Cited by 735Cannabis and Cannabinoid ResearchParkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

Kreitzer, Anatol C., Malenka, Robert C.·2007·Nature

DOI 10.1038/nature05506

Open this paper in CoChat — free account

Abstract

The striatum is a major forebrain nucleus that integrates cortical and thalamic afferents and forms the input nucleus of the basal ganglia. Striatal projection neurons target the substantia nigra pars reticulata (direct pathway) or the lateral globus pallidus (indirect pathway). Imbalances between neural activity in these two pathways have been proposed to underlie the profound motor deficits observed in Parkinson's disease and Huntington's disease. However, little is known about differences in cellular and synaptic properties in these circuits. Indeed, current hypotheses suggest that these cells express similar forms of synaptic plasticity. Here we show that excitatory synapses onto indirect-pathway medium spiny neurons (MSNs) exhibit higher release probability and larger N-methyl-d-aspartate receptor currents than direct-pathway synapses. Moreover, indirect-pathway MSNs selectively express endocannabinoid-mediated long-term depression (eCB-LTD), which requires dopamine D2 receptor activation. In models of Parkinson's disease, indirect-pathway eCB-LTD is absent but is rescued by a D2 receptor agonist or inhibitors of endocannabinoid degradation. Administration of these drugs together in vivo reduces parkinsonian motor deficits, suggesting that endocannabinoid-mediated depression of indirect-pathway synapses has a critical role in the control of movement. These findings have implications for understanding the normal functions of the basal ganglia, and also suggest approaches for the development of therapeutic drugs for the treatment of striatal-based brain disorders.

Integrity signals

Registry

Crossref · 10.1038/nature05506

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Glutamate receptor ion channels
Mayer, M. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.004 · Cited by 3,655
The Synaptic Organization of the Brain
(2004) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195159561.001.1 · Cited by 3,574
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Modulation of anxiety through blockade of anandamide hydrolysis
Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Rana, G. L., Calignano, A., et al. (2003) · Nature Medicine · doi:10.1038/nm803 · Cited by 1,293
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. A., & Bonner, T. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5780 · Cited by 1,078
The basal ganglia
Graybiel, A. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00593-5 · Cited by 1,051

