Protein translocation across the inner membrane of Gram-negative bacteria: the Sec and Tat dependent protein transport pathways.

The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

Nissen, P., Hansen, J., Ban, N., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.920 · Cited by 2,269 · see citing works

The complete general secretory pathway in gram-negative bacteria

Pugsley, A. P. (1993) · Microbiological Reviews · doi:10.1128/mr.57.1.50-108.1993 · Cited by 1,761 · see citing works

X-ray structure of a protein-conducting channel

van den Berg, B., Clemons, W., Collinson, I. R., Modis, Y., Hartmann, E., Harrison, S. C., & Rapoport, T. A. (2003) · Nature · doi:10.1038/nature02218 · Cited by 1,236 · see citing works

The signal peptide

von HEIJNE, G. (1990) · The Journal of Membrane Biology · doi:10.1007/bf01868635 · Cited by 1,140 · see citing works

Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.

Rapoport, T. A. (2007) · Nature · doi:10.1038/nature06384 · Cited by 977 · see citing works

A common export pathway for proteins binding complex redox cofactors?

Berks, B. C. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.00114.x · Cited by 669 · see citing works

Protein Translocation Across the Bacterial Cytoplasmic Membrane

Driessen, A. J. M., & Nouwen, N. P. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061606.160747 · Cited by 610 · see citing works

The Tat protein export pathway

Berks, B. C., Sargent, F., & Palmer, T. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01719.x · Cited by 578 · see citing works

The binding cascade of SecB to SecA to SecYE mediates preprotein targeting to the E. coli plasma membrane

Hartl, F.-U., Lecker, S., Schiebel, E., Hendrick, J. P., & Wickner, W. (1990) · Cell · doi:10.1016/0092-8674(90)90160-g · Cited by 562 · see citing works

The ATPase activity of secA is regulated by acidic phospholipids, secY, and the leader and mature domains of precursor proteins

Lill, R., Dowhan, W., & Wickner, W. (1990) · Cell · doi:10.1016/0092-8674(90)90742-w · Cited by 550 · see citing works

YidC mediates membrane protein insertion in bacteria.

Samuelson, J. C., Chen, M., Jiang, F., Möller, I., Wiedmann, M., Kuhn, A., Phillips, G. J., & Dalbey, R. E. (2000) · Nature · doi:10.1038/35020586 · Cited by 538 · see citing works

Overlapping functions of components of a bacterial Sec‐independent protein export pathway

Sargent, F., Bogsch, E. G., Stanley‐Wall, N. R., Wexler, M., Robinson, C., Berks, B. C., & Palmer, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3640 · Cited by 534 · see citing works

Trigger factor and DnaK cooperate in folding of newly synthesized proteins

Deuerling, E., Schulze‐Specking, A., Tomoyasu, T., Mogk, A., & Bukau, B. (1999) · Nature · doi:10.1038/23301 · Cited by 502 · see citing works

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

Krämer, G., Boehringer, D., Ban, N., & Bukau, B. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1614 · Cited by 478 · see citing works

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

Bernstein, H. D., Poritz, M. A., Strub, K., Hoben, P. J., Brenner, S., & Walter, P. (1989) · Nature · doi:10.1038/340482a0 · Cited by 470 · see citing works

Structure of a complex of the ATPase SecA and the protein-translocation channel.

Zimmer, J., Nam, Y., & Rapoport, T. A. (2008) · Nature · doi:10.1038/nature07335 · Cited by 459 · see citing works

ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase

Schiebel, E., Driessen, A. J. M., Hartl, F. U., & Wickner, W. T. (1991) · Cell · doi:10.1016/0092-8674(91)90317-r · Cited by 457 · see citing works

Selective Ribosome Profiling Reveals the Cotranslational Chaperone Action of Trigger Factor In Vivo

Oh, E., Becker, A. H., Sandikci, A., Huber, D., Chaba, R., Gloge, F., Nichols, R. J., Typas, A., Gross, C. A., Krämer, G., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.044 · Cited by 445 · see citing works

GENETIC ANALYSIS OF PROTEIN EXPORT IN ESCHERICHIA COLI K12

Benson, S. A., Hall, M. N., & Silhavy, T. J. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.000533 · Cited by 428 · see citing works

Polypeptide Flux through Bacterial Hsp70

Teter, S. A., Houry, W. A., Ang, D., Tradler, T., Rockabrand, D., Fischer, G., Blum, P., Georgopoulos, C., & Hartl, F. U. (1999) · Cell · doi:10.1016/s0092-8674(00)80787-4 · Cited by 424 · see citing works

Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins

Ferbitz, L., Maier, T., Patzelt, H., Bukau, B., Deuerling, E., & Ban, N. (2004) · Nature · doi:10.1038/nature02899 · Cited by 419 · see citing works

Structure of the signal recognition particle interacting with the elongation-arrested ribosome

Halić, M., Becker, T. A., Pool, M., Spahn, C. M. T., Grassucci, R. A., Frank, J., & Beckmann, R. (2004) · Nature · doi:10.1038/nature02342 · Cited by 418 · see citing works

Crystal Structure of the Ribonucleoprotein Core of the Signal Recognition Particle

Batey, R., Rambo, R. P., Lucast, L. J., Rha, B., & Doudna, J. A. (2000) · Science · doi:10.1126/science.287.5456.1232 · Cited by 384 · see citing works

DnaK Functions as a Central Hub in the E. coli Chaperone Network

Calloni, G., Chen, T., Schermann, S. M., Chang, H.-C., Genevaux, P., Agostini, F., Tartaglia, G. G., Hayer-Hartl, M. K., & Hartl, F. U. (2012) · Cell Reports · doi:10.1016/j.celrep.2011.12.007 · Cited by 384 · see citing works

A novel Sec‐independent periplasmic protein translocation pathway in Escherichia coli

Santini, C., Ize, B., Chanal, A., Müller, M., Giordano, G., & Wu, L. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.101 · Cited by 380 · see citing works

YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase.

