Increased cell-to-cell variation in gene expression in ageing mouse heart

Cited by (603)

Items 301–400 of 603

  1. Human genetic analyses of organelles highlight the nucleus in age-related trait heritability
    Rahul Gupta, Konrad J. Karczewski, Daniel P. Howrigan, Benjamin M. Neale, Vamsi K. Mootha · 2021 · eLife
  2. Increased gene expression noise in human cancers is correlated with low p53 and immune activities as well as late stage cancer
    Rongfei Han, Guanqun Huang, Yejun Wang, Yafei Xu, Yueming Hu, Wenqi Jiang, Tianfu Wang, Tian Xiao, Duo Zheng · 2016 · Oncotarget
  3. Chromosome-wide co-fluctuation of stochastic gene expression in mammalian cells
    Mengyi Sun, Jianzhi Zhang · 2019 · PLoS Genetics
  4. The evolution of senescence through decelerating selection for system reliability
    Robert A. Laird, Thomas N. Sherratt · 2009 · Journal of Evolutionary Biology
  5. Loss of coordination between basic cellular processes in human aging
    Ana Carolina Leote, Francisco José Calheiros Craveiro Lopes, Andreas Beyer · 2024 · Nature Aging
  6. Cell-to-cell variation in gene expression and the aging process
    Alexander Mendenhall, George M. Martin, Matt R. Kaeberlein, Rozalyn M. Anderson · 2021 · GeroScience
  7. Age-related ocular surface failure: A narrative review
    Antonio Di Zazzo, Marco Coassin, Pier Luigi Surico, Stefano Bonini · 2022 · Experimental Eye Research
  8. Copy neutral loss of heterozygosity is more frequent in older ovarian cancer patients
    Brent S. Pedersen, Panagiotis A. Konstantinopoulos, Monique A. Spillman, Subhajyoti De · 2013 · Genes Chromosomes and Cancer
  9. Why Is Modern Medicine Stuck in a Rut?
    Indraneel Mittra · 2009 · Perspectives in biology and medicine
  10. Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions
    Xiao Dong, Shixiang Sun, Lei Zhang, Seungsoo Kim, Zhidong Tu, Cristina Montagna, Alexander Y. Maslov, Yousin Suh, Tao Wang, Judith Campisi et al. · 2021 · Aging Cell
  11. Population genetics of non-genetic traits: Evolutionary roles of stochasticity in gene expression
    Katsuhiko Mineta, Tomotaka Matsumoto, Naoki Osada, Hitoshi Araki · 2015 · Gene
  12. Protagonistic pleiotropy: Why cancer may be the only pathogenic effect of accumulating nuclear mutations and epimutations in aging
    Aubrey D.N.J. de Grey · 2007 · Mechanisms of Ageing and Development
  13. Brain Aging and Regeneration after Injuries: an Organismal approach.
    Ana-Maria Buga, Raluca Vintilescu, Oltin T. Pop, Aurel Popa‐Wagner · 2011 · Europe PMC (PubMed Central)
  14. Functional relationships between genes associated with differentiation potential of aged myogenic progenitors
    Nagarajan · 2010 · Frontiers in Psychiatry
  15. Circadian Rhythms and Their Impact on Aging
    S. Michal Jazwinski, Victoria P. Belancio, Steven M. Hill, Springer International Publishing · 2017 · Healthy ageing and longevity
