Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain
Open accessAbstract
Myelination of the central nervous system requires the generation of functionally mature oligodendrocytes from oligodendrocyte precursor cells (OPCs). Electrically active neurons may influence OPC function and selectively instruct myelination of an active neural circuit. In this work, we use optogenetic stimulation of the premotor cortex in awake, behaving mice to demonstrate that neuronal activity elicits a mitogenic response of neural progenitor cells and OPCs, promotes oligodendrogenesis, and increases myelination within the deep layers of the premotor cortex and subcortical white matter. We further show that this neuronal activity-regulated oligodendrogenesis and myelination is associated with improved motor function of the corresponding limb. Oligodendrogenesis and myelination appear necessary for the observed functional improvement, as epigenetic blockade of oligodendrocyte differentiation and myelin changes prevents the activity-regulated behavioral improvement.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The density of BCAS1+ oligodendrocytes in the cortex remains high throughout life, in contrast to white matter, supporting a physiological role in neuronal function.
“the density of BCAS1+ oligodendrocytes in the cortex remains high throughout life—in stark contrast to the white matter—supporting a physiological role in neuronal function, e.g. as effectors of adaptive cortical myelination and circuit modulation.49,50”
From BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis (2025) · cites this paper as [49]
The Discussion reports that neuronal activity promotes oligodendrocyte formation and myelination in cortical circuits, with associated behavioral improvement. But the paper does not report BCAS1+ cell density or show that it remains high throughout life in cortex relative to white matter. Its density measurements concern newly generated EdU+/CC1+ oligodendrocytes at two mouse ages, not BCAS1+ cells. (LLM, conf=0.86)
Experimental — accuracy not yet measuredBoth intrinsic and extrinsic factors influence myelination.
“Both intrinsic and extrinsic factors have been shown to influence myelination. For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are linked.”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Gibson et al., 2014
Synaptogenesis and myelination are linked.
“For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are linked.”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Gibson et al., 2014
Electrical activity drives myelination.
“For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are linked.”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Gibson et al., 2014
Myelination changes can occur over a period much shorter than the six-week intervention used here.
“These and other studies have shown that myelination changes can occur in a time frame much less than the six-week intervention used here (Yeung et al., 2014; Gibson et al., 2014).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Gibson et al., 2014
Neuronal activity-dependent myelination changes have been observed in cell culture and in vivo experiments.
“Neuronal activity-dependent changes in myelination have been observed in cell culture (Wake et al., 2011; Fields, 2010) as well as in recent in vivo experiments (Gibson et al., 2014).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Gibson et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works
Self-citationDriver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Schwartzentruber, J., Korshunov, A., Liu, X.-Y., Jones, D. T. W., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D.-A. K., Tönjes, M., et al. (2012) · Nature · doi:10.1038/nature10833 · Cited by 2,631 · see citing works
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works
Self-citationOptogenetics in neural systems
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881 · see citing works
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
Miron, V. E., Boyd, A., Zhao, J.-W., Yuen, T. J., Ruckh, J. M., Shadrach, J. L., van Wijngaarden, P., Wagers, A. J., Williams, A., Franklin, R. J. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3469 · Cited by 1,788 · see citing works
St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project (2012) · Nature Genetics · doi:10.1038/ng.1102 · Cited by 1,724 · see citing works
(1967) · Medical Entomology and Zoology · Cited by 1,713 · see citing works
