Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

Krivtsov, Andrei V., Twomey, David, Feng, Zhaohui, Stubbs, Matthew C., Wang, Yingzi, Faber, Joerg, Levine, Jason E., Wang, Jing, Hahn, William C., Gilliland, D. Gary, Golub, Todd R., Armstrong, Scott A.·2006·Nature
DOI 10.1038/nature04980

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    Xi Jiang, Chao Hu, Stephen Arnovitz, Jason Bugno, Miao Yu, Zhixiang Zuo, Ping Chen, Hao Huang, Bryan C. Ulrich, Sandeep K. Gurbuxani et al. · 2016 · Nature Communications
  2. c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis
    T. Shimizu, T. Ishikawa, E. Sugihara, S. Kuninaka, T. Miyamoto, Y. Mabuchi, Y. Matsuzaki, T. Tsunoda, F. Miya, H. Morioka et al. · 2010 · Oncogene
  3. Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development
    Rui Lu, Ping Wang, Trevor Parton, Yang Zhou, Kaliopi Chrysovergis, Shira Rockowitz, Wei‐Yi Chen, Omar Ibrahim Abdel-Wahab, Paul A. Wade, Deyou Zheng et al. · 2016 · Cancer Cell
  4. Arsenic Exposure Transforms Human Epithelial Stem/Progenitor Cells into a Cancer Stem-like Phenotype
    Erik J. Tokar, Bhalchandra A. Diwan, Michael P. Waalkes · 2009 · Environmental Health Perspectives
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  6. Notch Signaling Specifies Megakaryocyte Development from Hematopoietic Stem Cells
    T. Mercher, Melanie Cornejo, C. Sears, T. Kindler, Sandra A. Moore, I. Maillard, W. Pear, J. Aster, D. Gilliland · 2008 · Cell Stem Cell
  7. MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment
    V. Calvanese, Andrew T. Nguyen, Timothy J. Bolan, A. Vavilina, Trent Su, Lydia K. Lee, Yanling Wang, Fides D. Lay, M. Magnusson, G. Crooks et al. · 2019 · Nature
  8. The Difficulty of Targeting Cancer Stem Cell Niches
    Mark A. LaBarge · 2010 · Clinical Cancer Research
  9. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
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  10. ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease
    Ji-Lu Zhang, Abdulraouf Ramadan, B. Griesenauer, Wei Li, M. Turner, Chen Liu, R. Kapur, H. Hanenberg, B. Blazar, I. Tawara et al. · 2015 · Science Translational Medicine
  11. Right on target: eradicating leukemic stem cells
    Daniela S. Krause, Richard A. Van Etten · 2007 · Trends in Molecular Medicine
  12. Leukemia stem cells in a genetically defined murine model of blast-crisis CML
    Sarah J. Neering, Timothy P. Bushnell, Selçuk Sözer, John M. Ashton, Randall M. Rossi, Pin-Yi Wang, Deborah R. Bell, David Heinrich, Andrea Bottaro, Craig T. Jordan · 2007 · Blood
  13. Cancer stem cells and oncology therapeutics
    Muhammad Al‐Hajj · 2006 · Current Opinion in Oncology
  14. Opportunities for improving the therapeutic ratio for patients with sarcoma
    Jay Steven Wunder, Torsten O. Nielsen, Robert G. Maki, Brian O’Sullivan, Benjamin Aaron Alman · 2007 · The Lancet Oncology
  15. The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis
    Claudia Scholl, Dimple Bansal, Konstanze Döhner, Karina Eiwen, Brian J.P. Huntly, Benjamin H. Lee, Frank G. Rücker, Richard F. Schlenk, Lars Bullinger, Hartmut Döhner et al. · 2007 · Journal of Clinical Investigation
  16. The methyltransferase G9a regulates HoxA9-dependent transcription in AML
    Bernhard Lehnertz, Caroline Pabst, Lieh-Yu Yi, Michelle Miller, Feng Liu, Lin Yi, Regan Zhang, Jana Krošl, Eric Yung, Jeanette Kirschner et al. · 2014 · Genes & Development
  17. Therapeutic Implications of the Cancer Stem Cell Hypothesis
    Maximilian Diehn, Robert W. Cho, Michael F. Clarke · 2009 · Seminars in Radiation Oncology
  18. Genetically distinct leukemic stem cells in human CD34− acute myeloid leukemia are arrested at a hemopoietic precursor-like stage