  16. Tissue‐disruption‐induced cellular stochasticity and epigenetic drift: Common origins of aging and cancer?
    Jean‐Pascal Capp, Frédéric Thomas A · 2020 · BioEssays
  17. Aging—RNA in development and disease
    Mark Cookson · 2011 · Wiley Interdisciplinary Reviews - RNA
  18. Cell biology: The cellular hullabaloo
    Helen Pearson · 2008 · Nature
  19. Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort
    Ana Viñuela, Andrew Anand Brown, Alfonso Buil, Pei-Chien Tsai, Matthew N Davies, Jordana T. Bell, Emmanouil T. Dermitzakis, Tim D. Spector, Kerrin S. Small · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
  20. Measuring cell-to-cell expression variability in single-cell RNA-sequencing data: a comparative analysis and applications to B cell aging
    Huiwen Zheng, Jan Vijg, Atefeh Taherian Fard, Jessica C. Mar · 2023 · Genome biology
  21. Regeneration leads to global tissue rejuvenation in aging sexual planarians
    Xiaoting Dai, Xinghua Li, Alexander Tyshkovskiy, Cassandra Zuckerman, Nan Cheng, Peter Lin, David Paris, Saad Qureshi, Leonid Kruglyak, Xiaoming Mao et al. · 2025 · Nature Aging
  22. Aging: A Sirtuin Shake-Up?
    Jan Vijg, Alexander Y. Maslov, Yousin Suh · 2008 · Cell
  23. Not all quiet on the noise front
    Emma McCullagh, Justin Farlow, Chris K. Fuller, Juliet R. Girard, Joanna Lipinski-Kruszka, Dan Lu, Thomas R. Noriega, Geoffrey C. Rollins, Russell Spitzer, Michael E. Todhunter et al. · 2009 · Nature Chemical Biology
  24. ARID5A orchestrates cardiac aging and inflammation through MAVS mRNA stabilization
    Yanling Fan, Yandong Zheng, Yiyuan Zhang, Gang Xu, Chun Liu, Jianli Hu, Qianzhao Ji, Shuo Zhang, Shuaiqi Fang, Jinghui Lei et al. · 2025 · Nature Cardiovascular Research
  25. Predicting Cytotoxic T-cell Age from Multivariate Analysis of Static and Dynamic Biomarkers
    Catherine A. Rivet, Abby S. Hill, Hang Lu, Melissa Lambeth Kemp · 2010 · Molecular & Cellular Proteomics
  26. Towards experimental manipulation of stochasticity in gene expression
    José Viñuelas, Gaël Kaneko, Antoine Coulon, Guillaume Beslon, Olivier Gandrillon · 2012 · Progress in Biophysics and Molecular Biology
  27. Age-Dependent Variability in Gene Expression in Male Fischer 344 Rat Retina
    Zhen Li, Fred A. Wright, Joyce E. Royland · 2008 · Toxicological Sciences
  28. Living in a noisy world—origins of gene expression noise and its impact on cellular decision‐making
    Sampriti Pal, Riddhiman Dhar · 2024 · FEBS Letters
  29. ImAge quantitates aging and rejuvenation
    Martin Alvarez-Kuglen, Kenta Ninomiya, Haodong Qin, Delany Rodriguez, Lorenzo Fiengo, Chen Farhy, Wei-Mien Hsu, Brian D. Kirk, Aaron P. Havas, Collin Kaufman et al. · 2024 · Nature Aging
  30. Circulating nucleic acids: a new class of physiological mobile genetic elements
    Indraneel Mittra · 2015 · F1000Research
  31. Transcriptomic Signatures of Ageing Vary in Solitary and Social Forms of an Orchid Bee
    Alice C. Séguret, Eckart Stolle, Fernando A. Fleites‐Ayil, José Javier G. Quezada‐Euán, Klaus Hartfelder, Karen Meusemann, Mark C. Harrison, Antonella Soro, Robert J. Paxton · 2021 · Genome Biology and Evolution
  32. Systems Biology of Parkinson's Disease
    Peter E. Wellstead, Mathieu Cloutier · 2012 · Springer eBooks
  33. Longitudinal measures of proteostasis in live neurons: Features that determine fate in models of neurodegenerative disease
    Gaia Skibinski, Steven M. Finkbeiner · 2013 · FEBS Letters
  34. Single‐Cell and Spatial Multiomics: Applications for Diseases
    Wentao Li, Chao Chen, Xin Zhu, Chenping Zhang · 2025 · MedComm
  35. An age of fewer histones
