Cited by 458Fungal and yeast genetics researchEvolution and Genetic DynamicsChromosomal and Genetic Variations

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Gene duplication and the adaptive evolution of a classic genetic switch

Hittinger, Chris Todd, Carroll, Sean B.·2007·Nature

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Abstract

How gene duplication and divergence contribute to genetic novelty and adaptation has been of intense interest, but experimental evidence has been limited. The genetic switch controlling the yeast galactose use pathway includes two paralogous genes in Saccharomyces cerevisiae that encode a co-inducer (GAL3) and a galactokinase (GAL1). These paralogues arose from a single bifunctional ancestral gene as is still present in Kluyveromyces lactis. To determine which evolutionary processes shaped the evolution of the two paralogues, here we assess the effects of precise replacement of coding and non-coding sequences on organismal fitness. We suggest that duplication of the ancestral bifunctional gene allowed for the resolution of an adaptive conflict between the transcriptional regulation of the two gene functions. After duplication, previously disfavoured binding site configurations evolved that divided the regulation of the ancestral gene into two specialized genes, one of which ultimately became one of the most tightly regulated genes in the genome.

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Evolution by Gene Duplication
Ohno, S. (1970) · doi:10.1007/978-3-642-86659-3 · Cited by 7,833
Principles of Population Genetics.
Cormack, R. M., Hartl, D. L., & Clark, A. G. (1990) · Biometrics · doi:10.2307/2531471 · Cited by 5,283
Preservation of Duplicate Genes by Complementary, Degenerative Mutations
Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y.-L., & Postlethwait, J. (1999) · Genetics · doi:10.1093/genetics/151.4.1531 · Cited by 3,529
Designer deletion strains derived fromSaccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
Brachmann, C. B., Davies, A., Cost, G. J., Caputo, E. M., Li, J., Hieter, P., & Boeke, J. D. (1998) · Yeast · doi:10.1002/(sici)1097-0061(19980130)14:2 · Cited by 3,418
Molecular evidence for an ancient duplication of the entire yeast genome
Wolfe, K. H., & Shields, D. C. (1997) · Nature · doi:10.1038/42711 · Cited by 1,785
Sequencing and comparison of yeast species to identify genes and regulatory elements
Kellis, M., Patterson, N. J., Endrizzi, M. G., Birren, B. W., & Lander, E. S. (2003) · Nature · doi:10.1038/nature01644 · Cited by 1,751
A new efficient gene disruption cassette for repeated use in budding yeast
Güldener, U. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.13.2519 · Cited by 1,657
Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
Kellis, M., Birren, B. W., & Lander, E. S. (2004) · Nature · doi:10.1038/nature02424 · Cited by 1,500
The evolution of functionally novel proteins after gene duplication
Hughes, A. (1994) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.1994.0058 · Cited by 1,040
Sequences That Regulate the Divergent GAL1-GAL10 Promoter in Saccharomyces cerevisiae
Johnston, M., & Davis, R. W. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.8.1440-1448.1984 · Cited by 980