Inflammation is detrimental for neurogenesis in adult brain
Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559 · see citing works
Training induces changes in white-matter architecture
Scholz, J., Klein, M. C., Behrens, T. E. J., & Johansen-Berg, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2412 · Cited by 1,508 · see citing works
Microglia-specific localisation of a novel calcium binding protein, Iba1
Ito, D., Imai, Y., Ohsawa, K., Nakajima, K., Fukuuchi, Y., & Kohsaka, S. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00040-0 · Cited by 1,476 · see citing works
Visuomotor integration is associated with zero time-lag synchronization among cortical areas
Roelfsema, P. R., Engel, A. K., König, P., & Singer, W. (1997) · Nature · doi:10.1038/385157a0 · Cited by 1,136 · see citing works
Diffusion tensor imaging of white matter tract evolution over the lifespan
Lebel, C., Gee, M., Camicioli, R., Wieler, M., Martin, W., & Beaulieu, C. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.094 · Cited by 1,100 · see citing works
Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus
Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062 · see citing works
Butovsky, O., Ziv, Y., Schwartz, A., Landa, G., Talpalar, A. E., Pluchino, S., Martino, G., & Schwartz, M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.006 · Cited by 923 · see citing works
A critical period for social experience-dependent oligodendrocyte maturation and myelination
Makinodan, M., Rosen, K. M., Ito, S., & Corfas, G. (2012) · Science · doi:10.1126/science.1220845 · Cited by 922 · see citing works
Imai, Y., Ibata, I., Ito, D., Ohsawa, K., & Kohsaka, S. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1112 · Cited by 872 · see citing works
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 872 · see citing works
Hughes, E. G., Kang, S. H., Fukaya, M., & Bergles, D. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3390 · Cited by 808 · see citing works
NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
Káradóttir, R. T., Cavelier, P., Bergersen, L. H., & Attwell, D. (2005) · Nature · doi:10.1038/nature04302 · Cited by 773 · see citing works
Arenkiel, B. R., Peca, J., Davison, I. G., Feliciano, C., Deisseroth, K., Augustine, G. J., Ehlers, M. D., & Feng, G. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.005 · Cited by 755 · see citing works
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures
Zhang, F., Gradinaru, V., Adamantidis, A. R., Durand, R., Airan, R. D., de Lecea, L., & Deisseroth, K. (2010) · Nature Protocols · doi:10.1038/nprot.2009.226 · Cited by 692 · see citing works
Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma
Liu, C., Sage, J. C., Miller, M. R., Verhaak, R. G. W., Hippenmeyer, S., Vogel, H. S., Foreman, O., Bronson, R. T., Nishiyama, A., Luo, L., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.014 · Cited by 692 · see citing works
Self-citationAstrocytes promote myelination in response to electrical impulses
Ishibashi, T., Dakin, K. A., Stevens, B., Lee, P. R., Kozlov, S. V., Stewart, C. L., & Fields, R. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.006 · Cited by 689 · see citing works
Impaired adult myelination in the prefrontal cortex of socially isolated mice
Liu, J., Dietz, K., DeLoyht, J. M., Pedre, X., Kelkar, D., Kaur, J., Vialou, V., Lobo, M. K., Dietz, D. M., Nestler, E. J., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3263 · Cited by 685 · see citing works
Induction of myelination in the central nervous system by electrical activity
Demerens, C., Stankoff, B., Logak, M., Anglade, P., Allinquant, B., Couraud, F., Zalc, B., & Lubetzki, C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9887 · Cited by 678 · see citing works
Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons
Barres, B. A., & Raff, M. C. (1993) · Nature · doi:10.1038/361258a0 · Cited by 673 · see citing works
Self-citationControl of local protein synthesis and initial events in myelination by action potentials
Wake, H., Lee, P. R., & Fields, R. D. (2011) · Science · doi:10.1126/science.1206998 · Cited by 636 · see citing works
Hamers, F. P. T., Lankhorst, A. J., van Laar, T. J., Veldhuis, W. B., & Gispen, W. H. (2001) · Journal of Neurotrauma · doi:10.1089/08977150150502613 · Cited by 500 · see citing works
Vesicular release of glutamate from unmyelinated axons in white matter
Ziskin, J. L., Nishiyama, A., Rubio, M. E., Fukaya, M., & Bergles, D. E. (2007) · Nature Neuroscience · doi:10.1038/nn1854 · Cited by 476 · see citing works