    Philipp Oberdoerffer · 2010 · Nature Cell Biology
  36. The Spatial Association of Gene Expression Evolves from Synchrony to Asynchrony and Stochasticity with Age
    Qi Wang, Jianhua Huang, Xinmin Zhang, Bin Wu, Xiaoyu Liu, Ziyin Shen · 2011 · PLoS ONE
  37. The human ΔNp53 isoform triggers metabolic and gene expression changes that activate mTOR and alter mitochondrial function
    Shih‐Chieh Lin, Edward D. Karoly, Dylan J. Taatjes · 2013 · Aging Cell
  38. Precision medicine for heart failure based on molecular mechanisms: The 2019 ISHR Research Achievement Award Lecture
    Seitaro Nomura, Issei Komuro · 2020 · Journal of Molecular and Cellular Cardiology
  39. Toward uncharted territory of cellular heterogeneity: advances and applications of single-cell RNA-seq
    Brandon Lieberman, Meena Kusi, Chia‐Nung Hung, Chih‐Wei Chou, He Ning, Yen‐Yi Ho, Josephine Amalia Taverna, Tim H.‐M. Huang, Chun‐Liang Chen · 2020 · Journal of Translational Genetics and Genomics
  40. Identification of differentially distributed gene expression and distinct sets of cancer-related genes identified by changes in mean and variability
    Aedan G. K. Roberts, Daniel Robin Catchpoole, Paul J Kennedy · 2022 · NAR Genomics and Bioinformatics
  41. Single-cell metabolic profiling of primary human hepatocytes shows heterogenous responses to drug metabolism
    Eva Sanchez-Quant, Maria Richter, Celia Pilar Martinez‐Jimenez, Maria Colomé‐Tatché · 2022 · Genome biology
  42. Methylation entropy landscape of Chinese long‐lived individuals reveals lower epigenetic noise related to human healthy aging
    Haotian Wang, Fu‐Hui Xiao, Zong‐Liang Gao, Li‐Yun Guo, Liqin Yang, Gong‐Hua Li, Qing‐Peng Kong · 2024 · Aging Cell
  43. RNA Regulatory Networks as a Control of Stochasticity in Biological Systems
    Marylène S. Vandevenne, Michaël Delmarcelle, Moreno Galleni · 2019 · Frontiers in Genetics
  44. Increased Variability of Genomic Transcription in Schizophrenia
    Fuquan Zhang, Yin Yao Shugart, Weihua Yue, Zaohuo Cheng, Guoqiang Wang, Zhenhe Zhou, Chunhui Jin, Jianmin Yuan, Sha Liu, Yong Ji Xu · 2015 · Scientific Reports
  45. Effects of Abies sibirica terpenes on cancer- and aging-associated pathways in human cells
    Anna V. Kudryavtseva, George Sergeevich Krasnov, Anastasiya V. Lipatova, B. Yа. Alekseev, Faniya Maganova, Mikhail Vyacheslavovich Shaposhnikov, Maria Fedorova, Anastasiya V. Snezhkina, Alexey Moskalev · 2016 · Oncotarget
  46. Experimental evolution reveals a general role for the methyltransferase Hmt1 in noise buffering
    Shu‐Ting You, Yu‐Ting Jhou, Cheng-Fu Kao, Jun‐Yi Leu · 2019 · PLoS Biology
  47. Advanced Maternal Age Differentially Affects Embryonic Tissues with the Most Severe Impact on the Developing Brain
    Caroline Kokorudz, Bethany N. Radford, Wendy Dean, Myriam Hemberger · 2022 · Cells
  48. Single‐worm quantitative proteomics reveals aging heterogeneity in isogenic Caenorhabditis elegans
    Tian‐Yi Zhu, Shang‐Tong Li, Dandan Liu, Xiajun Zhang, Lianqi Zhou, Rong Zhou, Bing Yang · 2023 · Aging Cell
  49. Label-free visualization and quantification of single cell signaling activity using metal-clad waveguide (MCWG)-based microscopy
    Thomas Söllradl, Frederic A. Banville, Ulrike Froehlich, Michael Canva, Paul G. Charette, Michel Grandbois · 2017 · Biosensors and Bioelectronics
  50. Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model
    Jennings C. Luu, Les Kallestad, Thanh V. Hoang, Dominik Lewandowski, Zhiqian Dong, Seth Blackshaw, Krzysztof Palczewski · 2020 · Human Molecular Genetics
  51. Transcriptome-Guided Identification of Drugs for Repurposing to Treat Age-Related Hearing Loss