Scotti, P. A., Urbanus, M. L., Brunner, J., de Gier, J. L., von Heijne, G., van der Does, C., Driessen, A. J. M., Oudega, B., & Luirink, J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.542 · Cited by 374 · see citing works

Nascent Membrane and Secretory Proteins Differ in FRET-Detected Folding Far inside the Ribosome and in Their Exposure to Ribosomal Proteins

Woolhead, C. A., McCormick, P. J., & Johnson, A. E. (2004) · Cell · doi:10.1016/s0092-8674(04)00169-2 · Cited by 368 · see citing works

Adaptation of protein secretion to extremely high‐salt conditions by extensive use of the twin‐arginine translocation pathway

Rose, R. W., Brüser, T., Kissinger, J. C., & Pohlschröder, M. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03090.x · Cited by 366 · see citing works

L23 protein functions as a chaperone docking site on the ribosome

Krämer, G., Rauch, T., Rist, W., Vorderwülbecke, S., Patzelt, H., Schulze‐Specking, A., Ban, N., Deuerling, E., & Bukau, B. (2002) · Nature · doi:10.1038/nature01047 · Cited by 359 · see citing works

Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex

Beckmann, R., Bubeck, D., Grassucci, R. A., Penczek, P. A., Verschoor, A., Blobel, G., & Frank, J. (1997) · Science · doi:10.1126/science.278.5346.2123 · Cited by 347 · see citing works

Signal Sequence Recognition in Posttranslational Protein Transport across the Yeast ER Membrane

Plath, K., Mothes, W., Wilkinson, B. M., Stirling, C. J., & Rapoport, T. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81738-9 · Cited by 345 · see citing works

Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

Hanein, D., Matlack, K. E. S., Jungnickel, B., Plath, K., Kalies, K., Miller, K. R., Rapoport, T. A., & Akey, C. W. (1996) · Cell · doi:10.1016/s0092-8674(00)81391-4 · Cited by 341 · see citing works

Differential Interactions between a Twin-Arginine Signal Peptide and Its Translocase in Escherichia coli

Alami, M., Lüke, I., Deitermann, S., Eisner, G., Koch, H.-G., Brunner, J., & Müller, M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00398-8 · Cited by 317 · see citing works

The Rieske protein from Paracoccus denitrificans is inserted into the cytoplasmic membrane by the twin‐arginine translocase

Bachmann, J., Bauer, B., Zwicker, K., Ludwig, B., & Anderka, O. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05480.x · Cited by 306 · see citing works

Phylogenetic and structural analyses of the oxa1 family of protein translocases

Yen, M., Harley, K. T., Tseng, Y.-H., & Saier, M. H. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10889.x · Cited by 306 · see citing works

The Twin Arginine Consensus Motif of Tat Signal Peptides Is Involved in Sec-independent Protein Targeting in Escherichia coli

Stanley‐Wall, N. R., Palmer, T., & Berks, B. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11591 · Cited by 305 · see citing works

Folding quality control in the export of proteins by the bacterial twin-arginine translocation pathway

DeLisa, M. P., Tullman, D., & Georgiou, G. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0937838100 · Cited by 305 · see citing works

Cryo-EM structure of the ribosome-SecYE complex in the membrane environment.

Frauenfeld, J., Gumbart, J., Sluis, E. O. V. D., Funes, S., Gartmann, M., Beatrix, B., Mielke, T., Berninghausen, O., Becker, T., Schulten, K., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2026 · Cited by 298 · see citing works

GENETIC ANALYSIS OF PROTEIN EXPORT IN ESCHERICHIA COLI

Schatz, P. J., & Beckwith, J. (1990) · Annual Review of Genetics · doi:10.1146/annurev.ge.24.120190.001243 · Cited by 294 · see citing works

The Escherichia coli SRP and SecB targeting pathways converge at the translocon

Valent, Q. A., Scotti, P. A., High, S., de Gier, J. L., von HEIJNE, G., Lentzen, G., Wintermeyer, W., Oudega, B., & Luirink, J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2504 · Cited by 291 · see citing works

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

Becker, T., Bhushan, S., Jarasch, A., Armache, J., Funes, S., Jossinet, F., Gumbart, J. C., Mielke, T., Berninghausen, O., Schulten, K. J., et al. (2009) · Science · doi:10.1126/science.1178535 · Cited by 291 · see citing works

Sec-independent Protein Translocation in Escherichia coli

Sargent, F., Stanley‐Wall, N. R., Berks, B. C., & Palmer, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36073 · Cited by 290 · see citing works

Substrate twinning activates the signal recognition particle and its receptor

Egea, P. F., Shan, S., Napetschnig, J., Savage, D. F., Walter, P., & Stroud, R. M. (2004) · Nature · doi:10.1038/nature02250 · Cited by 288 · see citing works

Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme

Duong, F., & Wickner, W. T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2756 · Cited by 285 · see citing works

Thylakoid ΔpH-dependent precursor proteins bind to a cpTatC–Hcf106 complex before Tha4-dependent transport

Cline, K., & Mori, H. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105149 · Cited by 285 · see citing works

It takes two to tango: regulation of G proteins by dimerization

Gasper, R., Meyer, S., Gotthardt, K., Sirajuddin, M., & Wittinghofer, A. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2689 · Cited by 282 · see citing works

Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides.

Valent, Q. A., Kendall, D. A., High, S., Kusters, R., Oudega, B., & Luirink, J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00236.x · Cited by 280 · see citing works

Untitled work

de Gier (1998) · doi:10.1093/emboj/18.11.2982 · Cited by 277 · see citing works

The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter

Gohlke, U., Pullan, L., McDevitt, C. A., Porcelli, I., de Leeuw, E., Palmer, T., Saibil, H. R., & Berks, B. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503558102 · Cited by 277 · see citing works

Bacterial protein secretion through the translocase nanomachine

Papanikou, E., Karamanou, S., & Economou, A. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1771 · Cited by 272 · see citing works

TatD Is a Cytoplasmic Protein with DNase Activity

Wexler, M., Sargent, F., Jack, R. L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000800200 · Cited by 271 · see citing works

Translation-Independent Localization of mRNA in E. coli

Nevo‐Dinur, K., Nussbaum‐Shochat, A., Ben‐Yehuda, S., & Amster‐Choder, O. (2011) · Science · doi:10.1126/science.1195691 · Cited by 271 · see citing works

Co-translocation of a Periplasmic Enzyme Complex by a Hitchhiker Mechanism through the Bacterial Tat Pathway

Rodrigue, A., Chanal, A., Beck, K., Müller, M. P., & Wu, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13223 · Cited by 268 · see citing works

TatB and TatC Form a Functional and Structural Unit of the Twin-arginine Translocase from Escherichia coli

Bolhuis, A., Mathers, J. E., Thomas, J. D., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100682200 · Cited by 265 · see citing works

FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit.

