The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models
Abstract
The striatum is a major forebrain nucleus that integrates cortical and thalamic afferents and forms the input nucleus of the basal ganglia. Striatal projection neurons target the substantia nigra pars reticulata (direct pathway) or the lateral globus pallidus (indirect pathway). Imbalances between neural activity in these two pathways have been proposed to underlie the profound motor deficits observed in Parkinson's disease and Huntington's disease. However, little is known about differences in cellular and synaptic properties in these circuits. Indeed, current hypotheses suggest that these cells express similar forms of synaptic plasticity. Here we show that excitatory synapses onto indirect-pathway medium spiny neurons (MSNs) exhibit higher release probability and larger N-methyl-d-aspartate receptor currents than direct-pathway synapses. Moreover, indirect-pathway MSNs selectively express endocannabinoid-mediated long-term depression (eCB-LTD), which requires dopamine D2 receptor activation. In models of Parkinson's disease, indirect-pathway eCB-LTD is absent but is rescued by a D2 receptor agonist or inhibitors of endocannabinoid degradation. Administration of these drugs together in vivo reduces parkinsonian motor deficits, suggesting that endocannabinoid-mediated depression of indirect-pathway synapses has a critical role in the control of movement. These findings have implications for understanding the normal functions of the basal ganglia, and also suggest approaches for the development of therapeutic drugs for the treatment of striatal-based brain disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“which may give rise to an aberrant learning that further impairs automatic motor behavior 45, 46.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [46]
Citations
Cites
The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Glutamate receptor ion channels
Mayer, M. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.004 · Cited by 3,655
The Synaptic Organization of the Brain
(2004) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195159561.001.1 · Cited by 3,574
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Modulation of anxiety through blockade of anandamide hydrolysis
Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Rana, G. L., Calignano, A., et al. (2003) · Nature Medicine · doi:10.1038/nm803 · Cited by 1,293
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. A., & Bonner, T. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5780 · Cited by 1,078
Graybiel, A. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00593-5 · Cited by 1,051
Cited by
Sorted by citations
Items 401–500 of 732
Renteria, R., Cazares, C., Baltz, E. T., Schreiner, D. C., Yalcinbas, E. A., Steinkellner, T., Hnasko, T. S., & Gremel, C. M. (2021) · eLife · doi:10.7554/elife.67065 · Cited by 25
Song, J., Kyriakatos, A., & Manira, A. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5850-11.2012 · Cited by 28
Willett, J. A., Cao, J., Dorris, D. M., Johnson, A. G., Ginnari, L. A., & Meitzen, J. (2019) · eNeuro · doi:10.1523/eneuro.0016-19.2019 · Cited by 24
Janković, M., Spasojević, N., Ferizović, H., Stefanović, B., & Dronjak, S. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113174 · Cited by 26
Cannabinoid Receptor 1 Is Required for Neurodevelopment of Striosome-Dendron Bouquets
Crittenden, J. R., Yoshida, T., Venu, S., Mahar, A., & Graybiel, A. M. (2022) · eNeuro · doi:10.1523/eneuro.0318-21.2022 · Cited by 24
Mango, D., & Ledonne, A. (2023) · Cells · doi:10.3390/cells12121588 · Cited by 25
Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
Zold, C. L., Escande, M. V., Pomata, P. E., Riquelme, L. A., & Murer, M. G. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.022 · Cited by 24
Drugs of abuse and Parkinson's disease
Mursaleen, L., & Stamford, J. A. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.013 · Cited by 24
Morita, K. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00625.2013 · Cited by 27
Xia, J., Meyers, A. M., & Beeler, J. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.87 · Cited by 24
Probing striatal microcircuitry to understand the functional role of cholinergic interneurons