    Nick M. A. Schubert, Marcel van Tuinen, Sonja J. Pyott · 2022 · Biomolecules
  52. Aging—From molecules to populations
    Miriam Sander, Kirsten Avlund, Martin Lauritzen, Tina Gottlieb, Barry B. Halliwell, Tinna Stevnsner, Ulla M. Wewer, Vilhelm A. Bohr · 2008 · Mechanisms of Ageing and Development
  53. Cell-to-cell variability in the diffusion constants of the plasma membrane proteins CD59 and CD147
    Stefan Wieser, Julian Weghuber, Michael Sams, Hannes S. J. Stockinger, Gerhard J. Schütz · 2009 · Soft Matter
  54. HPASubC: A suite of tools for user subclassification of human protein atlas tissue images
    Toby C. Cornish, Aravinda Chakravarti, Ashish Kapoor, Marc K. Halushka · 2015 · Journal of Pathology Informatics
  55. Using measures of single‐cell physiology and physiological state to understand organismic aging
    Alexander Mendenhall, Monica Driscoll, Roger Brent · 2015 · Aging Cell
  56. Quantitative proteomics to study aging in rabbit liver
    Bushra Amin, Katarena I. Ford, Renã A. S. Robinson · 2020 · Mechanisms of Ageing and Development
  57. Quantitative genetic analysis deciphers the impact of cis and trans regulation on cell-to-cell variability in protein expression levels
    Michael David Morgan, Étienne Patin, Bernd Jagla, Milena Hasan, Lluís Quintana‐Murci, John C. Marioni · 2020 · PLoS Genetics
  58. Metabolomic Changes Are Predictive of Aging in Laying Hens
    Inna Bendikov-Bar, Sergey Malitsky, Maxim Itkin, Mark Rusal, Dror Sagi · 2021 · The Journals of Gerontology Series A
  59. Transcriptomic reprogramming for neuronal age reversal
    Alexandru M. Pleşa, Michael Shadpour, Edward S. Boyden, George McDonald Church · 2023 · Human Genetics
  60. Genomic Instability Evolutionary Footprints on Human Health: Driving Forces or Side Effects?
    Laura Veschetti, Mirko Treccani, Elisa De Tomi, Giovanni Malerba · 2023 · International Journal of Molecular Sciences
  61. Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes
    James M. Flynn, Luis Fernando Santana, Simon Melov · 2011 · Journal of Visualized Experiments
  62. Pathway-Based Factor Analysis of Gene Expression Data Produces Highly Heritable Phenotypes That Associate with Age
    Andrew Anand Brown, Zhihao Ding, Ana Viñuela, Dan Glass, Leopold Parts, Tim D. Spector, John Michael Winn, Richard Michael Durbin · 2015 · G3 Genes Genomes Genetics
  63. Global mapping of transcription factor motifs in human aging
    David Alfego, Ulrich Rodeck, Andres Kriete · 2018 · PLoS ONE
  64. First-passage time calculations for a gene expression model
    Khem Raj Ghusinga, Abhyudai Singh · 2014 · IEEE Conference on Decision and Control (CDC)
  65. Block-tridiagonal state-space realization of Chemical Master Equations: A tool to compute explicit solutions
    Alessandro Borri, Francesco Carravetta, Gabriella Mavelli, Pasquale J Palumbo · 2015 · Journal of Computational and Applied Mathematics
  66. Aging Epigenetics
    Duygu Ucar, Bérénice Anath Benayoun · 2017 · Elsevier eBooks
  67. Diverse relaxation rates exist among rat cardiomyocytes isolated from a single myocardial region
    Jeffery A. Clark, Stuart G. Campbell · 2018 · The Journal of Physiology
  68. Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges
    Manuela Cabiati, Costanza Salvadori, Annalaura Sapio, Silvia Burchielli, Lucia Carlucci, Stefania Moscato, Laura Sabatino, Chiara Caselli, Letizia Mattii, Silvia Del Ry · 2020 · Experimental Gerontology
  69. Quantification of Age-Related Decline in Transcriptional Homeostasis
    Krishan Gupta, Princey Yadav, Sidrah Maryam, Gaurav Ahuja, Debarka Sengupta · 2021 · Journal of Molecular Biology
