Cited by 735Cannabis and Cannabinoid ResearchParkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

Kreitzer, Anatol C., Malenka, Robert C.·2007·Nature

DOI 10.1038/nature05506

Open this paper in CoChat — free account

Abstract

The striatum is a major forebrain nucleus that integrates cortical and thalamic afferents and forms the input nucleus of the basal ganglia. Striatal projection neurons target the substantia nigra pars reticulata (direct pathway) or the lateral globus pallidus (indirect pathway). Imbalances between neural activity in these two pathways have been proposed to underlie the profound motor deficits observed in Parkinson's disease and Huntington's disease. However, little is known about differences in cellular and synaptic properties in these circuits. Indeed, current hypotheses suggest that these cells express similar forms of synaptic plasticity. Here we show that excitatory synapses onto indirect-pathway medium spiny neurons (MSNs) exhibit higher release probability and larger N-methyl-d-aspartate receptor currents than direct-pathway synapses. Moreover, indirect-pathway MSNs selectively express endocannabinoid-mediated long-term depression (eCB-LTD), which requires dopamine D2 receptor activation. In models of Parkinson's disease, indirect-pathway eCB-LTD is absent but is rescued by a D2 receptor agonist or inhibitors of endocannabinoid degradation. Administration of these drugs together in vivo reduces parkinsonian motor deficits, suggesting that endocannabinoid-mediated depression of indirect-pathway synapses has a critical role in the control of movement. These findings have implications for understanding the normal functions of the basal ganglia, and also suggest approaches for the development of therapeutic drugs for the treatment of striatal-based brain disorders.

Integrity signals

Registry

Crossref · 10.1038/nature05506

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Glutamate receptor ion channels
Mayer, M. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.004 · Cited by 3,655
The Synaptic Organization of the Brain
(2004) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195159561.001.1 · Cited by 3,574
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Modulation of anxiety through blockade of anandamide hydrolysis
Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Rana, G. L., Calignano, A., et al. (2003) · Nature Medicine · doi:10.1038/nm803 · Cited by 1,293
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. A., & Bonner, T. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5780 · Cited by 1,078
The basal ganglia
Graybiel, A. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00593-5 · Cited by 1,051

