The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.
Intrinsic functional architecture in the anaesthetized monkey brain
Abstract
The traditional approach to studying brain function is to measure physiological responses to controlled sensory, motor and cognitive paradigms. However, most of the brain's energy consumption is devoted to ongoing metabolic activity not clearly associated with any particular stimulus or behaviour. Functional magnetic resonance imaging studies in humans aimed at understanding this ongoing activity have shown that spontaneous fluctuations of the blood-oxygen-level-dependent signal occur continuously in the resting state. In humans, these fluctuations are temporally coherent within widely distributed cortical systems that recapitulate the functional architecture of responses evoked by experimentally administered tasks. Here, we show that the same phenomenon is present in anaesthetized monkeys even at anaesthetic levels known to induce profound loss of consciousness. We specifically demonstrate coherent spontaneous fluctuations within three well known systems (oculomotor, somatomotor and visual) and the 'default' system, a set of brain regions thought by some to support uniquely human capabilities. Our results indicate that coherent system fluctuations probably reflect an evolutionarily conserved aspect of brain functional organization that transcends levels of consciousness.
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In the citing paper
“Functional architecture associated with sensory, motor, and cognitive tasks in humans are preserved during isoflurane anesthesia in nonhuman primates [149].”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [149]
In the citing paper
“there is ample evidence of robust functional connectivity between brain regions that lack direct structural connections28-29, 31.”
From Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety (2014) · cites this paper as [28]
In the citing paper
“fMRI-derived measures of intrinsic functional connectivity are particularly useful because they are sensitive to functional networks spanning polysynaptic circuits27-29”
From Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety (2014) · cites this paper as [28]
In the citing paper
“In addition, we report all injection sites by their stereotaxic coordinates in the F99 atlas space. This provides an even finer granularity for objectively comparing our connectivity data to alternative parcellation schemes and to other data modalities such as functional connectivity revealed by functional magnetic resonance imaging (fMRI) (Vincent et al. 2007) and structural connectivity revealed”
From A Weighted and Directed Interareal Connectivity Matrix for Macaque Cerebral Cortex (2014) · cites this paper as Vincent et al. 2007
Citations
Cites
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A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Self-citationCo-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553
Self-citationCo-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Neuronal Oscillations in Cortical Networks
Buzsáki, G., & Draguhn, A. (2004) · Science · doi:10.1126/science.1099745 · Cited by 6,576
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358
(2023) · doi:10.1126/science · Cited by 6,063
Signals from Chloroplasts Converge to Regulate Nuclear Gene Expression
Koussevitzky, S., Nott, A., Mockler, T. C., Hong, F., Sachetto‐Martins, G., Surpin, M. A., Lim, J. C.-S., Mittler, R., & Chory, J. (2007) · Science · doi:10.1126/science.1140516 · Cited by 5,765
Research works printed but not linked: 2
- Brodmann, K. Localisation in the Cerebral Cortex (Smith-Gordon, London, 1994)
- Lewis, J. W. & Van Essen, D. C. Mapping of architectonic subdivisions in the macaque monkey, with emphasis on parieto-occipital cortex. J. Comp. Neurol. 428, 79–111 (2000) · DOI
Cited by
Sorted by citations
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Thomas Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., Roffman, J. L., Smoller, J. W., Zöllei, L., Polimeni, J. R., et al. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00338.2011 · Cited by 9,182
The organization of the human cerebellum estimated by intrinsic functional connectivity
Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., & Yeo, B. T. T. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00339.2011 · Cited by 7,304
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700
Self-citationHow do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657
Metadata
- Authors
- Vincent, J. L., Patel, G. H., Fox, M. D., Snyder, A. Z., Baker, J. T., Van Essen, D. C., Zempel, J. M., Snyder, L. H., Corbetta, M., & Raichle, M. E.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Raichle, M. E.
- ORCID
- Venue
- Nature
- Published
- 2007-05
- Volume
- 447
- Issue
- 7140
- Pages
- 83-86
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2027781650
- Cited by
- 1,786
- References
- 46
- Citations by year
- 2026: 25 · 2025: 34 · 2024: 58 · 2023: 61 · 2022: 67 · 2021: 65 · 2020: 81 · 2019: 81 · 2018: 107 · 2017: 100 · 2016: 111 · 2015: 132 · 2014: 125 · 2013: 150 · 2012: 120
- FWCI
- 51.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (F31NS051972)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- spontaneous neural fluctuations, resting-state brain activity, default mode network, oculomotor system, visual system, functional architecture, primate brain evolution, cross-species conservation, BOLD signal
- MeSH terms
- Anesthesia, Animals, Brain, Brain Mapping, Consciousness, Humans, Isoflurane, Macaca fascicularis, Macaca mulatta, Magnetic Resonance Imaging, Visual Cortex, Anesthetics, Inhalation
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