  70. Nutrition, Epigenetics and Aging
    John Cummings Mathers, Hyang‐Min Byun · 2016 · WORLD SCIENTIFIC eBooks
  71. Divergent effects of oxidatively induced modification to the C8 of 2′‐deoxyadenosine on transcription factor binding: 8,5′(S)‐cyclo‐2′‐deoxyadenosine inhibits the binding of multiple sequence specific transcription factors, while 8‐oxo‐2′‐deoxyadenosine increases binding of CREB and NF‐kappa B to DNA
    Jessy Abraham, Philip John Brooks · 2010 · Environmental and Molecular Mutagenesis
  72. Exploiting Cell-To-Cell Variability To Detect Cellular Perturbations
    Gautam Dey, Gagan D. Gupta, Balaji Ramalingam, Mugdha Sathe, Satyajit Mayor, Mukund Thattai · 2014 · PLoS ONE
  73. Gene expression variation and parental allele inheritance in a Xiphophorus interspecies hybridization model
    Yuan Lü, Mikki Boswell, William T. Boswell, Susanne Kneitz, Barbara J. Klotz, Markita G. Savage, Raquel Y. Salinas, Rebecca Marks, Janine Regneri, John H. Postlethwait et al. · 2018 · PLoS Genetics
  74. Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases
    Alessia Mongelli, Sandra Atlante, Veronica Barbi, Tiziana Bachetti, Fabio Martelli, Antonella Farsetti, Carlo Gaetano · 2020 · International Journal of Molecular Sciences
  75. Physiologic noise obscures genotype–phenotype correlations
    Richárd Kellermayer · 2007 · American Journal of Medical Genetics Part A
  76. A model selection approach to discover age-dependent gene expression patterns using quantile regression models
    Joshua W. K. Ho, Maurizio Stefani, Cristobal G. dos Remedios, Michael Charleston · 2009 · BMC Genomics
  77. Suv39h-catalyzed H3K9me3 is critical for euchromatic genome organization and the maintenance of gene transcription
    Christine R. Keenan, Hannah D. Coughlan, Nadia Iannarella, Andrés Tapia del Fierro, Andrew Keniry, Timothy M. Johanson, Wing Fuk Chan, Alexandra L. Garnham, Lachlan W. Whitehead, Marnie E. Blewitt et al. · 2024 · Genome Research
  78. Exploring cell-to-cell variability and functional insights through differentially variable gene analysis
    Victoria Gatlin, Shreyan Gupta, Selim Romero, Robert S. Chapkin, James J. Cai · 2025 · npj Systems Biology and Applications
  79. Single cell gene expression profiling of cortical osteoblast lineage cells
    James M. Flynn, Steven C. Spusta, Clifford james Rosen, Simon Melov · 2012 · Bone
  80. Age-associated bimodal transcriptional drift reduces intergenic disparities in transcription
    Byungkuk Min, Myungsun Park, Kyuheum Jeon, Jung Sun Park, Hyemyung Seo, Sangkyun Jeong, Yong‐Kook Kang · 2018 · Aging
  81. Nutrition, Epigenetics, And Aging
    John Cummings Mathers, Dianne Ford · 2009 · CRC Press eBooks
  82. Cellular age explains variation in age-related cell-to-cell transcriptome variability
    Yang, Ming, Harrison, Benjamin R., Promislow, Daniel E.L. · 2023 · Genome Research
  83. New single nucleotide polymorphisms (SNPs) in homologous recombination repair genes detected by microarray analysis in Polish breast cancer patients
    Hanna Romanowicz, Dominik Strapagiel, Marcin Słomka, Marta Sobalska‐Kwapis, Ewa Kępka, Anna Siewierska-Górska, Marek Zadrożny, Jan Bieńkiewicz, Beata Smolarz · 2016 · Clinical and Experimental Medicine
  84. Toluene effects on the motor activity of adolescent, young-adult, middle-age and senescent male Brown Norway rats
    Robert C. MacPhail, Jackie D. Farmer, Kimberly A. Jarema · 2011 · NeuroToxicology
  85. Analysis of the polymorphisms in non-homologous DNA end joining (NHEJ) gene Ku70 and Ligase IV in sporadic breast cancer in women.
