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Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart
Abstract
Understanding cellular response to environmental stress has broad implications for human disease. AMP-activated protein kinase (AMPK) orchestrates the regulation of energy-generating and -consuming pathways, and protects the heart against ischaemic injury and apoptosis. A role for circulating hormones such as adiponectin and leptin in the activation of AMPK has received recent attention. Whether local autocrine and paracrine factors within target organs such as the heart modulate AMPK is unknown. Here we show that macrophage migration inhibitory factor (MIF), an upstream regulator of inflammation, is released in the ischaemic heart, where it stimulates AMPK activation through CD74, promotes glucose uptake and protects the heart during ischaemia-reperfusion injury. Germline deletion of the Mif gene impairs ischaemic AMPK signalling in the mouse heart. Human fibroblasts with a low-activity MIF promoter polymorphism have diminished MIF release and AMPK activation during hypoxia. Thus, MIF modulates the activation of the cardioprotective AMPK pathway during ischaemia, functionally linking inflammation and metabolism in the heart. We anticipate that genetic variation in MIF expression may impact on the response of the human heart to ischaemia by the AMPK pathway, and that diagnostic MIF genotyping might predict risk in patients with coronary artery disease.
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“Mechanically, AMPK increased glucose uptake and glucose transporter 4 translocation [171], decreased apoptosis, improved post-ischemic recovery, and limited myocardial infarction (MI) [172,173].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [171]
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Metadata
- Authors
- Miller, E. J., Li, J., Leng, L., McDonald, C., Atsumi, T., Bucala, R., & Young, L. H.
- Affiliations
- Yale University (US)
- Hokkaido University (JP)
- Corresponding author
- Young, Lawrence H.
- Venue
- Nature
- Published
- 2008-01
- Volume
- 451
- Issue
- 7178
- Pages
- 578-582
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2039411604
- Cited by
- 429
- References
- 33
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 14 · 2023: 14 · 2022: 18 · 2021: 22 · 2020: 16 · 2019: 30 · 2018: 29 · 2017: 20 · 2016: 26 · 2015: 33 · 2014: 27 · 2013: 38 · 2012: 34
- FWCI
- 11.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- macrophage migration inhibitory factor, AMPK, ischemia-reperfusion injury, CD74, glucose uptake, cardioprotection, inflammation, hypoxia, coronary artery disease, autocrine and paracrine signaling, energy metabolism
- MeSH terms
- Animals, Hypoxia, Antigens, Differentiation, B-Lymphocyte, Histocompatibility Antigens Class II, Coronary Artery Disease, Enzyme Activation, Genotype, Glucose, Humans, Macrophage Migration-Inhibitory Factors, Multienzyme Complexes, Myocardium, Polymorphism, Genetic, Promoter Regions, Genetic, Signal Transduction, Myocardial Reperfusion Injury, Myocardial Ischemia, Protein Serine-Threonine Kinases, Genetic Predisposition to Disease, Mice, Rats, AMP-Activated Protein Kinases
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