    Lynn Swun Quek, Georg Otto, Catherine Garnett, Ludovic Lhermitte, Dimitris Karamitros, Bilyana Stoilova, I‐Jun Lau, Jessica B. Doondeea, Batchimeg Usukhbayar, Alison Kennedy et al. · 2016 · The Journal of Experimental Medicine
  19. An elegant miRror: microRNAs in stem cells, developmental timing and cancer
    Rachael A. Nimmo, Frank John Slack · 2009 · Chromosoma
  20. In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling
    Peter Grant Miller, Fátima Al‐Shahrour, Kimberly A. Hartwell, Lisa P. Chu, Marcus Järås, Rishi V. Puram, Alexandre Puissant, Kevin Patrick Callahan, John M. Ashton, Marie Ellen McConkey et al. · 2013 · Cancer Cell
  21. Recent advances in acute myeloid leukemia stem cell biology
    Sarah J. Horton, Brian J.P. Huntly · 2012 · Haematologica
  22. Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis
    Jan‐Henning Klusmann, Frank J. Godinho, Kirsten Heitmann, Aliaksandra Maroz, Mia Lee Koch, Dirk Reinhardt, Stuart H. Orkin, Zhe Li · 2010 · Genes & Development
  23. Dormancy and cancer stem cells: An enigma for cancer therapeutic targeting
    Sarmistha Talukdar, Praveen Bhoopathi, Luni Emdad, Swadesh Kumar Das, Devanand Sarkar, Paul B. Fisher · 2019 · Advances in cancer research
  24. Targeting transcription cycles in cancer
    Stephin J. Vervoort, Jennifer R. Devlin, Nicholas P. Kwiatkowski, Mingxing Teng, Nathanael S. Gray, Ricky W. Johnstone · 2021 · Nature reviews. Cancer
  25. CD99 is a therapeutic target on disease stem cells in myeloid malignancies
    Stephen S. Chung, William S. Eng, Wenhuo Hu, Mona Khalaj, Francine E. Garrett-Bakelman, Montreh Tavakkoli, Ross L. Levine, Martin P Carroll, Virginia M. Klimek, Ari M. Melnick et al. · 2017 · Science Translational Medicine
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    Elif Eroğlu, Thomas Rainer Burkard, Yanrui Jiang, Nidhi Saini, Catarina C. F. Homem, Heinrich Reichert, Juergen A. Knoblich · 2014 · Cell
  27. Epigenetic regulation of aging stem cells
    Pollina, E A, Brunet, A · 2011 · Oncogene
  28. Controversies in Cancer Stem Cells: Targeting Embryonic Signaling Pathways
    Naoko Takebe, S. Percy Ivy · 2010 · Clinical Cancer Research
  29. ETV6-NTRK3 Fusion Oncogene Initiates Breast Cancer from Committed Mammary Progenitors via Activation of AP1 Complex
    Zhe Li, Cristina E. Tognon, Frank J. Godinho, Laura C. Yasaitis, Hanno R. Hock, Jason I. Herschkowitz, Chris L. Lannon, Eunah Cho, Seong‐Jin Kim, Roderick Terry Bronson et al. · 2007 · Cancer Cell
  30. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
    Trowbridge, Jennifer J., Sinha, Amit U., Zhu, Nan, Li, Mingjie, Armstrong, Scott A., Orkin, Stuart H. · 2012 · Genes & Development
  31. Meeting the Challenge of Targeting Cancer Stem Cells
    Alice Turdo, Veronica Veschi, Miriam Gaggianesi, Aurora Chinnici, Paola Bianca, Matilde Todaro, Giorgio Stassi · 2019 · Frontiers in Cell and Developmental Biology
  32. Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner
    Yahya Saleh Al-Matary, Lacramioara Botezatu, Bertram Opalka, Judith Maria Hönes, Robert F. Lams, Aniththa Thivakaran, Judith Schütte, R. Koster, Klaus Lennartz, Thomas A. Schroeder et al. · 2016 · Haematologica
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    Liubin Yang, Benjamin A.T. Rodriguez, Allison Mayle, Hyun Jung Park, Xueqiu Lin, Min Luo, Mira Jeong, Choladda V. Curry, Sang-Bae Kim, David Ruau et al. · 2016 · Cancer Cell
  34. The Cancer Stem Cell Hypothesis: Failures and Pitfalls
    Maryam Rahman, Loic P. Deleyrolle, Vinata Vedam‐Mai, Hassan Azari, Muhammad M. Abd‐El‐Barr, Brent A. Reynolds · 2010 · Neurosurgery