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Paradigmatic Role of Galactose Switch
(2008) · Springer eBooks · doi:10.1007/978-3-540-74015-5_8
Gene Duplication
Greenbaum, D. S., & Gardiner, K. (2004) · Dictionary of Bioinformatics and Computational Biology · doi:10.1002/9780471650126.dob0262.pub2
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Lee, U., Arsala, D., Xia, S., Li, C., Ali, M., Svetec, N., Langer, C. B., Sobreira, D. R., Eres, I. E., Sosa, D., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.30.518413
The Nature of Living Things
Ramsden, J. J. (2023) · Computational biology · doi:10.1007/978-3-030-45607-8_14
Functional Diversification of Gene Duplicates under the Constraint of Protein StructurePreprint
Guo, K., Yang, Y., You, T., & Zhu, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.06.583810
Evolution of Cellular Complexity
Lynch, M. (2024) · Oxford University Press eBooks · doi:10.1093/oso/9780192847287.003.0006 · Cited by 1
Additional file 3 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Additional file 9 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Additional file 8 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Additional file 5 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Additional file 4 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Additional file 11 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Additional file 6 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Additional file 2 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Additional file 7 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Additional file 12 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Additional file 10 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
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Dutta, A., Chowdhury, A., Roy, P., & Bhowmik, P. (2025) · The Protein Journal · doi:10.1007/s10930-025-10284-7
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Froyd, C. A. (2012) · DukeSpace (Duke University)
Additional file 1 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
Sun, X., Feng, D., Liu, M., Qin, R., Li, Y., Lu, Y., Zhang, X., Wang, Y., 申书兴, Ma, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22604005
Additional file 5 of Characterization and gene expression analysis reveal universal stress proteins respond to abiotic stress in Gossypium hirsutum
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Additional file 4 of Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
Lyubetsky, V., Израилевич, Р. Л., Tereshina, M. B., Ivanova, A. S., Araslanova, K. R., Урошлев, Л. А., Goremykina, G. I., Yang, J.-R., Kanovei, V. G., Zverkov, O. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26609874
Additional file 3 of Characterization and gene expression analysis reveal universal stress proteins respond to abiotic stress in Gossypium hirsutum
Li, Y., Zheng, A., Li, Z., Hu, W., Wang, J., Dong, Z., Yao, L., Han, X., & Wei, F. (2024) · Figshare · doi:10.6084/m9.figshare.26671452
Additional file 9 of Characterization and gene expression analysis reveal universal stress proteins respond to abiotic stress in Gossypium hirsutum
Li, Y., Zheng, A., Li, Z., Hu, W., Wang, J., Dong, Z., Yao, L., Han, X., & Wei, F. (2024) · Figshare · doi:10.6084/m9.figshare.26671470
Additional file 1 of Characterization and gene expression analysis reveal universal stress proteins respond to abiotic stress in Gossypium hirsutum
Li, Y., Zheng, A., Li, Z., Hu, W., Wang, J., Dong, Z., Yao, L., Han, X., & Wei, F. (2024) · Figshare · doi:10.6084/m9.figshare.26671446
Additional file 8 of Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
Lyubetsky, V., Израилевич, Р. Л., Tereshina, M. B., Ivanova, A. S., Araslanova, K. R., Урошлев, Л. А., Goremykina, G. I., Yang, J.-R., Kanovei, V. G., Zverkov, O. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26609886
Additional file 6 of Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
Lyubetsky, V., Израилевич, Р. Л., Tereshina, M. B., Ivanova, A. S., Araslanova, K. R., Урошлев, Л. А., Goremykina, G. I., Yang, J.-R., Kanovei, V. G., Zverkov, O. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26609880
Additional file 1 of From pairs of most similar sequences to phylogenetic best matches
Stadler, P. F., Geiß, M., Schaller, D., Sánchez, A. L., González-Laffitte, M., Valdivia, D. I., Hellmuth, M., & Hernández-Rosales, M. (2020) · Figshare · doi:10.6084/m9.figshare.12109560
Additional file 5 of Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
Lyubetsky, V., Израилевич, Р. Л., Tereshina, M. B., Ivanova, A. S., Araslanova, K. R., Урошлев, Л. А., Goremykina, G. I., Yang, J.-R., Kanovei, V. G., Zverkov, O. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26609877
Additional file 10 of Characterization and gene expression analysis reveal universal stress proteins respond to abiotic stress in Gossypium hirsutum
Li, Y., Zheng, A., Li, Z., Hu, W., Wang, J., Dong, Z., Yao, L., Han, X., & Wei, F. (2024) · Figshare · doi:10.6084/m9.figshare.26671473
Additional file 8 of Characterization and gene expression analysis reveal universal stress proteins respond to abiotic stress in Gossypium hirsutum
Li, Y., Zheng, A., Li, Z., Hu, W., Wang, J., Dong, Z., Yao, L., Han, X., & Wei, F. (2024) · Figshare · doi:10.6084/m9.figshare.26671467
Additional file 3 of Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
Lyubetsky, V., Израилевич, Р. Л., Tereshina, M. B., Ivanova, A. S., Araslanova, K. R., Урошлев, Л. А., Goremykina, G. I., Yang, J.-R., Kanovei, V. G., Zverkov, O. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26609871
Additional file 6 of Characterization and gene expression analysis reveal universal stress proteins respond to abiotic stress in Gossypium hirsutum
Li, Y., Zheng, A., Li, Z., Hu, W., Wang, J., Dong, Z., Yao, L., Han, X., & Wei, F. (2024) · Figshare · doi:10.6084/m9.figshare.26671461
Additional file 7 of Characterization and gene expression analysis reveal universal stress proteins respond to abiotic stress in Gossypium hirsutum
Li, Y., Zheng, A., Li, Z., Hu, W., Wang, J., Dong, Z., Yao, L., Han, X., & Wei, F. (2024) · Figshare · doi:10.6084/m9.figshare.26671464
Additional file 2 of Characterization and gene expression analysis reveal universal stress proteins respond to abiotic stress in Gossypium hirsutum
Li, Y., Zheng, A., Li, Z., Hu, W., Wang, J., Dong, Z., Yao, L., Han, X., & Wei, F. (2024) · Figshare · doi:10.6084/m9.figshare.26671449
Additional file 4 of Characterization and gene expression analysis reveal universal stress proteins respond to abiotic stress in Gossypium hirsutum
Li, Y., Zheng, A., Li, Z., Hu, W., Wang, J., Dong, Z., Yao, L., Han, X., & Wei, F. (2024) · Figshare · doi:10.6084/m9.figshare.26671455
Additional file 7 of Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
Lyubetsky, V., Израилевич, Р. Л., Tereshina, M. B., Ivanova, A. S., Araslanova, K. R., Урошлев, Л. А., Goremykina, G. I., Yang, J.-R., Kanovei, V. G., Zverkov, O. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26609883
Additional file 13 of Single-cell transcriptome reveals dominant subgenome expression and transcriptional response to heat stress in Chinese cabbage
Sun, X., Feng, D., Liu, M., Qin, R., Li, Y., Lu, Y., Zhang, X., Wang, Y., 申书兴, Ma, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22604047
Additional file 1 of Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
Lyubetsky, V., Израилевич, Р. Л., Tereshina, M. B., Ivanova, A. S., Araslanova, K. R., Урошлев, Л. А., Goremykina, G. I., Yang, J.-R., Kanovei, V. G., Zverkov, O. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26609865
Additional file 2 of Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations
Lyubetsky, V., Израилевич, Р. Л., Tereshina, M. B., Ivanova, A. S., Araslanova, K. R., Урошлев, Л. А., Goremykina, G. I., Yang, J.-R., Kanovei, V. G., Zverkov, O. A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26609868
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Authors: Hittinger, C. T., & Carroll, S. B.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Carroll, Sean B.
ORCID: Hittinger, Chris Todd
Carroll, Sean B.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-10
Volume: 449
Issue: 7163
Pages: 677-681
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06151
OpenAlex: W1996490834
Cited by: 439
References: 51
Citations by year: 2026: 7 · 2025: 14 · 2024: 26 · 2023: 24 · 2022: 21 · 2021: 23 · 2020: 17 · 2019: 22 · 2018: 17 · 2017: 28 · 2016: 20 · 2015: 30 · 2014: 27 · 2013: 25 · 2012: 27
FWCI: 11.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords: gene duplication, gene divergence, adaptive evolution, genetic novelty, genetic switch, galectin-3, GAL1, paralogs, transcriptional regulation, Saccharomyces cerevisiae, Kluyveromyces lactis, fitness
MeSH terms: Base Sequence, Binding Sites, DNA-Binding Proteins, Galactokinase, Models, Genetic, Molecular Sequence Data, Promoter Regions, Genetic, Saccharomyces cerevisiae, Transcription Factors, Gene Expression Regulation, Fungal, Evolution, Molecular, Genes, Duplicate, Gene Duplication, Saccharomyces cerevisiae Proteins

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Gene duplication and the adaptive evolution of a classic genetic switch

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