The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Open accessAbstract
Mammalian ageing is associated with reduced regenerative capacity in tissues that contain stem cells. It has been proposed that this is at least partially caused by the senescence of progenitors with age; however, it has not yet been tested whether genes associated with senescence functionally contribute to physiological declines in progenitor activity. Here we show that progenitor proliferation in the subventricular zone and neurogenesis in the olfactory bulb, as well as multipotent progenitor frequency and self-renewal potential, all decline with age in the mouse forebrain. These declines in progenitor frequency and function correlate with increased expression of p16INK4a, which encodes a cyclin-dependent kinase inhibitor linked to senescence. Ageing p16INK4a-deficient mice showed a significantly smaller decline in subventricular zone proliferation, olfactory bulb neurogenesis, and the frequency and self-renewal potential of multipotent progenitors. p16INK4a deficiency did not detectably affect progenitor function in the dentate gyrus or enteric nervous system, indicating regional differences in the response of neural progenitors to increased p16INK4a expression during ageing. Declining subventricular zone progenitor function and olfactory bulb neurogenesis during ageing are thus caused partly by increasing p16INK4a expression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The NPC defect that we discovered is partly regulated by Cdkn2a, a central component of aging responsible for decreased neurogenesis and differentiation of NPCs (Abdouh et al., 2012; Molofsky et al., 2006).”
From Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model (2022) · cites this paper as Molofsky et al., 2006
Experimental — accuracy not yet measuredIn the citing paper
“Age-dependent reduction in stem cell number or perturbed cell-cycle activity has been reported in skeletal muscle stem cells, neural stem cells and germline stem cells110, 120–122.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [121]
In the citing paper
“other tumor suppressors (e.g., p16Ink4a) which appear to suppress cancer at the cost of tissue resident stem cells and therefore may contribute to decreased regenerative potential during the aging process (Krishnamurthy et al., 2006; Molofsky et al., 2006).”
From FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis (2009) · cites this paper as Molofsky et al., 2006
In the citing paper
“Because several studies have established a role for the polycomb group protein Bmi1 in the regulation of p16Ink4a (26–28), we analyzed the levels of Bmi1.”
From Age-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in Mice (2009) · cites this paper as [28]
In the citing paper
“age-induced expression of p16INK4a in adult stem cells seems to be associated with widespread impairment in tissue regeneration 23, 24, 25”
From The common biology of cancer and ageing (2007) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160
Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
Johansson, C. B., Momma, S., Clarke, D. L., Risling, M., Lendahl, U., & Frisén, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80956-3 · Cited by 1,875
Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486
Self-citationBmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
Molofsky, A. V., Pardal, R., Iwashita, T., Park, I.-K., Clarke, M. F., & Morrison, S. J. (2003) · Nature · doi:10.1038/nature02060 · Cited by 1,317
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 801–900 of 970
Regulation of Life Span in Adult Stem Cells
Davy, P. M. C., & Allsopp, R. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-002-7_9 · Cited by 2
Senolytics Target Senescent Cells and Improve Aging and Age-Related Diseases
Buffard, T., & Ferbeyre, G. (2020) · Healthy ageing and longevity · doi:10.1007/978-3-030-44903-2_4 · Cited by 2
Cellular Reprogramming and Aging
Pereira, S. N., & de Jesus, B. B. (2020) · Learning materials in biosciences · doi:10.1007/978-3-030-43939-2_5 · Cited by 2
Senescence in Aging, Within the Brain and Other Diseases: Mechanisms and Interventions
Chakrabarti, S. K., & Chattopadhyay, D. (2023) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2023.00018 · Cited by 1
Gutierrez, L. G., & Ju, Z. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_8 · Cited by 2
Modifiers of Neural Stem Cells and Aging: Pulling the Trigger of a Neurogenic Decline
Nivet, E. (2016) · Current Stem Cell Reports · doi:10.1007/s40778-016-0047-3 · Cited by 2
Interferon regulates stem cell function at all ages by orchestrating mTOR and cell cyclePreprint
Ibañez, D. C., Skabkin, M. A., Hooli, J., Cerrizuela, S., Göpferich, M., Jolly, A., Zumwinkel, M., Bertolini, M., Höfer, T., Kramer, G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.03.478954 · Cited by 2
“Although the prevalence of senescent cells increases with age in the neurogenic niches in the brain (Fernández-Fernández et al, 2012; Molofsky et al, 2006; Ogrodnik et al, 2019; Jin et al, 2021), how NSCs are protected from senescence remains unknown.”