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    Qian‐Fei Wang, George Y. Wu, Shuangli Mi, Fuhong He, Jun Wu, Jingfang Dong, Roger T. Luo, Ryan J. Mattison, Joseph J. Kaberlein, Shyam Prabhakar et al. · 2011 · Blood
  36. Pancreatic Cancer Stem Cells
    Cheong Jun Lee, Joseph S. Dosch, Diane M. Simeone · 2008 · Journal of Clinical Oncology
  37. Tumor Dormancy and Cancer Stem Cells: Two Sides of the Same Coin?
    Sonja Kleffel, Tobias Schatton · 2012 · Advances in experimental medicine and biology
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    Xunlei Kang, Zhigang Lu, Changhao Cui, Mi Deng, Yuqi Fan, Baijun Dong, Xin Han, Fuchun Xie, Jeffrey W Tyner, John E. Coligan et al. · 2015 · Nature Cell Biology
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    Hong Zhang, Meritxell Alberich-Jordà, Giovanni Amabile, Henry He Yang, Philipp Bernhard Staber, Annalisa Di Ruscio, Robert S. Welner, Alexander K. Ebralidze, Junyan Zhang, Elena Levantini et al. · 2013 · Cancer Cell
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    Yusuke Tarumoto, Bin Lu, Tim D.D. Somerville, Yuhan Huang, Joseph P. Milazzo, Xiaoli Wu, Olaf Klingbeil, Osama E. Demerdash, Junwei Shi, Christopher R. Vakoc · 2018 · Molecular Cell
  41. Complexity of cancer stem cells
    E. Sugihara, H. Saya · 2013 · International Journal of Cancer
  42. Functional Crosstalk between Bmi1 and MLL/Hoxa9 Axis in Establishment of Normal Hematopoietic and Leukemic Stem Cells
    Lan‐Lan Smith, Jenny Yeung, Bernd B. Zeisig, Nikolay Popov, Ivo Johan Huijbers, Josephine L. Barnes, Amanda Wilson, Erdogan Taskesen, Ruud Delwel, Jesús Gil et al. · 2011 · Cell stem cell
  43. Hematopoietic developmental pathways: on cellular basis
    Hiromi Iwasaki, Koichi Akashi · 2007 · Oncogene
  44. The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential
    Stephen H.K. Wong, David L. Goode, 正幸 岩崎, Michael C. Wei, Hsu-Ping Kuo, Li Zhu, Dominik Schneidawind, Jesús Duque‐Afonso, Ziming Weng, Michael L. Cleary · 2015 · Cancer Cell
  45. Targeting Breast Cancer Stem Cells
    Suling Liu, Max S. Wicha · 2010 · Journal of Clinical Oncology
  46. Accumulation of a differentiation regulator specifies transit amplifying division number in an adult stem cell lineage
    Megan L. Insco, Arlene Leon, C. Tam, D. Mckearin, M. Fuller · 2009 · Proceedings of the National Academy of Sciences of the United States of America
  47. Clonal hematopoiesis
    Max Jan, Benjamin L. Ebert, Siddhartha Jaiswal · 2016 · Seminars in Hematology
  48. Insights into the stem cells of chronic myeloid leukemia
    I. Sloma, Xiao-Yan Jiang, A. Eaves, C. Eaves · 2010 · Leukemia
  49. Non-genetic determinants of malignant clonal fitness at single-cell resolution
    Katie A. Fennell, Dane Vassiliadis, Enid Y.N. Lam, Luciano Gastón Martelotto, Jesse J. Balic, Sebastian Hollizeck, Tom Weber, Timothy J. Semple, Qing Wang, Denise C. Miles et al. · 2021 · Nature
  50. Estrogen Signaling Selectively Induces Apoptosis of Hematopoietic Progenitors and Myeloid Neoplasms without Harming Steady-State Hematopoiesis
    Abel Sánchez‐Aguilera, Lorena Arranz, Daniel Martín-Pérez, Andrés García‐García, Vaia Stavropoulou, Lucia Kubovčáková, Joan Isern, Sandra Martín-Salamanca, Xavier Langa, Radek C. Skoda et al. · 2014 · Cell stem cell
  51. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts
    Maria Krevvata, Barbara Campolina Carvalho Silva, John Sanil Manavalan, Marta Galán-Díez, Aruna Kode, Brya G. Matthews, David S. Park, Chiyuan Amy Zhang, Naomi Galili, Thomas L. Nickolas et al. · 2014 · Blood
  52. mTORC1 is essential for leukemia propagation but not stem cell self-renewal