Kihara, A., Akiyama, Y., & Ito, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4532 · Cited by 262 · see citing works

Heterodimeric GTPase Core of the SRP Targeting Complex

Focia, P. J., Shepotinovskaya, I. V., Seidler, J. A., & Freymann, D. M. (2004) · Science · doi:10.1126/science.1090827 · Cited by 255 · see citing works

Both Lumenal and Cytosolic Gating of the Aqueous ER Translocon Pore Are Regulated from Inside the Ribosome during Membrane Protein Integration

Liao, S., Lin, J., Do, H., & Johnson, A. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80311-6 · Cited by 255 · see citing works

The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer

Martoglio, B., Hofmann, M. W., Brunner, J., & Dobberstein, B. (1995) · Cell · doi:10.1016/0092-8674(95)90330-5 · Cited by 252 · see citing works

Three-dimensional structure of the bacterial protein-translocation complex SecYEG

Breyton, C., Haase, W., Rapoport, T. A., Kühlbrandt, W., & Collinson, I. R. (2002) · Nature · doi:10.1038/nature00827 · Cited by 250 · see citing works

An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY.

Luirink, J., ten Hagen‐Jongman, C. M., van der Weijden, C. C., Oudega, B., High, S., Dobberstein, B., & Kusters, R. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06511.x · Cited by 249 · see citing works

Structure of the E. coli protein-conducting channel bound to a translating ribosome

Mitra, K., Schaffitzel, C., Shaikh, T. R., Tama, F., Jenni, S., Brooks, C. L., Ban, N., & Frank, J. (2005) · Nature · doi:10.1038/nature04133 · Cited by 246 · see citing works

A twin arginine signal peptide and the pH gradient trigger reversible assembly of the thylakoid ΔpH/Tat translocase

Mori, H., & Cline, K. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202048 · Cited by 239 · see citing works

Protein translocation across the ER membrane

Zimmermann, R., Eyrisch, S., Ahmad, M., & Helms, V. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.06.015 · Cited by 232 · see citing works

Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor

Miller, J. D., Bernstein, H. D., & Walter, P. (1994) · Nature · doi:10.1038/367657a0 · Cited by 222 · see citing works

Structure and function of a membrane component SecDF that enhances protein export

Tsukazaki, T., Mori, H., Echizen, Y., Ishitani, R., Fukai, S., Tanaka, T., Perederina, A., Vassylyev, D. G., Kohno, T., Maturana, A. D., et al. (2011) · Nature · doi:10.1038/nature09980 · Cited by 219 · see citing works

Inversion of the Membrane Topology of SecG Coupled with SecA-Dependent Preprotein Translocation

Nishiyama, K., Suzuki, T., & Tokuda, H. (1996) · Cell · doi:10.1016/s0092-8674(00)81083-1 · Cited by 218 · see citing works

Conformational transition of Sec machinery inferred from bacterial SecYE structures

Tsukazaki, T., Mori, H., Fukai, S., Ishitani, R., Mori, T., Dohmae, N., Perederina, A. A., Sugita, Y., Vassylyev, D. G., Ito, K., et al. (2008) · Nature · doi:10.1038/nature07421 · Cited by 217 · see citing works

Skp, a molecular chaperone of Gram-negative bacteria, is required for the formation of soluble periplasmic intermediates of outer membrane proteins.

Schäfer, U., Beck, K., & Müller, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24567 · Cited by 214 · see citing works

F1F0 ATP synthase subunit c is a substrate of the novel YidC pathway for membrane protein biogenesis

van der Laan, M., Bechtluft, P., Kol, S., Nouwen, N. P., & Driessen, A. J. M. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200402100 · Cited by 213 · see citing works

Following the signal sequence from ribosomal tunnel exit to signal recognition particle

Halić, M., Blau, M., Becker, T. A., Mielke, T., Pool, M., Wild, K., Sinning, I., & Beckmann, R. (2006) · Nature · doi:10.1038/nature05326 · Cited by 208 · see citing works

Role of YidC in folding of polytopic membrane proteins

Nagamori, S., Смирнова, И. Н., & Kaback, H. R. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200402067 · Cited by 207 · see citing works

Coordinating assembly and export of complex bacterial proteins

Jack, R. L., Buchanan, G., Dubini, A., Hatzixanthis, K., Palmer, T., & Sargent, F. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600409 · Cited by 202 · see citing works

SecYEG assembles into a tetramer to form the active protein translocation channel

Manting, E. H., van der Does, C., Remigy, H., Engel, A. H., & Driessen, A. J. M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.852 · Cited by 201 · see citing works

Involvement of stress protein PspA (phage shock protein A) of Escherichia coli in maintenance of the protonmotive force under stress conditions.

Kleerebezem, M., Crielaard, W., & Tommassen, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00344.x · Cited by 198 · see citing works

BIOGENESIS OF INNER MEMBRANE PROTEINS IN ESCHERICHIA COLI

Luirink, J., von HEIJNE, G., Houben, E. N. G., & Gier, J. D. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121246 · Cited by 198 · see citing works

Recognition of a signal peptide by the signal recognition particle

Janda, C. Y., Li, J., Oubridge, C., Hernández, H., Robinson, C. V., & Nagai, K. (2010) · Nature · doi:10.1038/nature08870 · Cited by 197 · see citing works

Characterization of membrane-associated and soluble states of SecA protein from wild-type and SecA51(TS) mutant strains of Escherichia coli.

Cabelli, R. J., Dolan, K. M., Qian, L. P., & Oliver, D. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54245-9 · Cited by 193 · see citing works

Structure of the TatC core of the twin-arginine protein transport system

Rollauer, S. E., Tarry, M. J., Graham, J. E., et al. (2012) · Nature · doi:10.1038/nature11683 · Cited by 191 · see citing works

The molecular chaperone SecB is released from the carboxy‐terminus of SecA during initiation of precursor protein translocation

Fekkes, P., van der Does, C., & Driessen, A. J. M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6105 · Cited by 191 · see citing works

Discrimination between SRP- and SecA/SecB-dependent substrates involves selective recognition of nascent chains by SRP and trigger factor.

Beck, K., Wu, L., Brunner, J., & Müller, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.1.134 · Cited by 189 · see citing works

SnapShot: Key Numbers in Biology

Moran, U., Phillips, R., & Milo, R. (2010) · Cell · doi:10.1016/j.cell.2010.06.019 · Cited by 189 · see citing works

Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging

Leake, M. C., Greene, N. P., Godun, R. M., Granjon, T., Buchanan, G., Chen, S., Berry, R. M., Palmer, T., & Berks, B. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806338105 · Cited by 179 · see citing works

Signal sequence-independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel.

