Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J., Farr, A. G., & Rudensky, A. Y. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.016 · Cited by 2,302

Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

Sakaguchi, S., Ono, M., Setoguchi, R., Yagi, H., Hori, S., Fehervari, Z. T., Shimizu, J., Takahashi, T., & Nomura, T. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00427.x · Cited by 1,589

Accumulation of miR-155 and BIC RNA in human B cell lymphomas

Eis, P. S., Tam, W., Sun, L., Chadburn, A., Li, Z., Gomez, M. F., Lund, E., & Dahlberg, J. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500613102 · Cited by 1,322

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

Wu, Y., Borde, M., Heissmeyer, V., Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L., Guo, L., Han, A., Ziegler, S. F., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.042 · Cited by 1,229

Foxp3-dependent programme of regulatory T-cell differentiation

Gavin, M. A., Rasmussen, J. P., Fontenot, J. D., Vasta, V., Manganiello, V. C., Beavo, J. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05543 · Cited by 1,127

Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues

Zhang, X., Odom, D. T., Koo, S.-H., Conkright, M. D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501076102 · Cited by 992

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

Fontenot, J. D., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1179 · Cited by 957

Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice

Costinean, S., Zanesi, N. A. O., Pekarsky, Y., Tili, E., Volinia, S., Heerema, N. A., & Croce, C. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602266103 · Cited by 952

FOXP3: Of Mice and Men

Ziegler, S. F. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090547 · Cited by 921

Regulatory T Cells and Immune Tolerance

Sakaguchi, S., Yamaguchi, T., Nomura, T., & Ono, M. (2008) · Cell · doi:10.1016/j.cell.2008.05.009 · Cited by 5,485

CTLA-4 Control over Foxp3 + Regulatory T Cell Function

Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586

A census of human transcription factors: function, expression and evolution

Vaquerizas, J. M., Kummerfeld, S. K., Teichmann, S. A., & Luscombe, N. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2538 · Cited by 1,573

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

Thornton, A. M., Korty, P. E., Tran, D. Q., Wohlfert, E. A., Murray, P. E., Belkaid, Y., & Shevach, E. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904028 · Cited by 1,382

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., & Campbell, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1731 · Cited by 1,258

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Zheng, Y., Josefowicz, S. Z., Chaudhry, A., Peng, X. P., Forbush, K. A., & Rudensky, A. Y. (2010) · Nature · doi:10.1038/nature08750 · Cited by 1,170

Foxp3-dependent programme of regulatory T-cell differentiation

Gavin, M. A., Rasmussen, J. P., Fontenot, J. D., Vasta, V., Manganiello, V. C., Beavo, J. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05543 · Cited by 1,127

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

Wing, K., & Sakaguchi, S. (2009) · Nature Immunology · doi:10.1038/ni.1818 · Cited by 1,140

MicroRNAs: new regulators of immune cell development and function

Baltimore, D., Boldin, M., O’Connell, R. M., Rao, D. S., & Taganov, K. D. (2008) · Nature Immunology · doi:10.1038/ni.f.209 · Cited by 1,097

Th17 and regulatory T cells in mediating and restraining inflammation

Littman, D. R., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.02.021 · Cited by 1,039

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

Chaudhry, A., Samstein, R. M., Treuting, P., Liang, Y., Pils, M. C., Heinrich, J.-M., Jack, R. S., Wunderlich, F. T., Brüning, J. C., Müller, W., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.018 · Cited by 980

Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

Lu, L.-F., Boldin, M. P., Chaudhry, A., Lin, L.-L., Taganov, K. D., Hanada, T., Yoshimura, A., Baltimore, D., & Rudensky, A. Y. (2010) · Cell · doi:10.1016/j.cell.2010.08.012 · Cited by 849

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

Zheng, Y., Chaudhry, A., Kas, A., deRoos, P., Kim, J. M., Chu, T.-T., Corcoran, L., Treuting, P., Klein, U., & Rudensky, A. Y. (2009) · Nature · doi:10.1038/nature07674 · Cited by 958

Regulatory T cells in tumor immunity

Nishikawa, H., & Sakaguchi, S. (2010) · International Journal of Cancer · doi:10.1002/ijc.25429 · Cited by 944

Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

Martin, J. P. D., Chang, C., Boschetti, G., Ungaro, R. C., Giri, M., Grout, J. A., Gettler, K., Chuang, L.-S. F., Nayar, S., Greenstein, A. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.008 · Cited by 890

Regulatory T cells: how do they suppress immune responses?