Show all 35 references

Sorted by citations

Items 501–600 of 732

Cannabinoids in Parkinson’s disease
Concannon, R. M., Finn, D. P., & Dowd, E. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-417041-4.00003-5 · Cited by 11
Endocannabinoids at the Synapse: Retrograde Signaling and Presynaptic Plasticity in the Brain
Gerdeman, G. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3_11 · Cited by 11
Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry
Schülke, J.-P., & Brandon, N. J. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-58811-7_2 · Cited by 11
Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37‐deficient mice
Morató, X., Gonçalves, F. Q., Lopes, J. P., Jáuregui, O., Soler, C., Fernández‐Dueñas, V., Cunha, R. A., & Ciruela, F. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14653 · Cited by 11
Axonal degeneration in Parkinson's disease – Basal ganglia circuitry and D2 receptor availability
Pelzer, E. A., Melzer, C., Schönberger, A. R., Hess, M., Timmermann, L., Eggers, C., & Tittgemeyer, M. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101906 · Cited by 11
Organization of Corticostriatal Projection Neuron Types
Reiner, A. J. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00018-4 · Cited by 11
mGlu5 in GABAergic neurons modulates spontaneous and psychostimulant-induced locomotor activity
Wu, C., Jew, C. P., Sun, H., Ballester‐Rosado, C. J., & Lu, H. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05367-0 · Cited by 11
Future Perspectives of NMDAR in CNS Disorders
Capó, T., Rebassa, J. B., Raïch, I., Lillo, J., Badia, P., Navarro, G., & Reyes‐Resina, I. (2025) · Molecules · doi:10.3390/molecules30040877 · Cited by 12
From avoidance to new action: the multifaceted role of the striatal indirect pathway
Lee, J., & Sabatini, B. L. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00925-2 · Cited by 10
Effects of cannabinoids in Parkinson’s disease animal models: a systematic review and meta-analysis
Urbi, B., Lee, Y., Hughes, I. P., Thorning, S., Broadley, S., Sabet, A., & Heshmat, S. (2022) · BMJ Open Science · doi:10.1136/bmjos-2022-100302 · Cited by 10
Opposite function of dopamine D1 and N‐methyl‐D‐aspartate receptors in striatal cannabinoid‐mediated signaling
Daigle, T. L., Wetsel, W. C., & Caron, M. G. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07874.x · Cited by 10
mGluR-mediated and endocannabinoid-dependent long-term depression in the hilar region of the rat dentate gyrus
Nahir, B., Lindsly, C., & Frazier, C. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.12.022 · Cited by 10
Endogenous dopamine and endocannabinoid signaling mediate cocaine-induced reversal of AMPAR synaptic potentiation in the nucleus accumbens shell
Ingebretson, A. E., Hearing, M. C., Huffington, E. D., & Thomas, M. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.011 · Cited by 10
The Endocannabinoid System is a Major Player in Schizophrenia
Köfalvi, A., & Fritzsche, M. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3_22 · Cited by 10
Electrophysiological Measurement of Cannabinoid‐Mediated Synaptic Modulation in Acute Mouse Brain Slices
Báldi, R., Ghosh, D., Grueter, B. A., & Patel, S. (2016) · Current Protocols in Neuroscience · doi:10.1002/cpns.8 · Cited by 10
GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum
Carlson, V. C. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_98 · Cited by 10
Marijuana improved motor impairments and changes in synaptic plasticity-related molecules in the striatum in 6-OHDA-treated rats
Komeili, G., Haghparast, E., & Sheibani, V. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113342 · Cited by 10
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease
Zhai, S., Cui, Q., Wokosin, D. L., Sun, L., Tkatch, T., Crittenden, J. R., Graybiel, A. M., & Surmeier, D. J. (2025) · Science Advances · doi:10.1126/sciadv.adv8224 · Cited by 11
Proteomic Profile of Carbonylated Proteins Screen Regulation of Apoptosis via CaMK Signaling in Response to Regular Aerobic Exercise
Liu, W., Li, L., Kuang, H., Xia, Y., Wang, Z., Liu, S., & Yin, D. (2018) · BioMed Research International · doi:10.1155/2018/2828143 · Cited by 9
Shedding light on dyskinesias
Castela, I., & Hernández, L. F. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14777 · Cited by 10
Age‐related behavioural and striatal dysfunctions in Shank3 ΔC/ΔC mouse model of autism spectrum disorder
Thabault, M., Turpin, V., Balado, É., Fernandes‐Gomes, C., Huot, A.-L., Cantereau, A., Fernagut, P., Jaber, M., & Galvan, L. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15919 · Cited by 9
Interplay between periodic stimulation and GABAergic inhibition in striatal network oscillations
Belić, J. J., Kumar, A., & Kotaleski, J. H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175135 · Cited by 9
Physiological aging at striatal synapses
Walsh, J. P., & Akopian, G. K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24484 · Cited by 9
Differences in GluN2B-Containing NMDA Receptors Result in Distinct Long-Term Plasticity at Ipsilateral versus Contralateral Cortico-Striatal Synapses
Li, W., & Pozzo‐Miller, L. D. (2019) · eNeuro · doi:10.1523/eneuro.0118-19.2019 · Cited by 9
Neurotransmissão glutamatérgica e plasticidade sináptica: aspectos moleculares, clínicos e filogenéticos
Ruggiero, R. N., Bueno-Júnior, L. S., Ross, J. B. D., Fachim, H., Padovan‐Neto, F. E., Merlo, S., Rohner, C. J. S., Ikeda, E. T., Brusco, J., & Moreira, J. E. (2011) · Medicina (Ribeirão Preto) · doi:10.11606/issn.2176-7262.v44i2p143-156 · Cited by 9