Girasole, A. E., & Nelson, A. (2015) · Movement Disorders · doi:10.1002/mds.26340 · Cited by 23
Generation of a model of l-DOPA-induced dyskinesia in two different mouse strains
Thiele, S. L., Warre, R., Khademullah, C. S., Fahana, N., Lo, C., Lam, D., Talwar, S., Johnston, T. H., Brotchie, J. M., & Nash, J. E. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.02.012 · Cited by 25
Flores-Barrera, E., Laville, A., Plata, V. T. G., Tapia, D., Bargas, J., & Galarraga, E. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9394-2 · Cited by 23
Dysregulation of striatal projection neurons in Parkinson’s disease
Beck, G., Singh, A. P., & Papa, S. M. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1744-5 · Cited by 25
Alterations in mGlu5 receptor expression and function in the striatum in a rat depression model
Mao, L., & Wang, J. Q. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14307 · Cited by 23
Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D1Receptor Signaling
Cirnaru, M., Melis, C., Fanutza, T., Naphade, S. B., Tshilenge, K., Muntean, B. S., Martemyanov, K. A., Plotkin, J. L., Ellerby, L., & Ehrlich, M. E. (2019) · eNeuro · doi:10.1523/eneuro.0305-19.2019 · Cited by 23
Endocannabinoid modulation of dopamine release during reward seeking, interval timing, and avoidance
Everett, T. J., Gomez, D. M., Hamilton, L. R., & Oleson, E. B. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110031 · Cited by 24
Differential CaMKII regulation by voltage-gated calcium channels in the striatum
Pasek, J. G., Wang, X., & Colbran, R. J. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.08.003 · Cited by 22
Baca, M., Allan, A. M., Partridge, L., & Wilson, M. C. (2013) · Brain Research · doi:10.1016/j.brainres.2013.08.012 · Cited by 22
Hawes, S., Salinas, A. G., Lovinger, D. M., & Blackwell, K. T. (2017) · The Journal of Physiology · doi:10.1113/jp274190 · Cited by 22
White, K. A., Zhang, Y. F., Zhang, Z., Bhattarai, J. P., Moberly, A. H., Zandt, E. E. I. ’., Pena-Bravo, J. I., Mi, H., Jia, X., Fuccillo, M. V., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1444-19.2019 · Cited by 22
Shou, Y., Yang, Y., Xu, M., Zhao, Y., Ge, L.-B., & Zhang, B. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/393460 · Cited by 22
Ferger, B., Buck, K., Shimasaki, M., Koroś, E., Voehringer, P., & Buerger, E. (2010) · Synapse · doi:10.1002/syn.20759 · Cited by 22
GluN1 deletions in D1- and A2A-expressing cell types reveal distinct modes of behavioral regulation
Joffe, M. E., Vitter, S. R., & Grueter, B. A. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.026 · Cited by 27
The Dysfunctional Mechanisms Throwing Tics: Structural and Functional Changes in Tourette Syndrome
Lamanna, J., Ferro, M., Spadini, S., Racchetti, G., & Malgaroli, A. (2023) · Behavioral Sciences · doi:10.3390/bs13080668 · Cited by 21
Davis, M. M., Olausson, P., Greengard, P., Taylor, J. R., & Nairn, A. C. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07956.x · Cited by 21
Bosier, B., Muccioli, G. G., & Lambert, D. M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02208.x · Cited by 21
New insights on endocannabinoid transmission in psychomotor disorders
Giuffrida, A., & Seillier, A. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.04.002 · Cited by 24
Parkinson's disease: emerging pharmacotherapy
Strecker, K., & Schwarz, J. (2008) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210802596906 · Cited by 21
Deng, Y., Shelby, E. S., & Reiner, A. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.003 · Cited by 22
Functional disturbances in the striatum by region-specific ablation of NMDA receptors
Ohtsuka, N., Tansky, M. F., Kuang, H., Kourrich, S., Thomas, M. J., Rubenstein, J. L. R., Ekker, M., Leeman, S. E., & Tsien, J. Z. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806180105 · Cited by 21
Regulation of Corticostriatal Synaptic Plasticity by G Protein-Coupled Receptors
de Maturana, R. L., & Sánchez‐Pernaute, R. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710793361531 · Cited by 21
He, Y., Li, Y., Chen, M., Pu, Z., Zhang, F., Chen, L., Ruan, Y., Pan, X., He, C., Chen, X., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00151 · Cited by 21
