Cited by 1,536Porphyrin Metabolism and DisordersFolate and B Vitamins ResearchAlgal biology and biofuel production

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Algae acquire vitamin B12 through a symbiotic relationship with bacteria

Croft, Martin T., Lawrence, Andrew D., Raux-Deery, Evelyne, Warren, Martin J., Smith, Alison G.·2005·Nature

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Abstract

Vitamin B12 (cobalamin) was identified nearly 80 years ago as the anti-pernicious anaemia factor in liver, and its importance in human health and disease has resulted in much work on its uptake, cellular transport and utilization. Plants do not contain cobalamin because they have no cobalamin-dependent enzymes. Deficiencies are therefore common in strict vegetarians, and in the elderly, who are susceptible to an autoimmune disorder that prevents its efficient uptake. In contrast, many algae are rich in vitamin B12, with some species, such as Porphyra yezoensis (Nori), containing as much cobalamin as liver. Despite this, the role of the cofactor in algal metabolism remains unknown, as does the source of the vitamin for these organisms. A survey of 326 algal species revealed that 171 species require exogenous vitamin B12 for growth, implying that more than half of the algal kingdom are cobalamin auxotrophs. Here we show that the role of vitamin B12 in algal metabolism is primarily as a cofactor for vitamin B12-dependent methionine synthase, and that cobalamin auxotrophy has arisen numerous times throughout evolution, probably owing to the loss of the vitamin B12-independent form of the enzyme. The source of cobalamin seems to be bacteria, indicating an important and unsuspected symbiosis.

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Nucleic acid techniques in bacterial systematics
Stackebrandt, E. S., & Goodfellow, M. (1991) · Wiley eBooks · Cited by 9,460
Primary production of the biosphere: Integrating terrestrial and oceanic components
Field, C. B., Behrenfeld, M. J., Randerson, J. T., & Falkowski, P. (1998) · Science · doi:10.1126/science.281.5374.237 · Cited by 6,371
The Genome of the Diatom Thalassiosira Pseudonana : Ecology, Evolution, and Metabolism
Armbrust, E. V., Berges, J. A., Bowler, C., Green, B. R., Martínez, D., Putnam, N. H., Zhou, S., Allen, A. E., Apt, K. E., Bechner, M., et al. (2004) · Science · doi:10.1126/science.1101156 · Cited by 2,029
Algal Physiology and Biochemistry.
Baalen, C. V., & Stewart, W. P. D. (1975) · Bulletin of the Torrey Botanical Club · doi:10.2307/2484419 · Cited by 1,453
Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D
Matsuzaki, M., Misumi, O., Shin‐I, T., Maruyama, S., Takahara, M., Miyagishima, S., Mori, T., Nishida, K., Yagisawa, F., Nishida, K., et al. (2004) · Nature · doi:10.1038/nature02398 · Cited by 1,086
The Many Faces of Vitamin B12: Catalysis by Cobalamin-Dependent Enzymes
Banerjee, R. V., & Ragsdale, S. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161828 · Cited by 795
VITAMIN B12 DEFICIENCY AS A WORLDWIDE PROBLEM
Stabler, S. P., & Allen, R. H. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132440 · Cited by 539
The biosynthesis of adenosylcobalamin (vitamin B12)
Warren, M. J., Raux, E., Schubert, H., & Escalante‐Semerena, J. C. (2002) · Natural Product Reports · doi:10.1039/b108967f · Cited by 484
Self-citation
Acquisition and Utilization of Transition Metal Ions by Marine Organisms
Butler, A. (1998) · Science · doi:10.1126/science.281.5374.207 · Cited by 295
The Ecology of the plankton off La Jolla, California,: In the period April through September, 1967
Strickland, J. (1970) · eScholarship (California Digital Library) · Cited by 248

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Authors: Croft, M. T., Lawrence, A. D., Raux-Deery, E., Warren, M. J., & Smith, A. G.
Affiliations: University of Cambridge (GB)
University of Kent (GB)
Corresponding author: Smith, Alison G.
ORCID: Lawrence, Andrew D.
Warren, Martin J.
Smith, Alison G.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2005-11
Volume: 438
Issue: 7064
Pages: 90-93
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04056
OpenAlex: W1980733427
Cited by: 1,536
References: 29
Citations by year: 2026: 106 · 2025: 112 · 2024: 120 · 2023: 144 · 2022: 144 · 2021: 118 · 2020: 93 · 2019: 109 · 2018: 101 · 2017: 87 · 2016: 59 · 2015: 51 · 2014: 57 · 2013: 49 · 2012: 43
FWCI: 6.02
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Kent Academic Repository (University of Kent) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Funders: Queen Mary University of London
Research Councils UK
European Commission
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Keywords: vitamin B12, algae, microalgae, symbiosis, symbiotic bacteria, methionine synthase, cobalamin-dependent enzymes, algal metabolism, seaweed, vitamin B12 deficiency
MeSH terms: Bacteria, Symbiosis, 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase, Vitamin B 12, Genome, Coculture Techniques, Halomonas, Genomics, Eukaryota

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Algae acquire vitamin B12 through a symbiotic relationship with bacteria

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