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  53. CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice
    Maria Paola Martelli, Valentina Pettirossi, Christian Thiede, E. Bonifacio, Federica Mezzasoma, Debora Cecchini, Roberta Pacini, Alessia Tabarrini, Raffaella Ciurnelli, Ilaria Gionfriddo et al. · 2010 · Blood
  54. (A)Symmetric Stem Cell Replication and Cancer
    David Dingli, Arne Traulsen, Franziska Michor · 2005 · PLoS Computational Biology
  55. MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment
    Matthew C. Stubbs, Yong‐Mi Kim, Andrei V. Krivtsov, Renee D. Wright, Zijie Feng, J Agarwal, Andrew L. Kung, Scott A. Armstrong · 2007 · Leukemia
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  57. Molecular Signatures of Quiescent, Mobilized and Leukemia-Initiating Hematopoietic Stem Cells
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  58. SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia
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  59. Molecular genetic tools shape a roadmap towards a more accurate prognostic prediction and personalized management of cancer
    Dimitrios H Roukos, Samuel J. Murray, Evangelos C. Briasoulis · 2007 · Cancer Biology & Therapy
  60. The vascular niche: home for normal and malignant hematopoietic stem cells
    Phuong L. Doan, John P. Chute · 2011 · Leukemia
  61. Regulation of Lymphoid versus Myeloid Fate 'choice' by the Transcription Factor Mef2c
    Stehling-Sun, Sandra, Dade, Jessica, Nutt, Stephen L, DeKoter, Rodney P, Camargo, Fernando D · 2009 · Nature Immunology
  62. Fasting selectively blocks development of acute lymphoblastic leukemia via leptin-receptor upregulation
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  63. The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia
    J-H Mikesch, Bjoern Steffen, Wolfgang E. Berdel, Hubert L. Serve, Carsten Müller‐Tidow · 2007 · Leukemia
  64. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance
    N. van Gastel, J. Spinelli, A. Sharda, A. Schajnovitz, N. Baryawno, Catherine Rhee, T. Oki, E. Grace, Heather J. Soled, Jelena Milošević et al. · 2020 · Cell Metabolism
  65. Cancer stem cell: Fundamental experimental pathological concepts and updates
    Farhadul Islam, Bin Qiao, Robert Anthony Smith, Vinod Gopalan, Alfred King-yin Lam · 2015 · Experimental and Molecular Pathology
  66. miR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia
    Xi Jiang, Hao Huang, Ze-Juan Li, Chunjiang He, Yuan-Yuan Li, Ping Chen, S. Gurbuxani, S. Arnovitz, Gia-ming Hong, C. Price et al. · 2012 · Proceedings of the National Academy of Sciences of the United States of America
  67. Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond
    Chun-Wei David Chen, Scott A. Armstrong · 2015 · Experimental Hematology
  68. In vitro generation of human cells with cancer stem cell properties
    Paola Scaffidi, Tom Misteli · 2011 · Nature Cell Biology
  69. Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents
    I. Cowell, C. Austin · 2012 · International Journal of Environmental Research and Public Health
  70. The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;NrasG12D acute myeloid leukemia
    Junwei Shi, Eric Wang, Johannes A. Zuber, Amy Rappaport, Meredith J. Taylor, Christopher Johns, Scott W. Lowe, Christopher R. Vakoc · 2012 · Oncogene
  71. Targeting breast cancer stem cells
    Sean McDermott, Max S. Wicha · 2010 · Molecular Oncology
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    Dulguun Amgalan, Thomas P. Garner, Ryan Pekson, Xiaotong F. Jia, Mounica Yanamandala, Victor M. Paulino, Felix G. Liang, J. Jose Corbalan, Jaehoon Lee, Yun Chen et al. · 2020 · Nature Cancer
