The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
Open accessAbstract
Glutamate-mediated damage to oligodendrocytes contributes to mental or physical impairment in periventricular leukomalacia (pre- or perinatal white matter injury leading to cerebral palsy), spinal cord injury, multiple sclerosis and stroke. Unlike neurons, white matter oligodendrocytes reportedly lack NMDA (N-methyl-d-aspartate) receptors. It is believed that glutamate damages oligodendrocytes, especially their precursor cells, by acting on calcium-permeable AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)/kainate receptors alone or by reversing cystine–glutamate exchange and depriving cells of antioxidant protection. Here we show that precursor, immature and mature oligodendrocytes in the white matter of the cerebellum and corpus callosum exhibit NMDA-evoked currents, mediated by receptors that are blocked only weakly by Mg2+ and that may contain NR1, NR2C and NR3 NMDA receptor subunits. NMDA receptors are present in the myelinating processes of oligodendrocytes, where the small intracellular space could lead to a large rise in intracellular ion concentration in response to NMDA receptor activation. Simulating ischaemia led to development of an inward current in oligodendrocytes, which was partly mediated by NMDA receptors. These results point to NMDA receptors of unusual subunit composition as a potential therapeutic target for preventing white matter damage in a variety of diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Glutamate neurotoxicity and diseases of the nervous system
CHOI, D. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 7,972
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,059
Neurobiology of Periventricular Leukomalacia in the Premature Infant
Volpe, J. J. (2001) · Pediatric Research · doi:10.1203/00006450-200111000-00003 · Cited by 948
Back, S. A., Luo, N. L., Borenstein, N. S., Levine, J. M., Volpe, J. J., & Kinney, H. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01302.2001 · Cited by 937
Glutamate excitotoxicity in a model of multiple sclerosis
Pitt, D., Werner, P., & Raine, C. S. (2000) · Nature Medicine · doi:10.1038/71555 · Cited by 744
Patneau, D., & Mayer, M. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-07-02385.1990 · Cited by 653
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury
Salter, M. G., & Fern, R. (2005) · Nature · doi:10.1038/nature04301 · Cited by 553
Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention
Oka, A., Belliveau, M., Rosenberg, P., & Volpe, J. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01441.1993 · Cited by 504
Transporters Buffer Synaptically Released Glutamate on a Submillisecond Time Scale
Diamond, J. S., & Jahr, C. E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04672.1997 · Cited by 470
Autoimmune encephalomyelitis ameliorated by AMPA antagonists
Smith, T., Groom, A., Zhu, B., & Turski, L. (2000) · Nature Medicine · doi:10.1038/71548 · Cited by 467
Cited by
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain
Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., et al. (2014) · Science · doi:10.1126/science.1252304 · Cited by 1,472
Electrical and synaptic integration of glioma into neural circuits
Venkatesh, H. S., Morishita, W., Geraghty, A. C., Silverbush, D., Gillespie, S. M., Arzt, M., Tam, L. T., Espenel, C., Ponnuswami, A., Ni, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1563-y · Cited by 1,366
Metadata
- Authors
- Káradóttir, R., Cavelier, P., Bergersen, L. H., & Attwell, D.
- Venue
- Nature
- Published
- 2005-12
- Volume
- 438
- Issue
- 7071
- Pages
- 1162-1166
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2114091391
- Cited by
- 772
- References
- 33
- FWCI
- 13.02
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. https://app.cochat.ai/papers/10.1038/nature04302
- The paper
- Káradóttir, R., Cavelier, P., Bergersen, L. H., & Attwell, D. (2005). NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature. https://doi.org/10.1038/nature04302
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