Astrocytes tell neurons when to listen up
Gittis, A. H., & Brasier, D. J. (2015) · Science · doi:10.1126/science.aad0678 · Cited by 11
Early synaptic dysfunction of striatal parvalbumin interneurons in a mouse model of Parkinson’s disease
He, Q., Zhang, X., Yang, H., Wang, D., Shu, Y., & Wang, X. (2024) · iScience · doi:10.1016/j.isci.2024.111253 · Cited by 8
Adenosine A2A receptor blockade improves neuroprosthetic learning by volitional control of population calcium signal in M1 cortical neurons
Zhang, L., Zhou, Y., Liu, C., Zheng, W., Yao, Z., Wang, Q., Jin, Y., Zhang, S., Chen, W., & Chen, J. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108250 · Cited by 8
CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice
Zhang, L., Zeng, Z.-H., Lu, X.-Y., Li, M., Yao, J., Zou, G.-J., Chen, Z., Li, Q., Li, C.-Q., & Li, F. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00640-9 · Cited by 8
Implication of regional selectivity of dopamine deficits in impaired suppressing of involuntary movements in Parkinson’s disease
Lee, H., Kim, H. F., & Hikosaka, O. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105719 · Cited by 8
Enhanced GABAergic Inhibition of Cholinergic Interneurons in the zQ175+/− Mouse Model of Huntington's Disease
Lim, S. A. O., & Surmeier, D. J. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.626412 · Cited by 8
Cannabinoids for the Treatment of Movement Disorders
Catlow, B. J., & Sanchez‐Ramos, J. (2015) · Current Treatment Options in Neurology · doi:10.1007/s11940-015-0370-5 · Cited by 8
The ins and outs of endocannabinoid signaling in healthy and diseased brain
Horne, E. A., & Stella, N. (2008) · Future Lipidology · doi:10.2217/17460875.3.4.435 · Cited by 8
The adjustment of γ-aminobutyric acid A tonic subunits in Huntington's disease: from transcription to translation to synaptic levels into the neostriatum
Rosas‐Arellano, A., Estrada‐Mondragón, A., Mantellero, C. A., Tejeda-Guzmán, C., & Castro, M. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.230270 · Cited by 8
Erasing “bad memories”: reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders
Shi, Z., Wen, K., Sammudin, N. H., LoRocco, N. C., & Zhuang, X. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03013-0 · Cited by 7
A positive allosteric modulator of mGlu4 receptors restores striatal plasticity in an animal model of l-Dopa-induced dyskinesia
Calabrese, V., Picconi, B., Heck, N., Campanelli, F., Natale, G., Marino, G., Sciaccaluga, M., Ghiglieri, V., Tozzi, A., Anceaume, E., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109205 · Cited by 8
Probable role of the hyperpolarization-activated current in the dual effects of CB1R antagonism on behaviors in a Parkinsonism mouse model
Soti, M., Ranjbar, H., Kohlmeier, K. A., Razavinasab, M., Masoumi‐Ardakani, Y., & Shabani, M. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.10.015 · Cited by 7
Retinoic Acid Signaling: A New Piece in the Spoken Language Puzzle
van Rhijn, J.-R., & Vernes, S. C. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01816 · Cited by 7
Dynamic Changes in the Bridging Collaterals of the Basal Ganglia Circuitry Control Stress-Related Behaviors in Mice.
Lee, Y., Han, N.-E., Kim, W., Kim, J. G., Lee, I. B., Choi, S. J., Chun, H., Seo, M., Lee, C. J., Koh, H.-Y., et al. (2020) · PubMed Central · doi:10.14348/molcells.2019.0279 · Cited by 7
Combination of group I mGlu receptors antagonist with dopaminergic agonists strengthens the synaptic transmission at corticostriatal synapses in culture
Burguière, A., Bundel, D. D., Valjent, E., Roger, J., Smolders, I. J., Fagni, L., & Perroy, J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.03.017 · Cited by 7
Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism
Cannella, M., Motolese, M., Bucci, D., Molinaro, G., Gradini, R., Bruno, V., Nicoletti, F., & Battaglia, G. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.02.024 · Cited by 7
The cannabinoid receptor 1 mediates exercise-induced improvements of motor skill learning and performance in parkinsonian mouse
Zikereya, T., Liu, C., Wei, L., Wang, Y., Zhang, Z., Han, C., Shi, K., & Chen, W. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115289 · Cited by 6
Alpha-synuclein and RNA viruses: Exploring the neuronal nexus
Gupta, A., Bohara, V. S., Banasavadi‐Siddegowda, Y., Chaudhary, N., & Kumar, S. (2024) · Virology · doi:10.1016/j.virol.2024.110141 · Cited by 6
Sound-Evoked Responses of Distinct Neuron Classes from the Tail of the Striatum
Nardoci, M. B., Lakunina, A. A., Henderling, D. C., Pedregon, J. C., Mohn, J. L., & Jaramillo, S. (2022) · eNeuro · doi:10.1523/eneuro.0201-22.2022 · Cited by 6
Effects of heterozygous deletion of autism-related gene Cullin-3 in mice
Xia, Q., Walker, A. K., Song, C., Wang, J., Singh, A., Mobley, J. A., Xuan, Z., Singer, J. D., & Powell, C. M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0283299 · Cited by 6
Striatonigral direct pathway 2-arachidonoylglycerol contributes to ethanol effects on synaptic transmission and behavior
Augustin, S. M., Gracias, A. L., Luo, G., Anumola, R. C., & Lovinger, D. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01671-8 · Cited by 6
The Corticostriatal Pathway in Parkinson’s Disease
Bamford, N. S., & Cepeda, C. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-252-0_6 · Cited by 6
Apomorphine‐induced modulation of neural activities in the ventrolateral striatum of rats