Bornemann, T., Jöckel, J., Rodnina, M. V., & Wintermeyer, W. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1402 · Cited by 178 · see citing works

Functional reconstitution of bacterial Tat translocation in vitro

Yahr, T. L., & Wickner, W. T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2472 · Cited by 174 · see citing works

Lateral opening of a translocon upon entry of protein suggests the mechanism of insertion into membranes

Egea, P. F., & Stroud, R. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012556107 · Cited by 174 · see citing works

Sec‐dependent membrane protein insertion: sequential interaction of nascent FtsQ with SecY and YidC

Urbanus, M. L., Scotti, P. A., Fröderberg, L., Sääf, A. M., de Gier, J. L., Brunner, J., Samuelson, J. C., Dalbey, R., Oudega, B., & Luirink, J. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve108 · Cited by 173 · see citing works

Folding at the birth of the nascent chain: coordinating translation with co-translational folding

Zhang, G., & Ignatova, Z. (2010) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2010.10.008 · Cited by 172 · see citing works

Nascent membrane and presecretory proteins synthesized in Escherichia coli associate with signal recognition particle and trigger factor

Valent, Q. A., de Gier, J. L., von HEIJNE, G., Kendall, D. A., ten Hagen‐Jongman, C. M., Oudega, B., & Luirink, J. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.4431808.x · Cited by 171 · see citing works

YidC, an assembly site for polytopic Escherichia coli membrane proteins located in immediate proximity to the SecYE translocon and lipids.

Beck, K., Eisner, G., Trescher, D., Dalbey, R. E., Brunner, J., & Müller, M. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve154 · Cited by 171 · see citing works

Disruption of the gene encoding p12 (SecG) reveals the direct involvement and important function of SecG in the protein translocation of Escherichia coli at low temperature.

Nishiyama, K., Hanada, M., & Tokuda, H. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06628.x · Cited by 170 · see citing works

The Sec-independent Twin-arginine Translocation System Can Transport Both Tightly Folded and Malfolded Proteins across the Thylakoid Membrane

Hynds, P. J., Robinson, D., Robinson, C., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.34868 · Cited by 170 · see citing works

Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase

Sharma, V., Arockiasamy, A., Ronning, D. R., Savva, C. G., Holzenburg, A., Braunstein, M., Jacobs, W. R., & Sacchettini, J. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0538077100 · Cited by 170 · see citing works

A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration

Ismail, N., Hedman, R., Schiller, N., & von HEIJNE, G. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2376 · Cited by 170 · see citing works

The action of cardiolipin on the bacterial translocon.

Gold, V. A. M., Robson, A., Bao, H., Romantsov, T., Duong, F., & Collinson, I. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914680107 · Cited by 168 · see citing works

Assembly of Bacterial Inner Membrane Proteins

Dalbey, R., Wang, P., & Kühn, A. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060409-092524 · Cited by 166 · see citing works

SecDFyajC forms a heterotetrameric complex with YidC

Nouwen, N. P., & Driessen, A. J. M. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02972.x · Cited by 165 · see citing works

Disulfide bridge formation between SecY and a translocating polypeptide localizes the translocation pore to the center of SecY

Cannon, K. S., Or, E., Clemons, W., Shibata, Y., & Rapoport, T. A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412019 · Cited by 164 · see citing works

Signal peptides are allosteric activators of the protein translocase

Gouridis, G., Karamanou, S., Gelis, I., Kalodimos, C., & Economou, A. (2009) · Nature · doi:10.1038/nature08559 · Cited by 161 · see citing works

Pathway specificity for a ΔpH‐dependent precursor thylakoid lumen protein is governed by a 'sec‐avoidance’ motif in the transfer peptide and a 'sec‐incompatible’ mature protein

Bogsch, E. G., Brink, S. C., & Robinson, C. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3851 · Cited by 160 · see citing works

Phage Shock Protein PspA of Escherichia coli Relieves Saturation of Protein Export via the Tat Pathway

DeLisa, M. P., Lee, P. M., Palmer, T., et al. (2003) · Journal of Bacteriology · doi:10.1128/jb.186.2.366-373.2004 · Cited by 159 · see citing works

The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome

Gu, S.-Q., Peske, F., Wieden, H., Rodnina, M. V., & Wintermeyer, W. (2003) · RNA · doi:10.1261/rna.2196403 · Cited by 159 · see citing works

Identification of a twin‐arginine leader‐binding protein

Oresnik, I. J., Ladner-Keay, C. L., & Turner, R. J. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02391.x · Cited by 157 · see citing works

SecB, one small chaperone in the complex milieu of the cell

Randall, L. L., & HARDY, S. J. S. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/pl00012488 · Cited by 155 · see citing works

Signal recognition particle-depencent protein targeting, universal to all kingdoms of life

Koch, H.-G., Moser, M., & Müller, M. (2003) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-002-0002-9 · Cited by 154 · see citing works

Protein targeting by the signal recognition particle

Grudnik, P., Bange, G., & Sinning, I. (2009) · Biological Chemistry · doi:10.1515/bc.2009.102 · Cited by 152 · see citing works

Sequential triage of transmembrane segments by Sec61α during biogenesis of a native multispanning membrane protein

Sadlish, H., Pitonzo, D., Johnson, A. E., & Skach, W. R. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb994 · Cited by 149 · see citing works

Molecular mechanism of signal sequence orientation in the endoplasmic reticulum

Goder, V., & Spiess, M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg361 · Cited by 149 · see citing works

Anionic phospholipids are involved in membrane association of FtsY and stimulate its GTPase activity

de Leeuw, E., Kaat, K. T., Moser, C., Menestrina, G., DEMEL, R. A., KRUIJFF, B. D., Oudega, B., Luirink, J., & Sinning, I. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.531 · Cited by 148 · see citing works

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

Ataide, S. F., Schmitz, N., Shen, K., Ke, A., Shan, S., Doudna, J. A., & Ban, N. (2011) · Science · doi:10.1126/science.1196473 · Cited by 147 · see citing works

The C Terminus of SecA Is Involved in Both Lipid Binding and SecB Binding

Breukink, E. J., Nouwen, N. P., Raalte, A. L. J. V., Mizushima, S., Tommassen, J., & KRUIJFF, B. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.7902 · Cited by 146 · see citing works

FtsY, the bacterial signal-recognition particle receptor, interacts functionally and physically with the SecYEG translocon.

