implying that more than half of the algal kingdom are cobalamin auxotrophs. Here we show that the role of vitamin B12 in algal metabolism is primarily as a cofactor for vitamin B12-dependent methionine synthase, and that cobalamin auxotrophy has arisen numerous times throughout evolution, probably owing to the loss of the vitamin B12-independent form of the enzyme. The source of cobalamin seems to be bacteria, indicating an important and unsuspected symbiosis.
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“Microalgae exude a part of the photosynthesized organics as dissolved organic carbon (DOC); these are assimilated by heterotrophic bacteria, and in return, bacteria contribute to algal growth through the generation of CO2, micronutrients (such as Fe), vitamins, macronutrients, specifically fixed N and phytohormones [15,17].”
From Toward the Enhancement of Microalgal Metabolite Production through Microalgae–Bacteria Consortia (2021) · cites this paper as [15]
In the citing paper
“Croft et al. [15] found that the vitamin B12 producer Halomonas sp., isolated from non-axenic cultures of Amphidinium operculatum, can support the growth of the cobalamin-auxotroph Porphyridium purpureum, similarly to exogenous vitamin B12.”
From Toward the Enhancement of Microalgal Metabolite Production through Microalgae–Bacteria Consortia (2021) · cites this paper as [15]
Citations
Cites
Nucleic acid techniques in bacterial systematics
Stackebrandt, E. S., & Goodfellow, M. (1991) · Wiley eBooks · Cited by 9,460
Primary production of the biosphere: Integrating terrestrial and oceanic components
Field, C. B., Behrenfeld, M. J., Randerson, J. T., & Falkowski, P. (1998) · Science · doi:10.1126/science.281.5374.237 · Cited by 6,371
The Genome of the Diatom Thalassiosira Pseudonana : Ecology, Evolution, and Metabolism
Armbrust, E. V., Berges, J. A., Bowler, C., Green, B. R., Martínez, D., Putnam, N. H., Zhou, S., Allen, A. E., Apt, K. E., Bechner, M., et al. (2004) · Science · doi:10.1126/science.1101156 · Cited by 2,029
Algal Physiology and Biochemistry.
Baalen, C. V., & Stewart, W. P. D. (1975) · Bulletin of the Torrey Botanical Club · doi:10.2307/2484419 · Cited by 1,453
Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D
Matsuzaki, M., Misumi, O., Shin‐I, T., Maruyama, S., Takahara, M., Miyagishima, S., Mori, T., Nishida, K., Yagisawa, F., Nishida, K., et al. (2004) · Nature · doi:10.1038/nature02398 · Cited by 1,086
The Many Faces of Vitamin B12: Catalysis by Cobalamin-Dependent Enzymes
Banerjee, R. V., & Ragsdale, S. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161828 · Cited by 795
VITAMIN B12 DEFICIENCY AS A WORLDWIDE PROBLEM
Stabler, S. P., & Allen, R. H. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132440 · Cited by 539
The biosynthesis of adenosylcobalamin (vitamin B12)
Warren, M. J., Raux, E., Schubert, H., & Escalante‐Semerena, J. C. (2002) · Natural Product Reports · doi:10.1039/b108967f · Cited by 484
Self-citationAcquisition and Utilization of Transition Metal Ions by Marine Organisms
Butler, A. (1998) · Science · doi:10.1126/science.281.5374.207 · Cited by 295
The Ecology of the plankton off La Jolla, California,: In the period April through September, 1967
Strickland, J. (1970) · eScholarship (California Digital Library) · Cited by 248
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Ruangsomboon, S., Sornchai, P., & Prachom, N. (2017) · Algal Research · doi:10.1016/j.algal.2017.11.028 · Cited by 28
Coquillé, N., Ménard, D., Rouxel, J., Dupraz, V., Éon, M., Pardon, P. R., Budzinski, H., Morin, S., Parlanti, E., & Stachowski‐Haberkorn, S. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.02.019 · Cited by 28
Vuong, T. T., Kwon, B., Eom, J.-I., Shin, B., & Kim, S. M. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-019-01931-5 · Cited by 28
Chakraborty, S., & Chattopadhyay, J. (2008) · Journal of Biological Systems · doi:10.1142/s0218339008002654 · Cited by 28
Organometallic Chemistry of B12 Coenzymes
Kräutler, B. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559333-00001 · Cited by 28
BRCA2 mutations in hereditary breast and ovarian cancer in France.