Fujita, S., Kato, R., Cui, Y., Terakado, M., Suga, K., Koshikawa, N., & Kobayashi, M. (2013) · Synapse · doi:10.1002/syn.21644 · Cited by 6
Introductory Chapter: Mechanisms and Function of Synaptic Plasticity
Heinbockel, T. (2017) · InTech eBooks · doi:10.5772/67891 · Cited by 6
D1 and D2 Dopamine Receptor Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons
Surmeier, D. J., Day, M., Gertler, T. S., Chan, C. S., & Shen, W. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00006-8 · Cited by 6
Alterations in Corticostriatal Synaptic Function in Huntington's and Parkinson's Diseases
Cepeda, C., Bamford, N. S., André, V. M., & Levine, M. S. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00035-4 · Cited by 6
Aberrant plasticity and "learned" motor inhibition in Parkinson's disease.
Zhuang, X. (2012) · PubMed · Cited by 6
Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice
Shi, Z., Bamford, I. J., McKinley, J. W., Devi, S. P. S., Vahedipour, A., & Bamford, N. S. (2020) · Brain Sciences · doi:10.3390/brainsci10120903 · Cited by 6
Cannabinoid type 1 receptors in A2a neurons contribute to cocaine-environment association
Turner, B. D., Smith, N. K., Manz, K. M., Chang, B. T., Delpire, E. J., Grueter, C. A., & Grueter, B. A. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05759-1 · Cited by 6
Regular firing of a single output neuron reduces its own inhibition through endocannabinoids in substantia nigra pars reticulata of juvenile mice
Parra, H. R., Misgeld, U., & Yanovsky, Y. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.02.062 · Cited by 6
Cannabis Resin Extract in Parkinson’s Disease: Behavioral, Neurochemical, and Histological Evaluation
ElShebiney, S. A. (2014) · Cell Biology Research & Therapy · doi:10.4172/2324-9293.1000112 · Cited by 5
The Bac Transgenic Approach to Study Parkinson's Disease in Mice
Yang, X. W., & Lu, X. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374028-1.00019-1 · Cited by 5
Deep-Brain Stimulation for Neurologic and Psychiatric Disorders
Wichmann, T., & DeLong, M. R. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00039-1 · Cited by 5
The Striatal Skeleton
Plenz, D., & Wickens, J. R. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00005-6 · Cited by 5
The Endocannabinoid System and Human Brain Functions
Ashton, J. C., Dowie, M. J., & Glass, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809666-6.00005-8 · Cited by 7
Early-life adversity selectively interrupts the dendritic differentiation of dorsolateral striatal neurons in male mice
He, Y., Xu, B., Chen, Y., Xu, L., Xu, L., Chen, Y., & Long, D. (2021) · Brain Structure and Function · doi:10.1007/s00429-020-02183-7 · Cited by 6
Collagen VI Regulates Motor Circuit Plasticity and Motor Performance by Cannabinoid Modulation
Lam, D. D., Williams, R. H., Lujan, E., Tanabe, K., Huber, G., Saw, N. L., Merl‐Pham, J., Salminen, A. V., Lohse, D., Spendiff, S., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0962-21.2021 · Cited by 5
A simple method for characterizing passive and active neuronal properties: application to striatal neurons
Lepora, N. F., Blomeley, C. P., Hoyland, D., Bracci, E., Overton, P. G., & GURNEY, K. N. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07879.x · Cited by 5
A journey through cannabidiol in Parkinson’s disease
Del-Bel, E., Barros, N., de Moraes, R. A. P. D. S., de Mattos, B. A., Alves-Fernandes, T. A., de Abreu, L. B., Nascimento, G. C., Escobar-Espinal, D. M., Pedrazzi, J. F. C., Jacob, G. A., et al. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.04.015 · Cited by 4
Endocannabinoid signaling in epilepsy
Zeng, C., & Chen, C. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107074 · Cited by 4
Dopaminergic tone inhibits spontaneous glutamate release and augments homeostatic synaptic plasticity
Uzay, B., Zhang, K. J., Monteggia, L. M., & Kavalali, E. T. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03374-6 · Cited by 4
Lactate dynamics in Parkinson’s disease: striatal circuit vulnerability, biomarker potential, and therapeutic windows
Kong, J., Yang, Z., Wang, Y., Liu, L., Liu, Y., & Chen, W. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01551-z · Cited by 4
Involvement of the Endocannabinoid System in Ethanol-Induced Corticostriatal Synaptic Depression
Cho, H. S., Jeun, S. H., Li, Q., Kim, K., Choi, S. J., & Sung, K.-W. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12118fp · Cited by 4
Bridging the Gap: Muscarinic M4 Receptors Promote Striatal Plasticity in Health and Disease
Girasole, A. E., & Nelson, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.11.007 · Cited by 4
Receptors and Second Messengers in the Basal Ganglia
Warren, E. B., Sillivan, S. E., & Konradi, C. L. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00028-3 · Cited by 6
Spiny Projection Neuron Dynamics in Toxin and Transgenic Models of Parkinson’s Disease
Du, Y., & Graves, S. M. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00017 · Cited by 4
Regenerative Medicine of Neural Tissues
Stocum, D. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384860-4.00011-3 · Cited by 4
Adaptive Gene Regulation in the Striatum of RGS9-Deficient Mice
Busse, K., Strotmann, R., Strecker, K., Wegner, F., Devanathan, V., Gohla, A., Schöneberg, T., & Schwarz, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092605 · Cited by 5
PQBP1: A New Player in Metabotropic Glutamate Receptor Signaling and Synaptic Plasticity
Su, L., & Shen, Y. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00720-w · Cited by 4
Connectivity and Excitability Shape Seizure Circuits