Myelination of Cortical-hippocampal Relays During Late Adolescence
Benes, F. M. (1989) · Schizophrenia Bulletin · doi:10.1093/schbul/15.4.585 · Cited by 448 · see citing works
Motor skill learning induces changes in white matter microstructure and myelination
Sampaio-Baptista, C., Khrapitchev, A. A., Foxley, S., Schlagheck, T., Scholz, J., Jbabdi, S., DeLuca, G. C., Miller, K. L., Taylor, A., Thomas, N., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3048-13.2013 · Cited by 417 · see citing works
bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS
Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D. (2004) · Science · doi:10.1126/science.1103709 · Cited by 416 · see citing works
Wang, H., Peça, J., Matsuzaki, M., Matsuzaki, K., Noguchi, J., Qiu, L., Wang, D., Zhang, F., Boyden, E. S., Deisseroth, K. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700384104 · Cited by 384 · see citing works
Role of myelin plasticity in oscillations and synchrony of neuronal activity
Pajevic, S., Basser, P. J., & Fields, R. D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.007 · Cited by 378 · see citing works
Shen, S., Li, J., & Casaccia‐Bonnefil, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412101 · Cited by 320 · see citing works
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma
Monje, M., Mitra, S., Freret, M., Raveh, T., Kim, J., Masek, M., Attema, J., Li, G., Haddix, T., Edwards, M. S., et al. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1101657108 · Cited by 316 · see citing works
Self-citationWhite Matter Structure Changes as Adults Learn a Second Language
Schlegel, A. A., Rudelson, J. J., & Tse, P. U. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00240 · Cited by 303 · see citing works
Excitability and synaptic communication within the oligodendrocyte lineage
De Biase, L. M., Nishiyama, A., & Bergles, D. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6000-09.2010 · Cited by 286 · see citing works
Myelinated nerve fibers: computed effect of myelin thickness on conduction velocity
Rs, S., & Koles, Z. J. (1970) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1970.219.5.1256 · Cited by 215 · see citing works
Graeber, M. B., Streit, W. J., Kiefer, R., Schoen, S. W., & Kreutzberg, G. W. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90061-q · Cited by 209 · see citing works
Climbing fiber innervation of NG2-expressing glia in the mammalian cerebellum.
Lin, S.-C., Huck, J., Roberts, J. D., Macklin, W. B., Somogyi, P., & Bergles, D. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.025 · Cited by 201 · see citing works
Control of Myelination by Specific Patterns of Neural Impulses
Stevens, B., Tanner, S. L., & Fields, R. D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09303.1998 · Cited by 170 · see citing works
Brazel, C. Y., Limke, T. L., Osborne, J. K., Miura, T., Cai, J., Pevny, L., & Rao, M. S. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00158.x · Cited by 166 · see citing works
NG2 Cells in White Matter But Not Gray Matter Proliferate in Response to PDGF
Hill, R., Patel, K. D., Medved, J., Reiss, A., & Nishiyama, A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2001-12.2013 · Cited by 165 · see citing works
Loss of Histone Deacetylase 2 Improves Working Memory and Accelerates Extinction Learning
Morris, M. J., Mahgoub, M., Na, E. S., Pranav, H., & Monteggia, L. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1001-12.2013 · Cited by 162 · see citing works
De Biase, L. M., Kang, S. H., Baxi, E. G., Fukaya, M., Pucak, M. L., Mishina, M., Calabresi, P. A., & Bergles, D. E. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2455-11.2011 · Cited by 161 · see citing works
Li, Q., Brus-Ramer, M., Martin, J. H., & McDonald, J. W. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.043 · Cited by 150 · see citing works
Kingham, P. J., Cuzner, M. L., & Pocock, J. M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730538.x · Cited by 141 · see citing works
A Critical Role for Dorsal Progenitors in Cortical Myelination
Yue, T., Xian, K., Hurlock, E., Xin, M., Kernie, S., Parada, L., & Lu, Q. R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4717-05.2006 · Cited by 91 · see citing works
Synapse microarray identification of small molecules that enhance synaptogenesis
Shi, P., Skylar‐Scott, M. A., Ghosh, B., Wan, D., Wissner-Gross, Z. D., Mazitschek, R., Haggarty, S. J., & Yanik, M. F. (2011) · Nature Communications · doi:10.1038/ncomms1518 · Cited by 90 · see citing works
Wu, M., Hernandez, M., Shen, S., Sabo, J. K., Kelkar, D., Wang, J., O’Leary, R., Phillips, G. R., Cate, H. S., & Casaccia, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4876-11.2012 · Cited by 89 · see citing works
Fruttiger, M., Calver, A. R., & Richardson, W. D. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00757-0 · Cited by 81 · see citing works
Mangin, J., Kunze, A., Chittajallu, R., & Gallo, V. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1355-08.2008 · Cited by 80 · see citing works
Premotor cortex is critical for goal-directed actions
Gremel, C. M., & Costa, R. M. (2013) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2013.00110 · Cited by 75 · see citing works
Goldsberry, G., Mitra, D., MacDonald, D. J., & Patay, Z. J. (2011) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.06.025 · Cited by 24 · see citing works
The quest for myelin in the adult brain
Zuccaro, E., & Arlotta, P. (2013) · Nature Cell Biology · doi:10.1038/ncb2750 · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [57]Franklin BJ Paxinos G The Mouse Brain 2008 Elsevier New York
Cited by
Sorted by citations
Glutamatergic synaptic input to glioma cells drives brain tumour progression
Venkataramani, V., Tanev, D. I., Strahle, C., Studier-Fischer, A., Fankhauser, L., Kessler, T., Körber, C., Kardorff, M., Ratliff, M., Xie, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1564-x · Cited by 1,197 · see citing works
Motor skill learning requires active central myelination
McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177 · see citing works
Regenerating CNS myelin — from mechanisms to experimental medicines
Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647 · see citing works
Oligodendrocytes in development, myelin generation and beyond
Kuhn, S., Gritti, L., Crooks, D., & Dombrowski, Y. (2019) · Cells · doi:10.3390/cells8111424 · Cited by 625 · see citing works
Development of structure–function coupling in human brain networks during youth
Baum, G. L., Cui, Z., Roalf, D. R., Ciric, R., Betzel, R. F., Larsen, B., Cieslak, M., Cook, P. A., Xia, C. H., Moore, T. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912034117 · Cited by 544 · see citing works
Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism
Saab, A. S., Tzvetavona, I. D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Möbius, W., Goetze, B., Jahn, H. M., Huang, W., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.016 · Cited by 590 · see citing works
“…signaling in oligodendrocyte differentiation and promoting myelinationhasbeensuggested, basedon in vitroobservations (Li et al., 2013; Lundgaard et al., 2013), which is compatible with neuronal activity stimulating OPC proliferation and myelination in vivo (Gibson et al., 2014; Liu et al., 2012).”
The neuroscience of working memory capacity and training
Constantinidis, C., & Klingberg, T. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.43 · Cited by 533 · see citing works
Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
Yeung, M. S. Y., Zdunek, S., Bergmann, O., Bernard, S., Salehpour, M., Alkass, K., Perl, S., Tisdale, J., Possnert, G., Brundin, L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.011 · Cited by 541 · see citing works
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
Fernández-Castañeda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M.-H., Wood, J., O’Dea, M. R., Dutton, S., Shamardani, K., Nwangwu, K., et al. (2022) · Cell · doi:10.1016/j.cell.2022.06.008 · Cited by 521 · see citing works
Self-citationMicroglia regulate central nervous system myelin growth and integrity
McNamara, N. B., Munro, D. A. D., Bestard-Cuche, N., Uyeda, A., Bogie, J. F. J., Hoffmann, A., Holloway, R. K., Molina-Gonzalez, I., Askew, K. E., Mitchell, S., et al. (2023) · Nature · doi:10.1038/s41586-022-05534-y · Cited by 507 · see citing works
Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning
Xiao, L., Ohayon, D., McKenzie, I. A., Sinclair-Wilson, A., Wright, J. L., Fudge, A. D., Emery, B., Li, H., & Richardson, W. D. (2016) · Nature Neuroscience · doi:10.1038/nn.4351 · Cited by 507 · see citing works
Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex
Hrvatin, S., Hochbaum, D. R., Nagy, M. A., Cicconet, M., Robertson, K., Cheadle, L., Zilionis, R., Ratner, A., Borges-Monroy, R., Klein, A. M., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0029-5 · Cited by 497 · see citing works