BackgroundCellular Senescence and Stem Cell Exhaustion: Implications for Aging and Regeneration
Kumar, N., & Walia, H. K. (2025) · Cellular Senescence, Age-Related Disorders, and Emerging Treatments · doi:10.1007/978-981-96-1041-9_6 · Cited by 1
The Role of Sirtuins in Cellular Senescence and the Development of Age-Associated Diseases
Markelov, V. A., Akhmadishina, L. Z., Кочетова, О. В., Эрдман, В. В., & Korytina, G. F. (2025) · Russian Journal of Genetics · doi:10.1134/s1022795425700152 · Cited by 1
“This suggestion is supported by the fact that an increase in the cellular senescence marker p16 (CDKN2A) in stem cells of different organs is associated with a decrease in their regenerative potential [86].”
Balancing senescence and apoptosis: therapeutic insights into aging and cancer
Jan, N., Sofi, S., Mir, A. A., Masoodi, G., & Mir, M. A. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05355-3 · Cited by 1
“More evidence for this comes from the fact that animals without p16 have a greater capacity for regeneration, while p16 expression is linked to tissue deterioration [119].”
Multivalent cannabinoid epigenotoxicities and multigenerational aging
Reece, A. S., & Hulse, G. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13492-0.00001-3 · Cited by 1
Liu, H., Yin, Z., Chen, X., & Wang, Z. (2025) · Clinical Epigenetics · doi:10.1186/s13148-025-01976-z · Cited by 1
“Studies have demonstrated an increased p16 expression with age in brain progenitor cells [50], a change correlated with a reduced proliferation rate in various mouse brain-derived progenitor cells.”
Coupling of stemness maintenance with cell cycle control in stem cells
Huang, X., Wang, Y., Li, Q., Li, X., & Wang, C. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1693489 · Cited by 1
Kadam, L., Chan, K., Ahuna, K., Marshall, N. E., & Myatt, L. (2026) · The FASEB Journal · doi:10.1096/fj.202503771rr · Cited by 2
Wei, Z., Li, Z., & Quan, N. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1702207 · Cited by 1
“…various stem cell tissues and mouse models, limiting regenerative capacity and suggesting an acceleration of senescent cell accumulation over time (Molofsky et al., 2006; Krishnamurthy et al., 2006; Janzen et al., 2006; Krishnamurthy et al., 2004; Burd et al., 2013; Herbig et al., 2006; Liu et…”
Zhao, X., Feitzinger, R. M., Na, J., Yan, X., Erickson, A., Contrepois, K., Zhou, O. Y., Vallania, F., Ellenberger, M., Kashiwagi, C. M., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeh9771 · Cited by 10
Jung, J., Lee, S., & Kang, K. (2012) · Springer eBooks · doi:10.1007/978-94-007-2993-3_23 · Cited by 1
Induction of Cellular Senescence: Role of Mitogen-Activated Protein Kinase-Interacting Kinase 1
Ziaei, S., & Shimada, N. (2013) · Springer eBooks · doi:10.1007/978-94-007-7726-2_12 · Cited by 1
Lineage Relationships Connecting Germinal Regions to Brain Tumors
Sanai, N., & Álvarez-Buylla, A. (2009) · Springer eBooks · doi:10.1007/978-0-387-89611-3_11 · Cited by 1
“When p16/INK4A is removed, SVZ cells from aging mice seem to retain the proliferative potential observed in younger mice (Molofsky et al. 2006).”