Angelini, S., Deitermann, S., & Koch, H. (2005) · The EMBO Reports · doi:10.1038/sj.embor.7400385 · Cited by 145 · see citing works

Role of 4.5 S RNA in Assembly of the Bacterial Signal Recognition Particle with Its Receptor

Peluso, P. S., Herschlag, D., Nock, S., Freymann, D. M., Johnson, A. E., & Walter, P. (2000) · Science · doi:10.1126/science.288.5471.1640 · Cited by 144 · see citing works

Oligomers of Tha4 Organize at the Thylakoid Tat Translocase during Protein Transport

Dabney‐Smith, C., Mori, H., & Cline, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m512453200 · Cited by 144 · see citing works

Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on theEscherichia coliribosome

Ullers, R. S., Houben, E. N. G., Raine, A., ten Hagen‐Jongman, C. M., Ehrenberg, M., Brunner, J., Oudega, B., Harms, N., & Luirink, J. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302130 · Cited by 142 · see citing works

The SecYEG preprotein translocation channel is a conformationally dynamic and dimeric structure

Bessonneau, P., Besson, V., Collinson, I. R., & Duong, F. (2002) · The EMBO Journal · doi:10.1093/emboj/21.5.995 · Cited by 142 · see citing works

Structure of Dimeric SecA, the Escherichia coli Preprotein Translocase Motor

Papanikolau, Y., Papadovasilaki, M., Ravelli, R. B. G., McCarthy, A. A., Cusack, S., Economou, A., & Petratos, K. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.12.049 · Cited by 141 · see citing works

A role for the two-helix finger of the SecA ATPase in protein translocation

Erlandson, K. J., Miller, S. B. M., Nam, Y., Osborne, A. R., Zimmer, J., & Rapoport, T. A. (2008) · Nature · doi:10.1038/nature07439 · Cited by 140 · see citing works

Function of YidC for the Insertion of M13 Procoat Protein inEscherichia coli

Samuelson, J. C., Jiang, F., Liang, Y., Chen, M., Gier, J. D., Kühn, A., & Dalbey, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105793200 · Cited by 140 · see citing works

Genetic Analysis of the Twin Arginine Translocator Secretion Pathway in Bacteria

DeLisa, M. P., Samuelson, P., Palmer, T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201956200 · Cited by 137 · see citing works

An alternative model of the twin arginine translocation system

Brüser, T., & Sanders, C. (2003) · Microbiological Research · doi:10.1078/0944-5013-00176 · Cited by 137 · see citing works

Structure of the E. coli signal recognition particle bound to a translating ribosome.

Schaffitzel, C., Oswald, M., Berger, I., Ishikawa, T., Abrahams, J. P., Koerten, H. K., Koning, R. I., & Ban, N. (2006) · Nature · doi:10.1038/nature05182 · Cited by 136 · see citing works

Use of Thioredoxin as a Reporter To Identify a Subset of Escherichia coli Signal Sequences That Promote Signal Recognition Particle-Dependent Translocation

Huber, D., Boyd, D. H., Xia, Y., Olma, M. H., Gerstein, M., & Beckwith, J. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.9.2983-2991.2005 · Cited by 136 · see citing works

Complex behavior in solution of homodimeric SecA.

Woodbury, R. L., Hardy, S. J. S., & Randall, L. L. (2002) · Protein Science · doi:10.1110/ps.4090102 · Cited by 136 · see citing works

SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein.

Neumann‐Haefelin, C., Schäfer, U., Müller, M., & Koch, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6419 · Cited by 135 · see citing works

Empty Site Forms of the SRP54 and SRα GTPases Mediate Targeting of Ribosome–Nascent Chain Complexes to the Endoplasmic Reticulum

Rapiejko, P. J., & Gilmore, R. (1997) · Cell · doi:10.1016/s0092-8674(00)80253-6 · Cited by 134 · see citing works

One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery.

Schatz, P. J., Bieker, K. L., Ottemann, K. M., Silhavy, T. J., & Beckwith, J. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07699.x · Cited by 134 · see citing works

YidC and Oxa1 Form Dimeric Insertion Pores on the Translating Ribosome

Kohler, R., Boehringer, D., Greber, B. J., Bingel-Erlenmeyer, R., Collinson, I. R., Schaffitzel, C., & Ban, N. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.019 · Cited by 133 · see citing works

The Rieske Fe/S Protein of the Cytochromeb /f Complex in Chloroplasts

Molik, S., Karnauchov, I., Weidlich, C., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106690200 · Cited by 131 · see citing works

Assembly and overexpression of membrane proteins in Escherichia coli

Drew, D., Fröderberg, L., Baars, L., & de Gier, J. L. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00707-1 · Cited by 131 · see citing works

Evolutionarily conserved binding of ribosomes to the translocation channel via the large ribosomal RNA.

Prinz, A., Behrens, C., Rapoport, T. A., Hartmann, E., & Kalies, K. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1900 · Cited by 129 · see citing works

PrlA (SecY) and PrlG (SecE) interact directly and function sequentially during protein translocation in E. coli

Bieker, K. L., & Silhavy, T. J. (1990) · Cell · doi:10.1016/0092-8674(90)90193-i · Cited by 129 · see citing works

Investigating the SecY plug movement at the SecYEG translocation channel

Tam, P. C. K., Maillard, A., Chan, K. K.-Y., & Duong, F. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600804 · Cited by 129 · see citing works

Export Pathway Selectivity of Escherichia coli Twin Arginine Translocation Signal Peptides

Tullman‐Ercek, D., DeLisa, M. P., Kawarasaki, Y., Iranpour, P., Ribnicky, B., Palmer, T., & Georgiou, G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610507200 · Cited by 129 · see citing works

A subset of bacterial inner membrane proteins integrated by the twin‐arginine translocase

Hatzixanthis, K., Palmer, T., & Sargent, F. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03642.x · Cited by 127 · see citing works

A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing

Bingel-Erlenmeyer, R., Kohler, R., Krämer, G., Sandikci, A., Antolić, S., Maier, T., Schaffitzel, C., Wiedmann, B., Bukau, B., & Ban, N. (2008) · Nature · doi:10.1038/nature06683 · Cited by 126 · see citing works

The Plug Domain of the SecY Protein Stabilizes the Closed State of the Translocation Channel and Maintains a Membrane Seal

Li, W., Schulman, S., Boyd, D. H., Erlandson, K. J., Beckwith, J., & Rapoport, T. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.002 · Cited by 124 · see citing works

SecYEG and SecA are the stoichiometric components of preprotein translocase.

Douville, K., Price, A., Eichler, J., Economou, A., & Wickner, W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.20106 · Cited by 123 · see citing works

Cysteine-Directed Cross-Linking Demonstrates That Helix 3 of SecE Is Close to Helix 2 of SecY and Helix 3 of a Neighboring SecE

Kaufmann, A. M., Manting, E. H., Veenendaal, A. K. J., Driessen, A. J. M., & van der Does, C. (1999) · Biochemistry · doi:10.1021/bi990539d · Cited by 122 · see citing works

Diversity and evolution of protein translocation.

Pohlschröder, M., Hartmann, E., Hand, N. J., Dilks, K., & Haddad, A. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121353 · Cited by 122 · see citing works

Crystal structure of the bacterial protein export chaperone secB.

Xu, Z., Knafels, J. D., & Yoshino‐Koh, K. (2000) · Nature Structural Biology · doi:10.1038/82040 · Cited by 120 · see citing works

YidC Is Strictly Required for Membrane Insertion of Subunits a and c of the F1F0ATP Synthase and SecE of the SecYEG Translocase

Liang, Y., Jiang, F., Chen, M., et al. (2003) · Biochemistry · doi:10.1021/bi034309h · Cited by 120 · see citing works

Concerted Action of the Ribosome and the Associated Chaperone Trigger Factor Confines Nascent Polypeptide Folding

Hoffmann, A., Becker, A. H., Zachmann-Brand, B., Deuerling, E., Bukau, B., & Krämer, G. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.018 · Cited by 119 · see citing works

A naturally occurring bacterial Tat signal peptide lacking one of the ‘invariant’ arginine residues of the consensus targeting motif

Hinsley, A. P., Stanley‐Wall, N. R., Palmer, T., et al. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02428-0 · Cited by 118 · see citing works

The Escherichia coli Twin-arginine Translocation Apparatus Incorporates a Distinct Form of TatABC Complex, Spectrum of Modular TatA Complexes and Minor TatAB Complex

Oates, J., Barrett, C. M. L., Barnett, J. P., et al. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.11.047 · Cited by 117 · see citing works

The Mechanosensitive Channel Protein MscL Is Targeted by the SRP to The Novel YidC Membrane Insertion Pathway of Escherichia coli

Facey, S. J., Neugebauer, S. A., Krauss, S., & Kühn, A. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.10.083 · Cited by 116 · see citing works

Three-State Equilibrium of Escherichia coli Trigger Factor

Patzelt, H., Krämer, G., Rauch, T., Schönfeld, H., Bukau, B., & Deuerling, E. (2002) · Biological Chemistry · doi:10.1515/bc.2002.182 · Cited by 116 · see citing works

Oligomeric Properties and Signal Peptide Binding by Escherichia coli Tat Protein Transport Complexes

de Leeuw, E., Granjon, T., Porcelli, I., et al. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00820-3 · Cited by 116 · see citing works

Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action

Baram, D., Pyetan, E., Sittner, A., Auerbach-Nevo, T., Bashan, A., & Yonath, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505581102 · Cited by 113 · see citing works

Different modes of SecY–SecA interactions revealed by site-directed in vivo photo-cross-linking

Mori, H., & Ito, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606390103 · Cited by 113 · see citing works

Efficient Twin Arginine Translocation (Tat) Pathway Transport of a Precursor Protein Covalently Anchored to Its Initial cpTatC Binding Site

Gérard, F., & Cline, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m512733200 · Cited by 112 · see citing works

Determining the Conductance of the SecY Protein Translocation Channel for Small Molecules

Saparov, S. M., Erlandson, K. J., Cannon, K. S., Schaletzky, J., Schulman, S., Rapoport, T. A., & Pohl, P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.022 · Cited by 112 · see citing works

Preprotein transfer to the <i>Escherichia coli</i> translocase requires the co‐operative binding of SecB and the signal sequence to SecA

Fekkes, P., De Wit, J. G., Van Der Wolk, J. P. W., Kimsey, H. H., Kumamoto, C. A., & Driessen, A. J. M. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00997.x · Cited by 111 · see citing works

Characterization and Membrane Assembly of the TatA Component of theEscherichiacoliTwin-Arginine Protein Transport System

Porcelli, I., de Leeuw, E., Wallis, R., et al. (2002) · Biochemistry · doi:10.1021/bi026142i · Cited by 110 · see citing works

SecA interacts with ribosomes in order to facilitate posttranslational translocation in bacteria.

Huber, D., Rajagopalan, N., Preissler, S., Rocco, M. A., Merz, F., Kramer, G., & Bukau, B. (2011) · Molecular Cell · doi:10.1016/j.molcel.2010.12.028 · Cited by 109 · see citing works

Energetics of Protein Transport across Biological Membranes

Alder, N. N., & Theg, S. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00032-1 · Cited by 109 · see citing works

Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting

Zhang, X., Rashid, R., Wang, K., & Shan, S. (2010) · Science · doi:10.1126/science.1186743 · Cited by 108 · see citing works

Cooperation of transmembrane segments during the integration of a double‐spanning protein into the ER membrane

Heinrich, S. U., & Rapoport, T. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg346 · Cited by 108 · see citing works

Ribosome binding of a single copy of the SecY complex: implications for protein translocation.

Ménétret, J.-F., Schaletzky, J., Clemons, W. M., Osborne, A. R., Skånland, S. S., Denison, C., Gygi, S. P., Kirkpatrick, D. S., Park, E., Ludtke, S. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.10.034 · Cited by 108 · see citing works

Multiple conformational switches in a GTPase complex control co-translational protein targeting

Zhang, X., Schaffitzel, C., Ban, N., & Shan, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808573106 · Cited by 107 · see citing works

Mapping an Interface of SecY (PrlA) and SecE (PrlG) by Using Synthetic Phenotypes and In Vivo Cross-Linking

Harris, C. R., & Silhavy, T. J. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.11.3438-3444.1999 · Cited by 107 · see citing works

Preserving the membrane barrier for small molecules during bacterial protein translocation

Park, E., & Rapoport, T. A. (2011) · Nature · doi:10.1038/nature10014 · Cited by 106 · see citing works

SecB functions as a cytosolic signal recognition factor for protein export in E. coli

Watanabe, M., & Blobel, G. (1989) · Cell · doi:10.1016/0092-8674(89)90104-9 · Cited by 106 · see citing works

Dynamics of Trigger Factor Interaction with Translating Ribosomes

Rutkowska, A., Mayer, M. P., Hoffmann, A., Merz, F., Zachmann-Brand, B., Schaffitzel, C., Ban, N., Deuerling, E., & Bukau, B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708294200 · Cited by 106 · see citing works