Metformin restores CNS remyelination capacity by rejuvenating aged stem cells
Neumann, B., Baror, R., Zhao, C., Segel, M., Dietmann, S., Rawji, K. S., Foerster, S., McClain, C. R., Chalut, K., van Wijngaarden, P., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.08.015 · Cited by 449 · see citing works
Disruption of oligodendrogenesis impairs memory consolidation in adult mice
Steadman, P. E., Xia, F., Ahmed, M., Mocle, A. J., Penning, A. R. A., Geraghty, A. C., Steenland, H. W., Monje, M., Josselyn, S. A., & Frankland, P. W. (2020) · Neuron · doi:10.1016/j.neuron.2019.10.013 · Cited by 426 · see citing works
Self-citationThe neurobiology of long COVID
Monje, M., & Iwasaki, A. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.006 · Cited by 415 · see citing works
Self-citationvan der Knaap, M. S., & Bugiani, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1739-1 · Cited by 403 · see citing works
Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo
Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., & Lyons, D. A. (2015) · Nature Neuroscience · doi:10.1038/nn.3991 · Cited by 398 · see citing works
Dynamics of oligodendrocyte generation in multiple sclerosis
Yeung, M. S. Y., Djelloul, M., Steiner, E., Bernard, S., Salehpour, M., Possnert, G., Brundin, L., & Frisén, J. (2019) · Nature · doi:10.1038/s41586-018-0842-3 · Cited by 376 · see citing works
Gibson, E. M., Nagaraja, S., Ocampo, A., Tam, L. T., Wood, L. S., Pallegar, P. N., Greene, J. J., Geraghty, A. C., Goldstein, A. K., Ni, L., et al. (2019) · Cell · doi:10.1016/j.cell.2018.10.049 · Cited by 372 · see citing works
Microglia phagocytose myelin sheaths to modify developmental myelination
Hughes, A. N., & Appel, B. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0654-2 · Cited by 344 · see citing works
Dynamics and Mechanisms of CNS Myelination
Bercury, K. K., & Macklin, W. B. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.016 · Cited by 320 · see citing works
Myelin plasticity: sculpting circuits in learning and memory
Xin, W., & Chan, J. R. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00379-8 · Cited by 329 · see citing works
Gacias, M., Gaspari, S., Santos, P.-M. G., Tamburini, S., Andrade, M., Zhang, F., Shen, N., Tolstikov, V., Kiebish, M. A., Dupree, J. L., et al. (2016) · eLife · doi:10.7554/elife.13442 · Cited by 308 · see citing works
Myelin plasticity and nervous system function
Monje, M. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061853 · Cited by 274 · see citing works
Self-citationGlia in mammalian development and disease
Zuchero, J. B., & Barres, B. A. (2015) · Development · doi:10.1242/dev.129304 · Cited by 304 · see citing works
Self-citationTranscriptional Convergence of Oligodendrocyte Lineage Progenitors during Development
Marques, S., van Bruggen, D., Vanichkina, D. P., Floriddia, E. M., Munguba, H., Väremo, L., Giacomello, S., Falcão, A. M., Meijer, M., Björklund, Å. K., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.005 · Cited by 290 · see citing works
Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment
Geraghty, A. C., Gibson, E. M., Ghanem, R. A., Greene, J. J., Ocampo, A., Goldstein, A. K., Ni, L., Yang, T., Marton, R. M., Paşca, S. P., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.032 · Cited by 288 · see citing works
Self-citationWhite matter involvement after TBI: clues to axon and myelin repair capacity
Armstrong, R. C., Mierzwa, A. J., Marion, C. M., & Sullivan, G. M. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2015.02.011 · Cited by 262 · see citing works
Olmos-Serrano, J. L., Kang, H. J., Tyler, W. A., Silbereis, J. C., Cheng, F., Zhu, Y., Pletikos, M., Jankovic-Rapan, L., Cramer, N. P., Galdzicki, Z., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.042 · Cited by 239 · see citing works
“For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are co-regulated.”
On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function
Almeida, R. G., & Lyons, D. A. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3185-16.2017 · Cited by 221 · see citing works
Lutz, P.-E., Tanti, A., Gasecka, A., Barnett-Burns, S., Kim, J. J., Zhou, Y., Chen, G. G., Wakid, M., Shaw, M., Almeida, D., et al. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.16111286 · Cited by 203 · see citing works
Figlia, G., Gerber, D., & Suter, U. (2018) · Glia · doi:10.1002/glia.23273 · Cited by 165 · see citing works
Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?