  73. Stem and progenitor cell alterations in myelodysplastic syndromes
    Aditi Shastri, Britta Will, Ulrich G. Steidl, Amit K. Verma · 2017 · Blood
  74. Therapeutic targeting of MLL.
    M. Liedtke, M. Cleary · 2009 · Blood
  75. Comment on "Tumor Growth Need Not Be Driven by Rare Cancer Stem Cells"
    James Andrew Kennedy, Frédéric Barabé, Armando G. Poeppl, Jean C. Y. Wang, John Edgar Dick · 2007 · Science
  76. Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review
    Kevin Dzobo, Dimakatso Alice Senthebane, Chelene Ganz, Nicholas Ekow Thomford, Ambroise Wonkam, Collet Dandara · 2020 · Cells
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    Jeffrey W. Schindler, Denille Van Buren, Adlen Foudi, Ondrej Krejci, Jinzhong Qin, Stuart H. Orkin, Hanno R. Hock · 2009 · Cell stem cell
  78. MLL fusions: Pathways to leukemia
    Han Liu, Emily H. Cheng, James J. Hsieh · 2009 · Cancer Biology & Therapy
  79. Inactivation of the Polycomb Group Protein Ring1B Unveils an Antiproliferative Role in Hematopoietic Cell Expansion and Cooperation with Tumorigenesis Associated with Ink4a Deletion
    Carmela Calés, Mónica Román-Trufero, Leticia Pavón, Iván Serrano, Teresa Melgar, Mitsuhiro Endoh, Claudia Pérez‐Martínez, Haruhiko Koseki, Miguel Vidal · 2007 · Molecular and Cellular Biology
  80. RB1 and p53 at the crossroad of EMT and triple-negative breast cancer
    Zhe Jiang, Robert A Jones, Jeffrey C. Liu, T. Deng, Tyler Robinson, Philip E. D. Chung, Sharon Wang, Jason I. Herschkowitz, S. Egan, C. Perou et al. · 2011 · Cell Cycle
  81. Role of symmetric and asymmetric division of stem cells in developing drug resistance
    C. Tomasetti, D. Levy · 2010 · Proceedings of the National Academy of Sciences of the United States of America
  82. Hematopoietic differentiation is required for initiation of acute myeloid leukemia
    M. Ye, Hong Zhang, Henry Yang, R. Koche, P. Staber, M. Cusan, E. Levantini, R. Welner, C. Bach, Jun-Yan Zhang et al. · 2015 · Cell Stem Cell
  83. ABC transporter expression in hematopoietic stem cells and the role in AML drug resistance
    Susan D.P.W.M. de Jonge-Peeters, Folkert Kuipers, Elisabeth G.E. de Vries, Edo Vellenga · 2007 · Critical Reviews in Oncology/Hematology
  84. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers
    Rushdia Zareen Yusuf, Borja Sáez, Azeem Sharda, Nick van Gastel, Vionnie W.C. Yu, Ninib Baryawno, Elizabeth W. Scadden, Sanket S. Acharya, Shrikanta Chattophadhyay, Cherrie Huang et al. · 2020 · Blood
  85. TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
    Yangchan Li, Meilin Xue, Xiaolan Deng, Lei Dong, Le Xuan Truong Nguyen, Lili Ren, Li Han, Chenying Li, Jianhuang Xue, Zhicong Zhao et al. · 2023 · Cell stem cell
  86. Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia
    Basit Salik, Hangyu Yi, Nunki Hassan, Nancy T. Santiappillai, Binje Vick, Patrick Connerty, Alastair M. P. Duly, Toby N. Trahair, Andrew J. Woo, Dominik Beck et al. · 2020 · Cancer Cell
  87. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells
    Kimberly A. Hartwell, Peter Grant Miller, Siddhartha Mukherjee, Alissa R. Kahn, Alison L. Stewart, David J. Logan, Joseph M. Negri, Mildred Duvet, Marcus Järås, Rishi V. Puram et al. · 2013 · Nature Chemical Biology
  88. Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms
    Edwin Chen, Rebekka K. Schneider, Lawrence J. Breyfogle, Emily A. Rosen, Luke Poveromo, Shannon Elf, Amy Ko, Kristina M. Brumme, Ross L. Levine, Benjamin L. Ebert et al. · 2014 · Blood
  89. Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells
    Amit J. Sabnis, Laurene S. Cheung, Monique Dail, Hio Chung Kang, Marianne A Santaguida, Michelle Lynn Hermiston, Emmanuelle A. Passegue, Kevin Shannon, Benjamin S. Braun · 2009 · PLoS Biology
  90. Stem cells in cancer initiation and progression
    Jeevisha Bajaj, Emily Diaz, Tannishtha Reya · 2019 · The Journal of Cell Biology
  91. Function of oncogenes in cancer development: a changing paradigm
    Carolina Vicente‐Dueñas, Isabel Romero-Camarero, César Cobaleda, Isidro Sánchez-Garcı́a · 2013 · The EMBO Journal
  92. Pitavastatin-induced angiogenesis and arteriogenesis is mediated by Notch1 in a murine hindlimb ischemia model without induction of VEGF
    R. Kikuchi, Kyosuke Takeshita, Y. Uchida, M. Kondo, Xian W. Cheng, T. Nakayama, Koji Yamamoto, Tadashi Matsushita, James K Liao, T. Murohara · 2011 · Laboratory Investigation
  93. Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex
    Michael Heuser, Haiyang Yun, Tobias Berg, Eric Yung, Bob Argiropoulos, Florian C. Kuchenbauer, Gyeongsin Park, Iyas Hamwi, Lars Palmqvist, Courteney K. Lai et al. · 2011 · Cancer Cell
  94. Harnessing the immune system in acute myeloid leukaemia
    Rebecca J. Austin, Mark John Smyth, Steven Lane · 2016 · Critical Reviews in Oncology/Hematology
  95. The cancer stem cell paradigm: a new understanding of tumor development and treatment
    Johnathan D. Ebben, Daniel M. Treisman, Michael Zorniak, Raman G. Kutty, Paul A. Clark, John S. Kuo · 2010 · Expert Opinion on Therapeutic Targets
  96. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy
    The Duy Nguyen, Shabnam Shaid, Olesya Vakhrusheva, Sebastian E. Koschade, Kevin Klann, Marlyn Thölken, Fatima Baker, Jing Zhang, Thomas Oellerich, Duran Sürün et al. · 2018 · Blood
  97. Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcomes
    Dan Ran, Mario Schubert, Larissa Pietsch, Isabel Taubert, Patrick Wuchter, Volker Eckstein, Thomas M. Bruckner, Margot Zoeller, Anthony Dick Ho · 2009 · Experimental Hematology
  98. Cancer stem cell and cancer stemloids: From biology to therapy
    M. Blagosklonny · 2007 · Cancer Biology & Therapy
  99. MLL–AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny
    Sarah J. Horton, Jenny Jaques, Carolien M. Woolthuis, J van Dijk, Maria Mesuraca, Gerwin A. Huls, Giovanni Morrone, Edo Vellenga, Jan Jacob Schuringa · 2012 · Leukemia
  100. Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells
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