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Cryo-EM Structures Reveal Relocalization of MetAP in the Presence of Other Protein Biogenesis Factors at the Ribosomal Tunnel Exit

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Global Conformational Changes of Ribosome Observed by Normal Mode Fitting for 3D Cryo-EM Structures

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Dealing with structural variability in molecular replacement and crystallographic refinement through normal-mode analysis

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The intriguing realm of protein biogenesis: Facing the green co-translational protein maturation networks

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Selective ribosome profiling reveals a role for SecB in the co-translational inner membrane protein biogenesis

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Conformation of the signal recognition particle in ribosomal targeting complexes

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Polyproteins in structural biology

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mRNA Targeting Eliminates the Need for the Signal Recognition Particle During Membrane Protein Insertion in Bacteria

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Signal-sequence induced conformational changes in the signal recognition particle

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Timing and specificity of cotranslational nascent protein modification in bacteria

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Access to Ribosomal Protein Rpl25p by the Signal Recognition Particle Is Required for Efficient Cotranslational Translocation

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Ribosome profiling reveals multiple roles of SecA in cotranslational protein export

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Structural basis of signal sequence surveillance and selection by the SRP–FtsY complex

von Loeffelholz, O., Knoops, K., Ariosa, A., Zhang, X., Karuppasamy, M., Huard, K., Schoehn, G., Berger, I., Shan, S., & Schaffitzel, C. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2546 · Cited by 19 · see citing works

Cryo‐electron microscopy of ribosomal complexes in cotranslational folding, targeting, and translocation

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ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts

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Single‐molecule dynamics of the molecular chaperone trigger factor in living cells

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The Principles of Protein Targeting and Transport Across Cell Membranes

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A Distinct Mechanism to Achieve Efficient Signal Recognition Particle (SRP)–SRP Receptor Interaction by the Chloroplast SRP Pathway

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Cotranslational Biogenesis of Membrane Proteins in Bacteria

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Mutagenesis of DsbAss is Crucial for the Signal Recognition Particle Mechanism in Escherichia coli: Insights from Molecular Dynamics Simulations

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A tale of two GTPases in cotranslational protein targeting

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Exploring the interactions between signal sequences and E. coli SRP by two distinct and complementary crosslinking methods

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Fingerloop activates cargo delivery and unloading during cotranslational protein targeting

Ariosa, A., Duncan, S. S., Saraogi, I., Lü, X., Brown, A., Phillips, G. J., & Shan, S. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-06-0434 · Cited by 13 · see citing works

Reprint of “Generation of ribosome nascent chain complexes for structural and functional studies” [J. Struct. Biol. 158 (2007) 463–471]☆

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How Quality Control Systems AID Sec-Dependent Protein Translocation

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Chapter 24 Measuring Cotranslational Folding of Nascent Polypeptide Chains on Ribosomes

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Concerted Complex Assembly and GTPase Activation in the Chloroplast Signal Recognition Particle

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Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest

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Domain Organization in the 54-kDa Subunit of the Chloroplast Signal Recognition Particle

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Exit Biology: Battle for the Nascent Chain

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Mapping Protein–Protein Interactions at Birth: Single-Particle Cryo-EM Analysis of a Ribosome–Nascent Globin Complex

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Mechanistic Insights into Protein Biogenesis and Maturation on the Ribosome

Lentzsch, A. M., Lee, J. H., & Shan, S. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169056 · Cited by 5 · see citing works

Stability and structure of the membrane protein transporter Ffh is modulated by substrates and lipids

Reinau, M. E., & Otzen, D. E. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.09.018 · Cited by 5 · see citing works

2IY3: Structure of the E. Coli Signal Regognition Particle

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Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon

Jomaa, A., Boehringer, D., Leibundgut, M., & Ban, N. (2016) · Nature Communications · doi:10.1038/ncomms10471 · Cited by 115 · see citing works

Signal recognition particle binds to translating ribosomes before emergence of a signal anchor sequence

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Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor

Estrozi, L. F., Boehringer, D., Shan, S., Ban, N., & Schaffitzel, C. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1952 · Cited by 74 · see citing works

Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome.

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