Ettle, B., Schlachetzki, J. C. M., & Winkler, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9205-3 · Cited by 160 · see citing works
Thomas, A. G., Dennis, A., Rawlings, N. B., Stagg, C. J., Matthews, L., Morris, M., Kolind, S. H., Foxley, S., Jenkinson, M., Nichols, T. E., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.090 · Cited by 152 · see citing works
“Neuronal activity-dependent changes in myelination have been observed in cell culture (Wake et al., 2011; Fields, 2010) as well as in recent in vivo experiments (Gibson et al., 2014).”
BackgroundInfluentialWalhovd, K. B., Johansen-Berg, H., & Káradóttir, R. T. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.058 · Cited by 156 · see citing works
Advanced MRI techniques to improve our understanding of experience-induced neuroplasticity
Tardif, C. L., Gauthier, C. J., Steele, C. J., Bazin, P.-L., Schäfer, A., Schaefer, A., Turner, R., & Villringer, A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.08.047 · Cited by 127 · see citing works
The molecular physiology of the axo-myelinic synapse
Micu, I., Plemel, J. R., Lachance, C., Proft, J., Jansen, A. J., Cummins, K., van Minnen, J., & Stys, P. K. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2015.10.006 · Cited by 140 · see citing works
Noori, R., Park, D., Griffiths, J. D., Bells, S., Frankland, P. W., Mabbott, D., & Lefebvre, J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916646117 · Cited by 137 · see citing works
Chronic social defeat reduces myelination in the mouse medial prefrontal cortex
Lehmann, M. L., Weigel, T. K., Elkahloun, A. G., & Herkenham, M. (2017) · Scientific Reports · doi:10.1038/srep46548 · Cited by 127 · see citing works
Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity
Kato, D., Wake, H., Lee, P. R., Tachibana, Y., Ono, R., Sugio, S., Tsuji, Y., Tanaka, Y. H., Tanaka, Y. R., Masamizu, Y., et al. (2020) · Glia · doi:10.1002/glia.23713 · Cited by 114 · see citing works
“In such a case, the synchronous input of myelinated long-range axons connecting distant areas, and information processes with a high signal-to-noise ratio, may be important (Gibson et al., 2014; McKenzie et al., 2014; Xiao et al., 2016).”
BackgroundInfluentialAyoub, R., Ruddy, R. M., Cox, E., Oyefiade, A., Derkach, D., Laughlin, S., Ades-aron, B., Shirzadi, Z., Fieremans, E., MacIntosh, B. J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0985-2 · Cited by 117 · see citing works
Remyelination alters the pattern of myelin in the cerebral cortex
Orthmann-Murphy, J., Call, C. L., Molina-Castro, G. C., Hsieh, Y. C., Rasband, M. N., Calabresi, P. A., & Bergles, D. E. (2020) · eLife · doi:10.7554/elife.56621 · Cited by 111 · see citing works
Hubs in the human fetal brain network
van den Heuvel, M. I., Turk, E., Manning, J. H., Hect, J., Hernandez-Andrade, E., Hassan, S. S., Romero, R., van den Heuvel, M. P., & Thomason, M. E. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.02.001 · Cited by 108 · see citing works
Crowell, A. L., Garlow, S. J., Riva-Posse, P., & Mayberg, H. S. (2015) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00041 · Cited by 105 · see citing works
Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration
Hughes, E. G., & Stockton, M. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.714169 · Cited by 98 · see citing works
Oligodendrocyte progenitor cells in Alzheimer's disease: from physiology to pathology
Zou, P., Wu, C., Liu, T. C.-Y., Duan, R., & Yang, L. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00385-7 · Cited by 97 · see citing works
Frontal theta activity and white matter plasticity following mindfulness meditation
Tang, Y.-Y., Tang, R., Rothbart, M. K., & Posner, M. I. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2019.04.004 · Cited by 91 · see citing works
Neurogenesis and Gliogenesis in Nervous System Plasticity and Repair
Frisén, J. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-124953 · Cited by 83 · see citing works
Liu, J., Dietz, K., Hodes, G. E., Russo, S. J., & Casaccia, P. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22533 · Cited by 75 · see citing works
Microglia promote remyelination independent of their role in clearing myelin debris
Baaklini, C. S., Ho, M. F. S., Lange, T., Hammond, B. P., Panda, S. P., Zirngibl, M., Zia, S., Himmelsbach, K., Rana, H., Phillips, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113574 · Cited by 73 · see citing works
Myelin replacement triggered by single-cell demyelination in mouse cortex
Snaidero, N., Schifferer, M., Mezydlo, A., Zalc, B., Kerschensteiner, M., & Misgeld, T. (2020) · Nature Communications · doi:10.1038/s41467-020-18632-0 · Cited by 63 · see citing works
Rivera, A. D., Pieropan, F., Chacon‐De‐La‐Rocha, I., Lecca, D., Abbracchio, M. P., Azim, K., & Butt, A. M. (2021) · Aging Cell · doi:10.1111/acel.13335 · Cited by 61 · see citing works
Organization of the gravity-sensing system in zebrafish
Liu, Z., Hildebrand, D. G. C., Morgan, J. L., Jia, Y., Slimmon, N., & Bagnall, M. W. (2022) · Nature Communications · doi:10.1038/s41467-022-32824-w · Cited by 51 · see citing works
From bed to bench side: Reverse translation to optimize neuromodulation for mood disorders
Rudebeck, P. H., Rich, E. L., & Mayberg, H. S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902287116 · Cited by 42 · see citing works
Jensen, S. K. G., Pangelinan, M., Björnholm, L., Klasnja, A., Leemans, A., Drakesmith, M., Evans, C. J., Barker, E. D., & Paus, T. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.10.033 · Cited by 44 · see citing works
Oligodendrocyte precursor cells facilitate neuronal lysosome release
Fang, L.-P., Lin, C.-H., Medlej, Y., Zhao, R., Chang, H.-F., Guo, Q., Wu, Z., Su, Y., Zhao, N., Gobbo, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56484-8 · Cited by 19 · see citing works
BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis
Bergner, C. G., van der Meer, F., Franz, J., Vakrakou, A., Würfel, T., Nessler, S., Schäfer, L., Nau-Gietz, C., Winkler, A., Lagumersindez-Denis, N., et al. (2025) · Brain · doi:10.1093/brain/awae293 · Cited by 16 · see citing works
“49,50 Here, we have shown that remyelination in human cortical MS lesions and animal models of toxic and inflammatory cortical demyelination is characterized by a morphological change of BCAS1+ oligodendrocytes from a resting towards an activated phenotype.”
On the development of optical peripheral nerve interfaces
Anderson, H., & Weir, R. F. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.245461 · Cited by 14 · see citing works
Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy
Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11 · see citing works
- Authors
- Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., Barres, B. A., Woo, P. J., Vogel, H., & Monje, M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Gibson, Erin M.
- Purger, David
- Monje, Michelle
- ORCID
- Venue
- Science
- Published
- 2014-05-02
- Volume
- 344
- Issue
- 6183
- Pages
- 1252304-1252304
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4096908
- OpenAlex
- W2157257192
- Cited by
- 1,472
- References
- 57
- Citations by year
- 2026: 122 · 2025: 130 · 2024: 136 · 2023: 134 · 2022: 121 · 2021: 152 · 2020: 135 · 2019: 145 · 2018: 98 · 2017: 106 · 2016: 97 · 2015: 76 · 2014: 18
- FWCI
- 34.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (UL1TR001085, 1s10rr026780-01)
- National Institute of Mental Health (T32MH020016)
- National Eye Institute (R01EY010257)
- National Institute of Neurological Disorders and Stroke (K08NS070926)
- National Center for Research Resources (UL1RR025744, 1S10RR02678001)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuronal activity, oligodendrogenesis, myelination, oligodendrocyte precursor cells, premotor cortex, optogenetic stimulation, neural progenitor cells, white matter, motor function, epigenetic regulation, oligodendrocyte differentiation, activity-dependent myelination
- MeSH terms
- Channelrhodopsins, Animals, Behavior, Animal, Cell Differentiation, Corpus Callosum, Mice, Mutant Strains, Motor Activity, Motor Cortex, Myelin Sheath, Nerve Fibers, Myelinated, Neurons, Oligodendroglia, Thy-1 Antigens, Cell Lineage, Cell Proliferation, Mice, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