Show all 35 references

Sorted by citations

Items 301–400 of 732

New synaptic and molecular targets for neuroprotection in Parkinson's disease
Calabresi, P., Filippo, M. D., Gallina, A., Wang, Y., Stankowski, J. N., Picconi, B., Dawson, V. L., & Dawson, T. M. (2012) · Movement Disorders · doi:10.1002/mds.25096 · Cited by 47
Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function
Longo, F., Mancini, M., Ibraheem, P. L., Aryal, S., Mesini, C., Patel, J. C., Penhos, E., Rahman, N., Mamcarz, M., Santini, E., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01099-w · Cited by 51
Cerebellar Influence on Motor Cortex Plasticity: Behavioral Implications for Parkinson’s Disease
Kishore, A., Meunier, S., & Popa, T. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00068 · Cited by 51
A neurocomputational account of catalepsy sensitization induced by D2 receptor blockade in rats: context dependency, extinction, and renewal
Wiecki, T. V., Riedinger, K., von Ameln-Mayerhofer, A., Schmidt, W., & Frank, M. J. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1457-4 · Cited by 46
Coordinated Regulation of Synaptic Plasticity at Striatopallidal and Striatonigral Neurons Orchestrates Motor Control
Trusel, M., Cavaccini, A., Gritti, M., Greco, B., Saintot, P., Nazzaro, C., Cerovic, M., Morella, I., Brambilla, R., & Tonini, R. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.009 · Cited by 50
Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders
Plotkin, J. L., & Goldberg, J. A. (2018) · The Neuroscientist · doi:10.1177/1073858418807887 · Cited by 49
Impairment of endocannabinoids activity in the dorsolateral striatum delays extinction of behavior in a procedural memory task in rats
Rueda‐Orozco, P. E., Montes-Rodríguez, C. J., Gómez, E. S., Méndez‐Díaz, M., & Prospero-Garcia, O. E. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.04.013 · Cited by 46
Optogenetic control of alcohol-seeking behavior via the dorsomedial striatal circuit
Roltsch, E. A., Binette, A. N., Zhuang, X., Lu, J., Ma, T., Jones, B. O., Williams, E., Jayavelu, S., & Wang, J. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.05.022 · Cited by 45
Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease
Chiodi, V., Uchigashima, M., Beggiato, S., Ferrante, A., Armida, M., Martire, A., Potenza, R. L., Ferraro, L., Tanganelli, S., Watanabe, M., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.017 · Cited by 45
The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico–subthalamic nucleus–globus pallidus pathway
Galati, S., Stanzione, P., D’Angelo, V., Fedele, E., Marzetti, F., Sancesario, G., Procopio, T., & Stefani, A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172759 · Cited by 45
Pharmacological evidence for different populations of postsynaptic adenosine A2A receptors in the rat striatum
Orrù, M., Quiroz, C., Guitart, X., & Ferré, S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.025 · Cited by 45
Neurochemical changes in the striatum of dyskinetic rats after administration of the cannabinoid agonist WIN55,212-2
Morgese, M. G., Cassano, T., Gaetani, S., Macheda, T., Laconca, L., Dipasquale, P., Ferraro, L., Antonelli, T., Cuomo, V., & Giuffrida, A. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.007 · Cited by 44
Excitatory and Inhibitory Synapses in Neuropeptide Y–Expressing Striatal Interneurons
Partridge, J. G., Janssen, M. J., Chou, D. Y.-T., Abe, K., Żukowska, Z., & Vicini, S. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00272.2009 · Cited by 44
Loss of huntingtin function slows synaptic vesicle endocytosis in striatal neurons from the httQ140/Q140 mouse model of Huntington's disease
McAdam, R. L., Morton, A., Gordon, S. L., Alterman, J. F., Khvorova, A., Cousin, M. A., & Smillie, K. J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104637 · Cited by 46
Activation of the basal ganglia and indirect pathway neurons during frontal lobe seizures
Brodovskaya, A., Shiono, S., & Kapur, J. (2021) · Brain · doi:10.1093/brain/awab119 · Cited by 44
Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function
Wu, D., Qiu, Y., Gao, X., Yuan, X., & Zhai, Q. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021759 · Cited by 43
Endocannabinoid Modulation in Neurodegenerative Diseases: In Pursuit of Certainty
Vasincu, A., Rusu, R.-N., Ababei, D. C., Larion, M., Bild, W., Stanciu, G. D., Solcan, C., & Bild, V. (2022) · Biology · doi:10.3390/biology11030440 · Cited by 44
Changing the tune: plasticity and adaptation of retrograde signals
Iremonger, K. J., Cusulin, J. I. W., & Bains, J. S. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.007 · Cited by 43
Evidence for the use of cannabinoids in Parkinson’s disease
Buhmann, C., Mainka, T., Ebersbach, G., & Gandor, F. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02018-8 · Cited by 42
Biological bases for a possible effect of cannabidiol in Parkinson’s disease
Ferreira‐Junior, N. C., Campos, A. C., Guimarães, F. S., Bel, E. A. D., Zimmermann, P. M. D. R., Brum, L., Hallak, J. E. C., Crippa, J. A. S., & Zuardi, A. W. (2019) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2019-0460 · Cited by 44
Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies
Reddy, V. P., Grogan, D. P., Ahluwalia, M., Salles, É. L., Ahluwalia, P. K., Khodadadi, H., Alverson, K., Nguyen, A., Raju, S. P., Gaur, P., et al. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00203-4 · Cited by 45
Δ9‐Tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors
Zani, A., Braida, D., Capurro, V., & Sala, M. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707514 · Cited by 42
Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease
Francelle, L., Galvan, L., & Brouillet, E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00295 · Cited by 45
Cocaine Experience Enhances Thalamo-Accumbens N-Methyl-D-Aspartate Receptor Function
Joffe, M. E., & Grueter, B. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.04.002 · Cited by 41
Endocannabinoids in striatal plasticity
Lovinger, D. M., & Mathur, B. N. (2011) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(11)70041-4 · Cited by 41
Postsynaptic synucleins mediate endocannabinoid signaling
Albarran, E., Sun, Y., Liu, Y., Raju, K., Dong, A., Li, Y., Wang, S., Südhof, T. C., & Ding, J. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01345-0 · Cited by 40
Cell type-specific synaptic encoding of ethanol exposure in the nucleus accumbens shell
Jeanes, Z. M., Buske, T. R., & Morrisett, R. A. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.063 · Cited by 40
The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens
Baimel, C., McGarry, L. M., & Carter, A. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.074 · Cited by 40
Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: relevance for schizophrenia
Fuxé, K., Marcellino, D. J., Woods, A. S., Leo, G., Antonelli, T., Ferraro, L., Tanganelli, S., & Agnati, L. F. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0174-9 · Cited by 40
Increased vulnerability to 6-hydroxydopamine lesion and reduced development of dyskinesias in mice lacking CB1 cannabinoid receptors
Pérez-Rial, S., García‐Gutiérrez, M. S., Molina, J. A., Perez‐Nievas, B. G., Ledent, C. A., Leiva, C., Leza, J. C., & Manzanares, J. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.017 · Cited by 40
Studying synaptic plasticity in the human brain and opportunities for drug discovery
Nathan, P. J., Cobb, S., Lu, B., Bullmore, E. T., & Davies, C. H. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.06.008 · Cited by 42
Fatty Acid Amide Hydrolase (FAAH) Inhibition Reduces l-3,4-Dihydroxyphenylalanine-Induced Hyperactivity in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Lesioned Non-Human Primate Model of Parkinson’s Disease
Johnston, T. H., Huot, P., Fox, S. H., WAKEFIELD, J. D., Sykes, K. A., Bartolini, W. P., Milne, G. T., Pearson, J. P., & Brotchie, J. M. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.169532 · Cited by 40
Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model
Sepers, M. D., Smith-Dijak, A., LeDue, J. M., Kołodziejczyk, K., Mackie, K., & Raymond, L. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1739-17.2017 · Cited by 39
Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine
Shen, W., Ren, W., Zhai, S., Yang, B., Vanoye, C. G., Mitra, A., George, A. L., & Surmeier, D. J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133398 · Cited by 40
Smart drugs and neuroenhancement: what do we know?
Esposito, M., Cocimano, G., Ministrieri, F., Rosi, G. L., Nunno, N. R. D., Messina, G., Sessa, F., & Salerno, M. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/4948 · Cited by 39
Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum
Xu, H., Siaume‐Perez, S., Cornil, A., Detraux, B., Prokin, I., Cui, Y., Degos, B., Berry, H., d’Exaerde, A. D. K., & Venance, L. (2018) · Nature Communications · doi:10.1038/s41467-018-06409-5 · Cited by 38
Dopamine D1 Receptors Regulate Spines in Striatal Direct‐Pathway and Indirect‐Pathway Neurons
Suárez, L. M., Solís, Ó., Sanz‐Magro, A., Alberquilla, S., & Moratalla, R. (2020) · Movement Disorders · doi:10.1002/mds.28174 · Cited by 38
Dopamine-Dependent Long-Term Depression at Subthalamo-Nigral Synapses Is Lost in Experimental Parkinsonism
Dupuis, J. P., Feyder, M. T., Miguélez, C., García, L., Morin, S., Choquet, D., Hosy, E., Bézard, E., Fisone, G., Bioulac, B. H., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1681-13.2013 · Cited by 38
The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing
Seif, T., Makriyannis, A., Kunos, G., Bonci, A., & Hopf, F. W. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.055 · Cited by 37
Optogenetic activation of striatal D1R and D2R cells differentially engages downstream connected areas beyond the basal ganglia
Grimm, C., Frässle, S., Steger, C., von Ziegler, L., Sturman, O., Shemesh, N., Peleg‐Raibstein, D., Burdakov, D., Bohacek, J., Stephan, K. E., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110161 · Cited by 38
Altered function of glutamatergic cortico-striatal synapses causes output pathway abnormalities in a chronic model of parkinsonism
