The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
Abstract
Lymph nodes prevent the systemic dissemination of pathogens such as viruses that infect peripheral tissues after penetrating the body's surface barriers. They are also the staging ground of adaptive immune responses to pathogen-derived antigens. It is unclear how virus particles are cleared from afferent lymph and presented to cognate B cells to induce antibody responses. Here we identify a population of CD11b+CD169+MHCII+ macrophages on the floor of the subcapsular sinus (SCS) and in the medulla of lymph nodes that capture viral particles within minutes after subcutaneous injection. Macrophages in the SCS translocated surface-bound viral particles across the SCS floor and presented them to migrating B cells in the underlying follicles. Selective depletion of these macrophages compromised local viral retention, exacerbated viraemia of the host, and impaired local B-cell activation. These findings indicate that CD169+ macrophages have a dual physiological function. They act as innate 'flypaper' by preventing the systemic spread of lymph-borne pathogens and as critical gatekeepers at the lymph-tissue interface that facilitate the recognition of particulate antigens by B cells and initiate humoral immune responses.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These macrophages can capture larger molecules, viruses, and bacteria (89, 90) and are capable of mounting a protective immune response even in the absence of antigen-presenting DCs (91).”
From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [90]
Citations
Cites
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
Mempel, T. R., Henrickson, S. E., & von Andrian, U. H. (2004) · Nature · doi:10.1038/nature02238 · Cited by 1,720
Self-citationMACROPHAGE RECEPTORS AND IMMUNE RECOGNITION
Taylor, P. R., Martínez‐Pomares, L., Stacey, M. A., Lin, H.-H., Brown, G. D., & Gordon, S. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115816 · Cited by 1,366
Homing and cellular traffic in lymph nodes
von Andrian, U. H., & Mempel, T. R. (2003) · Nature reviews. Immunology · doi:10.1038/nri1222 · Cited by 1,271
Self-citationCD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
Shiow, L. R., Rosen, D. B., Brdičková, N., Xu, Y., An, J., Lanier, L. L., Cyster, J. G., & Matloubian, M. (2006) · Nature · doi:10.1038/nature04606 · Cited by 1,189
Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies
Ochsenbein, A. F., Fehr, T. H., Lutz, C., Suter, M., Brombacher, F., Hengartner, H., & Zinkernagel, R. M. (1999) · Science · doi:10.1126/science.286.5447.2156 · Cited by 911
Okada, T., Miller, M. J., Parker, I., Krummel, M. F., Neighbors, M., Hartley, S. B., O’Garra, A., Cahalan, M. D., & Cyster, J. G. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030150 · Cited by 586
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
Reif, K., Ekland, E. H., Ohl, L., Nakano, H., Lipp, M., Förster, R., & Cyster, J. G. (2002) · Nature · doi:10.1038/416094a · Cited by 572
B cell receptor signal strength determines B cell fate
Casola, S. S., Otipoby, K. L., Alimzhanov, M. B., Humme, S., Uyttersprot, N., Kutok, J. L., Carroll, M. C., & Rajewsky, K. (2004) · Nature Immunology · doi:10.1038/ni1036 · Cited by 561
Extrafollicular Activation of Lymph Node B Cells by Antigen-Bearing Dendritic Cells
Qi, H., Egen, J. G., Huang, A. Y.-C., & Germain, R. N. (2006) · Science · doi:10.1126/science.1125703 · Cited by 521
Wessels, M. R., Butko, P., Ma, M., Warren, H. B., Lage, A. L., & Carroll, M. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11490 · Cited by 503
Cited by
Sorted by citations
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
Bachmann, M. F., & Jennings, G. T. (2010) · Nature reviews. Immunology · doi:10.1038/nri2868 · Cited by 2,120
Nanoparticles target distinct dendritic cell populations according to their size
Manolova, V., Flace, A., Bauer, M., Schwarz, K., Saudan, P., & Bachmann, M. F. (2008) · European Journal of Immunology · doi:10.1002/eji.200737984 · Cited by 1,296
Bio-inspired, bioengineered and biomimetic drug delivery carriers
Yoo, J., Irvine, D. J., Discher, D. E., & Mitragotri, S. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3499 · Cited by 1,251
Metadata
- Authors
- Junt, T., Moseman, E. A., Iannacone, M., Massberg, S., Lang, P. A., Boes, M., Fink, K., Henrickson, S. E., Shayakhmetov, D. M., Di Paolo, N. C., van Rooijen, N., Mempel, T. R., Whelan, S. P., & von Andrian, U. H.
- Affiliations
- Harvard University (US)
- University Hospital Zurich (CH)
- Brigham and Women's Hospital (US)
- Novartis Institute For Tropical Diseases (SG)
- University of Washington (US)
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- von Andrian, Ulrich H.
- ORCID
- Venue
- Nature
- Published
- 2007-10-14
- Volume
- 450
- Issue
- 7166
- Pages
- 110-114
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2019206924
- Cited by
- 846
- References
- 29
- Citations by year
- 2026: 21 · 2025: 38 · 2024: 37 · 2023: 34 · 2022: 35 · 2021: 55 · 2020: 46 · 2019: 49 · 2018: 53 · 2017: 53 · 2016: 46 · 2015: 53 · 2014: 46 · 2013: 38 · 2012: 66
- FWCI
- 17.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007753)
- National Institute of Allergy and Infectious Diseases (R01AI059371)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- subcapsular sinus macrophages, lymph node macrophages, CD169+ macrophages, viral clearance, B cell activation, antigen presentation, afferent lymph, humoral immune response, viremia, macrophage depletion
- MeSH terms
- Animals, Antibody Formation, B-Lymphocytes, Cell Line, Lymph, Lymph Nodes, Macrophages, Membrane Glycoproteins, Mice, Inbred C57BL, Receptors, Immunologic, Vesiculovirus, CD11b Antigen, Mice, Sialic Acid Binding Ig-like Lectin 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
