Increased cell-to-cell variation in gene expression in ageing mouse heart

Bahar, Rumana, Hartmann, Claudia H., Rodriguez, Karl A., Denny, Ashley D., Busuttil, Rita A., Dollé, Martijn E. T., Calder, R. Brent, Chisholm, Gary B., Pollock, Brad H., Klein, Christoph A., Vijg, Jan·2006·Nature

DOI 10.1038/nature04844

Cited by (603)

Items 101–200 of 603

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Dongping Liu, Linda Ye Ou, Gregory Dane Clemenson, Connie Chao, Marshall Eli Lutske, Gerard P. Zambetti, Fred H. Gage, Yang Xu · 2010 · Nature Cell Biology
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Positive selection for elevated gene expression noise in yeast
Zhihua Zhang, Wenfeng Qian, Jianzhi Zhang · 2009 · Molecular Systems Biology
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Hematopoietic stem cell aging and self-renewal
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Dynamics of protein noise can distinguish between alternate sources of gene‐expression variability
Abhyudai Singh, Brandon S. Razooky, Roy D. Dar, Leor S. Weinberger · 2012 · Molecular Systems Biology
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Jude M. Phillip, Pei-Hsun Wu, Daniele M. Gilkes, Wadsworth A. Williams, Shaun McGovern, Jena Daya, Jonathan Chen, Ivie Aifuwa, Jerry S. H. Lee, Rong Fan et al. · 2017 · Nature Biomedical Engineering
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Adam S. Adler, Tiara L.A. Kawahara, Eran Segal, Howard Y. Chang · 2008 · Cell Cycle
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Stuart K. Kim · 2007 · Journal of Experimental Biology
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Peter M. Lansdorp · 2022 · Blood
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Dominick G. A. Burton, Richard Faragher · 2015 · AGE
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Maria Giulia Bacalini, Simonetta Friso, Fabiola Olivieri, Chiara Pirazzini, Cristina Giuliani, Miriam Capri, Aurelia Santoro, Claudio Franceschi, Paolo Garagnani · 2014 · Mechanisms of Ageing and Development
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Stuart M. Chambers, Margaret A. Goodell · 2007 · Stem Cell Reviews and Reports
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Vasily V. Ashapkin, Lyudmila I. Kutueva, B. F. Vanyushin · 2017 · Current Genomics
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Tristan V. de Jong, Yuri M. Moshkin, Victor Guryev · 2019 · Physiological Genomics
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Paul J.M. Wijnker, Vasco Sequeira, Diederik W.D. Kuster, Jolanda van der Velden · 2018 · Antioxidants and Redox Signaling
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Komal P. Singh, Christine A. Miaskowski, Anand Dhruva, Elena Flowers, Kord M. Kober · 2018 · Biological Research For Nursing
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J. Rose, Stefan Söder, Catherine Skhirtladze, Norbert Schmitz, Pia Margarethe Gebhard, Stefan Sesselmann, Thomas G Aigner · 2012 · Osteoarthritis and Cartilage
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Co-detection and sequencing of genes and transcripts from the same single cells facilitated by a microfluidics platform
Han, Lin, Zi, Xiaoyuan, Garmire, Lana X., Wu, Yu, Weissman, Sherman M., Pan, Xinghua, Fan, Rong · 2014 · Scientific Reports
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David A. Sinclair, Philipp Oberdoerffer · 2009 · Ageing Research Reviews
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Anne Brunet, Thomas A. Rando · 2017 · Current Opinion in Cell Biology
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Han Li, James R. Mitchell, Paul Hasty · 2008 · Mechanisms of Ageing and Development
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Burgess, Rebecca C, Misteli, Tom, Oberdoerffer, Philipp · 2012 · Current Opinion in Cell Biology
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Fareid Asphahani, Kui Wang, Myo Thein, Omid Veiseh A, Sandy Yung, Jian Xu, Miqin Zhang · 2011 · Physical Biology
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Winnok Harald De Vos, Leander Van Neste, Birger Victor Dieriks, G. Joss, Patric Van Oostveldt · 2009 · Cytometry Part A
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Alexander Loewer, Galit Lahav · 2011 · Current Opinion in Genetics & Development
Nutrition and ageing: knowledge, gaps and research priorities
John Cummings Mathers · 2013 · Proceedings of The Nutrition Society
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Diane Fatkin, Robyn Otway, Jamie I. Vandenberg · 2007 · Circulation
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Andriy Marusyk, James V. DeGregori · 2007 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
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Gene expression profiling of single cells on large-scale oligonucleotide arrays
Claudia H. Hartmann, Christoph A. Klein · 2006 · Nucleic Acids Research
Aging: not all DNA damage is equal
Wilbert P. Vermeij, Jan H.J. Hoeijmakers, Joris Pothof · 2014 · Current Opinion in Genetics & Development
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Ayelet M Rosenberg, Shannon Rausser, Junting Ren, Eugene V. Mosharov, Gabriel Sturm, Robert Todd Ogden, Purvi R. Patel, Rajesh Kumar Soni, Clay Lacefield, Desmond John Tobin et al. · 2021 · eLife
Validation of suitable internal control genes for expression studies in aging
Michele Zampieri, Fabio Ciccarone, Tiziana Guastafierro, Maria Giulia Bacalini, R. Calabrese, María Moreno‐Villanueva, Anna Reale, Marta Chevanne, Alexander Bürkle, Paola Caiafa · 2009 · Mechanisms of Ageing and Development
Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability
Kim, Jeongkyu, Sturgill, David, Tran, Andy D., Sinclair, David A., Oberdoerffer, Philipp · 2016 · Nucleic Acids Research
DNA methylation, ageing and the influence of early life nutrition
Karen A. Lillycrop, Samuel P. Hoile, Leonie R. Grenfell, Graham C. Burdge · 2014 · Proceedings of The Nutrition Society
Splicing regulatory factors, ageing and age-related disease
Eva Latorre, Lorna W. Harries · 2017 · Ageing Research Reviews
circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan
Shahnaz Haque, Ryan M. Ames, Karen Moore, Luke C. Pilling, Luanne L. Peters, Stefania Bandinelli, Luigi Ferrucci, Lorna W. Harries · 2019 · GeroScience
High-resolution array comparative genomic hybridization of single micrometastatic tumor cells
Christine Fuhrmann, Oleg Schmidt‐Kittler, Nikolas Hendrik Stoecklein, Karina Petat‐Dutter, Christian Vay, Kerstin Bockler, Richard Reinhardt, Thomas Ragg, Christoph A. Klein · 2008 · Nucleic Acids Research
Cellular Metabolism and Aging
André Catic · 2018 · Progress in molecular biology and translational science
Genome Instability and DNA Repair in Somatic and Reproductive Aging
Stephanie Panier, Siyao Wang, Björn Schumacher · 2023 · Annual Review of Pathology Mechanisms of Disease
Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations
Stefan Schoeftner, Raquel Blanco, Isabel López de Silanes, Purificacı́on Muñoz, Gonzalo Goméz-López, Juana María Flores, Marı́a A. Blasco · 2009 · Proceedings of the National Academy of Sciences
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Marlene J. Végh, Antonio Rausell, Maarten Loos, Céline M Heldring, Wiktor Jurkowski, Pim van Nierop, Iryna Paliukhovich, Ka Wan Li, Antonio del Sol, August Benjamin Smit et al. · 2014 · Molecular & Cellular Proteomics
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Leah Cannon, Alexander C. Zambon, Anthony Cammarato, Zhi Zhang, Georg Vogler, Matthew D. Munoz, Erika Taylor, Jérôme Cartry, Sanford I. Bernstein, Simon Melov et al. · 2017 · Aging Cell
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Annibale Alessandro Puca, Chiara Spinelli, Giulia Accardi, Francesco Villa, Calogero Caruso · 2017 · Mechanisms of Ageing and Development
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Stephen Smith, Ramon Grima · 2018 · Nature Communications
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Andrew R. Mendelsohn, James W. Larrick · 2017 · Rejuvenation Research
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Yi Zhang, Mingying Shi, Mingxuan Li, Shaojie Qin, Daiyu Miao, Yu Bai · 2025 · Nature Communications
Transcriptional instability is not a universal attribute of aging
Luigi A. Warren, Derrick J. Rossi, Geoffrey R. Schiebinger, Irving L. Weissman, Stuart K. Kim, Stephen R. Quake · 2007 · Aging Cell
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Monica Pibiri · 2018 · Aging
Detection of drug-induced cellular changes using confocal Raman spectroscopy on patterned single-cell biosensors
Ryan Buckmaster, Fareid Asphahani, Myo Thein, Jian Xu, Miqin Zhang · 2009 · The Analyst
Back and forth in time: Directing age in iPSC-derived lineages
Cornacchia, Daniela, Studer, Lorenz · 2017 · Brain Research
Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity
Hamit İzgi, DingDing Han, Ulas Isildak, Shuyun Huang, Ece Kocabiyik, Philipp Khaitovich, Mehmet Somel, Handan Melike Dönertaş · 2022 · eLife
Systems biology of aging in four species
Jacob M. Zahn, Stuart K. Kim · 2007 · Current Opinion in Biotechnology
Age-associated loss of selectivity in human olfactory sensory neurons
Nancy E. Rawson, George Gomez, Beverly J. Cowart, Andres Kriete, Edmund A. Pribitkin, Diego Restrepo · 2011 · Neurobiology of Aging
An Xpb Mouse Model for Combined Xeroderma Pigmentosum and Cockayne Syndrome Reveals Progeroid Features upon Further Attenuation of DNA Repair
Jaan‐Olle Andressoo, Geert Weeda, Jan de Wit, James R. Mitchell, Rudolf B. Beems, Harry VAN STEEG, Gijsbertus T. J. van der Horst, Jan H.J. Hoeijmakers · 2008 · Molecular and Cellular Biology
Nonspecific transcription factor binding can reduce noise in the expression of downstream proteins
Mohammad Soltani, Pavol Bokes, Zachary Fox, Abhyudai Singh · 2015 · Physical Biology
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Vikas Misra, Hannah Lee, Anju Singh, Kewu Huang, Rajesh Kumar Thimmulappa, Wayne Mitzner, Shyam S. Biswal, Clarke G. Tankersley · 2007 · Physiological Genomics
Temporal changes in the gene expression heterogeneity during brain development and aging
Işıldak, Ulaş, Somel, Mehmet, Thornton, Janet M., Dönertaş, Handan Melike · 2020 · Scientific Reports
DNA methylation and cognitive aging
X.Z. Shawn Xu · 2015 · Oncotarget
Mesenchymal stem cell-derived inflammatory fibroblasts mediate interstitial fibrosis in the aging heart
JoAnn Trial, Mark L. Entman, Katarzyna A. Cieslik · 2015 · Journal of Molecular and Cellular Cardiology
Aging Uncouples Heritability and Expression-QTL in Caenorhabditis elegans
Ana Viñuela, Basten L. Snoek, Joost A. G. Riksen, Jan E. Kammenga · 2012 · G3 Genes Genomes Genetics
Noise-driven cellular heterogeneity in circadian periodicity
Yan Li, Yongli Shan, Ravi V. Desai, Kimberly H. Cox, Leor S. Weinberger, Joseph S. Takahashi · 2020 · Proceedings of the National Academy of Sciences
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Wan, Tengfei, Weir, Emma J., Johnson, Mary, Korolchuk, Viktor I., Saretzki, Gabriele C. · 2021 · Progress in Neurobiology
IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration
Omid Omrani, Anna Křepelová, Seyed Mohammad Mahdi Rasa, Dovydas Širvinskas, Jing Nan Lu, Francesco Annunziata, George B. Garside, Seerat Bajwa, Susanne Reinhardt, Lisa Adam et al. · 2023 · Nature Communications
The connections between general and reproductive senescence and the evolutionary basis of menopause
Thomas B. L. Kirkwood, Daryl P. Shanley · 2010 · Annals of the New York Academy of Sciences
Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegansaging
Kristen Fortney, Max Kotlyar, Igor Jurišica · 2010 · Genome biology
Gene expression changes associated with aging in C. elegans-revision1
Tamara R. Golden · 2007 · WormBook
Topologically associated domains enriched for lineage-specific genes reveal expression-dependent nuclear topologies during myogenesis
Daniel S. Neems, Arturo G. Garza-Gongora, Erica D. Smith, Steven T. Kosak · 2016 · Proceedings of the National Academy of Sciences
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Bronwen Martin, Michele Pearson, Randall Brenneman, Erin Golden, Alex Keselman, Titilola Iyun, Olga D. Carlson, Josephine Mary Egan, Kevin G. Becker, William H. Wood et al. · 2008 · PLoS ONE
How does evolution tune biological noise?
Magali Richard, Gaël Yvert · 2014 · Frontiers in Genetics
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Yong Chen Lu, Angélique Biancotto, Foo Cheung, Elaine F. Remmers, Naisha Shah, John Philip McCoy, John S. Tsang · 2016 · Immunity
The central role of chromatin maintenance in aging
Gianluca Pegoraro, Tom Misteli · 2009 · Aging