Neurexin1α Differentially Regulates Synaptic Efficacy within Striatal Circuits
Davatolhagh, M. F., & Fuccillo, M. V. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.108773 · Cited by 21
Altered Hippocampal Synaptic Physiology in Aged Parkin-Deficient Mice
Hanson, J. E., Orr, A., & Madison, D. V. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-010-8113-y · Cited by 21
Buendia, J. D. J. A., Rueda‐Orozco, P. E., Hernandez-Martinez, R., Galarraga, E., & Bargas, J. (2011) · Learning & Memory · doi:10.1101/lm.023432.111 · Cited by 21
Zhang, X., Feng, Z.-J., & Chergui, K. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu052 · Cited by 20
Mechanisms of Antiparkinsonian Anticholinergic Therapy Revisited
Paz, R. M., & Murer, M. G. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.05.026 · Cited by 22
Huang, C., Liang, Y.-C., Lee, C. C., & Hsu, K. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8926-z · Cited by 20
Lovelace, J. W., Vieira, P. A., Corches, A., Mackie, K., & Korzus, E. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.15 · Cited by 20
Zhou, R., Wang, S., & Zhu, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042443 · Cited by 20
Excitability decreasing central motor plasticity is retained in multiple sclerosis patients
Zeller, D., Dang, S., Weise, D., Rieckmann, P., Toyka, K. V., & Claßen, J. (2012) · BMC Neurology · doi:10.1186/1471-2377-12-92 · Cited by 20
Escamilla-Ramírez, Á., Garcı́a, E., Palencia, G., Colín-González, A. L., Galván‐Arzate, S., Túnez, I., Sotelo, J., & Santamarı́a, A. (2017) · Neurotoxicity Research · doi:10.1007/s12640-016-9698-1 · Cited by 20
Molecular Imaging of the Cannabinoid System in Idiopathic Parkinson's Disease
Cilia, R. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.08.004 · Cited by 20
Functional and behavioral consequences of Parkinson's disease-associated LRRK2-G2019S mutation
Benson, D. L., Matikainen‐Ankney, B. A., Hussein, A., & Huntley, G. W. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180468 · Cited by 20
Predicting the response of striatal spiny neurons to sinusoidal input
Wilson, C. J. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00143.2017 · Cited by 20
Cytokine-, Neurotrophin-, and Motor Rehabilitation-Induced Plasticity in Parkinson’s Disease
Policastro, G., Brunelli, M., Tinazzi, M., Chiamulera, C., Emerich, D. F., & Paolone, G. (2020) · Neural Plasticity · doi:10.1155/2020/8814028 · Cited by 21
Fieblinger, T., Li, C., Espa, E., & Cenci, M. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105470 · Cited by 19
The antipsychotic landscape: dopamine and beyond
Morrison, P. D., & Murray, R. M. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125317752915 · Cited by 19
The Endocannabinoid System in the Physiology and Pathology of the Basal Ganglia
Gerdeman, G. L., & Fernández‐Ruíz, J. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3_21 · Cited by 19
Literature-Related Discovery (LRD)
Kostoff, R. N., Block, J. A., Solka, J. L., Briggs, M. B., Rushenberg, R. L., Stump, J. A., Johnson, D., Lyons, T. J., & Wyatt, J. R. (2007) · Defense Technical Information Center (DTIC) · doi:10.21236/ada473438 · Cited by 19
Zold, C. L., Kasanetz, F., Pomata, P. E., Belluscio, M., Escande, M. V., Galiñanes, G. L., Riquelme, L. A., & Murer, M. G. (2011) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2011.06.002 · Cited by 18
Wu, X., Shi, M., Ling, H.-L., Wei, C., Liu, Y., Liu, Z., & Ren, W. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.09.015 · Cited by 18
Adermark, L. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.039 · Cited by 19
Chepkova, A. N., Fleischer, W., Kazmierczak, T., Doreulee, N., Haas, H. L., & Sergeeva, O. A. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0714-7 · Cited by 18
Berthet, P., Lindahl, M., Tully, P. J., Kotaleski, J. H., & Lansner, A. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00053 · Cited by 19
Huntley, G. W., & Benson, D. L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00265 · Cited by 18
Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum
Jeun, S. H., Cho, H. S., Kim, K., Li, Q. Z., & Sung, K.-W. (2009) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2009.13.3.209 · Cited by 20
The Striatal Skeleton: Medium Spiny Projection Neurons and Their Lateral Connections