Crystal Structure of a Bacterial Signal Peptidase Apoenzyme

Paetzel, M., Dalbey, R., & Strynadka, N. C. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110983200 · Cited by 105 · see citing works

Functional complexity of the twin‐arginine translocase TatC component revealed by site‐directed mutagenesis

Buchanan, G., de Leeuw, E., Stanley‐Wall, N. R., et al. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02853.x · Cited by 105 · see citing works

In vitro Analysis of the Process of Translocation of OmpA across the Escherichia coli Cytoplasmic Membrane

Tani, K., Shiozuka, K., Tokuda, H., & Mizushima, S.-I. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51507-6 · Cited by 103 · see citing works

Sec/SRP Requirements and Energetics of Membrane Insertion of Subunits a, b, and c of the Escherichia coli F1F0 ATP Synthase

Liang, Y., Celebi, N., Chen, M., & Dalbey, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405490200 · Cited by 103 · see citing works

Dimeric SecA is essential for protein translocation

Jilaveanu, L. B., Zito, C. R., & Oliver, D. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502774102 · Cited by 103 · see citing works

The lateral gate of SecYEG opens during protein translocation.

du Plessis, D. J. F., Berrelkamp, G., Nouwen, N., & Driessen, A. J. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901855200 · Cited by 102 · see citing works

Sequence analysis of bacterial redox enzyme maturation proteins (REMPs)

Turner, R. J., Papish, A. L., & Sargent, F. (2004) · Canadian Journal of Microbiology · doi:10.1139/w03-117 · Cited by 102 · see citing works

The Binding Mode of the Trigger Factor on the Ribosome: Implications for Protein Folding and SRP Interaction

Schlünzen, F., Wilson, D. N., Tian, P., Harms, J., McInnes, S. J., Hansen, H. A. S., Albrecht, R., Buerger, J., Wilbanks, S. M., & Fucini, P. (2005) · Structure · doi:10.1016/j.str.2005.08.007 · Cited by 102 · see citing works

The efficient export of NADP‐containing glucose‐fructose oxidoreductase to the periplasm of Zymomonas mobilis depends both on an intact twin‐arginine motif in the signal peptide and on the generation of a structural export signal induced by cofactor binding

Halbig, D., Wiegert, T., Blaudeck, N., Freudl, R., & Sprenger, G. A. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00536.x · Cited by 102 · see citing works

Escherichia coli Signal Recognition Particle Receptor FtsY Contains an Essential and Autonomous Membrane-binding Amphipathic Helix

Parlitz, R., Eitan, A., Stjepanović, G., Bahari, L., Bange, G., Bibi, E., & Sinning, I. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705430200 · Cited by 101 · see citing works

Inserting membrane proteins: The YidC/Oxa1/Alb3 machinery in bacteria, mitochondria, and chloroplasts

Wang, P., & Dalbey, R. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.08.014 · Cited by 99 · see citing works

Targeting of Unfolded PhoA to the TAT Translocon of Escherichia coli

Richter, S., & Brüser, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509570200 · Cited by 99 · see citing works

Separate Analysis of Twin-arginine Translocation (Tat)-specific Membrane Binding and Translocation in Escherichia coli

Alami, M., Trescher, D., Wu, L., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201711200 · Cited by 98 · see citing works

Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system

Tarry, M. J., Schäfer, E., Chen, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901566106 · Cited by 97 · see citing works

In vivo dissection of the Tat translocation pathway in Escherichia coli

Ize, B., Gérard, F., Zhang, M., et al. (2002) · Journal of Molecular Biology · doi:10.1006/jmbi.2002.5431 · Cited by 96 · see citing works

Defining the Regions of Escherichia coli YidC That Contribute to Activity

Jiang, F., Chen, M., Liang, Y., Gier, J. D., Kühn, A., & Dalbey, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307362200 · Cited by 95 · see citing works

Biogenesis of inner membrane proteins in Escherichia coli

Gier, J. D., & Luirink, J. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02392.x · Cited by 94 · see citing works

Two electrical potential–dependent steps are required for transport by the Escherichia coli Tat machinery

Bageshwar, U. K., & Musser, S. M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702082 · Cited by 93 · see citing works

F1F0 ATP synthase subunit c is targeted by the SRP to YidC in the E. coli inner membrane

van Bloois, E., Haan, G. J., Gier, J. D., Oudega, B., & Luirink, J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.08.069 · Cited by 93 · see citing works

Genetic and molecular characterization of the Escherichia coli secD operon and its products

Pogliano, K., & Beckwith, J. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.3.804-814.1994 · Cited by 92 · see citing works

Transport of cytochrome c derivatives by the bacterial Tat protein translocation system

Sanders, C., Wethkamp, N., & Lill, H. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02514.x · Cited by 90 · see citing works

Direct association of messenger RNA with microsomal membranes in human diploid fibroblasts.

Lande, M. A., Adesnik, M., Sumida, M., et al. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.65.3.513 · Cited by 90 · see citing works

Assembly of Tat‐dependent [NiFe] hydrogenases: identification of precursor‐binding accessory proteins

Dubini, A., & Sargent, F. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00802-0 · Cited by 90 · see citing works

Solution NMR Structure of the TatA Component of the Twin-Arginine Protein Transport System from Gram-Positive Bacterium Bacillus subtilis

Hu, Y., Zhao, E., Li, H., et al. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1053785 · Cited by 89 · see citing works

Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation

Cheng, Z., Jiang, Y. Z., Mandon, E. C., & Gilmore, R. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200408188 · Cited by 89 · see citing works

Subunit a of Cytochrome o Oxidase Requires Both YidC and SecYEG for Membrane Insertion

du Plessis, D. J. F., Nouwen, N. P., & Driessen, A. J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600048200 · Cited by 88 · see citing works

DnaK Plays a Pivotal Role in Tat Targeting of CueO and Functions beside SlyD as a General Tat Signal Binding Chaperone

Graubner, W., Schierhorn, A., & Brüser, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608235200 · Cited by 88 · see citing works

Isolation and Characterization of Bifunctional Escherichia coli TatA Mutant Proteins That Allow Efficient Tat-dependent Protein Translocation in the Absence of TatB

Blaudeck, N., Kreutzenbeck, P., Müller, M., Sprenger, G. A., & Freudl, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411210200 · Cited by 88 · see citing works

Identification of Nascent Chain Interaction Sites on Trigger Factor

Lakshmipathy, S. K., Tomic, S., Kaiser, C., Chang, H.-C., Genevaux, P., Georgopoulos, C. P., Barral, J. M., Johnson, A. E., Hartl, F. U., & Etchells, S. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609871200 · Cited by 88 · see citing works

Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the<i>Escherichia coli</i>signal recognition particle

Welte, T., Kudva, R., Kuhn, P., Sturm, L., Braig, D., Müller, M., Warscheid, B., Drepper, F., & Koch, H.-G. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-07-0590 · Cited by 87 · see citing works

Membrane interactions and self‐association of the TatA and TatB components of the twin‐arginine translocation pathway

de Leeuw, E., Porcelli, I., Sargent, F., et al. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02904-0 · Cited by 85 · see citing works

Unusual Signal Peptide Directs Penicillin Amidase from Escherichia coli to the Tat Translocation Machinery

Ignatova, Z., Hörnle, C., Nurk, A., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6420 · Cited by 83 · see citing works

Twin-arginine-dependent translocation of folded proteins

Fröbel, J., Rose, P., & Müller, M. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0202 · Cited by 83 · see citing works

Dynamic switch of the signal recognition particle from scanning to targeting.