Sinilnikova, O. M., Barbollat‐Boutrand, L., Stoppa‐Lyonnet, D., Paillerets, B. B., Dubois, V., Lasset, C., Janin, N., Bignon, Y., Longy, M., Maugard, C. M., et al. (1997) · Europe PMC (PubMed Central) · Cited by 28
Zhao, J., Nair, S., Zhang, Z., Wang, Z., Jiao, N., & Zhang, Y. (2024) · The ISME Journal · doi:10.1093/ismejo/wrae083 · Cited by 27
Álvarez-Yela, A. C., Mosquera-Rendón, J., Noreña-P, A., Cristancho, M., & López, D. (2019) · Frontiers in Marine Science · doi:10.3389/fmars.2019.00338 · Cited by 27
Karimi, E., Geslain, E., KleinJan, H., Tanguy, G., Legeay, E., Corre, E., & Dittami, S. M. (2019) · Genome Biology and Evolution · doi:10.1093/gbe/evz278 · Cited by 27
Niche dimensions of a marine bacterium are identified using invasion studies in coastal seawater
Nowinski, B., & Moran, M. A. (2021) · Nature Microbiology · doi:10.1038/s41564-020-00851-2 · Cited by 27
Stenger, P., Ky, C., REISSER, C. M. O., Duboisset, J., Dicko, H., Durand, P., Quintric, L., Planes, S., & Vidal‐Dupiol, J. (2021) · Genes · doi:10.3390/genes12030421 · Cited by 27
Calatrava, V., Tejada‐Jiménez, M., Sanz‐Luque, E., Fernández, E. M., Galván, A., & Llamas, Á. (2023) · Plants · doi:10.3390/plants12040788 · Cited by 28
Chen, Y., Mao, W., Wang, J., Zhu, W., Zhao, C., Li, N., Wang, C., Yan, M., Guo, T., & Liu, X. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.05.004 · Cited by 27
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Oh, J., Kim, M.-J., Lee, J.-Y., Ko, I.-J., Kim, W., & Kim, S. W. (2011) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-011-0232-2 · Cited by 27
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Balakirev, E. S., Krupnova, T. N., & Ayala, F. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039587 · Cited by 30
Kusari, F., O’Doherty, A., Hodges, N. J., & Wojewodzic, M. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-12148-2 · Cited by 28
Prieto, A., Barber, E. M., Hernández‐Ruiz, M., Martínez‐García, S., Fernández, E., & Teira, E. (2015) · Journal of Plankton Research · doi:10.1093/plankt/fbv101 · Cited by 27
Effect of Different Extraction Methods on Vitamin B12 from Blue Green Algae, Spirulina Platensis
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Tian, L., Li, Y., Yang, J. L., Qin, L., Ma, H., Zhu, L., & Yin, Z. (2024) · Energy Conversion and Management · doi:10.1016/j.enconman.2024.118981 · Cited by 28
Advances in understanding biofilm-based marine microbial corrosion
Zuo, Z., Zhang, J., Mathivanan, K., Wang, F., Duan, J., & Hou, B. (2024) · Corrosion Reviews · doi:10.1515/corrrev-2024-0033 · Cited by 27
Mapping the metagenomic diversity of the multi-kingdom glacier-fed stream microbiome
Michoud, G., Peter, H., Busi, S. B., Bourquin, M., Kohler, T. J., Geers, A. U., Ezzat, L., The Vanishing Glaciers Field Team, Styllas, M. N., Schön, M., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-024-01874-9 · Cited by 27
Koláčková, M., Chaloupský, P., Cernei, N., Klejdus, B., Húska, D., & Adam, V. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122088 · Cited by 26
Luo, W., Ding, H., Li, H., Ji, Z., Huang, K., Zhao, W., Yu, Y., & Zeng, Y. (2020) · Polar Biology · doi:10.1007/s00300-020-02716-0 · Cited by 26
Yesuraj, D., Deepika, C., Ravishankar, G. A., & Rao, A. R. (2022) · Springer eBooks · doi:10.1007/978-3-030-92174-3_14 · Cited by 26
Nef, C., Dittami, S. M., Kaas, R., Briand, E., Noël, C., Mairet, F., & Garnier, M. (2022) · Microorganisms · doi:10.3390/microorganisms10071337 · Cited by 26
Poulsen, N., Davutoglu, M. G., & Suchanova, J. Z. (2022) · Springer eBooks · doi:10.1007/978-3-030-92499-7_14 · Cited by 26
Bruns, S., Wienhausen, G., Scholz‐Böttcher, B. M., & Wilkes, H. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-04317-8 · Cited by 26
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Torrents, E., Trevisiol, C., Rotte, C., Hellman, U., Martin, W. F., & Reichard, P. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m512962200 · Cited by 26
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Lage, O. M., & Graça, A. P. (2016) · InTech eBooks · doi:10.5772/63053 · Cited by 27
Effect of the epiphytic bacterium Bacillus sp. WPySW2 on the metabolism of Pyropia haitanensis
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Zakharova, Y. R., Adelshin, R. V., Parfenova, V. V., Bedoshvili, Y. D., & Likhoshway, Y. V. (2010) · Microbiology · doi:10.1134/s0026261710050139 · Cited by 26
Phycosphere associated bacteria; a prospective source of bioactive compounds
Variem, S. S., & Koyadan, V. K. (2020) · Biologia · doi:10.2478/s11756-020-00640-6 · Cited by 26
Acosta, K., Sree, K. S., Okamoto, N., Koseki, K., Sorrels, S., Jahreis, G., Watanabe, F., Appenroth, K., & Lam, E. (2024) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2024.106603 · Cited by 25
Duxbury, S. J. N., Raguideau, S., Cremin, K., Richards, L., Medvecký, M., Rosko, J., Coates, M., Randall, K., Chen, J., Quince, C., et al. (2025) · The ISME Journal · doi:10.1093/ismejo/wraf126 · Cited by 25
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Oh, R. M., Bollati, E., Maithani, P., Huang, D., & Wainwright, B. J. (2021) · Microorganisms · doi:10.3390/microorganisms9050898 · Cited by 25
Wen, J., & Li, H. L. (2022) · Journal of Thermal Spray Technology · doi:10.1007/s11666-022-01345-9 · Cited by 25
Fortin, S. G., Song, B., Anderson, I. C., & Reece, K. S. (2022) · Harmful Algae · doi:10.1016/j.hal.2022.102216 · Cited by 25
Symbiodiniaceae photophysiology and stress resilience is enhanced by microbial associations
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Sun, J., Khan, E., Şimşek, Ş., Ohm, J., & Şimşek, H. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.07.153 · Cited by 25
Guidi, F., Pezzolesi, L., & Vanucci, S. (2018) · MicrobiologyOpen · doi:10.1002/mbo3.584 · Cited by 25
Wang, S., Liu, J., Li, C., & Chung, B. M. (2018) · Environmental Technology · doi:10.1080/09593330.2018.1444103 · Cited by 25
Suárez‐Suárez, A., Tovar‐Sánchez, A., & Rossello-Mora, R. A. (2011) · Analytica Chimica Acta · doi:10.1016/j.aca.2011.04.040 · Cited by 25
Vitamin auxotrophies shape microbial community assembly on model marine particles
Gregor, R., Vercelli, G. T., Szabo, R. E., Gralka, M., Reynolds, R., Qu, E. B., Levine, N. M., & Cordero, O. X. (2025) · The ISME Journal · doi:10.1093/ismejo/wraf184 · Cited by 24
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Filho, M. M. B., Walker, M., Ashworth, M. P., & Morris, J. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.00269-21 · Cited by 24
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Deng, Y., Vallet, M., & Pohnert, G. (2021) · Annual Review of Marine Science · doi:10.1146/annurev-marine-042021-012353 · Cited by 24
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Nowruzi, B., Shishir, M. A., Porzani, S. J., & Ferdous, U. T. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220504141047 · Cited by 27
Smith, D. J., Kharbush, J. J., Kersten, R. D., & Dick, G. J. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.01803-21 · Cited by 24
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Wu, P., Teng, J.-C., Lin, Y., & Hwang, S. J. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.01.109 · Cited by 24
Wang, R., & Seyedsayamdost, M. R. (2017) · Nature Reviews Chemistry · doi:10.1038/s41570-017-0021 · Cited by 24
McCully, A. L., LaSarre, B., & McKinlay, J. B. (2017) · mBio · doi:10.1128/mbio.01620-17 · Cited by 24
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Ramundo, S., & Rochaix, J. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2014.10.035 · Cited by 24
Semple, A., & Pandhal, J. (2024) · Applied Phycology · doi:10.1080/26388081.2024.2435040 · Cited by 23
Xia, X., Zheng, Q., Leung, S. K., Wang, Y., Lee, P. Y., Jing, H., Jiao, N., & Liu, H. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.149208 · Cited by 23
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Jakob, G. (2013) · Journal of Petroleum & Environmental Biotechnology · doi:10.4172/2157-7463.1000153 · Cited by 24
Xia, X., Leung, S. K., Cheung, S., Zhang, S., & Liu, H. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135107 · Cited by 23
Joglar, V., Álvarez–Salgado, X. A., Gago-Martı́nez, A., Leão, J. M., Pérez‐Martínez, C., Pontiller, B., Lundin, D., Pinhassi, J., Fernández, E., & Teira, E. (2020) · Environmental Microbiology · doi:10.1111/1462-2920.15367 · Cited by 23
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Zhu, S., Higa, L., Barela, A., Lee, C., Chen, Y., & Du, Z. (2023) · Energies · doi:10.3390/en16020884 · Cited by 22
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Crofts, T. S., Men, Y., Alvarez‐Cohen, L., & Taga, M. E. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00592 · Cited by 22
Effective role of medium supplementation in microalgal lipid accumulation
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Ceapă, C. D., Vázquez‐Hernández, M., Rodríguez-Luna, S. D., Vázquez, A. P. C., Jiménez-Suárez, V., Rodríguez-Sanoja, R., Alvarez-Buylla, E. R., & Sánchez, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192618 · Cited by 22
Teixeira, I. G., Arbones, B., Froján, M., Nieto‐Cid, M., Álvarez–Salgado, X. A., Castro, C. G., Fernández, E., Sobrino, C., Teira, E., & Figueiras, F. G. (2018) · Estuarine Coastal and Shelf Science · doi:10.1016/j.ecss.2018.06.005 · Cited by 22
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Gude, S., & Taga, M. E. (2019) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.08.005 · Cited by 23
Gao, S., Kong, Y., Yu, J. H., Miao, L., Ji, L., Song, L., & Zeng, C. (2020) · BMC Biotechnology · doi:10.1186/s12896-020-00656-5 · Cited by 22
Bowman, J. P. (2013) · Springer eBooks · doi:10.1007/978-3-642-30123-0_46 · Cited by 22
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Nneoma, U. C., Chukwudi, O. F., Nnenna, U. J., & Paul-Chima, U. O. (2025) · Frontiers in Energy Research · doi:10.3389/fenrg.2025.1654079 · Cited by 21
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Akbar, M. A., Ahmad, A., Usup, G., & Bunawan, H. (2018) · Journal of Marine Science and Engineering · doi:10.3390/jmse6010013 · Cited by 21
Yi, Y., Liang, L., Wang, Z., Ai, P., You, X., Bian, C., Shi, Q., & Dong, B. (2019) · Animals · doi:10.3390/ani9090660 · Cited by 21
Ji, X., Luo, X., Zhang, J., & Huang, D. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11720-0 · Cited by 21
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Wang, Z., Zeng, Y., Cheng, K., Cai, Z., & Zhou, J. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.158354 · Cited by 21
Andrew, S. M., Wilson, T., Smith, S. N., Marchetti, A., & Septer, A. N. (2022) · ISME Communications · doi:10.1038/s43705-022-00181-w · Cited by 21
Den, T. Q., Neu, T. R., Sultana, S., Giebel, H., Simon, M., & Billerbeck, S. (2022) · Journal of Phycology · doi:10.1111/jpy.13308 · Cited by 24
Zhang, M., Xu, X., Zhao, R.-P., Huang, C., Yuan-da, S., Zhao, Z., Zhao, Y.-B., Ren, X.-J., & Zhao, X. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.130232 · Cited by 21
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Longnecker, K., Soule, M. C. K., Swarr, G. J., Parsons, R. J., Liu, S., Johnson, W. M., Widner, B., Curry, R., Carlson, C. A., & Kujawinski, E. B. (2024) · Limnology and Oceanography · doi:10.1002/lno.12497 · Cited by 21
Dinc, E., Ramundo, S., Croce, R., & Rochaix, J. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.11.020 · Cited by 21
Al-Gheethi, A. A. S., Mohamed, R. M. S. R., Jais, N. M. B., Noman, E. A., Halid, A. A., Wurochekke, A. A., & Amir-Hashim, M. K. (2017) · Journal of Water and Health · doi:10.2166/wh.2017.080 · Cited by 21
Caputo, A., Stenegren, M., Pernice, M. C., & Foster, R. A. (2018) · Frontiers in Marine Science · doi:10.3389/fmars.2018.00002 · Cited by 21
Higgins, B. T., Wang, Q., Du, S., Hennebelle, M., Taha, A. Y., Fiehn, O., & VanderGheynst, J. S. (2018) · Algal Research · doi:10.1016/j.algal.2018.05.019 · Cited by 21
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Metadata
- Authors
- Croft, M. T., Lawrence, A. D., Raux-Deery, E., Warren, M. J., & Smith, A. G.
- Affiliations
- University of Cambridge (GB)
- University of Kent (GB)
- Corresponding author
- Smith, Alison G.
- Venue
- Nature
- Published
- 2005-11
- Volume
- 438
- Issue
- 7064
- Pages
- 90-93
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1980733427
- Cited by
- 1,536
- References
- 29
- Citations by year
- 2026: 106 · 2025: 112 · 2024: 120 · 2023: 144 · 2022: 144 · 2021: 118 · 2020: 93 · 2019: 109 · 2018: 101 · 2017: 87 · 2016: 59 · 2015: 51 · 2014: 57 · 2013: 49 · 2012: 43
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Kent Academic Repository (University of Kent) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- Queen Mary University of London
- Research Councils UK
- European Commission
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Keywords
- vitamin B12, algae, microalgae, symbiosis, symbiotic bacteria, methionine synthase, cobalamin-dependent enzymes, algal metabolism, seaweed, vitamin B12 deficiency
- MeSH terms
- Bacteria, Symbiosis, 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase, Vitamin B 12, Genome, Coculture Techniques, Halomonas, Genomics, Eukaryota
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