Warre, R., Thiele, S. L., Talwar, S., Kamal, M., Johnston, T. H., Wang, S., Lam, D., Lo, C., Khademullah, C. S., Perera, G., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.10.013 · Cited by 37
The small‐conductance calcium‐activated potassium channel is a key modulator of firing and long‐term depression in the dorsal striatum
Hopf, F. W., Seif, T., Mohamedi, M. L., Chen, B. T., & Bonci, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07231.x · Cited by 36
Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior
Bilbao, A., Neuhofer, D., Sepers, M. D., Wei, S., Eisenhardt, M., Hertle, S., Lassalle, O., Ramos, A., Puente, N., Lerner, R., et al. (2020) · iScience · doi:10.1016/j.isci.2020.100951 · Cited by 39
Electrophysiological properties of medium spiny neurons in the nucleus accumbens core of prepubertal male and female Drd1a-tdTomato line 6 BAC transgenic mice
Cao, J., Dorris, D. M., & Meitzen, J. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00257.2018 · Cited by 39
Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease
Moreno‐Delgado, D., Puigdellívol, M., Moreno, E., Rodríguez-Ruiz, M., Botta, J. A., Gasperini, P., Chiarlone, A., Howell, L. A., Scarselli, M., Casadó, V., et al. (2020) · eLife · doi:10.7554/elife.51093 · Cited by 35
Microglial activation in the dorsal striatum participates in anxiety-like behavior in Cyld knockout mice
Han, Y.-Y., Jin, K., Pan, Q.-S., Li, B., Wu, Z.-Q., Gan, L., Yang, L., & Long, C. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.07.011 · Cited by 35
Roles of the Cannabinoid System in the Basal Ganglia in Parkinson’s Disease
Wang, M., Liu, H., & Ma, Z. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.832854 · Cited by 36
In vivo pharmacology of endocannabinoids and their metabolic inhibitors: Therapeutic implications in Parkinson's disease and abuse liability
Giuffrida, A., & McMahon, L. R. (2009) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2009.05.004 · Cited by 40
Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion
Peterson, J. D., Goldberg, J. A., & Surmeier, D. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.08.030 · Cited by 35
The acid-sensing ion channel ASIC1a mediates striatal synapse remodeling and procedural motor learning
Yu, Z., Wu, Y., Wang, Y., Liu, D.-S., Song, X.-L., Jiang, Q., Li, Y., Zhang, S., Xu, N., Zhu, M. X., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aar4481 · Cited by 34
From apathy to addiction: Insights from neurology and psychiatry
Kirschner, M., Rabinowitz, A. G., Singer, N., & Dagher, A. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109926 · Cited by 37
Distinctive Evidence Involved in the Role of Endocannabinoid Signalling in Parkinson’s Disease: A Perspective on Associated Therapeutic Interventions
Behl, T., Kaur, G., BUNGAU, S. G., Jhanji, R., Kumar, A., Mehta, V., Zengin, G., Brata, R. D., Hassan, S. S. U., & Frățilă, O. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176235 · Cited by 34
Metaplasticity of Hypothalamic Synapses following In Vivo Challenge
Kuzmiski, J. B., Pittman, Q. J., & Bains, J. S. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.027 · Cited by 34
Marijuana Compounds: A Nonconventional Approach to Parkinson’s Disease Therapy
Babayeva, M., Assefa, H., Basu, P., Chumki, S. R., & Loewy, Z. G. (2016) · Parkinson s Disease · doi:10.1155/2016/1279042 · Cited by 38
Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors
Zhuang, Q., Xu, H., Lu, X.-J., Li, B., Yung, W., Wang, J., & Zhu, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0976-1 · Cited by 34
Endocannabinoid Modulation of Dopaminergic Motor Circuits
Morera‐Herreras, T., Miguélez, C., Aristieta, A., Ruíz-Ortega, J. Á., & Ugedo, L. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00110 · Cited by 35
P2Y1receptor modulation of Ca2+-activated K+currents in medium-sized neurons from neonatal rat striatal slices
Coppi, E., Pedata, F., & Gibb, A. J. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00816.2009 · Cited by 33
Cyclic AMP and Afferent Activity Govern Bidirectional Synaptic Plasticity in Striatopallidal Neurons
Augustin, S. M., Beeler, J. A., McGehee, D. S., & Zhuang, X. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3906-13.2014 · Cited by 34
Alterations of striatal indirect pathway neurons precede motor deficits in two mouse models of Huntington's disease
Sebastianutto, I., Cenci, M. A., & Fieblinger, T. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.05.011 · Cited by 36
Loss of Tsc1 from striatal direct pathway neurons impairs endocannabinoid-LTD and enhances motor routine learning
Benthall, K. N., Cording, K. R., Agopyan-Miu, A. H. C. W., Wong, C. D., Chen, E. Y., & Bateup, H. S. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109511 · Cited by 33
Distinct Hypothalamic Paraventricular Nucleus Inputs to the Cingulate Cortex and Paraventricular Thalamic Nucleus Modulate Anxiety and Arousal
Liu, Y., Rao, B., Li, S., Zheng, N., Wang, J., Bi, L., & Xu, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.814623 · Cited by 34
Ongoing movement controls sensory integration in the dorsolateral striatum
de la Torre‐Martínez, R., Ketzef, M., & Silberberg, G. (2023) · Nature Communications · doi:10.1038/s41467-023-36648-0 · Cited by 32
Synaptic plasticity in the basal ganglia: A similar code for physiological and pathological conditions
Berretta, N., Nisticò, R., Bernardi, G., & Mercuri, N. B. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.12.004 · Cited by 32
Striatopallidal Neuron NMDA Receptors Control Synaptic Connectivity, Locomotor, and Goal-Directed Behaviors
Lambot, L., Rodriguez, E. C., Houtteman, D., Li, Y., Schiffmann, S. N., Gall, D., & d’Exaerde, A. D. K. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2717-15.2016 · Cited by 32
Maladaptive Synaptic Plasticity in L-DOPA-Induced Dyskinesia
Wang, Q., & Zhang, W. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00105 · Cited by 33
Cannabinoid receptor as a potential therapeutic target for Parkinson’s Disease
Baul, H. S., Manikandan, C., & Sen, D. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.016 · Cited by 32
Indirect Medium Spiny Neurons in the Dorsomedial Striatum Regulate Ethanol-Containing Conditioned Reward Seeking
Hong, S., Kang, S., Chen, J., & Choi, D. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0876-19.2019 · Cited by 32
A cAMP Pathway Underlying Reward Prediction in Associative Learning
Kheirbek, M. A., Beeler, J. A., Ishikawa, Y., & Zhuang, X. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4115-08.2008 · Cited by 33
Regional changes in the type 1 cannabinoid receptor are associated with cognitive dysfunction in Parkinson’s disease
Ceccarini, J., Casteels, C., Ahmad, R. U., Crabbé, M., de Vliet, L. V., Vanhaute, H., Vandenbulcke, M., Vandenberghe, W., & Laere, K. V. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04445-x · Cited by 31
The cannabinoid system in Parkinson's disease: Multiple targets to motor effects
Papa, S. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.03.009 · Cited by 31
Convergent mechanisms in etiologically-diverse dystonias
Thompson, V. B., Jinnah, H. A., & Hess, E. J. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.641533 · Cited by 31
Kainate Receptors Inhibit Glutamate Release Via Mobilization of Endocannabinoids in Striatal Direct Pathway Spiny Projection Neurons
Marshall, J. J., Xu, J., & Contractor, A. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1788-17.2018 · Cited by 30
Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons
Molchanova, S. M., Comhair, J., Karadurmus, D., Piccart, E., Harvey, R. J., Rigo, J., Schiffmann, S. N., Brône, B., & Gall, D. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00442 · Cited by 30
Nicotinic Acetylcholine Receptor Density in Cognitively Intact Subjects at an Early Stage of Parkinson’s Disease
Isaias, I., Spiegel, J., Brumberg, J., Cosgrove, K. P., Marotta, G., Oishi, N., Higuchi, T., Küsters, S., Schiller, M., Dillmann, U., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00213 · Cited by 27
The expression of cannabinoid type 1 receptor and 2-arachidonoyl glycerol synthesizing/degrading enzymes is altered in basal ganglia during the active phase of levodopa-induced dyskinesia
Rojo-Bustamante, E., Abellanas, M. A., Clavero, P., Thiolat, M.-L., Li, Q., Luquín, M. R., Bézard, E., & Aymerich, M. S. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.06.019 · Cited by 30
Preservation of function in Parkinson's disease: What's learning got to do with it?
Beeler, J. A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.09.040 · Cited by 29
Developmental Changes in Dendritic Spine Morphology in the Striatum and Their Alteration in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease
Parajuli, L. K., Wako, K., Maruo, S., Kakuta, S., Taguchi, T., Ikuno, M., Yamakado, H., Takahashi, R., & Koike, M. (2020) · eNeuro · doi:10.1523/eneuro.0072-20.2020 · Cited by 29
Striatopallidal adenosine A2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility
Chen, J., Choi, D., & Cunha, R. A. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109421 · Cited by 29
Dopamine Depletion Induces Distinct Compensatory Gene Expression Changes in DARPP-32 Signal Transduction Cascades of Striatonigral and Striatopallidal Neurons
Meurers, B. H., Dziewczapolski, G., Shi, T., Bittner, A., Kamme, F., & Shults, C. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5310-08.2009 · Cited by 30
Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases
Pillarisetti, S., Alexander, C. W., & Khanna, I. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.08.002 · Cited by 29
Motor learning in animal models of Parkinson's disease: Aberrant synaptic plasticity in the motor cortex
Xu, T., Wang, S., Lalchandani, R. R., & Ding, J. (2017) · Movement Disorders · doi:10.1002/mds.26938 · Cited by 31
Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons
Kronman, H. G., Richter, F., Labonté, B., Chandra, R., Zhao, S., Hoffman, G. E., Lobo, M. K., Schadt, E. E., & Nestler, E. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-44798-9 · Cited by 29