BackgroundThe regulation of signaling in hematopoietic stem cell maintenance
Lee, J. Y. (2012) · Cited by 1
Adult Cardiac Stem Cells: Identity, Location and Potential
Ellison, G. M., Smith, A. J., Waring, C. D., Henning, B. J., Burdina, A. O., Polydorou, J., Vicinanza, C., Lewis, F., Nadal‐Ginard, B., & Torella, D. (2013) · Stem cell biology and regenerative medicine · doi:10.1007/978-1-4614-9569-7_4 · Cited by 1
Cancer, Senescence, and Aging: Translation from Basic Research to Clinics
LLeonart, M. E., Carnero, A., Paciucci, R., Wang, Z., & Shomron, N. (2011) · Journal of Aging Research · doi:10.4061/2011/692301 · Cited by 1
Progeroid syndromes: models for stem cell aging?
Bellantuono, I., Sanguinetti, G., & Keith, W. N. (2011) · Biogerontology · doi:10.1007/s10522-011-9347-2 · Cited by 1
Bmi1 in Self-Renewal and Homeostasis of Pancreas
Sangiorgi, E., & Capecchi, M. R. (2010) · Stem cell biology and regenerative medicine · doi:10.1007/978-1-60761-860-7_3 · Cited by 1
“Overexpression of Ink4a/Arf locus in vivo in different organs is responsible for early aging, indicating that most of the phenotypic effects in Bmi1 KO mice are probably mediated through the activation of the 50 E. Sangiorgi and M. Capecchi Ink4a/Arf locus [25, 26 ].”
BackgroundSlow-Cycling Cancer Cells: A Dissertation
Moore, N. F. (2012) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/0rvq-7r49 · Cited by 1
Establishing the microcrustacean Daphnia as a model system for research on aging
Schumpert, C. A. (2015) · Scholar Commons (University of South Carolina) · Cited by 1
Ávila, J. (2011) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000102e · Cited by 1
“Indeed, evidence suggests that a loss of neuronal precursors may underlie the decline in neurogenesis [5] and the loss of cognitive functions [6] associated with aging.”
BackgroundCellular Senescence and Senescent Cell*
Wang, P., Chen, L.-P., Li, Q., Tang, Q., Shen, Y., & Zhu, J. (2012) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2012.00013 · Cited by 1
Neurogenesis in the Adult Subventricular Zone and Olfactory Bulb
Kempermann, G. (2010) · Oxford University Press eBooks · doi:10.1093/med/9780199729692.003.0005 · Cited by 1
Co-transplantation Strategies and Combination Therapies for Stroke
Popa‐Wagner, A., Sandu, R. E., & Ciobanu, O. (2016) · Springer eBooks · doi:10.1007/978-981-10-2929-5_8 · Cited by 1
Modeling Aging and Age-Associated Pathology in Zebrafish
houcke, J. V., Bollaerts, I., Groef, L. D., & Moons, L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00025-7 · Cited by 1
Progenitor Cells from the Adult Heart
Ellison, G. M., & Lewis, F. (2017) · Cardiac and vascular biology · doi:10.1007/978-3-319-56106-6_2 · Cited by 1
Aging and Malignant Hemopathies: A Complex Multistep Process
Chi, V. L. D., Sibille, C., Willard-Gallo, K. E., & Bron, D. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_142-1 · Cited by 1
Tu, S. (2010) · Cancer treatment and research · doi:10.1007/978-1-4419-5968-3_6 · Cited by 1
Soriano‐Tárraga, C., Jiménez-Conde, J., & Roquer, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-31143-2_123-1 · Cited by 1
Aging and Malignant Hemopathies: A Complex Multistep Process
Chi, V. L. D., Sibille, C., Willard-Gallo, K. E., & Bron, D. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_142 · Cited by 1
Kempermann, G. (2010) · Oxford University Press eBooks · doi:10.1093/med/9780199729692.003.0009 · Cited by 1
Zhu, P., & Peek, C. B. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839167553-00505 · Cited by 1
Role of telomere binding protein TRF2 in neural differentiation of human embryonic stem cells
Ovando-Roche, P. (2013) · doi:10.25560/24848 · Cited by 1
Herrera-Merchan, A., Hidalgo, I., Arranz, L., & González, S. (2012) · InTech eBooks · doi:10.5772/32121 · Cited by 1
“The self-renewal function of Bmi1 in adult stem cells relies largely on the silencing of one of its targets, the locus encoding the p16INK4a and ARF tumor suppressors (Molofsky et al., 2006).”