Holtkamp, W., Lee, S., Bornemann, T., Senyushkina, T., Rodnina, M. V., & Wintermeyer, W. (2012) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.2421 · Cited by 81 · see citing works

Modeling the Effects of prl Mutations on the Escherichia coli SecY Complex

Smith, M. A., Clemons, W., DeMars, C. J., & Flower, A. M. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.18.6454-6465.2005 · Cited by 81 · see citing works

Overproduction, purification and characterization of SecD and SecF, integral membrane components of the protein translocation machinery of Escherichia coli

Matsuyama, S., Fujita, Y., Sagara, K., & Mizushima, S. (1992) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(92)90130-6 · Cited by 81 · see citing works

Domain Interactions in E. coli SRP: Stabilization of M Domain by RNA Is Required for Effective Signal Sequence Modulation of NG Domain

Zheng, N., & Gierasch, L. M. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80009-x · Cited by 80 · see citing works

The Sec translocon mediated protein transport in prokaryotes and eukaryotes.

Denks, K., Vogt, A., Sachelaru, I., Petriman, N.-A., Kudva, R., & Koch, H.-G. (2014) · Molecular Membrane Biology · doi:10.3109/09687688.2014.907455 · Cited by 170 · see citing works

Chaperone networking facilitates protein targeting to the bacterial cytoplasmic membrane.

Castanié-Cornet, M.-P., Bruel, N., & Genevaux, P. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.11.007 · Cited by 129 · see citing works

Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon

Jomaa, A., Boehringer, D., Leibundgut, M., & Ban, N. (2016) · Nature Communications · doi:10.1038/ncomms10471 · Cited by 115 · see citing works

The Dynamic SecYEG Translocon

Oswald, J., Njenga, R., Natriashvili, A., Sarmah, P., & Koch, H.-G. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.664241 · Cited by 88 · see citing works

Co-translational protein targeting in bacteria.

Steinberg, R., Knüpffer, L., Origi, A., Asti, R., & Koch, H.-G. (2018) · FEMS Microbiology Letters · doi:10.1093/femsle/fny095 · Cited by 81 · see citing works

The interaction network of the YidC insertase with the SecYEG translocon, SRP and the SRP receptor FtsY

Petriman, N.-A., Jauß, B., Hufnagel, A., Franz, L., Sachelaru, I., Drepper, F., Warscheid, B., & Koch, H.-G. (2018) · Scientific Reports · doi:10.1038/s41598-017-19019-w · Cited by 66 · see citing works

YidC and SecYEG form a heterotetrameric protein translocation channel.

Sachelaru, I., Winter, L., Knyazev, D. G., Zimmermann, M., Vogt, A., Kuttner, R., Ollinger, N., Siligan, C., Pohl, P., & Koch, H.-G. (2017) · Scientific Reports · doi:10.1038/s41598-017-00109-8 · Cited by 58 · see citing works

Noncompetitive binding of PpiD and YidC to the SecYEG translocon expands the global view on the SecYEG interactome in Escherichia coli

Jauss, B., Petriman, N.-A., Drepper, F., Franz, L., Sachelaru, I., Welte, T., Steinberg, R., Warscheid, B., & Koch, H.-G. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010686 · Cited by 43 · see citing works

Dynamic interaction of the Sec Translocon with the chaperone PpiD.

Sachelaru, I., Petriman, N.-A., Kudva, R., & Koch, H.-G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.577916 · Cited by 37 · see citing works

The bacterial SRP receptor, FtsY, is activated on binding to the translocon.

Draycheva, A., Bornemann, T., Ryazanov, S., Lakomek, N., & Wintermeyer, W. (2016) · Molecular Microbiology · doi:10.1111/mmi.13452 · Cited by 34 · see citing works

Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle.

Steinberg, R., Origi, A., Natriashvili, A., Sarmah, P., Licheva, M., Walker, P. M., Kraft, C., High, S., Luirink, J., Shi, W. Q., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000874 · Cited by 34 · see citing works

Molecular mimicry of SecA and signal recognition particle binding to the bacterial ribosome.

Knüpffer, L., Fehrenbach, C., Denks, K., Erichsen, V., Petriman, N.-A., & Koch, H.-G. (2019) · mBio · doi:10.1128/mbio.01317-19 · Cited by 28 · see citing works

Involvement of PpiD in Sec-dependent protein translocation.

Fürst, M., Zhou, Y., Merfort, J., & Müller, M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.10.012 · Cited by 26 · see citing works

Sec62 Protein Mediates Membrane Insertion and Orientation of Moderately Hydrophobic Signal Anchor Proteins in the Endoplasmic Reticulum (ER)

Reithinger, J. H., Kim, J. E. H., & Kim, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.473009 · Cited by 48 · see citing works

YidC mediates membrane protein insertion in bacteria.

Samuelson, J. C., Chen, M., Jiang, F., Möller, I., Wiedmann, M., Kuhn, A., Phillips, G. J., & Dalbey, R. E. (2000) · Nature · doi:10.1038/35020586 · Cited by 538 · see citing works

Novel mechanism of outer membrane targeting of proteins in Gram‐negative bacteria

Ferrandez, Y., & Condemine, G. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06366.x · Cited by 69 · see citing works

The Molecular Biodiversity of Protein Targeting and Protein Transport Related to the Endoplasmic Reticulum

Tirincsi, A., Sicking, M., Hadzibeganovic, D., Haßdenteufel, S., & Lang, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010143 · Cited by 30 · see citing works

Protein transport across the ER membrane

Rapoport, T. A. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90076-n · Cited by 74 · see citing works