Plenz, D., & Wickens, J. R. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00006-4 · Cited by 17
Li, Y., Pan, X., He, Y., Ruan, Y., Huang, L., Zhou, Y., Hou, Z., He, C., Wang, Z., Zhang, X., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00393 · Cited by 17
Nelson, A. B., Girasole, A. E., Lee, H.-Y., Ptáček, L. J., & Kreitzer, A. C. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1614-20.2022 · Cited by 17
Self-citationD1 / D5 Inverse Agonists Restore Striatal Cholinergic Interneuron Physiology in Dyskinetic Mice
Paz, R. M., Stahl, A. M., Rela, L., Murer, M. G., & Tubert, C. (2022) · Movement Disorders · doi:10.1002/mds.29055 · Cited by 17
Oscillations in the basal ganglia in Parkinson's disease: Role of the striatum
Belluscio, M., Escande, M. V., Keifman, E., Riquelme, L. A., Murer, M. G., & Zold, C. L. (2013) · Basal Ganglia · doi:10.1016/j.baga.2013.11.003 · Cited by 17
Cannabinoid regulation in identified synapse of terrestrial snail
Lemak, M. S., Bravarenko, N. I., Bobrov, М. Y., Безуглов, В. В., Ierusalimsky, V. N., Storozhuk, M., Malyshev, A. Y., & Balaban, P. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05945.x · Cited by 17
Endocannabinoid Signaling in the Striatum
Lovinger, D. M., Davis, M. I., & Costa, R. M. (2010) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-374767-9.00009-3 · Cited by 16
Martella, G., Madeo, G., Schirinzi, T., Tassone, A., Sciamanna, G., Spadoni, F., Stefani, A., Shen, J., Pisani, A., & Bonsi, P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.12.057 · Cited by 16
Madeo, G., Schirinzi, T., Maltese, M., Martella, G., Rapino, C., Fezza, F., Mastrangelo, N., Bonsi, P., Maccarrone, M., & Pisani, A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.021 · Cited by 17
Organization of Corticostriatal Projection Neuron Types
Reiner, A. J., & Deng, Y. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00020-9 · Cited by 16
Are we listening to everything the PARK genes are telling us?
Benson, D. L., & Huntley, G. W. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24642 · Cited by 17
Herold, C. (2010) · Behavioral Neuroscience · doi:10.1037/a0019504 · Cited by 18
Acetylcholine demixes heterogeneous dopamine signals for learning and moving
Jang, H. J., Ward, R. M., Golden, C. E. M., & Constantinople, C. M. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02227-x · Cited by 20
Cunha, C., Smiley, J. F., Chuhma, N., Shah, R., Bleiwas, C., Menezes, E. D. C., Seal, R. P., Edwards, R. H., Rayport, S., Ansorge, M. S., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0763-z · Cited by 15
Ebrahimi-Ghiri, M., Shahini, F., & Zarrindast, M. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00851-z · Cited by 15
Chronic THC intake modifies fundamental cerebellar functions
Stella, N. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70226 · Cited by 15
Ueda, Y., Yamanaka, K., Noritake, A., Enomoto, K., Matsumoto, N., Yamada, H., Samejima, K., Inokawa, H., Hori, Y., Nakamura, K., et al. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00066 · Cited by 15
He, Y., Huang, L., Wang, K., Pan, X., Cai, Q., Zhang, F., Yang, J., Fang, G., Zhao, X., You, F., et al. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab244 · Cited by 14
Morera‐Herreras, T., Ruíz-Ortega, J. Á., Linazasoro, G., & Ugedo, L. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2043-0 · Cited by 14
Wang, Y., Zhang, G., Sun, Y., Yao, L., Wang, H., Du, C., Zhang, L., & Liu, J. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.03.020 · Cited by 15
Gorodetski, L., Zeira, R., Lavian, H., & Korngreen, A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14105 · Cited by 14
Beckley, J. T., Randall, P. K., Smith, R. J., Hughes, B. A., Kalivas, P. W., & Woodward, J. J. (2015) · Addiction Biology · doi:10.1111/adb.12235 · Cited by 14
Shimizu, T., & Yokotani, K. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.12.020 · Cited by 14
Guo, X., Liu, T., Zhao, D., Wang, X., Liu, D., He, Y., Shan, C., Kong, Y., Hu, W., Tao, B., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.007 · Cited by 14
Potential Neuroprotective Effect of the Endocannabinoid System on Parkinson’s Disease
Urmeneta-Ortíz, M. F., Tejeda-Martínez, A. R., González‐Reynoso, O., & Flores-Soto, M. E. (2024) · Parkinson s Disease · doi:10.1155/2024/5519396 · Cited by 14
Sharma, P., & Pienaar, I. S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.026 · Cited by 13
Medical Cannabis for the Treatment of Inflammation
Namdar, D., & Koltai, H. (2018) · Natural Product Communications · doi:10.1177/1934578x1801300304 · Cited by 13
The Endocannabinoid System and Parkinson Disease
Giuffrida, A., & Martinez, A. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809666-6.00003-4 · Cited by 13
Aberrant learning in Parkinson's disease: A neurocomputational study on bradykinesia
Ursino, M., & Baston, C. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13960 · Cited by 13
He, Y., Li, Y., Pu, Z., Chen, M., Gao, Y., Chen, L., Ruan, Y., Pan, X., Zhou, Y., Ge, Y., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz172 · Cited by 13
Zhai, S., Otsuka, S., Xu, J., Clarke, V. R. J., Tkatch, T., Wokosin, D. L., Xie, Z., Tanimura, A., Agarwal, H. K., Ellis‐Davies, G. C. R., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114540 · Cited by 13
Malhotra, S., Donneger, F., Farrell, J. S., Dudok, B., Losonczy, A., & Soltész, I. (2025) · Neuron · doi:10.1016/j.neuron.2025.03.016 · Cited by 14
Kuhlmann, N., Valladolid, M. W., Quesada-Ramírez, L., Farrer, M. J., & Milnerwood, A. J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.569031 · Cited by 14
Di, Y., Diao, Z., Zheng, Q., Li, J., Cheng, Q., Li, Z., Fang, S., Wang, H., Wei, C., Zheng, Q., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0623-22.2022 · Cited by 12
Morita, K., & Kawaguchi, Y. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12994 · Cited by 12
Differential mitochondrial morphology in ventral striatal projection neuron subtypes
Chandra, R., Calarco, C. A., & Lobo, M. K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24511 · Cited by 14
Koranda, J. L., Krok, A. C., Xu, J., Contractor, A., McGehee, D. S., Beeler, J. A., & Zhuang, X. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2754-15.2016 · Cited by 13
Molecular Imaging in Huntington's Disease
Wilson, H., & Politis, M. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.08.007 · Cited by 12
Todorov, G., Mayilvahanan, K., Ashurov, D., & Cunha, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-45325-6 · Cited by 11
RetractedD2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia
Florio, E., Serra, M., Lewis, R. G., Kramár, E. A., Freidberg, M. D., Wood, M. A., Morelli, M., & Borrelli, E. (2022) · iScience · doi:10.1016/j.isci.2022.105263 · Cited by 12
Hamid, A. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.07.005 · Cited by 11
Parkinson’s disease related alterations in cannabinoid transmission
Soti, M., Ranjbar, H., Kohlmeier, K. A., & Shabani, M. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.11.009 · Cited by 11
Metadata
- Authors
- Kreitzer, A. C., & Malenka, R. C.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Malenka, Robert C.
- Venue
- Nature
- Published
- 2007-02
- Volume
- 445
- Issue
- 7128
- Pages
- 643-647
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2003314029
- Cited by
- 735
- References
- 35
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 21 · 2023: 17 · 2022: 17 · 2021: 34 · 2020: 28 · 2019: 41 · 2018: 41 · 2017: 45 · 2016: 37 · 2015: 34 · 2014: 37 · 2013: 31 · 2012: 47
- FWCI
- 44.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- striatum, indirect pathway, direct pathway, medium spiny neurons, dopamine D2 receptor, basal ganglia, motor impairment, synaptic plasticity, NMDA receptor currents, release probability, transgenic mouse model, therapeutic target, Huntington's disease, substantia nigra pars reticulata
- MeSH terms
- Animals, Benzamides, Carbamates, Disease Models, Animal, Dopamine, Mice, Transgenic, Morpholines, Naphthalenes, Neuronal Plasticity, Parkinson Disease, Piperidines, Psychomotor Performance, Pyrazoles, Reserpine, Synapses, Receptors, N-Methyl-D-Aspartate, Oxidopamine, Neostriatum, Receptors, Dopamine D2, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Receptor, Cannabinoid, CB1, Benzoxazines, Mice, Cannabinoid Receptor Modulators, Endocannabinoids, Dopamine D2 Receptor Antagonists, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review