BackgroundResultHeterotopic bone formation derived from multipotent stromal cells is not inhibited in aged mice
Carbonneau, C. L., Despars, G., Moquin‐Beaudry, G., Benabdallah, B., Bouhanik, S., Dépôt, J., Moreau, A., & Beausejour, C. M. (2014) · Cytotherapy · doi:10.1016/j.jcyt.2014.03.004 · Cited by 1
Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer
Huang, X., & Ju, Z. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-879-9_6 · Cited by 1
“decline in the regenerative capacity of different stem cell compartments including HSCs (88), neural stem cells ( 89 ), and pancreatic stem cells (90).”
BackgroundFunctional properties of progenitor-like cells in the spinal cord
Russo, R. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102807-0.00010-7 · Cited by 1
Alternative stromal cell-based therapies for aging and regeneration
Deka, D., Das, A., Bhatiya, M., Pathak, S., & Banerjee, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00011-6 · Cited by 2
A Review on the Role of Stem Cells against SARS-CoV-2 in Children and Pregnant Women
Sanie‐Jahromi, F., NejatyJahromy, Y., & Jahromi, R. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111787 · Cited by 1
Charruyer, A., & Ghadially, R. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_19 · Cited by 1
Neurogenesis in the damaged mammalian brain
Nakafuku, M., & Grande, A. W. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00023-0 · Cited by 1
The Role of Stem Cell Genomic Instability in Aging
Sieben, C. J., Childs, B. G., & Baker, D. J. (2015) · Current Stem Cell Reports · doi:10.1007/s40778-015-0020-6 · Cited by 1
The role of polyhomeotic in polycomb group-mediatedregulation of the tumour suppressor P16INK4A
de Breed, L. A. (2010) · UCL Discovery (University College London) · Cited by 1
Ohm, J. E., & Baylin, S. B. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-227-8_19 · Cited by 1
“[56–61], GATA transcription factors that regulate differentiation [62], morphogenesis control genes such as CDH1, and anti-apoptotic genes such as DAP-kinase [15] suggests that the underlying epigenetic controls responsible for controlling expression of these genes in normal stem and progenitor cells may provide an ex…”
BackgroundGene expression changes in normal haematopoietic cells
Lionberger, J. M., & Stirewalt, D. L. (2009) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2009.05.005 · Cited by 1
Wang, J. (2011) · OPen Access Repositorium der Universität Ulm (OPARU) (Ulm University) · doi:10.18725/oparu-1953 · Cited by 1
“Of note, tumor suppressor checkpoints can also limit the regenerative capacity of tissues during aging, e.g. p53, p16, p21 (Signer et al. 2008, Janzen et al. 2006, Liu et al. 2011, Molofsky et al. 2006, Nishino et al. 2008, Choudhury et al. 2007, Sharpless and DePinho 2007).”
BackgroundEmran, S. (2015) · UCL Discovery (University College London) · Cited by 1
Senescence Induced by Repression of Human Papillomavirus Oncogenes in Cervical Cancer Cells
DiMaio, D., Johung, K. L., Goodwin, E. C., Horner, S. M., & Yates, K. E. (2008) · CRC Press eBooks · doi:10.3109/9781420020502-14 · Cited by 1
Molecular Mechanisms Underlying Cardiometabolic Disease in Aging
Fanjul, V. (2019) · doi:10.4321/repisalud.8343 · Cited by 1
Cellular Senescence and Its Effects on Carcinogenesis
Campisi, J. (2008) · CRC Press eBooks · doi:10.3109/9781420020502-12 · Cited by 1
Wang, H. H., Bian, Y., Yu, S., Su, T., Wang, H., Xu, Y., & Pi, J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00070-1 · Cited by 1
Burrow, K. L. (2014) · Research Explorer (The University of Manchester) · Cited by 1
Ink4a Locus: Beyond Cell Cycle
Enders, G. H. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0711-0_10
p16INK4a and Stem Cell Ageing: A Telomere-Independent Process?
Sharpless, N. E. (2007) · Springer eBooks · doi:10.1007/978-3-540-73709-4_9
Self-citationDNMT3b's Role in Hematopoietic Stem Cells
Boyer, M. J. (2010) · D-Scholarship@Pitt (University of Pittsburgh)
Stem Cell Chromatin Patterns and DNA Hypermethylation
Ohm, J. E., & Baylin, S. B. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-933-8_7
Dietary Restriction: A Model System Probing the Cell Fate Decision Between Cancer and Senescence
Ertl, R. P., & Harrison, D. E. (2008) · Springer eBooks · doi:10.1007/978-0-387-69132-9_6
p16INK4A – Connecting Cell Cycle Control to Cell Death Regulation in Human Leukemia
Obexer, P., Hagenbuchner, J., & Michael, J. (2011) · InTech eBooks · doi:10.5772/25284
Hypoxia-inducible regulatory networks and their roles in aging in C. elegans
Zhang, Y. (2009) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-2696
“It has been suggested that senescence-associated suppression of stem-cell proliferation and tissue regeneration may be a major cause of aging (JANZEN et al. 2006; KRISHNAMURTHY et al. 2006; MOLOFSKY et al. 2006).”
BackgroundMechanism of Functional Alterations in Hematopoietic Stem Cell Aging
Morita, Y. (2014) · Else Kröner-Fresenius Symposia · doi:10.1159/000366570 · Cited by 1
Participación de p19INK4d en la inducción de senescencia genotóxica y replicativa
Sonzogni, S. V. (2012) · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
Spermatogonial stem cell (SSCs) system
Gallicano, G. I., & Chen, S. (2013) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.201200002
Chromatin Structure in Cell Differentiation, Aging and Cancer
Kia, S. K. (2009)
Neural stem cell characteristics affected by oncogenic pathways and in a human motoneuron disease
Kerosuo, L. (2009) · Työväentutkimus Vuosikirja
Information reuse in comparative genomics
Szklarczyk, R. (2007) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
Hematopoietic Stem Cell Aging and Fate Decision
Illing, A., & Ju, Z. (2010) · Else Kröner-Fresenius Symposia · doi:10.1159/000312645
The Role of Neuroinflammation in Regulating the Age-Related Decline in Neurogenesis
Bachstetter, A. D. (2009) · Digital Commons - University of South Florida (University of South Florida)
Ageing and the Immune Response in the CNS
Raj, D. D. A., Eggen, B. J. L., & Boddeke, H. W. G. M. (2014) · Wiley eBooks · doi:10.1002/9781118406557.ch4
Telomere Dysfunction and Senescence in Stem Cell and Tissues Aging
Nalapareddy, K., & Rudolph, K. L. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1075-2_9
“In contrast, studies on p16 specific knockout have revealed experimental evidence that upregulation of p16 limits the function of adult stem cells and organ regeneration in different tissue compartments of aging Terc+/+ mice with long telomere reserves (Janzen et al. 2006; Krishnamurthy et al. 2006; Molofsky et al. 20…”
BackgroundChromatin in Senescent Cells: A Conduit for the Anti-Aging Effects of Wnt Signaling?
Gowrishankar, B., & Adams, P. D. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0639-7_6
Charruyer, A., & Ghadially, R. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_19
Balancing self-renewal and ageing
Kritikou, E. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2036
Basics of Stem and Progenitor Cells
Harting, M. T. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-965-9_1
“In certain systems, such as the central nervous and hematopoietic systems, deletion of a cell senescence gene, p16, increases proliferation and prolongs the life of stem cells (Molofsky et al. 2006; Pan et al. 2007), confirming that intrinsic molecular and cellular changes can have significant impact on stem/progenito…”
BackgroundInvestigating the role of Bmi-1 in liver growth and function
Elder, A. K. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)
Contributions of Tumor Suppressors to the Epigenetic Regulation of Aging Cells
Bose, P., Ganapathy, A., & Riabowol, K. T. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0639-7_13
Discovery of Molecule Important in Stem Cell Aging and Cancer
Komaroff, A. L. (2006) · Journal watch · doi:10.1056/jw200610100000004
Therapeutic Polycomb Targeting in Human Cancer
Arranz, L., Herrera-Merchan, A., & González, S. (2012) · Recent Patents on Regenerative Medicine · doi:10.2174/2210296511202010022
“Deletion of p16INK4a and/or ARF partially rescues the self-renewal defects observed in various stem cell populations from Bmi1-null mice [45-47].”
BackgroundEffect of Caloric Restriction on Stem Cells for the Repair of Aged Heart
Saba, M. (2012) · HEC National Digital Library
Sorrentino, J. A. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/jsmf-v470
Aging, Nutrients, and Endogenous Stem Cell Populations
Zuba‐Surma, E. K., Elias, H. K., & Dawn, B. (2013) · CRC Press eBooks · doi:10.1201/b14663-12
Characterization of neural progenitor/stem cells derived from human embryonic stem cells
Noisa, P. (2010) · Spiral (Imperial College London) · doi:10.25560/5712
Senescence Regulation in Cancer Therapy
Rebbaa, A. (2008) · CRC Press eBooks · doi:10.3109/9781420020502-16
Neurobiology of Postischemic Recuperation in the Aged Mammalian Brain
Popa‐Wagner, A., Balseanu, A., Zăgrean, L., Shah, I. M., Napoli, M. D., Ahlenius, H., & Kokaia, Z. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195326697.003.0017
Control of stress signaling in stem cells: crossroads of stem cells and cancer
Cho, S.-J., Koo, J., Chun, K., & Cha, H. (2016) · Tumor Biology · doi:10.1007/s13277-016-5249-x
“been found to be involved in defective stemness as well as stem cell aging [34, 35, 74, 75].”
Campisi, J. (2008) · Elsevier eBooks · doi:10.1016/b978-141603703-3.10016-0 · Cited by 1
A Telomere-Independent Process?
Sharpless, N. E. (2008)
Self-citationRegulation of the G1-S transition by cyclin-dependent kinase inhibitors
Ramsey, M. R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/sfvt-t742
Tai, L., Huang, C.-J., Choo, K., Wong, C., Cheong, S. K., & Abidin, T. T. Z. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.02.282
Stem Cell Applications in Rejuvenation
Almadori, A., & Kalaskar, D. M. (2017) · Stem cells in clinical applications · doi:10.1007/978-3-319-55687-1_13
of GATA3 and Restrains Mammary Luminal Progenitor Cell Proliferation and Tumorigenesis
Pei, X., Bai, F., Smith, M. D., Usary, J., Fan, H., Pai, S., Ho, I., Perou, C. M., & Xiong, Y. (2009)
Faiz, M., & Morshead, C. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804036-2.00005-4
Study of T Cell Immunosenescence in Various Tissue Compartments
Miron, M., Thome, J. J. C., Gordon, C. L., & Färber, D. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_79-1
O'Sullivan, E. D., & Ferenbach, D. A. (2019) · Oxford University Press eBooks · doi:10.1093/med/9780190611620.003.0005
Metadata
- Authors
- Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Morrison, Sean J.
- ORCID
- Venue
- Nature
- Published
- 2006-09
- Volume
- 443
- Issue
- 7110
- Pages
- 448-452
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2586960
- OpenAlex
- W2065564965
- Cited by
- 972
- References
- 30
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 18 · 2023: 23 · 2022: 43 · 2021: 37 · 2020: 39 · 2019: 47 · 2018: 47 · 2017: 55 · 2016: 41 · 2015: 48 · 2014: 53 · 2013: 60 · 2012: 54
- FWCI
- 23.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Ellison Medical Foundation
- Sidney Kimmel Foundation for Cancer Research
- Sidney Kimmel Foundation
- National Institutes of Health
- National Institute on Aging (R01AG024945)
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- p16INK4a, cellular senescence, aging, neurogenesis, subventricular zone, olfactory bulb, multipotent progenitors, stem cell self-renewal, tumour suppressor, cyclin-dependent kinase inhibitors, type 2 diabetes, pancreatic islet regeneration
- MeSH terms
- Aging, Animals, Neurons, Olfactory Bulb, Regeneration, Stem Cells, Prosencephalon, Cyclin-Dependent Kinase Inhibitor p16, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