Sakaguchi, S., Wing, K., Onishi, Y., Martín, P. P., & Yamaguchi, T. (2009) · International Immunology · doi:10.1093/intimm/dxp095 · Cited by 892

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

Williams, L. M., & Rudensky, A. Y. (2007) · Nature Immunology · doi:10.1038/ni1437 · Cited by 873

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

Malek, T. R., & Castro, I. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.004 · Cited by 882

Regulatory T cells and Foxp3

Rudensky, A. Y. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01018.x · Cited by 839

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

Korn, T., Reddy, J., Gao, W., Bettelli, E., Awasthi, A., Petersen, T. R., Bäckström, B. T., Sobel, R. A., Wucherpfennig, K. W., Strom, T. B., et al. (2007) · Nature Medicine · doi:10.1038/nm1564 · Cited by 824

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

Lu, L., Thai, T., Calado, D. P., Chaudhry, A., Kubo, M., Tanaka, K., Loeb, G. B., Lee, H., Yoshimura, A., Rajewsky, K., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.010 · Cited by 797

Development and Maintenance of Regulatory T cells

Ohkura, N., Kitagawa, Y., & Sakaguchi, S. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.002 · Cited by 742

Dynamic regulatory network controlling TH17 cell differentiation

Yosef, N., Shalek, A. K., Gaublomme, J. T., Jin, H., Lee, Y., Awasthi, A., Wu, C., Karwacz, K., Xiao, S., Jorgolli, M., et al. (2013) · Nature · doi:10.1038/nature11981 · Cited by 682

Foxp3 in control of the regulatory T cell lineage

Zheng, Y., & Rudensky, A. Y. (2007) · Nature Immunology · doi:10.1038/ni1455 · Cited by 707

How do Regulatory T Cells Work?

Corthay, A. (2009) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2009.02308.x · Cited by 691

Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.

Hill, J., Feuerer, M., Tash, K., Haxhinasto, S., Perez, J., Melamed, R., Mathis, D., & Benoist, C. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.010 · Cited by 671

The Integrated Genome Browser: free software for distribution and exploration of genome-scale datasets

Nicol, J. W., Helt, G. A., Blanchard, S. G., Raja, A. N., & Loraine, A. E. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp472 · Cited by 623

The regulation of immune tolerance by FOXP3

Lu, L., Barbi, J., & Pan, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.75 · Cited by 580

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

Cretney, E., Xin, A., Shi, W., Minnich, M., Masson, F., Miasari, M., Belz, G. T., Smyth, G. K., Busslinger, M., Nutt, S. L., et al. (2011) · Nature Immunology · doi:10.1038/ni.2006 · Cited by 605

Polycomb group proteins: navigators of lineage pathways led astray in cancer

Bracken, A. P., & Helin, K. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2736 · Cited by 523

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

Wohlfert, E. A., Grainger, J. R., Bouladoux, N., Konkel, J. E., Oldenhove, G., Ribeiro, C. H., Hall, J. A., Yagi, R., Naik, S., Bhairavabhotla, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57456 · Cited by 556

Tregs and rethinking cancer immunotherapy

Curiel, T. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31202 · Cited by 558

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

Schildberg, F. A., Klein, S. R., Freeman, G. J., & Sharpe, A. H. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.002 · Cited by 560

Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

Zhou, X., Jeker, L. T., Fife, B. T., Zhu, S., Anderson, M. S., McManus, M. T., & Bluestone, J. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080707 · Cited by 520

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

Feuerer, M., Hill, J. A., Mathis, D. J., & Benoist, C. O. (2009) · Nature Immunology · doi:10.1038/ni.1760 · Cited by 507

Multiple sclerosis

Nylander, A., & Hafler, D. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58649 · Cited by 495

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

Samstein, R. M., Arvey, A., Josefowicz, S. Z., Peng, X., Reynolds, A., Sandstrom, R., Neph, S., Sabo, P., Kim, J. M., Liao, W., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.053 · Cited by 472

Regulation of the MIR155 host gene in physiological and pathological processes

Elton, T. S., Selemon, H., Elton, S. M., & Parinandi, N. L. (2013) · Gene · doi:10.1016/j.gene.2012.12.009 · Cited by 393

Micromanagement of the immune system by microRNAs

Lodish, H. F., Zhou, B., Liu, G., & Chen, C. (2008) · Nature reviews. Immunology · doi:10.1038/nri2252 · Cited by 452

Transcription factor Foxp3 and its protein partners form a complex regulatory network

Rudra, D., DeRoos, P. C., Chaudhry, A., Niec, R. E., Arvey, A. J., Samstein, R. M., Leslie, C. S., Shaffer, S. A., Goodlett, D. R., & Rudensky, A. Y. (2012) · Nature Immunology · doi:10.1038/ni.2402 · Cited by 448

Multistep Pathogenesis of Autoimmune Disease

Goodnow, C. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.033 · Cited by 436

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

Duhen, T., Duhen, R., Lanzavecchia, A., Sallusto, F., & Campbell, D. J. (2012) · Blood · doi:10.1182/blood-2011-11-392324 · Cited by 413

Novel Foxo1-dependent transcriptional programs control Treg cell function

Ouyang, W., Liao, W., Luo, C. T., Yin, N., Huse, M., Kim, M. V., Peng, M., Chan, P., Ma, Q., Mo, Y., et al. (2012) · Nature · doi:10.1038/nature11581 · Cited by 430

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

Xia, X., Lemieux, M. E., Li, W., Carroll, J. S., Brown, M., Liu, X. S., & Kung, A. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810067106 · Cited by 410

Treg and CTLA-4: Two intertwining pathways to immune tolerance

Walker, L. S. K. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.06.006 · Cited by 425

BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

Roychoudhuri, R., Hirahara, K., Mousavi, K., Clever, D. C., Klebanoff, C. A., Bonelli, M. M., Sciumè, G., Zare, H., Vahedi, G., Dema, B., et al. (2013) · Nature · doi:10.1038/nature12199 · Cited by 412

Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target

Sojka, D. K., Huang, Y., & Fowell, D. J. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02813.x · Cited by 393

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

Banchereau, J., Pascual, V., & O’Garra, A. (2012) · Nature Immunology · doi:10.1038/ni.2406 · Cited by 409

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

Bailey-Bucktrout, S. L., Martínez‐Llordella, M., Zhou, X., Anthony, B. A., Rosenthal, W. L., Luche, H., Fehling, H. J., & Bluestone, J. A. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.016 · Cited by 409

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

Xu, T., Stewart, K. M., Wang, X., Liu, K., Xie, M., Ryu, J. K., Li, K., Ma, T., Wang, H., Ni, L., et al. (2017) · Nature · doi:10.1038/nature23475 · Cited by 395

Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis

Yang, R., Qu, C., Zhou, Y., Konkel, J. E., Shi, S., Liu, Y., Chen, C., Liu, S., Liu, D., Yibu, C., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.017 · Cited by 392

Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells

Kohlhaas, S. L., Garden, O. A., Scudamore, C. L., Turner, M., Okkenhaug, K., & Vigorito, E. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803162 · Cited by 381

Regulatory T Cells Reinforce Intestinal Homeostasis

Barnes, M. J., & Powrie, F. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.011 · Cited by 393

Regulation and Functions of Blimp-1 in T and B Lymphocytes

Martins, G. A., & Calame, K. L. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090241 · Cited by 390

At the Bench: Preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy

Intlekofer, A. M., & Thompson, C. B. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1212621 · Cited by 387

Regulatory T cells – a brief history and perspective

Sakaguchi, S., Wing, K., & Miyara, M. (2007) · European Journal of Immunology · doi:10.1002/eji.200737593 · Cited by 375

MicroRNA-mediated regulation of T helper cell differentiation and plasticity

Baumjohann, D., & Ansel, K. M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3494 · Cited by 363

Immunogenetics of autoimmune thyroid diseases: a comprehensive review

Lee, H. J., Li, C. W., Hammerstad, S. S., Stefan, M., & Tomer, Y. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.07.009 · Cited by 351

Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases

Ohkura, N., & Sakaguchi, S. (2020) · Cell Research · doi:10.1038/s41422-020-0324-7 · Cited by 374

Foxp3 Expression in Pancreatic Carcinoma Cells as a Novel Mechanism of Immune Evasion in Cancer

Hinz, S., Raluy, L. P., Oberg, H., Ammerpohl, O., Grüssel, S., Sipos, B., Grützmann, R., Pilarsky, C. P., Ungefroren, H., Saeger, H., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3304 · Cited by 354

T Helper Cell Differentiation, Heterogeneity, and PlasticityPreprint

Zhu, J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a030338 · Cited by 374

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation

Bacchetta, R., Barzaghi, F., & Roncarolo, M. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13011 · Cited by 346

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

Ravi, R., Noonan, K. A., Pham, V., Bedi, R., Zhavoronkov, A., Ozerov, I. V., Makarev, E., V. Artemov, A., Wysocki, P. T., Mehra, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02696-6 · Cited by 325

Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer

Granier, C., Guillebon, É. D., Blanc, C., Roussel, H., Badoual, C., Colin, E., Saldmann, A., Gey, A., Oudard, S. M., & Tartour, É. (2017) · ESMO Open · doi:10.1136/esmoopen-2017-000213 · Cited by 330

Discrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during T Helper Cell Differentiation

Wei, L., Vahedi, G., Sun, H., Watford, W. T., Takatori, H., Ramos, H. L., Takahashi, H., Liang, J. Z., Gutierrez-Cruz, G., Zang, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.003 · Cited by 332

Environmental determinants of allergy and asthma in early life

Burbank, A. J., Sood, A. K., Kesic, M. J., Peden, D. B., & Hernandez, M. L. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.010 · Cited by 299

The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

Chen, Z., Barbi, J. J., Bu, S., Yang, H., Li, Z., Gao, Y., Jinasena, D., Fu, J. L., Lin, F., Chen, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.006 · Cited by 300

MicroRNA in the immune system, microRNA as an immune system

Lu, L., & Liston, A. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03092.x · Cited by 300

CTLA-4: From mechanism to autoimmune therapy

Hosseini, A., Gharibi, T., Marofi, F., Babaloo, Z., & Baradaran, B. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106221 · Cited by 308

Identification of the Transcriptional Targets of FOXP2, a Gene Linked to Speech and Language, in Developing Human Brain

Spiteri, E., Konopka, G., Coppola, G., Bomar, J. M., Oldham, M. C., Ou, J., Vernes, S. C., Fisher, S. E., Ren, B., & Geschwind, D. H. (2007) · The American Journal of Human Genetics · doi:10.1086/522237 · Cited by 288

Epigenetic control of innate and adaptive immune memory

Lau, C. M., Adams, N. M., Geary, C. D., Weizman, O.-E., Rapp, M., Pritykin, Y., Leslie, C. S., & Sun, J. C.-Y. (2018) · Nature Immunology · doi:10.1038/s41590-018-0176-1 · Cited by 292

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

Xiao, S., Yosef, N., Yang, J., Wang, Y., Zhou, L., Zhu, C. Y., Wu, C., Baloglu, E., Schmidt, D. R., Ramesh, R., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.004 · Cited by 283

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: Forkhead box protein 3 mutations and lack of regulatory T cells

Torgerson, T. R., & Ochs, H. D. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.08.044 · Cited by 266

High-Throughput Analysis of Promoter Occupancy Reveals Direct Neural Targets of FOXP2, a Gene Mutated in Speech and Language Disorders

Vernes, S. C., Spiteri, E., Nicod, J., Groszer, M., Taylor, J. M., Davies, K. E., Geschwind, D. H., & Fisher, S. E. (2007) · The American Journal of Human Genetics · doi:10.1086/522238 · Cited by 268

CD4 T-cell differentiation and inflammatory bowel disease

Zenewicz, L. A., Antov, A., & Flavell, R. A. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.03.002 · Cited by 270

FOXP3 modifies the phenotypic and functional properties of regulatory T cells

Campbell, D., & Ziegler, S. F. (2007) · Nature reviews. Immunology · doi:10.1038/nri2061 · Cited by 265

Altered microRNA expression profile with miR-146a upregulation in CD4+T cells from patients with rheumatoid arthritis

Li, J., Wan, Y., Guo, Q., Zou, L., Zhang, J., Fang, Y., Zhang, J., Zhang, J., Fu, X., Liu, H., et al. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3006 · Cited by 261

miR‐142‐3p restricts cAMP production in CD4+CD25− T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA

Huang, B., Zhao, J., Zhang, L., Shen, S., Li, D., Shen, G., Zhang, G., & Feng, Z. (2008) · EMBO Reports · doi:10.1038/embor.2008.224 · Cited by 255

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2

Koch, M. A., Thomas, K. R., Perdue, N., Smigiel, K. S., Srivastava, S., & Campbell, D. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.031 · Cited by 260

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

Isomura, I., Palmer, S. E., Grumont, R. J., Bunting, K., Hoyne, G. F., Wilkinson, N., Banerjee, A., Proietto, A. I., Gugasyan, R., Wu, L., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091411 · Cited by 269

Role of regulatory T cells and FOXP3 in human diseases

Bacchetta, R., Gambineri, E., & Roncarolo, M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.06.023 · Cited by 260

FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2

Zuo, T., Liu, R., Zhang, H., Chang, X., Liu, Y., Wang, L., Zheng, P., & Liu, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32538 · Cited by 246

Once a Treg, always a Treg?

Sawant, D. V., & Vignali, D. A. A. (2014) · Immunological Reviews · doi:10.1111/imr.12173 · Cited by 255

Function and Role of Regulatory T Cells in Rheumatoid Arthritis

Jiang, Q., Yang, G., Liu, Q., Wang, S., & Cui, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.626193 · Cited by 254

Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

Jacobs, J. F. M., Nierkens, S., Figdor, C. G., de Vries, I. J. M., & Adema, G. J. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70155-3 · Cited by 254

Treg functional stability and its responsiveness to the microenvironment

Barbi, J. J., Pardoll, D. M., & Pan, F. (2014) · Immunological Reviews · doi:10.1111/imr.12172 · Cited by 252

Emerging Challenges in Regulatory T Cell Function and Biology

Sakaguchi, S., & Powrie, F. M. (2007) · Science · doi:10.1126/science.1142331 · Cited by 247

Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells

Arvey, A. J., van der Veeken, J., Samstein, R. M., Feng, Y., Stamatoyannopoulos, J. A., & Rudensky, A. Y. (2014) · Nature Immunology · doi:10.1038/ni.2868 · Cited by 247

Differentiation of regulatory Foxp3 + T cells in the thymic cortex

Liston, A., Nutsch, K., Farr, A. G., Lund, J. M., Rasmussen, J. P., Koni, P. A., & Rudensky, A. Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801506105 · Cited by 238

Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction

Bauer, C. A., Kim, E. Y., Marangoni, F., Carrizosa, E., Claudio, N., & Mempel, T. R. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66375 · Cited by 246

Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions

Yamaguchi, T., Wing, J. B., & Sakaguchi, S. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.10.002 · Cited by 240

Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells

Hatzis, P., van der Flier, L. G., van Driel, M. A., Guryev, V., Nielsen, F. G. G., Denissov, S., Nijman, I. J., Köster, J., Santo, E. E., Welboren, W.-J., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02175-07 · Cited by 230

FOXP3 and scurfy: how it all began

Ramsdell, F., & Ziegler, S. F. (2014) · Nature reviews. Immunology · doi:10.1038/nri3650 · Cited by 225

Regulatory T Cells: History and Perspective

Sakaguchi, S. (2011) · Methods in molecular biology · doi:10.1007/978-1-61737-979-6_1 · Cited by 232

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

Bour‐Jordan, H., & Bluestone, J. A. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00775.x · Cited by 229

Foxp3 drives oxidative phosphorylation and protection from lipotoxicity

Howie, D., Cobbold, S. P., Adams, E., ten Bokum, A., Necula, A. S., Zhang, W., Huang, H., Roberts, D. J., Thomas, B. C., Hester, S., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.89160 · Cited by 225

Treg cells in health and autoimmune diseases: New insights from single cell analysis

Scheinecker, C., Göschl, L., & Bonelli, M. M. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102376 · Cited by 224

Regulatory T‐cell gene expression: ChIP'ing away at Foxp3

Sundrud, M. S., & Rao, A. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100051 · Cited by 1

ChIP-on-Chip for FoxP3

Zheng, Y. (2011) · Methods in molecular biology · doi:10.1007/978-1-61737-979-6_6 · Cited by 2

Insights into transcriptional regulation by FOXP3

Carson, B. D. (2006) · Frontiers in bioscience · doi:10.2741/1908 · Cited by 14

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724

Genome-Wide Identification of Human FOXP3 Target Genes in Natural Regulatory T Cells

Sadlon, T. J., Wilkinson, B. G., Pederson, S., Brown, C. Y., Bresatz, S., Gargett, T., Melville, E. L., Peng, K., D’Andrea, R. J., Glonek, G. G., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000082 · Cited by 146