Brodovskaya, A., & Kapur, J. (2022) · Epiliepsy currents/Epilepsy currents · doi:10.1177/15357597221136961 · Cited by 4
Distinctive physiology of molecularly identified medium spiny neurons in the macaque putamen
Ting, J. T., Johansen, N., Kalmbach, B. E., Taskin, N., Lee, B., Clark, J. K., Kendrick, R. M., Ng, L., Radaelli, C., Weed, N., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114963 · Cited by 6
Endocannabinoids and Dopamine Balance Basal Ganglia Output
Gorodetski, L., Loewenstern, Y., Faynveitz, A., Bar‐Gad, I., Blackwell, K. T., & Korngreen, A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.639082 · Cited by 3
Elevated striatal dopamine attenuates nigrothalamic inputs and impairs transthalamic cortico-cortical communication in schizophrenia: A hypothesis
Vukadinovic, Z. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.11.014 · Cited by 3
Phasic Dopaminergic Signaling: Implications for Parkinson’s Disease
Sandberg, S. G., & Phillips, P. E. M. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-252-0_3 · Cited by 3
Relationship between regional gray matter volumes and dopamine D2 receptor and transporter in living human brains
Kurose, S., Kubota, M., Takahata, K., Yamamoto, Y., Fujiwara, H., Kimura, Y., Ito, H., Takeuchi, H., Mimura, M., Suhara, T., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25538 · Cited by 3
Synaptic scaling of corticostriatal circuits underlies hyperactivity in GABA Transporter-1 deficient mice
Wu, Y., Yi, X., Gu, X. F., Wang, Q., Jiang, Q., Li, Y., Zhu, M. X., Ding, J., Li, W., & Xu, T. (2023) · iScience · doi:10.1016/j.isci.2023.106322 · Cited by 3
Neuroprotective activity of cannabinoid receptor‐2 against oxidative stress and apoptosis in rat pups having experimentally‐induced congenital hypothyroidism
Alçığır, M. E., Doğan, H. O., Vural, S. A., & Yılmaz, F. M. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22516 · Cited by 3
Cannabinoids in the Treatment of Parkinson’s Disease
Gandor, F., & Ebersbach, G. (2017) · Neurology International Open · doi:10.1055/s-0043-115359 · Cited by 3
Regional heterogeneity in the membrane properties of mouse striatal neurons
Chuhma, N., & Rayport, S. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1412897 · Cited by 2
The Inhibition of Fatty Acid Amide Hydrolase-4 Affords Neuroprotection in a Toxic Model Induced by 6-Hydroxydopamine in Caenorhabditis elegans Nematodes
Estrada-Valencia, R., Túnez, I., Tinkov, A. A., Aschner, M., López, T., Pedraza‐Chaverrí, J., & Santamarı́a, A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05104-z · Cited by 2
Transcranial magneto-acoustic stimulation improves corticostriatal transmission in direct medium spiny neurons and rescues neuroplasticity of Parkinson’s disease model mice
Xu, Y., Zhang, S., Mi, J., Lu, X., An, Y., Liu, J., Sun, J., Wang, Y., & Xu, G. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01333-8 · Cited by 2
Synaptic Triad in the Neostriatum
Klug, J. R., Deutch, A. Y., Colbran, R. J., & Winder, D. J. (2011) · Frontiers in neuroscience · doi:10.1201/b11284-5 · Cited by 2
Functional foods and Parkinson's disease: A focus on omega-3 fatty acids
Li, P., & Song, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91747-6.00007-x · Cited by 2
Reduced inhibitory synaptic transmission onto striatopallidal neurons may underlie aging-related motor skill deficits
Shan, Q., Yu, X., Lin, X., & Tian, Y. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106582 · Cited by 2
Behavioral inflexibility through overtraining is mediated by reduced mGluR1/5 signaling capacity in the dorsolateral striatum
Paget-Blanc, V., Cavaccini, A., Longaretti, A., Nava, L., Trusel, M., Rocchi, A., Pennuto, M., Marcello, E. E., Gardoni, F., Greco, B., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003288 · Cited by 2
Facing the Unique Challenges of Dyskinesias In Parkinson‘s Disease
Homayoun, H., & Goetz, C. G. (2012) · Future Neurology · doi:10.2217/fnl.12.4 · Cited by 2
A Molecular Switch for Induction of Long-Term Depression of Corticostriatal Transmission: Figure 1.
Kheirbek, M. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2938-07.2007 · Cited by 2
Dopamine–Endocannabinoid Interactions in Parkinson’s Disease
McCallum, S. E., & Cheer, J. F. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-252-0_12 · Cited by 2
Conclusions: Therapeutic Potential of Novel Cannabinoid Receptors
Abood, M. E., Sorensen, R. G., & Stella, N. (2012) · The Receptors · doi:10.1007/978-1-4614-4669-9_12 · Cited by 2
Estudio funcional del receptor dopaminérgico D2 en el sistema nervioso central mediante el uso de ratones mutantes inducibles
del Pilar, E. (2012) · Cited by 2
Brain Imaging of Cannabinoid Receptors
Casteels, C., Bormans, G. M., & Laere, K. V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418677-4.00003-8 · Cited by 2
Dopaminergic Modulation of Glutamatergic Signaling in Striatal Spiny Projection Neurons
Shen, W., Plokin, J. L., Zhai, S., & Surmeier, D. J. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00009-x · Cited by 2
Endocannabinoid-Dependent Synaptic Plasticity in the Striatum
Atwood, B. K., & Lovinger, D. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-57371-7_5 · Cited by 2
Regenerative Medicine of Neural Tissues
Stocum, D. L. (2006) · Elsevier eBooks · doi:10.1016/b978-012369371-6/50023-x · Cited by 2
Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons
Shen, W., & Surmeier, D. J. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-333-6_7 · Cited by 2