Contributions of the basal ganglia to action sequence learning and performance
Garr, E. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.017 · Cited by 30
Association study of Cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia
Tiwari, A. K., Zai, C. C. H., Likhodi, O., Voineskos, A. N., Meltzer, H. Y., Lieberman, J. A., Potkin, S. G., Remington, G. J., Müller, D., & Kennedy, J. L. (2011) · The Pharmacogenomics Journal · doi:10.1038/tpj.2010.93 · Cited by 28
Adenosine A2A–cannabinoid CB1 receptor interaction: An integrative mechanism in striatal glutamatergic neurotransmission
Tebano, M. T., Martire, A., & Popoli, P. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.051 · Cited by 28
Metabolic, synaptic and behavioral impact of 5‐week chronic deep brain stimulation in hemiparkinsonian rats
Chassain, C., Melon, C., Salin, P., Vitale, F., Couraud, S., Durif, F., Goff, L. K., & Gubellini, P. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13438 · Cited by 29
Altered Synaptic Vesicle Release and Ca2+ Influx at Single Presynaptic Terminals of Cortical Neurons in a Knock-in Mouse Model of Huntington’s Disease
Chen, S., Yu, C., Rong, L., Li, C. H., Qin, X., Ryu, H., & Park, H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00478 · Cited by 29
Pathway-Specific Control of Striatal Neuron Vulnerability by Corticostriatal Cannabinoid CB1 Receptors
Ruiz-Calvo, A., Maroto, I. B., Bajo‐Grañeras, R., Chiarlone, A., Gaudioso, Á., Ferrero, J. J., Resel, E., Sánchez‐Prieto, J., Rodríguez‐Navarro, J. A., Marsicano, G., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx285 · Cited by 28
Utility of genetically modified mice for understanding the neurobiology of substance use disorders
Fowler, C. D., & Kenny, P. J. (2011) · Human Genetics · doi:10.1007/s00439-011-1129-z · Cited by 30
Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D2-induced formation of anandamide
Solinas, M., Tanda, G., Wertheim, C. E., & Goldberg, S. R. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1789-8 · Cited by 28
Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice
Wei, W., Li, L., Yu, G., Ding, S., Li, C., & Zhou, F.-M. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00161.2013 · Cited by 26
Understanding Alzheimer's disease by global quantification of protein phosphorylation and sialylated N-linked glycosylation profiles: A chance for new biomarkers in neuroproteomics?
Lassen, P. S., Thygesen, C., Larsen, M. R., & Kempf, S. J. (2017) · Journal of Proteomics · doi:10.1016/j.jprot.2017.04.003 · Cited by 26
Levodopa Causes Striatal Cholinergic Interneuron Burst‐Pause Activity in Parkinsonian Mice
Paz, R. M., Tubert, C., Stahl, A. M., Amarillo, Y., Rela, L., & Murer, M. G. (2021) · Movement Disorders · doi:10.1002/mds.28516 · Cited by 26
DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons
Andreska, T., Lüningschrör, P., Wolf, D., McFleder, R. L., Ayon-Olivas, M., Rattka, M., Drechsler, C., Perschin, V., Blum, R., Aufmkolk, S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112575 · Cited by 27
The Use of Compounds Derived from Cannabis sativa in the Treatment of Epilepsy, Painful Conditions, and Neuropsychiatric and Neurodegenerative Disorders
Stasiłowicz-Krzemień, A., Nogalska, W., Maszewska, Z., Maleszka, M., Dobroń, M., Szary, A., Kępa, A., Żarowski, M., Hojan, K., Łukowicz, M., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115749 · Cited by 28
The decrease of dopamine D2/D3 receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CB1 cannabinoid receptors in Parkinson's disease: A preliminary autoradiographic study with the selective dopamine D2/D3 antagonist [3H]raclopride and the novel CB1 inverse agonist [125I]SD7015
Farkas, S., Nagy, K., Jia, Z., Harkany, T., Palkovits, M., Donohou, S. R., Pike, V. W., Halldin, C., Máthé, D., Csiba, L., et al. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.02.012 · Cited by 26
Decreased Striatal Dopamine Release Underlies Increased Expression of Long-Term Synaptic Potentiation at Corticostriatal Synapses 24 h after 3-Nitropropionic-Acid-Induced Chemical Hypoxia
Akopian, G. K., Crawford, C. A., Beal, M. F., Cappelletti, M., Jakowec, M. W., Petzinger, G. M., Zheng, L., Gheorghe, S. L., Reichel, C. M., Chow, R. H.-P., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5698-07.2008 · Cited by 26
Brain 2‐Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased Under Acute Ischemia‐Injury Which Is Prevented by Microwave Irradiation
Brose, S. A., Golovko, S. A., & Golovko, M. Y. (2016) · Lipids · doi:10.1007/s11745-016-4144-y · Cited by 26
Haloperidol Selectively Remodels Striatal Indirect Pathway Circuits
Sebel, L. E., Graves, S. M., Chan, C. S., & Surmeier, D. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.173 · Cited by 27
Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease
Tozzi, A., Durante, V., Bastioli, G., Mazzocchetti, P., Novello, S., Mechelli, A., Morari, M., Costa, C., Mancini, A., Filippo, M. D., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.06.008 · Cited by 26

Authors: Kreitzer, A. C., & Malenka, R. C.
Affiliations: Stanford Medicine (US)
Corresponding author: Malenka, Robert C.
ORCID: Kreitzer, Anatol C.
Malenka, Robert C.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-02
Volume: 445
Issue: 7128
Pages: 643-647
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05506
OpenAlex: W2003314029
Cited by: 735
References: 35
Citations by year: 2026: 12 · 2025: 21 · 2024: 21 · 2023: 17 · 2022: 17 · 2021: 34 · 2020: 28 · 2019: 41 · 2018: 41 · 2017: 45 · 2016: 37 · 2015: 34 · 2014: 37 · 2013: 31 · 2012: 47
FWCI: 44.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: striatum, indirect pathway, direct pathway, medium spiny neurons, dopamine D2 receptor, basal ganglia, motor impairment, synaptic plasticity, NMDA receptor currents, release probability, transgenic mouse model, therapeutic target, Huntington's disease, substantia nigra pars reticulata
MeSH terms: Animals, Benzamides, Carbamates, Disease Models, Animal, Dopamine, Mice, Transgenic, Morpholines, Naphthalenes, Neuronal Plasticity, Parkinson Disease, Piperidines, Psychomotor Performance, Pyrazoles, Reserpine, Synapses, Receptors, N-Methyl-D-Aspartate, Oxidopamine, Neostriatum, Receptors, Dopamine D2, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Receptor, Cannabinoid, CB1, Benzoxazines, Mice, Cannabinoid Receptor Modulators, Endocannabinoids, Dopamine D2 Receptor Antagonists, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks