The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
An African origin for the intimate association between humans and Helicobacter pylori
Open accessAbstract
Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic differentiation, the age of an association between these bacteria with humans remains highly controversial. Here we show, using sequences from a large data set of bacterial strains that, as in humans, genetic diversity in H. pylori decreases with geographic distance from east Africa, the cradle of modern humans. We also observe similar clines of genetic isolation by distance (IBD) for both H. pylori and its human host at a worldwide scale. Like humans, simulations indicate that H. pylori seems to have spread from east Africa around 58,000 yr ago. Even at more restricted geographic scales, where IBD tends to become blurred, principal component clines in H. pylori from Europe strongly resemble the classical clines for Europeans described by Cavalli-Sforza and colleagues. Taken together, our results establish that anatomically modern humans were already infected by H. pylori before their migrations from Africa and demonstrate that H. pylori has remained intimately associated with their human host populations ever since.
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Cites
Going east: new genetic and archaeological perspectives on the modern human colonization of Eurasia
Mellars, P. (2006) · Science · doi:10.1126/science.1128402 · Cited by 494
Evidence for Gradients of Human Genetic Diversity Within and Among Continents
Serre, D., & Pääbo, S. (2004) · Genome Research · doi:10.1101/gr.2529604 · Cited by 436
The effect of the Neolithic expansion on European molecular diversity
Currat, M., & Excoffier, L. (2005) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2004.2999 · Cited by 210
Cited by
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
The human microbiome: at the interface of health and disease
Cho, I., & Blaser, M. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3182 · Cited by 3,449
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877
Dominy, S. S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau3333 · Cited by 1,966
Blanco-Míguez, A., Beghini, F., Cumbo, F., McIver, L. J., Thompson, K. N., Zolfo, M., Manghi, P., Dubois, L., Huang, K. D., Thomas, A. M., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01688-w · Cited by 1,442
Metadata
- Authors
- Linz, B., Balloux, F., Moodley, Y., Manica, A., Liu, H., Roumagnac, P., Falush, D., Stamer, C., Prugnolle, F., van der Merwe, S. W., Yamaoka, Y., Graham, D. Y., Perez-Trallero, E., Wadstrom, T., Suerbaum, S., & Achtman, M.
- Venue
- Nature
- Published
- 2007-02
- Volume
- 445
- Issue
- 7130
- Pages
- 915-918
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2108018752
- Cited by
- 978
- References
- 3
- FWCI
- 75.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Linz, B., Balloux, F., Moodley, Y., Manica, A., Liu, H., Roumagnac, P., Falush, D., Stamer, C., Prugnolle, F., van der Merwe, S. W., Yamaoka, Y., Graham, D. Y., Perez-Trallero, E., Wadstrom, T., Suerbaum, S., & Achtman, M. (2007). An African origin for the intimate association between humans and Helicobacter pylori. Nature. https://doi.org/10.1038/nature05562
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