    Anna Sobczuk, Beata Smolarz, Hanna Romanowicz, Marek Zadrożny, Jakub Baszczyński, Bogusław Westfal, Tomasz Pertyński · 2010 · PubMed
  86. Is it possible to prove the existence of an aging program by quantitative analysis of mortality dynamics?
    Gregory A. Shilovsky, T. S. Putyatina, Sergei N. Lysenkov, Vasily V. Ashapkin, O. S. Luchkina, Alexander V Markov, Vladimir P. Skulachev · 2016 · Biochemistry (Moscow)
  87. Reappraisal of the Concept of Accelerated Aging in Neurodegeneration and Beyond
    Yauhen A. Statsenko, Nikolai V. Kuznetsov, Daria Morozova, Katsiaryna Liaonchyk, Gillian Lylian Simiyu, Darya Smetanina, Aidar Kashapov, Sarah Meribout, Klaus Gorkom, Rifat Hamoudi et al. · 2023 · Cells
  88. REPRODUCTIVE AGEING: Altered histone modification landscapes underpin defects in uterine stromal cell decidualization in aging females
    Laura M. Woods, Wendy Dean, Myriam Hemberger · 2024 · Reproduction
  89. Basic statistical recipes for the emergence of biochemical discernment
    Denis Michel · 2011 · Progress in Biophysics and Molecular Biology
  90. Orthogonal tuning of gene expression noise using CRISPR–Cas
    Fan Wu, Jiyoung Shim, Ting Gong, Cheemeng Tan · 2020 · Nucleic Acids Research
  91. Out-of-equilibrium gene expression fluctuations in the presence of extrinsic noise
    Marta Biondo, Abhyudai Singh, Michele Caselle, Matteo Osella · 2023 · Physical Biology
  92. Macroautophagy and normal aging of the nervous system: Lessons from animal models
    Emmanouela Kallergi, Vassiliki Nikoletopoulou · 2021 · Cell Stress
  93. Evolution, Chance, and Aging
    Stewart A. Frankel, Blanka Rogina · 2021 · Frontiers in Genetics
  94. Nuclear Origins of Cell-to-Cell Variability
    Zeev Waks, Pamela A. Silver · 2010 · Cold Spring Harbor Symposia on Quantitative Biology
  95. Exercise and the hallmarks of cardiovascular aging
    Dan Zhong, Benjamín Fernández‐Garcia, Priyanka Gokulnath, Kexin Lin, Guoping Li, Guido Kroemer, Carlos López-Otı́n, Junjie Xiao · 2026 · Ageing Research Reviews
  96. The mechanisms shaping the single-cell transcriptional landscape
    Celia Pilar Martinez‐Jimenez, Duncan T. Odom · 2016 · Current Opinion in Genetics & Development
  97. Orthogonal tuning of gene expression noise using CRISPR–Cas
    Fan Wu, Jiyoung Shim, Ting Gong, Cheemeng Tan · 2020 · Nucleic Acids Research
  98. The Evolving Concept of Oxidative Stress
    Denise de Castro Fernandes, Diego Bonatto, Francisco Rafael Martins Laurindo · 2010 · Humana Press eBooks
  99. Aging, longevity and health
    Lene Juel Rasmussen, Miriam Sander, Ulla M. Wewer, Vilhelm A. Bohr · 2011 · Mechanisms of Ageing and Development
  100. A mathematical model which examines age-related stochastic fluctuations in DNA maintenance methylation
    Loukas Zagkos, Jason A. Roberts, Mark T. Mc Auley · 2021 · Experimental Gerontology