Authors: Kreitzer, A. C., & Malenka, R. C.
Affiliations: Stanford Medicine (US)
Corresponding author: Malenka, Robert C.
ORCID: Kreitzer, Anatol C.
Malenka, Robert C.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-02
Volume: 445
Issue: 7128
Pages: 643-647
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05506
OpenAlex: W2003314029
Cited by: 735
References: 35
Citations by year: 2026: 12 · 2025: 21 · 2024: 21 · 2023: 17 · 2022: 17 · 2021: 34 · 2020: 28 · 2019: 41 · 2018: 41 · 2017: 45 · 2016: 37 · 2015: 34 · 2014: 37 · 2013: 31 · 2012: 47
FWCI: 44.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: striatum, indirect pathway, direct pathway, medium spiny neurons, dopamine D2 receptor, basal ganglia, motor impairment, synaptic plasticity, NMDA receptor currents, release probability, transgenic mouse model, therapeutic target, Huntington's disease, substantia nigra pars reticulata
MeSH terms: Animals, Benzamides, Carbamates, Disease Models, Animal, Dopamine, Mice, Transgenic, Morpholines, Naphthalenes, Neuronal Plasticity, Parkinson Disease, Piperidines, Psychomotor Performance, Pyrazoles, Reserpine, Synapses, Receptors, N-Methyl-D-Aspartate, Oxidopamine, Neostriatum, Receptors, Dopamine D2, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Receptor, Cannabinoid, CB1, Benzoxazines, Mice, Cannabinoid Receptor Modulators, Endocannabinoids, Dopamine D2 Receptor Antagonists, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks