Cited by 368Hematopoietic Stem Cell TransplantationT-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

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Adult T-cell progenitors retain myeloid potential

Wada, Haruka, Masuda, Kyoko, Satoh, Rumi, Kakugawa, Kiyokazu, Ikawa, Tomokatsu, Katsura, Yoshimoto, Kawamoto, Hiroshi·2008·Nature

DOI 10.1038/nature06839

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Abstract

During haematopoiesis, pluripotent haematopoietic stem cells are sequentially restricted to give rise to a variety of lineage-committed progenitors. The classical model of haematopoiesis postulates that, in the first step of differentiation, the stem cell generates common myelo-erythroid progenitors and common lymphoid progenitors (CLPs). However, our previous studies in fetal mice showed that myeloid potential persists even as the lineage branches segregate towards T and B cells. We therefore proposed the 'myeloid-based' model of haematopoiesis, in which the stem cell initially generates common myelo-erythroid progenitors and common myelo-lymphoid progenitors. T-cell and B-cell progenitors subsequently arise from common myelo-lymphoid progenitors through myeloid-T and myeloid-B stages, respectively. However, it has been unclear whether this myeloid-based model is also valid for adult haematopoiesis. Here we provide clonal evidence that the early cell populations in the adult thymus contain progenitors that have lost the potential to generate B cells but retain substantial macrophage potential as well as T-cell, natural killer (NK)-cell and dendritic-cell potential. We also show that such T-cell progenitors can give rise to macrophages in the thymic environment in vivo. Our findings argue against the classical dichotomy model in which T cells are derived from CLPs; instead, they support the validity of the myeloid-based model for both adult and fetal haematopoiesis.

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Authors: Wada, H., Masuda, K., Satoh, R., Kakugawa, K., Ikawa, T., Katsura, Y., & Kawamoto, H.
Affiliations: RIKEN (JP)
Nihon University (JP)
Corresponding author: Kawamoto, Hiroshi
ORCID: Wada, Haruka
Kakugawa, Kiyokazu
Ikawa, Tomokatsu
Kawamoto, Hiroshi
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-04
Volume: 452
Issue: 7188
Pages: 768-772
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06839
OpenAlex: W2047137615
Cited by: 368
References: 28
Citations by year: 2026: 4 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 12 · 2021: 11 · 2020: 10 · 2019: 12 · 2018: 10 · 2017: 14 · 2016: 19 · 2015: 17 · 2014: 21 · 2013: 33 · 2012: 32
FWCI: 30.18
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: T cell progenitors, common lymphoid progenitors, thymus, macrophage differentiation, natural killer cells, dendritic cells, lineage restriction, clonal analysis, hematopoietic stem cells
MeSH terms: Aging, Animals, B-Lymphocytes, Cells, Cultured, Dendritic Cells, Fetus, Hematopoiesis, Hematopoietic Stem Cells, Killer Cells, Natural, Macrophages, Models, Biological, T-Lymphocytes, Thymus Gland, Stromal Cells, Coculture Techniques, Cell Lineage, Myeloid Cells, Mice

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Adult T-cell progenitors retain myeloid potential

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