Cited by 837T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisGenomics and Chromatin Dynamics

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Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

Zheng, Ye, Josefowicz, Steven Z., Kas, Arnold, Chu, Tin-Tin, Gavin, Marc A., Rudensky, Alexander Y.·2007·Nature

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Abstract

Transcription factor Foxp3 (forkhead box P3), restricted in its expression to a specialized regulatory CD4+ T-cell subset (T(R)) with a dedicated suppressor function, controls T(R) lineage development. In humans and mice, Foxp3 deficiency results in a paucity of T(R) cells and a fatal breach in immunological tolerance, causing highly aggressive multi-organ autoimmune pathology. Here, through genome-wide analysis combining chromatin immunoprecipitation with mouse genome tiling array profiling, we identify Foxp3 binding regions for approximately 700 genes and for an intergenically encoded microRNA. We find that a large number of Foxp3-bound genes are up- or downregulated in Foxp3+ T cells, suggesting that Foxp3 acts as both a transcriptional activator and repressor. Foxp3-mediated regulation unique to the thymus affects, among others, genes encoding nuclear factors that control gene expression and chromatin remodelling. In contrast, Foxp3 target genes shared by the thymic and peripheral T(R) cells encode primarily plasma membrane proteins, as well as cell signalling proteins. Together, our studies suggest that distinct transcriptional sub-programmes implemented by Foxp3 establish T(R) lineage during differentiation and its proliferative and functional competence in the periphery.

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Borneman, A. R., Zhang, Z. D., Rozowsky, J. S., Seringhaus, M. R., Gerstein, M., & Snyder, M. P. (2007) · Functional & Integrative Genomics · doi:10.1007/s10142-007-0054-7 · Cited by 25
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Herzog, R. W., Kuteyeva, V., Saboungi, R., Terhorst, C., & Biswas, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00274 · Cited by 24
Tipping the balance: inhibitory checkpoints in intestinal homeostasis
Joosse, M. E., Nederlof, I., Walker, L. S. K., & Samsom, J. N. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0113-5 · Cited by 24
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Andersen, L., Gülich, A. F., Alteneder, M., Preglej, T., Orola, M. J., Dhele, N., Stolz, V., Schebesta, A., Hamminger, P., Hladik, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.089 · Cited by 25
Molecular Insights Into Regulatory T-Cell Adaptation to Self, Environment, and Host Tissues: Plasticity or Loss of Function in Autoimmune Disease
Brown, C. Y., Sadlon, T. J., Hope, C. M., Wong, Y. Y., Wong, S. W., Liu, N., Withers, H., Brown, K. A., Bandara, V., Gundsambuu, B., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01269 · Cited by 25
Suppressive Effects of Oral Administration of Heat-Killed Lactobacillus acidophilus on T Helper-17 Immune Responses in a Bovine β-Lactoglobulin-Sensitized Mice Model
Li, A., Meng, X., Duan, C., Gui-cheng, H., Zheng, Q.-L., & Li, D. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00437 · Cited by 24
Predicting combinatorial binding of transcription factors to regulatory elements in the human genome by association rule mining
Morgan, X. C., Ni, S., Miranker, D. P., & Iyer, V. R. (2007) · BMC Bioinformatics · doi:10.1186/1471-2105-8-445 · Cited by 23
CCR7 with S1P1 Signaling through AP-1 for Migration of Foxp3+ Regulatory T-Cells Controls Autoimmune Exocrinopathy
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Biased Expression of the FOXP3Δ3 Isoform in Aggressive Bladder Cancer Mediates Differentiation and Cisplatin Chemotherapy Resistance
Zhang, H., Prado, K. B., Zhang, K. X., Peek, E. M., Lee, J. J., Wang, X., Huang, J., Li, G., Pellegrini, M. A., & Chin, A. I. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2581 · Cited by 24
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Kioussis, D., & Georgopoulos, K. (2007) · Science · doi:10.1126/science.1143777 · Cited by 24
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Benallegue, N., Kébir, H., & Alvarez, J. I. (2022) · Immunological Reviews · doi:10.1111/imr.13122 · Cited by 25
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Piccioni, M., Chen, Z., Tsun, A., & Li, B. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-9487-9_4 · Cited by 24
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Interleukin (IL)-35 is raising our expectations
Zhao, N. (2010) · Revista médica de Chile · doi:10.4067/s0034-98872010000600015 · Cited by 23
Developmental Plasticity of Murine and Human Foxp3+ Regulatory T Cells
Liston, A., & Piccirillo, C. A. (2013) · Advances in immunology · doi:10.1016/b978-0-12-407707-2.00003-5 · Cited by 23
Silencing of Foxp3 enhances the antitumor efficacy of GM-CSF genetically modified tumor cell vaccine against B16 melanoma
Miguel, A., Sendra, L., Noé, V., Ciudad, C. J., Dası́, F., Hervás, D., Herrero, M. J., & Aliño, S. F. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s104393 · Cited by 23
FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing
Du, J., Wang, Q., Ziegler, S. F., & Zhou, B. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001349 · Cited by 26
Decreased Treg-derived miR-181a and miR-155 correlated with reduced number and function of Treg cells in allergic rhinitis children
Liu, W., Ouyang, H., Zeng, Q., Luo, R., & Lu, G. (2019) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-019-05304-z · Cited by 23
Bcl10 is required for the development and suppressive function of Foxp3+ regulatory T cells
Yang, D., Zhao, X., & Lin, X. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0297-y · Cited by 23
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Yang, G., Dong, K., Zhang, Z., Zhang, E., Liang, B.-Y., Chen, X., & Huang, Z. (2020) · Journal of Cancer · doi:10.7150/jca.40673 · Cited by 23
Immune Dysregulation in Primary Immunodeficiency Disorders
Torgerson, T. R. (2008) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2008.02.002 · Cited by 23

Authors: Zheng, Y., Josefowicz, S. Z., Kas, A., Chu, T.-T., Gavin, M. A., & Rudensky, A. Y.
Affiliations: University of Washington (US)
Amgen (United States) (US)
Howard Hughes Medical Institute (US)
Corresponding author: Rudensky, Alexander Y.
ORCID: Zheng, Ye
Josefowicz, Steven Z.
Gavin, Marc A.
Rudensky, Alexander Y.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-01-21
Volume: 445
Issue: 7130
Pages: 936-940
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature05563
OpenAlex: W1992641327
Cited by: 835
References: 19
Citations by year: 2026: 11 · 2025: 12 · 2024: 22 · 2023: 17 · 2022: 26 · 2021: 30 · 2020: 36 · 2019: 48 · 2018: 36 · 2017: 37 · 2016: 32 · 2015: 40 · 2014: 49 · 2013: 62 · 2012: 63
FWCI: 31.71
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Cancer Research Institute
National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: Foxp3, regulatory T cells, transcriptional regulation, chromatin binding, microRNA, thymic Treg development, chromatin remodeling, nuclear transcription factors, immune tolerance, autoimmune disease, CD4+ T cells
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Mice, Inbred C57BL, Protein Binding, Thymus Gland, Genome, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Genomics, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors

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Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

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